AP2006003699A0 - Piperidinylcarbonyl-pyrrolidines and their use as melanocortin agonists - Google Patents

Piperidinylcarbonyl-pyrrolidines and their use as melanocortin agonists

Info

Publication number: AP2006003699A0
Authority: AP; ARIPO
Prior art keywords: piperidinylcarbonyl; pyrrolidines; melanocortin agonists; melanocortin; agonists
Prior art date: 2004-02-04

Application number

AP2006003699A

Other languages

English (en)

Inventor

David Sebastein Fradet

David Hepworth

Mark Lansdell

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-02-04

Filing date

2005-01-26

Publication date

2006-08-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34864830&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP2006003699(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-06-03 Priority claimed from GB0412417A external-priority patent/GB0412417D0/en

2004-11-19 Priority claimed from GB0425530A external-priority patent/GB0425530D0/en

2005-01-26 Application filed by Pfizer filed Critical Pfizer

2006-08-31 Publication of AP2006003699A0 publication Critical patent/AP2006003699A0/xx

Links

108010008364 Melanocortins Proteins 0.000 title 1
239000000556 agonist Substances 0.000 title 1
239000002865 melanocortin Substances 0.000 title 1
IOONOXRAIWLNPF-UHFFFAOYSA-N piperidin-1-yl(pyrrolidin-1-yl)methanone Chemical class C1CCCCN1C(=O)N1CCCC1 IOONOXRAIWLNPF-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Immunology (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Gynecology & Obstetrics (AREA)
Pain & Pain Management (AREA)
Gastroenterology & Hepatology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Addiction (AREA)
Pregnancy & Childbirth (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Child & Adolescent Psychology (AREA)
Cardiology (AREA)
Anesthesiology (AREA)
Emergency Medicine (AREA)

AP2006003699A 2004-02-04 2005-01-26 Piperidinylcarbonyl-pyrrolidines and their use as melanocortin agonists AP2006003699A0 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB0402492.3A GB0402492D0 (en)	2004-02-04	2004-02-04	Pharmaceutically active compounds
GB0412417A GB0412417D0 (en)	2004-06-03	2004-06-03	Pharmaceutically active compounds
GB0425530A GB0425530D0 (en)	2004-11-19	2004-11-19	Pharmaceutically active compounds
PCT/IB2005/000208 WO2005077935A1 (fr)	2004-02-04	2005-01-26	Piperidinylcarbonyl-pyrrolidines et leur utilisation en tant qu'agonistes de la melanocortine

Publications (1)

Publication Number	Publication Date
AP2006003699A0 true AP2006003699A0 (en)	2006-08-31

Family

ID=34864830

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2006003699A AP2006003699A0 (en)	2004-02-04	2005-01-26	Piperidinylcarbonyl-pyrrolidines and their use as melanocortin agonists

Country Status (25)

Country	Link
EP (1)	EP1716135B1 (fr)
JP (1)	JP4031814B2 (fr)
KR (1)	KR100830763B1 (fr)
CN (1)	CN1930146A (fr)
AP (1)	AP2006003699A0 (fr)
AR (1)	AR048232A1 (fr)
AT (1)	ATE511507T1 (fr)
AU (1)	AU2005213538A1 (fr)
BR (1)	BRPI0507435A (fr)
CA (1)	CA2555800C (fr)
CR (1)	CR8545A (fr)
EA (1)	EA011159B1 (fr)
EC (1)	ECSP066751A (fr)
GB (1)	GB0402492D0 (fr)
GE (1)	GEP20084361B (fr)
IL (1)	IL177004A0 (fr)
MA (1)	MA28348A1 (fr)
NL (1)	NL1028193C2 (fr)
NO (1)	NO20063944L (fr)
PA (1)	PA8623101A1 (fr)
PE (1)	PE20050772A1 (fr)
TW (1)	TWI300066B (fr)
UY (1)	UY28737A1 (fr)
WO (1)	WO2005077935A1 (fr)
ZA (1)	ZA200606236B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2617654A1 (fr) *	2005-08-04	2007-02-08	Pfizer Limited	Composes piperidinoyl-pyrrolidine et piperidinoyl-piperidine
KR20080048502A (ko) *	2005-09-29	2008-06-02	머크 앤드 캄파니 인코포레이티드	멜라노코르틴-4 수용체 조절제로서의 아실화스피로피페리딘 유도체
CA2625877A1 (fr) *	2005-10-18	2007-04-26	Merck & Co., Inc.	Derives de spiropiperidine acyles utilises en tant que modulateurs vis-a-vis du recepteur de melanocortine-4
CN101426782B (zh) *	2006-02-23	2012-10-31	辉瑞股份有限公司	黑皮质素4型受体激动剂哌啶羰基吡咯烷
AU2007219236B2 (en) *	2006-02-23	2012-06-21	Pfizer Limited	Melanocortin type 4 receptor agonist piperidinoylpyrrolidines
MY159910A (en)	2007-08-07	2017-02-15	Takeda Pharmaceuticals Co	Pyrrolidin-2-one derivatives as androgen receptor modulator
UA99555C2 (en)	2008-11-12	2012-08-27	Элджи Лайф Саенсез Лтд.	Melanocortin receptor agonists
US8476227B2 (en)	2010-01-22	2013-07-02	Ethicon Endo-Surgery, Inc.	Methods of activating a melanocortin-4 receptor pathway in obese subjects
US9044606B2 (en)	2010-01-22	2015-06-02	Ethicon Endo-Surgery, Inc.	Methods and devices for activating brown adipose tissue using electrical energy
PT3150578T (pt)	2014-05-29	2021-01-18	Mitsubishi Tanabe Pharma Corp	Novo composto de pirrolidina e aplicação como agonista do recetor de melanocortina
US10092738B2 (en)	2014-12-29	2018-10-09	Ethicon Llc	Methods and devices for inhibiting nerves when activating brown adipose tissue
US10080884B2 (en)	2014-12-29	2018-09-25	Ethicon Llc	Methods and devices for activating brown adipose tissue using electrical energy
PE20180690A1 (es)	2015-04-27	2018-04-23	Intercept Pharmaceuticals Inc	Composiciones de acido obeticolico y metodos de uso
PT3333165T (pt)	2015-08-04	2019-10-29	Astellas Pharma Inc	Derivado de piperazina
CN112694436B (zh) *	2020-12-30	2022-07-08	济南周行医药科技有限公司	一种槟榔碱的合成方法
CN117255786A (zh) *	2021-05-06	2023-12-19	株式会社Lg 化学	黑皮质素受体激动剂化合物的晶型vii及其制备方法
CN114211258B (zh) *	2021-11-04	2023-09-26	江阴市大久金属科技有限公司	高精密无缝钢管制备工艺
WO2026112237A1 (fr)	2024-11-21	2026-05-28	Astelza Therapeutics, Inc.	Isotopologues d'agoniste de mc4r et leurs utilisations

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE341327T1 (de) *	2001-02-28	2006-10-15	Merck & Co Inc	Acylierte piperidin-derivate als melanocortin-4- rezeptor-agonisten
CA2439152C (fr) *	2001-02-28	2008-06-17	Merck & Co., Inc.	Derives de piperidine acylee tels que les agonistes du recepteur 4 de la melanocortine

2004
- 2004-02-04 GB GBGB0402492.3A patent/GB0402492D0/en not_active Ceased
2005
- 2005-01-26 EP EP05702363A patent/EP1716135B1/fr not_active Expired - Lifetime
- 2005-01-26 AP AP2006003699A patent/AP2006003699A0/xx unknown
- 2005-01-26 EA EA200601279A patent/EA011159B1/ru not_active IP Right Cessation
- 2005-01-26 CA CA2555800A patent/CA2555800C/fr not_active Expired - Fee Related
- 2005-01-26 AU AU2005213538A patent/AU2005213538A1/en not_active Abandoned
- 2005-01-26 GE GEAP20059564A patent/GEP20084361B/en unknown
- 2005-01-26 CN CNA2005800075736A patent/CN1930146A/zh active Pending
- 2005-01-26 JP JP2006551945A patent/JP4031814B2/ja not_active Expired - Fee Related
- 2005-01-26 WO PCT/IB2005/000208 patent/WO2005077935A1/fr not_active Ceased
- 2005-01-26 KR KR1020067015811A patent/KR100830763B1/ko not_active Expired - Fee Related
- 2005-01-26 BR BRPI0507435-5A patent/BRPI0507435A/pt not_active IP Right Cessation
- 2005-01-26 AT AT05702363T patent/ATE511507T1/de not_active IP Right Cessation
- 2005-02-02 PE PE2005000122A patent/PE20050772A1/es not_active Application Discontinuation
- 2005-02-03 AR ARP050100409A patent/AR048232A1/es not_active Application Discontinuation
- 2005-02-03 TW TW094103372A patent/TWI300066B/zh active
- 2005-02-03 UY UY28737A patent/UY28737A1/es not_active Application Discontinuation
- 2005-02-04 NL NL1028193A patent/NL1028193C2/nl not_active IP Right Cessation
- 2005-02-04 PA PA20058623101A patent/PA8623101A1/es unknown
2006
- 2006-07-20 IL IL177004A patent/IL177004A0/en unknown
- 2006-07-27 ZA ZA200606236A patent/ZA200606236B/xx unknown
- 2006-08-03 CR CR8545A patent/CR8545A/es not_active Application Discontinuation
- 2006-08-03 EC EC2006006751A patent/ECSP066751A/es unknown
- 2006-08-04 MA MA29242A patent/MA28348A1/fr unknown
- 2006-09-04 NO NO20063944A patent/NO20063944L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
WO2005077935A1 (fr)	2005-08-25
AU2005213538A1 (en)	2005-08-25
PE20050772A1 (es)	2005-10-31
EP1716135B1 (fr)	2011-06-01
EP1716135A1 (fr)	2006-11-02
CN1930146A (zh)	2007-03-14
UY28737A1 (es)	2005-09-30
BRPI0507435A (pt)	2007-07-03
KR20060127125A (ko)	2006-12-11
IL177004A0 (en)	2006-12-10
TWI300066B (en)	2008-08-21
ZA200606236B (en)	2008-04-30
JP2007534668A (ja)	2007-11-29
NL1028193C2 (nl)	2006-04-20
EA011159B1 (ru)	2009-02-27
CA2555800C (fr)	2010-06-15
EA200601279A1 (ru)	2006-12-29
CA2555800A1 (fr)	2005-08-25
ATE511507T1 (de)	2011-06-15
MA28348A1 (fr)	2006-12-01
JP4031814B2 (ja)	2008-01-09
NL1028193A1 (nl)	2005-08-08
NO20063944L (no)	2006-10-31
GEP20084361B (en)	2008-04-29
AR048232A1 (es)	2006-04-12
ECSP066751A (es)	2006-11-16
CR8545A (es)	2007-09-03
PA8623101A1 (es)	2006-05-16
KR100830763B1 (ko)	2008-05-19
GB0402492D0 (en)	2004-03-10
TW200526625A (en)	2005-08-16

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IL181670A0 (en)	2007-07-04	Substituted phenylaminothiazoles and use thereof
EP1802588A4 (fr)	2010-02-17	Amino-pyrimidones substitues et utilisation de ceux-ci
IL189609A0 (en)	2008-06-05	4-substituted pyrrolidin-2-ones and their use
EP1951680A4 (fr)	2011-08-10	Nouveaux derives de 2-aminopyrimidinone et leur utilisation
GB0512940D0 (en)	2005-08-03	Compounds and their use
IL189252A0 (en)	2008-08-07	Dihydroxyanthraquinones and their use
ZA200606236B (en)	2008-04-30	Piperidinylcarbonyl-pyrrolidines and their use as melanocortin agonists
IL184062A0 (en)	2007-10-31	Visco-supplement composition and methods
EP1951682A4 (fr)	2011-06-15	Novequx 2-aminopyrimidinone ou derives de 2-aminopyridinone et leur utilisation
IL179497A0 (en)	2011-08-01	Carboranylporphyrins and uses thereof
GB0520743D0 (en)	2005-11-23	Compounds and their use
PL2215908T3 (pl)	2012-03-30	2-alkilo-cykloalk(en)ylo-karboksamidy i ich zastosowanie jako fungicydów
IL180365A0 (en)	2007-06-03	Carboranylporphyrins and uses thereof
ZA200706038B (en)	2008-12-31	Visco-supplement composition and methods
TWI366941B (en)	2012-06-21	Electrolyte containing oxocarbons and its use
GB0804899D0 (en)	2008-04-23	Compound composition and use
GB0608797D0 (en)	2006-06-14	Novel agents and the use thereof
EP1930406A4 (fr)	2009-05-06	Cellule migrant au cerveau et son utilisation
ZA200804378B (en)	2009-10-28	Iminopropene compound and use thereof
GB0503111D0 (en)	2005-03-23	Receptor agonists and their use
GB0502843D0 (en)	2005-03-16	Jig-was and jig-will
GB0513176D0 (en)	2005-08-03	Compounds and their use
GB0521278D0 (en)	2005-11-30	Compounds and their use