AP2228A - Tricyclic pyrazole derivatives as cannabinoid receptor modulators. - Google Patents

Tricyclic pyrazole derivatives as cannabinoid receptor modulators.

Info

Publication number: AP2228A
Authority: AP; ARIPO
Prior art keywords: receptor modulators; cannabinoid receptor; pyrazole derivatives; tricyclic pyrazole; tricyclic
Prior art date: 2004-07-12

Application number

AP2007003880A

Other languages

English (en)

Other versions

AP2007003880A0 (en

Inventor

Braj Lohray

Vidya Bhushan Lohray

Brijesh Srivastava

Original Assignee

Cadila Healthcare Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-07-12

Filing date

2005-07-08

Publication date

2011-04-01

2005-07-08 Application filed by Cadila Healthcare Ltd filed Critical Cadila Healthcare Ltd

2007-02-28 Publication of AP2007003880A0 publication Critical patent/AP2007003880A0/xx

2011-04-01 Application granted granted Critical

2011-04-01 Publication of AP2228A publication Critical patent/AP2228A/xx

Links

239000003520 cannabinoid receptor affecting agent Substances 0.000 title 1
150000003217 pyrazoles Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AP2007003880A 2004-07-12 2005-07-08 Tricyclic pyrazole derivatives as cannabinoid receptor modulators. AP2228A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IN745MU2004		2004-07-12
PCT/IN2005/000237 WO2006025069A2 (en)	2004-07-12	2005-07-08	Tricyclic pyrazole derivatives as cannabinoid receptor modulators

Publications (2)

Publication Number	Publication Date
AP2007003880A0 AP2007003880A0 (en)	2007-02-28
AP2228A true AP2228A (en)	2011-04-01

Family

ID=35636669

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2007003880A AP2228A (en)	2004-07-12	2005-07-08	Tricyclic pyrazole derivatives as cannabinoid receptor modulators.

Country Status (20)

Country	Link
US (2)	US8030345B2 (es)
EP (2)	EP2343302A1 (es)
JP (1)	JP2008505965A (es)
KR (1)	KR20070041717A (es)
CN (1)	CN101014605A (es)
AP (1)	AP2228A (es)
AU (1)	AU2005278781B2 (es)
BR (1)	BRPI0513104A (es)
CA (1)	CA2586011C (es)
EA (1)	EA011307B1 (es)
EC (1)	ECSP077167A (es)
GE (1)	GEP20094682B (es)
IL (1)	IL180637A0 (es)
MX (1)	MX2007000491A (es)
NO (1)	NO20070299L (es)
NZ (2)	NZ580387A (es)
TN (1)	TNSN07006A1 (es)
UA (1)	UA88910C2 (es)
WO (1)	WO2006025069A2 (es)
ZA (1)	ZA200700162B (es)

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* Cited by examiner, † Cited by third party
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CA2586011C (en) *	2004-07-12	2011-07-19	Cadila Healthcare Limited	Tricyclic pyrazole derivatives as cannabinoid receptor modulators
EP2470508A1 (en)	2009-08-28	2012-07-04	Arena Pharmaceuticals, Inc.	Cannabinoid receptor modulators
US9597340B2 (en)	2011-02-25	2017-03-21	Arena Pharmaceuticals, Inc.	Cannabinoid receptor modulators
MX392150B (es) *	2011-02-25	2025-03-21	Arena Pharm Inc	Moduladores de receptores canabinoides.
JP5945554B2 (ja)	2011-02-25	2016-07-05	アリーナファーマシューティカルズ，インコーポレイテッド	縮合型アザ環の結晶形およびその調製プロセス（カンナビノイド受容体モジュレーター）
US10351576B2 (en) *	2015-04-30	2019-07-16	Novartis Ag	Fused tricyclic pyrazole derivatives useful for farnesoid X receptors
WO2017123826A1 (en)	2016-01-14	2017-07-20	Beth Israel Deaconess Medical Center, Inc.	Mast-cell modulators and uses thereof
US20200078358A1 (en)	2017-05-08	2020-03-12	Arena Pharmaceuticals, Inc.	Compounds and Methods for Treatment of Visceral Pain
JP2021511364A (ja) *	2018-01-29	2021-05-06	カディラヘルスケアリミティド	抗菌剤として有用な複素環式化合物
CN121319008B (zh) *	2025-10-21	2026-07-31	江苏师范大学	一种作为小檗碱结构类似物的喹唑啉稠合苯并硫氮杂䓬四环化合物及其制备方法与其在制备治疗乳腺癌药物中的用途

Citations (2)

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WO2001032629A1 (fr) *	1999-11-03	2001-05-10	Sanofi-Synthelabo	Derives trycycliques d'acides 1-benzylpyrazole-3-carboxylique comme antagonistes des recepteurs de cannabinoides
WO2001032663A2 (fr) *	1999-11-03	2001-05-10	Sanofi-Synthelabo	Derives tricycliques d'acide pyrazolecarboxylique, leur preparation, les compositions pharmaceutiques en contenant

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EP0003115A1 (en) *	1978-01-16	1979-07-25	Sandoz Ag	Penicillins, per se and for use as antibacterially active antibiotics and their production
EP0122952B1 (en)	1983-04-22	1987-10-28	Mitsubishi Rayon Co., Ltd.	Apparatus for measuring gas partial pressure in living body
FR2692575B1 (fr)	1992-06-23	1995-06-30	Sanofi Elf	Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2713225B1 (fr)	1993-12-02	1996-03-01	Sanofi Sa	N-pipéridino-3-pyrazolecarboxamide substitué.
CA2106642C (en) *	1992-10-14	2005-08-16	Peter Bod	Carbazolone derivatives and process for preparing the same
FR2714057B1 (fr)	1993-12-17	1996-03-08	Sanofi Elf	Nouveaux dérivés du 3-pyrazolecarboxamide, procédé pour leur préparation et compositions pharmaceutiques les contenant.
US5547975A (en) *	1994-09-20	1996-08-20	Talley; John J.	Benzopyranopyrazolyl derivatives for the treatment of inflammation
FR2741621B1 (fr)	1995-11-23	1998-02-13	Sanofi Sa	Nouveaux derives de pyrazole, procede pour leur preparation et compositions pharmaceutiques en contenant
FR2742148B1 (fr)	1995-12-08	1999-10-22	Sanofi Sa	Nouveaux derives du pyrazole-3-carboxamide, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2758723B1 (fr)	1997-01-28	1999-04-23	Sanofi Sa	Utilisation des antagonistes des recepteurs aux cannabinoides centraux pour la preparation de medicaments
FR2761266B1 (fr)	1997-03-28	1999-07-02	Sanofi Sa	Composition pharmaceutique formee par granulation humide pour l'administration orale d'un derive du n-piperidino-3- pyrazolecarboxamide, de ses sels et de leurs solvates
FR2789079B3 (fr)	1999-02-01	2001-03-02	Sanofi Synthelabo	Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant
FR2804604B1 (fr)	2000-02-09	2005-05-27	Sanofi Synthelabo	Utilisation d'un antagoniste des recepteurs aux cannabinoides centraux pour la preparation de medicaments utiles pour faciliter l'arret de la consommation de tabac
FR2809621B1 (fr)	2000-05-12	2002-09-06	Sanofi Synthelabo	Utilisation d'un antagoniste des recepteurs aux cannabinoides centraux pour la preparation de medicaments utiles comme antidiarrheiques
FR2816938B1 (fr)	2000-11-22	2003-01-03	Sanofi Synthelabo	Derives de 3-aroylindole, leur procede de preparation et les compositions pharmaceutiques en contenant
JP2005507875A (ja)	2001-08-31	2005-03-24	ユニバーシティオブコネチカット	カンナビノイド受容体に作用する新規なピラゾール類似体
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TWI231757B (en)	2001-09-21	2005-05-01	Solvay Pharm Bv	1H-Imidazole derivatives having CB1 agonistic, CB1 partial agonistic or CB1-antagonistic activity
KR100950430B1 (ko)	2001-09-21	2010-04-02	솔베이 파마슈티칼스 비. 브이	효력있는 ｃｂ1-길항 작용을 가지는4,5-디하이드로-1ｈ-피라졸 유도체
US6509367B1 (en)	2001-09-22	2003-01-21	Virginia Commonwealth University	Pyrazole cannabinoid agonist and antagonists
CA2476665A1 (en) *	2002-02-19	2003-08-28	Pharmacia Corporation	Tricyclic pyrazole derivatives for the treatment of inflammation
ITMI20041033A1 (it) *	2004-05-24	2004-08-24	Neuroscienze S C A R L	Composti farmaceutici
CA2586011C (en) *	2004-07-12	2011-07-19	Cadila Healthcare Limited	Tricyclic pyrazole derivatives as cannabinoid receptor modulators

2005
- 2005-07-08 CA CA2586011A patent/CA2586011C/en not_active Expired - Fee Related
- 2005-07-08 NZ NZ580387A patent/NZ580387A/en not_active IP Right Cessation
- 2005-07-08 AU AU2005278781A patent/AU2005278781B2/en not_active Ceased
- 2005-07-08 UA UAA200700981A patent/UA88910C2/ru unknown
- 2005-07-08 CN CNA200580030114XA patent/CN101014605A/zh active Pending
- 2005-07-08 EP EP10182912A patent/EP2343302A1/en not_active Withdrawn
- 2005-07-08 NZ NZ552670A patent/NZ552670A/en not_active IP Right Cessation
- 2005-07-08 US US11/632,236 patent/US8030345B2/en not_active Expired - Fee Related
- 2005-07-08 AP AP2007003880A patent/AP2228A/xx active
- 2005-07-08 KR KR1020077000654A patent/KR20070041717A/ko not_active Ceased
- 2005-07-08 EA EA200700246A patent/EA011307B1/ru not_active IP Right Cessation
- 2005-07-08 MX MX2007000491A patent/MX2007000491A/es not_active Application Discontinuation
- 2005-07-08 JP JP2007520976A patent/JP2008505965A/ja not_active Withdrawn
- 2005-07-08 WO PCT/IN2005/000237 patent/WO2006025069A2/en not_active Ceased
- 2005-07-08 BR BRPI0513104-9A patent/BRPI0513104A/pt not_active IP Right Cessation
- 2005-07-08 GE GEAP20059851A patent/GEP20094682B/en unknown
- 2005-07-08 EP EP05815697A patent/EP1781668A2/en not_active Withdrawn
2007
- 2007-01-05 ZA ZA200700162A patent/ZA200700162B/xx unknown
- 2007-01-10 IL IL180637A patent/IL180637A0/en unknown
- 2007-01-11 TN TNP2007000006A patent/TNSN07006A1/en unknown
- 2007-01-12 EC EC2007007167A patent/ECSP077167A/es unknown
- 2007-01-17 NO NO20070299A patent/NO20070299L/no not_active Application Discontinuation
2010
- 2010-04-29 US US12/769,861 patent/US20100273791A1/en not_active Abandoned

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2001032629A1 (fr) *	1999-11-03	2001-05-10	Sanofi-Synthelabo	Derives trycycliques d'acides 1-benzylpyrazole-3-carboxylique comme antagonistes des recepteurs de cannabinoides
WO2001032663A2 (fr) *	1999-11-03	2001-05-10	Sanofi-Synthelabo	Derives tricycliques d'acide pyrazolecarboxylique, leur preparation, les compositions pharmaceutiques en contenant

Also Published As

Publication number	Publication date
EP1781668A2 (en)	2007-05-09
KR20070041717A (ko)	2007-04-19
JP2008505965A (ja)	2008-02-28
WO2006025069A2 (en)	2006-03-09
US20100273791A1 (en)	2010-10-28
US20080051386A1 (en)	2008-02-28
AP2007003880A0 (en)	2007-02-28
AU2005278781A1 (en)	2006-03-09
CA2586011C (en)	2011-07-19
WO2006025069A3 (en)	2006-04-27
CN101014605A (zh)	2007-08-08
IL180637A0 (en)	2007-06-03
MX2007000491A (es)	2007-03-28
ZA200700162B (en)	2009-09-30
EA011307B1 (ru)	2009-02-27
BRPI0513104A (pt)	2008-04-29
AU2005278781B2 (en)	2009-06-18
UA88910C2 (ru)	2009-12-10
TNSN07006A1 (en)	2008-06-02
EP2343302A1 (en)	2011-07-13
ECSP077167A (es)	2007-05-30
US8030345B2 (en)	2011-10-04
CA2586011A1 (en)	2006-03-09
NZ580387A (en)	2011-06-30
NO20070299L (no)	2007-03-26
NZ552670A (en)	2010-02-26
WO2006025069A8 (en)	2007-03-15
EA200700246A1 (ru)	2007-08-31
GEP20094682B (en)	2009-05-10

Publication	Publication Date	Title
EP1670460A4 (en)	2008-09-03	PYRAZOLE DERIVATIVES AS MODULATORS OF THE CANNABINOID RECEPTOR
IL180637A0 (en)	2007-06-03	Tricyclic pyrazole derivatives as cannabinoid receptor modulators
EP1644335A4 (en)	2008-06-04	TETRAHYDROQUINOLINE DERIVATIVES COMPRISING MODULATORS OF CANNABINOID RECEPTORS
IL178290A0 (en)	2006-12-31	Tetrahydro-indazole cannabinoid modulators
ZA200604645B (en)	2007-11-28	Azabicyclic heterocycles as cannabinoid receptor modulators
ZA200700684B (en)	2008-10-29	Tricyclic indeno-pyrrole derivatives as serotonin receptor modulators
IL190349A0 (en)	2009-09-22	Tetrahydro-indazolyl cannabinoid modulators
ZA201004939B (en)	2012-12-27	Aminopyrazole derivatives
ZA200510304B (en)	2007-04-25	Cannabinoid receptor modulator
AU2008334489A1 (en)	2009-06-18	Cannabinoid receptor modulators
IL191936A0 (en)	2008-12-29	4,5-dihydro-(1h)-pyrazole derivatives as cannabinoid cb1 receptor modulators
IL190278A0 (en)	2009-09-22	Tetrahydro-cyclopentyl pyrazole cannabinoid modulators
IL188388A0 (en)	2008-04-13	Pyrazole derivatives as cb1 modulators
ZA200805405B (en)	2009-11-25	Substituted 5-heteroaryl-1-phenyl-pyrazole cannabinoid modulators
PL2094684T3 (pl)	2011-05-31	1,5-difenylo-3-benzyloamino-1,5-dihydropirolidyn-2-ony jako modulatory receptora CB1
ZA200609234B (en)	2008-08-27	Substituted azeplne derivatives as serotonin receptor modulators
IL180044A0 (en)	2007-05-15	Pyrazole derivatives
ZA200706351B (en)	2008-09-25	1H-imidazole derivatives as cannabinoid CB2 receptor modulators
IL188924A0 (en)	2008-08-07	Imidazopyridine derivatives as cannabinoid receptor ligands
GB0622569D0 (en)	2006-12-20	Cannabinoid receptor modulators
ZA200804926B (en)	2009-04-29	4,5-Dihydro-(1H)-Pyrazole derivatives as cannabinoid CB1 receptor modulators
IL200953A0 (en)	2010-05-17	Hexahydro-cyclooctyl pyrazole cannabinoid modulators
ZA200800354B (en)	2008-12-31	Imidazopyridine derivatives as cannabinoid receptor ligands
GB0625197D0 (en)	2007-01-24	Cannabinoid receptor modulators
HK1111349A (en)	2008-08-08	Tricyclic indeno-pyrrole derivatives as serotonin receptor modulators