AP3286A - Glucagon analogues - Google Patents

Glucagon analogues

Info

Publication number: AP3286A
Authority: AP; ARIPO
Prior art keywords: glucagon analogues; glucagon; analogues
Prior art date: 2010-06-23

Application number

AP2013006669A

Other languages

English (en)

Other versions

AP2013006669A0 (en

Inventor

Eddi Meier

Ditte Riber

Jens Rosengren Daugaard

Original Assignee

Zealand Pharma As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-06-23

Filing date

2011-06-23

Publication date

2015-05-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44630045&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP3286(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2011-06-23 Application filed by Zealand Pharma As filed Critical Zealand Pharma As

2013-01-31 Publication of AP2013006669A0 publication Critical patent/AP2013006669A0/xx

2015-05-31 Application granted granted Critical

2015-05-31 Publication of AP3286A publication Critical patent/AP3286A/xx

Links

MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical class C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Epidemiology (AREA)
Biophysics (AREA)
Toxicology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Cardiology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Obesity (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Child & Adolescent Psychology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AP2013006669A 2010-06-23 2011-06-23 Glucagon analogues AP3286A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DKPA201000550		2010-06-23
US35862310P	2010-06-25	2010-06-25
PCT/DK2011/000067 WO2011160630A2 (en)	2010-06-23	2011-06-23	Glucagon analogues

Publications (2)

Publication Number	Publication Date
AP2013006669A0 AP2013006669A0 (en)	2013-01-31
AP3286A true AP3286A (en)	2015-05-31

Family

ID=44630045

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2013006669A AP3286A (en)	2010-06-23	2011-06-23	Glucagon analogues

Country Status (23)

Country	Link
US (2)	US9403894B2 (xx)
EP (1)	EP2585481B1 (xx)
JP (1)	JP5937582B2 (xx)
KR (1)	KR20130086339A (xx)
CN (1)	CN103038250A (xx)
AP (1)	AP3286A (xx)
AR (1)	AR081975A1 (xx)
AU (1)	AU2011269427A1 (xx)
BR (1)	BR112012033227A2 (xx)
CA (1)	CA2802889A1 (xx)
CL (1)	CL2012003643A1 (xx)
CO (1)	CO6660484A2 (xx)
EA (1)	EA201291233A1 (xx)
EC (1)	ECSP12012351A (xx)
MX (1)	MX2012014774A (xx)
NZ (1)	NZ604033A (xx)
PE (1)	PE20130326A1 (xx)
PH (1)	PH12012502461A1 (xx)
SG (1)	SG186276A1 (xx)
TN (1)	TN2012000567A1 (xx)
TW (1)	TW201202265A (xx)
UY (1)	UY33462A (xx)
WO (1)	WO2011160630A2 (xx)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX2007013431A (es)	2005-05-04	2008-01-18	Zealand Pharma As	Analogos del peptido 2 semejante al glucagon.
AU2007319066B2 (en)	2006-11-08	2013-09-19	Zealand Pharma A/S	Selective glucagon-like-peptide-2 (GLP-2) analogues
PL2370462T3 (pl)	2008-12-15	2015-01-30	Zealand Pharma As	Analogi glukagonu
AU2008365557A1 (en)	2008-12-15	2011-07-21	Zealand Pharma A/S	Glucagon analogues
EA020537B1 (ru)	2008-12-15	2014-11-28	Зилэнд Фарма А/С	Аналоги глюкагона
MX2011006314A (es)	2008-12-15	2011-09-22	Zealand Pharma As	Analogos de glucagon.
AP3329A (en)	2009-07-13	2015-06-30	Zealand Pharma As	Acylated glucagon analogues
UY33462A (es)	2010-06-23	2012-01-31	Zealand Pharma As	Analogos de glucagon
KR20130086343A (ko)	2010-06-24	2013-08-01	질랜드 파마 에이/에스	글루카곤 유사체
SG192038A1 (en) *	2011-01-20	2013-08-30	Zealand Pharma As	Combination of acylated glucagon analogues with insulin analogues
MY167234A (en)	2011-09-23	2018-08-14	Novo Nordisk As	Novel glucagon analogues
KR20140114845A (ko) *	2011-12-23	2014-09-29	질랜드 파마 에이/에스	글루카곤 유사체
TR201802689T4 (tr) *	2012-05-03	2018-03-21	Zealand Pharma As	Glukagon benzeri peptit-2 (glp-2) analogları.
NZ702333A (en)	2012-05-03	2017-06-30	Zealand Pharma As	Gip-glp-1 dual agonist compounds and methods
SG11201407860PA (en)	2012-06-14	2014-12-30	Sanofi Sa	Exendin-4 peptide analogues
MX356957B (es)	2012-07-23	2018-06-20	Zealand Pharma As	Analogos del glucagon.
US9546205B2 (en)	2012-09-17	2017-01-17	Imperial Innovations Limited	Peptide analogues of glucagon and GLP1
GB2505941A (en) *	2012-09-17	2014-03-19	Imp Innovations Ltd	Peptide analogues of glucagon for the treatment of obesity and diabetes
TWI608013B (zh)	2012-09-17	2017-12-11	西蘭製藥公司	升糖素類似物
UA116217C2 (uk) *	2012-10-09	2018-02-26	Санофі	Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
JP2016506401A (ja)	2012-12-21	2016-03-03	サノフイ	二重ｇｌｐ１／ｇｉｐまたは三方ｇｌｐ１／ｇｉｐ／グルカゴンアゴニストとしてのエキセンジン−４誘導体
CN105102427B (zh)	2013-03-21	2018-09-07	赛诺菲-安万特德国有限公司	含有环状酰亚胺的肽产物的合成
HUE034308T2 (en)	2013-03-21	2018-02-28	Sanofi Aventis Deutschland	Preparation of hydantoin-containing peptide products
AR095986A1 (es)	2013-04-03	2015-11-25	Sanofi Sa	Proteínas modificadas que regulan glucosa en sangre con perfil alterado de actividad farmacológica y preparación de las mismas
MY174727A (en)	2013-04-18	2020-05-11	Novo Nordisk As	Stable, protracted glp-1/glucagon receptor co-agonists for medical use
US9988429B2 (en)	2013-10-17	2018-06-05	Zealand Pharma A/S	Glucagon analogues
LT3057984T (lt)	2013-10-17	2018-12-27	Zealand Pharma A/S	Acilinti gliukagono analogai
AU2014345569B2 (en)	2013-11-06	2020-08-13	Zealand Pharma A/S	GIP-GLP-1 dual agonist compounds and methods
KR102310392B1 (ko)	2013-11-06	2021-10-13	질랜드 파마 에이/에스	글루카곤-ｇｌｐ-1-ｇｉｐ 삼원 효능제 화합물
TW201609799A (zh)	2013-12-13	2016-03-16	賽諾菲公司	雙重ｇｌｐ－１／ｇｉｐ受體促效劑
TW201609796A (zh)	2013-12-13	2016-03-16	賽諾菲公司	非醯化之艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物
EP3080150B1 (en)	2013-12-13	2018-08-01	Sanofi	Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
WO2015086731A1 (en)	2013-12-13	2015-06-18	Sanofi	Exendin-4 peptide analogues as dual glp-1/glucagon receptor agonists
WO2015086733A1 (en)	2013-12-13	2015-06-18	Sanofi	Dual glp-1/glucagon receptor agonists
TW201625668A (zh)	2014-04-07	2016-07-16	賽諾菲公司	作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物
TW201625669A (zh)	2014-04-07	2016-07-16	賽諾菲公司	衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑
TW201625670A (zh)	2014-04-07	2016-07-16	賽諾菲公司	衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑
US10570184B2 (en)	2014-06-04	2020-02-25	Novo Nordisk A/S	GLP-1/glucagon receptor co-agonists for medical use
US9932381B2 (en)	2014-06-18	2018-04-03	Sanofi	Exendin-4 derivatives as selective glucagon receptor agonists
RU2716985C2 (ru)	2014-10-29	2020-03-17	Зилэнд Фарма А/С	Соединения-агонисты gip и способы
TN2017000349A1 (en)	2015-02-17	2019-01-16	Lilly Co Eli	Nasal powder formulation for treatment of hypoglycemia
EA035791B1 (ru)	2015-03-18	2020-08-11	Зилэнд Фарма А/С	Аналоги амилина
WO2016168388A2 (en)	2015-04-14	2016-10-20	Palatin Technologies, Inc.	Therapies for obesity, diabetes and related indications
JP6989385B2 (ja)	2015-04-16	2022-01-05	ジーランドファーマアクティーゼルスカブ	アシル化グルカゴン類似体
AR105319A1 (es)	2015-06-05	2017-09-27	Sanofi Sa	Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
WO2016198628A1 (en)	2015-06-12	2016-12-15	Sanofi	Non-acylated exendin-4 derivatives as dual glp-1/glucagon receptor agonists
WO2016198624A1 (en)	2015-06-12	2016-12-15	Sanofi	Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists
TW201706291A (zh)	2015-07-10	2017-02-16	賽諾菲公司	作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物
EP3888667B1 (en)	2016-06-09	2023-10-25	AmideBio LLC	Glucagon analog and methods of use thereof
RS61937B1 (sr)	2016-08-05	2021-07-30	Boehringer Ingelheim Int	Oksadiazolopiridin derivati za primenu kao inhibitori grelin o-acil transferaze (goat)
AR109514A1 (es)	2016-09-09	2018-12-19	Zealand Pharma As	Análogos de amilina
KR101887577B1 (ko) *	2016-10-19	2018-09-10	(주)케어젠	항비만 및 항당뇨 효능을 갖는 펩타이드 및 이의 용도
TW201832783A (zh)	2016-12-02	2018-09-16	法商賽諾菲公司	包含ｇｌｐ－１／胰高血糖素雙重激動劑、連接子和透明質酸的接合物
SG10201911851VA (en)	2016-12-09	2020-02-27	Zealand Pharma As	Acylated glp-1/glp-2 dual agonists
ES2894629T3 (es)	2017-06-16	2022-02-15	Zealand Pharma As	Pautas posológicas para la administración de análogos del péptido 2 similar al glucagón (GLP-2)
SMT202400097T1 (it) *	2017-08-16	2024-05-14	Dong A St Co Ltd	Analogo peptidico acilato dell'ossitomodulina
JOP20200187A1 (ar)	2018-02-02	2020-07-29	Boehringer Ingelheim Int	مشتقات ترايازولو بيريميدين للاستخدام كمثبطات جريلين o- أسيل ترانسفيراز (goat)
CN111630055B (zh)	2018-02-02	2023-07-14	勃林格殷格翰国际有限公司	用作饥饿素o-酰基转移酶(goat)抑制剂的吡唑取代的和吲唑取代的噁二唑并吡啶衍生物
MX2020008116A (es)	2018-02-02	2020-09-25	Boehringer Ingelheim Int	Derivados de oxadiazolopiridina sustituidos con heterociclilo para usar como inhibidores de ghrelin o-aciltransferasa (goat).
CN111655700B (zh)	2018-02-02	2023-07-18	勃林格殷格翰国际有限公司	作为饥饿素o-酰基转移酶(goat)抑制剂的噁二唑并吡啶衍生物
CN112543763B (zh) *	2018-04-10	2024-11-05	赛诺菲-安万特德国有限公司	从固相裂解固相结合肽的方法
ES2928207T5 (en)	2018-04-10	2026-02-16	Sanofi Aventis Deutschland	Lixisenatide synthesis with capping
CA3123979A1 (en)	2018-12-21	2020-06-25	Jiangsu Hengrui Medicine Co., Ltd.	Bispecific protein
TWI771669B (zh)	2019-04-26	2022-07-21	美商美國禮來大藥廠	製備穩定胜肽調配物之方法
CN115380043A (zh) *	2019-08-13	2022-11-22	安医健有限公司	艾塞那肽类似物及其用途
MX2022005661A (es)	2019-11-11	2022-09-07	Boehringer Ingelheim Int	Agonistas del receptor npy2.
EP4153599B1 (en)	2020-05-22	2024-03-13	Boehringer Ingelheim International GmbH	Process for manufacturing alkyl 7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridine-carboxylate
PL4153600T3 (pl)	2020-05-22	2024-12-16	Boehringer Ingelheim International Gmbh	Sposób ciągły wytwarzania 7-amino-5-metylo-[1,2,5]oksadiazolo[3,4- b]pirydynokarboksylanu alkilu
CN113278060B (zh) *	2020-05-29	2022-03-25	东莞云璟生物技术有限公司	Glp-1/胰高血糖素双重激动剂融合蛋白
UA130066C2 (uk)	2020-08-07	2025-10-29	Бьорінгер Інгельхайм Інтернаціональ Гмбх	Розчинні агоністи рецепторів npy2
MX2024005969A (es)	2022-05-30	2024-06-11	Zealand Pharma As	Formulaciones liquidas de analogos de amilina.
WO2024165571A2 (en)	2023-02-06	2024-08-15	E-Therapeutics Plc	Inhibitors of expression and/or function
WO2025125576A2 (en)	2023-12-15	2025-06-19	E-Therapeutics Plc	Inhibitors of expression and/or function
WO2025133348A1 (en)	2023-12-22	2025-06-26	E-Therapeutics Plc	Inhibitors of expression and/or function
EP4686757A1 (en)	2024-07-31	2026-02-04	e-therapeutics PLC	Inhibitors of expression and/or function
WO2025196502A1 (en)	2024-03-20	2025-09-25	North Carolina Agricultural & Technical State University	Choline kinase inhibitors as a therapeutic treatment for obesity

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2008152403A1 (en) *	2007-06-15	2008-12-18	Zealand Pharma A/S	Glucagon analogues
WO2010070255A1 (en) *	2008-12-15	2010-06-24	Zealand Pharma A/S	Glucagon analogues
WO2011088837A1 (en) *	2010-01-20	2011-07-28	Zealand Pharma A/S	Treatment of cardiac conditions

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ202757A (en)	1981-12-23	1985-11-08	Novo Industri As	Peptides and medicaments
JP3149958B2 (ja)	1996-08-30	2001-03-26	ノボノルディスクアクティーゼルスカブ	Ｇｌｐ―１誘導体
EP0932614A1 (en)	1996-09-09	1999-08-04	Zealand Pharmaceuticals A/S	Peptide prodrugs containing an alpha-hydroxyacid linker
CZ295838B6 (cs)	1996-09-09	2005-11-16	Zealand Pharma A/S	Způsob výroby peptidů
JP2003522721A (ja)	1997-11-14	2003-07-29	アミリン・ファーマシューティカルズ，インコーポレイテッド	新規なエキセンジンアゴニスト化合物
AU757658B2 (en)	1998-03-09	2003-02-27	Zealand Pharma A/S	Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
WO2000034331A2 (en)	1998-12-07	2000-06-15	Societe De Conseils De Recherches Et D'applications Scientifiques Sas	Analogues of glp-1
US6451987B1 (en)	1999-03-15	2002-09-17	Novo Nordisk A/S	Ion exchange chromatography of proteins and peptides
HUP0200297A3 (en)	1999-03-17	2002-09-30	Novo Nordisk As	Method for acylating peptides and the glutaminic acid derivatives as acylating agents
EP1076066A1 (en)	1999-07-12	2001-02-14	Zealand Pharmaceuticals A/S	Peptides for lowering blood glucose levels
GB0121709D0 (en)	2001-09-07	2001-10-31	Imp College Innovations Ltd	Food inhibition agent
AU2002346491A1 (en)	2001-12-19	2003-07-09	Eli Lilly And Company	Crystalline compositions for controlling blood glucose
CZ2004710A3 (cs)	2001-12-20	2005-02-16	Eli Lilly And Company	Inzulínová sloučenina s protrahovaným účinkem
GB0300571D0 (en)	2003-01-10	2003-02-12	Imp College Innovations Ltd	Modification of feeding behaviour
US20060217290A1 (en)	2003-04-29	2006-09-28	Kohn Wayne D	Insulin analogs having protracted time action
CA2612063A1 (en)	2005-06-13	2006-12-21	Imperial Innovations Limited	Oxyntomodulin analogues and their effects on feeding behaviour
US20090202497A1 (en)	2005-08-23	2009-08-13	The General Hospital Corporation	Use of glp-1, glp-1 derivatives or glp-1 fragments for skin regeneration, stimulation of hair growth, or treatment of diabetes
CA2628241C (en)	2005-11-07	2016-02-02	Indiana University Research And Technology Corporation	Glucagon analogs exhibiting physiological solubility and stability
WO2007081824A2 (en)	2006-01-06	2007-07-19	Case Western Reserve University	Fibrillation resistant proteins
EP2471810A1 (en)	2006-02-22	2012-07-04	Merck Sharp & Dohme Corporation	Oxyntomodulin derivatives
EA020324B1 (ru)	2006-07-18	2014-10-30	Санофи-Авентис	АНТИТЕЛА К РЕЦЕПТОРУ ЭФРИНА EphA2 И ИХ ПРИМЕНЕНИЕ
WO2008043033A2 (en)	2006-10-04	2008-04-10	Case Western Reserve University	Fibrillation-resistant insulin and insulin analogues
TWI428346B (zh)	2006-12-13	2014-03-01	Imp Innovations Ltd	新穎化合物及其等對進食行為影響
MX2009008241A (es)	2007-02-15	2009-10-08	Univ Indiana Res & Tech Corp	Co-agonistas de receptor de glucagon/glp-1.
EP2025684A1 (en)	2007-08-15	2009-02-18	Zealand Pharma A/S	Glucagon analogues
ES2632504T3 (es)	2007-11-20	2017-09-13	Ambrx, Inc.	Polipéptidos de insulina modificados y sus usos
AU2009203809B2 (en)	2008-01-09	2013-07-25	Sanofi-Aventis Deutschland Gmbh	Novel insulin derivatives having an extremely delayed time-action profile
DE102008003566A1 (de)	2008-01-09	2009-07-16	Sanofi-Aventis Deutschland Gmbh	Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE102008003568A1 (de)	2008-01-09	2009-07-16	Sanofi-Aventis Deutschland Gmbh	Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
BRPI0907119A2 (pt)	2008-01-09	2015-07-14	Sanofi Aventis Deutschland	Derivados de insulina tendo um perfil de ação de tempo extremamente retardado
US8993516B2 (en)	2008-04-14	2015-03-31	Case Western Reserve University	Meal-time insulin analogues of enhanced stability
WO2009132129A2 (en)	2008-04-22	2009-10-29	Case Western Reserve University	Isoform-specific insulin analogues
TWI451876B (zh)	2008-06-13	2014-09-11	Lilly Co Eli	聚乙二醇化之離脯胰島素化合物
EP2300037B1 (en)	2008-06-17	2016-03-30	Indiana University Research and Technology Corporation	Glucagon/glp-1 receptor co-agonists
TWI541023B (zh)	2008-06-17	2016-07-11	印第安納大學科技研究公司	在生理ｐｈ緩衝液中呈現增強之溶解度及穩定性之升糖激素類似物
PL219335B1 (pl)	2008-07-04	2015-04-30	Inst Biotechnologii I Antybiotyków	Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna
ES2552636T3 (es)	2008-07-31	2015-12-01	Case Western Reserve University	Insulina estabilizada por halógenos
AU2008365557A1 (en)	2008-12-15	2011-07-21	Zealand Pharma A/S	Glucagon analogues
EA020537B1 (ru)	2008-12-15	2014-11-28	Зилэнд Фарма А/С	Аналоги глюкагона
MX2011006314A (es)	2008-12-15	2011-09-22	Zealand Pharma As	Analogos de glucagon.
JP5789515B2 (ja)	2008-12-19	2015-10-07	インディアナユニバーシティーリサーチアンドテクノロジーコーポレーションＩｎｄｉａｎａＵｎｉｖｅｒｓｉｔｙＲｅｓｅａｒｃｈＡｎｄＴｅｃｈｎｏｌｏｇｙＣｏｒｐｏｒａｔｉｏｎ	インスリン類似体
CN102245624B (zh)	2008-12-19	2016-08-10	印第安纳大学研究及科技有限公司	基于酰胺的胰岛素前药
CN101519446A (zh)	2009-03-31	2009-09-02	上海一就生物医药有限公司	一种重组人胰岛素及其类似物的制备方法
AP3329A (en)	2009-07-13	2015-06-30	Zealand Pharma As	Acylated glucagon analogues
UY33462A (es)	2010-06-23	2012-01-31	Zealand Pharma As	Analogos de glucagon
KR20130086343A (ko)	2010-06-24	2013-08-01	질랜드 파마 에이/에스	글루카곤 유사체
SG192038A1 (en)	2011-01-20	2013-08-30	Zealand Pharma As	Combination of acylated glucagon analogues with insulin analogues
KR20140114845A (ko)	2011-12-23	2014-09-29	질랜드 파마 에이/에스	글루카곤 유사체
TWI608013B (zh)	2012-09-17	2017-12-11	西蘭製藥公司	升糖素類似物
LT3057984T (lt)	2013-10-17	2018-12-27	Zealand Pharma A/S	Acilinti gliukagono analogai
US9988429B2 (en)	2013-10-17	2018-06-05	Zealand Pharma A/S	Glucagon analogues

2011
- 2011-06-22 UY UY0001033462A patent/UY33462A/es not_active Application Discontinuation
- 2011-06-22 AR ARP110102166A patent/AR081975A1/es unknown
- 2011-06-23 PH PH1/2012/502461A patent/PH12012502461A1/en unknown
- 2011-06-23 CA CA2802889A patent/CA2802889A1/en not_active Abandoned
- 2011-06-23 EP EP11741513.3A patent/EP2585481B1/en active Active
- 2011-06-23 PE PE2012002434A patent/PE20130326A1/es not_active Application Discontinuation
- 2011-06-23 TW TW100122081A patent/TW201202265A/zh unknown
- 2011-06-23 EA EA201291233A patent/EA201291233A1/ru unknown
- 2011-06-23 NZ NZ604033A patent/NZ604033A/en not_active IP Right Cessation
- 2011-06-23 AP AP2013006669A patent/AP3286A/xx active
- 2011-06-23 JP JP2013515697A patent/JP5937582B2/ja not_active Expired - Fee Related
- 2011-06-23 US US13/702,841 patent/US9403894B2/en not_active Expired - Fee Related
- 2011-06-23 KR KR1020137000529A patent/KR20130086339A/ko not_active Withdrawn
- 2011-06-23 BR BR112012033227A patent/BR112012033227A2/pt not_active IP Right Cessation
- 2011-06-23 WO PCT/DK2011/000067 patent/WO2011160630A2/en not_active Ceased
- 2011-06-23 SG SG2012090890A patent/SG186276A1/en unknown
- 2011-06-23 AU AU2011269427A patent/AU2011269427A1/en not_active Abandoned
- 2011-06-23 MX MX2012014774A patent/MX2012014774A/es not_active Application Discontinuation
- 2011-06-23 CN CN2011800305150A patent/CN103038250A/zh active Pending
2012
- 2012-11-30 TN TNP2012000567A patent/TN2012000567A1/en unknown
- 2012-12-20 EC ECSP12012351 patent/ECSP12012351A/es unknown
- 2012-12-21 CL CL2012003643A patent/CL2012003643A1/es unknown
- 2012-12-21 CO CO12232550A patent/CO6660484A2/es unknown
2016
- 2016-06-27 US US15/194,025 patent/US20160304576A1/en not_active Abandoned

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2008152403A1 (en) *	2007-06-15	2008-12-18	Zealand Pharma A/S	Glucagon analogues
WO2010070255A1 (en) *	2008-12-15	2010-06-24	Zealand Pharma A/S	Glucagon analogues
WO2011088837A1 (en) *	2010-01-20	2011-07-28	Zealand Pharma A/S	Treatment of cardiac conditions

Also Published As

Publication number	Publication date
US9403894B2 (en)	2016-08-02
JP5937582B2 (ja)	2016-06-22
UY33462A (es)	2012-01-31
SG186276A1 (en)	2013-01-30
AU2011269427A1 (en)	2012-12-20
US20130157935A1 (en)	2013-06-20
CO6660484A2 (es)	2013-04-30
PE20130326A1 (es)	2013-03-17
WO2011160630A3 (en)	2012-02-16
US20160304576A1 (en)	2016-10-20
CL2012003643A1 (es)	2013-08-02
EA201291233A1 (ru)	2013-07-30
AP2013006669A0 (en)	2013-01-31
NZ604033A (en)	2014-12-24
WO2011160630A2 (en)	2011-12-29
TW201202265A (en)	2012-01-16
ECSP12012351A (es)	2013-01-31
MX2012014774A (es)	2013-01-29
JP2013534919A (ja)	2013-09-09
KR20130086339A (ko)	2013-08-01
CA2802889A1 (en)	2011-12-29
EP2585481B1 (en)	2015-08-19
BR112012033227A2 (pt)	2017-06-20
PH12012502461A1 (en)	2013-02-18
AR081975A1 (es)	2012-10-31
EP2585481A2 (en)	2013-05-01
TN2012000567A1 (en)	2014-04-01
CN103038250A (zh)	2013-04-10

Publication	Publication Date	Title
AP2013006669A0 (en)	2013-01-31	Glucagon analogues
AP2013006671A0 (en)	2013-01-31	Glucagon analogues
ZA201206838B (en)	2013-06-26	Novel glucagon analogues
IL232800A0 (en)	2014-07-31	Glucagon analog
ZA201702364B (en)	2019-05-29	Glucagon analogues
IL231199A0 (en)	2014-04-30	New analogs of glucagon
IL237518A0 (en)	2015-04-30	Glucagon analog
ZA201306514B (en)	2014-05-28	Novel glucagon analogues
ZA201104592B (en)	2013-11-27	Glucagon analogues
IL213478A0 (en)	2011-07-31	Glucagon analogues
IL213477A0 (en)	2011-07-31	Glucagon analogues
ZA201104591B (en)	2014-11-26	Glucagon analogues
SG10201606027VA (en)	2016-09-29	Scaffolding
EP2576612A4 (en)	2014-07-09	INSULIN ANALOG
GB2479441B (en)	2017-08-23	Coelenterazine analogues
GB201018245D0 (en)	2010-12-15	Platform slot recovery
HUP1100726A2 (en)	2012-09-28	Component
GB201004491D0 (en)	2010-05-05	Quinazoline analogues
GB201116856D0 (en)	2011-11-09	Schraubspindellagerung
HK1177622A (en)	2013-08-23	Glucagon analogues
HK1177621A (en)	2013-08-23	Glucagon analogues
GB201018136D0 (en)	2010-12-08	Project
AU337827S (en)	2011-07-26	Ladder
ZA201109183B (en)	2012-08-29	Prop