AP3346A - Novel compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same - Google Patents

Novel compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same

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Publication number
AP3346A
AP3346A AP2012006191A AP2012006191A AP3346A AP 3346 A AP3346 A AP 3346A AP 2012006191 A AP2012006191 A AP 2012006191A AP 2012006191 A AP2012006191 A AP 2012006191A AP 3346 A AP3346 A AP 3346A
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AP
ARIPO
Prior art keywords
same
preparing
pharmaceutical composition
composition containing
novel compounds
Prior art date
Application number
AP2012006191A
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English (en)
Other versions
AP2012006191A0 (en
Inventor
Tae Hun Kim
Eun Sil Choi
Heui Sul Park
Original Assignee
Lg Life Sciences Ltd
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43857261&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP3346(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lg Life Sciences Ltd filed Critical Lg Life Sciences Ltd
Publication of AP2012006191A0 publication Critical patent/AP2012006191A0/xx
Application granted granted Critical
Publication of AP3346A publication Critical patent/AP3346A/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AP2012006191A 2009-10-07 2010-10-04 Novel compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same AP3346A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20090095363 2009-10-07
PCT/KR2010/006760 WO2011043568A2 (fr) 2009-10-07 2010-10-04 Nouveaux composés efficaces comme inhibiteurs de la xanthine oxydase, leur procédé de préparation et composition pharmaceutique les contenant

Publications (2)

Publication Number Publication Date
AP2012006191A0 AP2012006191A0 (en) 2012-04-30
AP3346A true AP3346A (en) 2015-07-31

Family

ID=43857261

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2012006191A AP3346A (en) 2009-10-07 2010-10-04 Novel compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same

Country Status (26)

Country Link
US (1) US8729273B2 (fr)
EP (1) EP2467378B1 (fr)
JP (1) JP5702392B2 (fr)
KR (1) KR101751325B1 (fr)
CN (1) CN102574839B (fr)
AP (1) AP3346A (fr)
AR (1) AR078504A1 (fr)
AU (1) AU2010304091B2 (fr)
BR (1) BR112012007828B8 (fr)
CA (1) CA2774133C (fr)
CL (1) CL2012000738A1 (fr)
CO (1) CO6430501A2 (fr)
EA (1) EA021025B1 (fr)
EC (1) ECSP12011793A (fr)
ES (1) ES2599829T3 (fr)
IL (1) IL218669A (fr)
MA (1) MA33880B1 (fr)
MX (1) MX2012003782A (fr)
MY (1) MY162813A (fr)
PE (1) PE20121088A1 (fr)
SG (1) SG179186A1 (fr)
TR (1) TR201203989T1 (fr)
TW (1) TWI423962B (fr)
UA (1) UA110197C2 (fr)
WO (1) WO2011043568A2 (fr)
ZA (1) ZA201202544B (fr)

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KR20260008164A (ko) 2016-12-02 2026-01-15 바이오버라티브 테라퓨틱스 인크. 키메라 응고 인자를 사용해 혈우병성 관절증을 치료하는 방법
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MA52630B1 (fr) 2018-05-18 2025-07-31 Bioverativ Therapeutics Inc. Procédés de traitement de l'hémophilie a
JP7177577B2 (ja) 2018-06-01 2022-11-24 オートファジーサイエンシーズ インコーポレイテッド 新規な化合物およびこれを含む薬学的組成物
CN111072647B (zh) * 2019-12-11 2021-02-26 沈阳药科大学 3-取代吲哚-5-氧代-4,5-二氢-1,2,4-噁二唑类化合物及其用途
CN111072634B (zh) * 2020-01-03 2022-07-22 中国医科大学 1-取代-3-取代-5-取代酰胺-1h-吲哚类化合物及其制备方法和应用
WO2022098057A1 (fr) * 2020-11-04 2022-05-12 주식회사 엘지화학 Procédé de préparation de particules cristallines d'acide 1-(3-cyano-1-isopropyl-indole-5-yl)pyrazole-4-carboxylique, et composition pharmaceutique les comprenant
CN116528852A (zh) * 2020-12-01 2023-08-01 株式会社Lg 化学 含有1-(3-氰基-1-异丙基-吲哚-5-基)吡唑-4-甲酸的稳定的口服制剂
EP4257124A4 (fr) * 2020-12-01 2024-05-29 Lg Chem, Ltd. Formulation orale comprenant de l'acide 1-(3-cyano-1-isopropyl-indole-5-yl)pyrazole-4-carboxylique et son procédé de préparation
CN112920170B (zh) * 2021-01-29 2023-06-20 中国医科大学 N-（吲哚-5-基）芳香杂环酰胺类化合物及其制备方法和用途
US20240216331A1 (en) * 2021-04-16 2024-07-04 Lg Chem, Ltd. Oral formulation containing 1-(3-cyano-1-isopropyl-indol-5-yl)pyrazole-4-carboxylic acid
CN117255785A (zh) * 2021-04-27 2023-12-19 株式会社Lg化学 用于合成黄嘌呤氧化酶抑制剂的中间体的制备方法
CN117203200A (zh) * 2021-04-27 2023-12-08 株式会社Lg化学 黄嘌呤氧化酶抑制剂的制备方法
CN117242062A (zh) * 2021-04-27 2023-12-15 株式会社Lg化学 用于合成黄嘌呤氧化酶抑制剂的中间体的制备方法
EP4335844A4 (fr) 2021-05-07 2025-08-27 Jiangsu Atom Bioscience And Pharmaceutical Co Ltd Classe d'inhibiteurs de xanthine oxydase
PE20240242A1 (es) * 2021-06-15 2024-02-16 Lg Chemical Ltd Una composicion farmaceutica que comprende acido 1-(3-ciano-1-isopropil-indol-5-il)pirazol-4-carboxilico
AR126164A1 (es) * 2021-06-17 2023-09-27 Lg Chemical Ltd Formulación compuesta para dosificación oral que comprende ácido 1-(3-ciano-1-isopropil-indol-5-il)pirazol-4-carboxílico
TWI822151B (zh) * 2021-07-02 2023-11-11 南韓商Ｌｇ化學股份有限公司 製備黃嘌呤氧化酶抑制劑的方法
BR112023026062A2 (pt) * 2021-07-02 2024-03-05 Lg Chemical Ltd Método para preparar um composto
CN116836154B (zh) * 2022-04-27 2026-01-23 杭州新元素药业股份有限公司 可用于痛风的化合物
WO2023208108A1 (fr) * 2022-04-27 2023-11-02 江苏新元素医药科技有限公司 Composé pour réduire l'acide urique
CN116283946B (zh) * 2023-03-27 2024-05-07 武汉工程大学 5-(n-取代吲哚-5-基)异噁唑-3-甲酸衍生物及其合成方法和应用
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Publication number Publication date
AU2010304091B2 (en) 2016-06-09
KR20110037883A (ko) 2011-04-13
CN102574839A (zh) 2012-07-11
EP2467378A2 (fr) 2012-06-27
MX2012003782A (es) 2012-08-31
IL218669A (en) 2016-08-31
UA110197C2 (ru) 2015-12-10
PE20121088A1 (es) 2012-08-17
BR112012007828A2 (pt) 2016-03-08
EP2467378A4 (fr) 2013-04-24
CL2012000738A1 (es) 2012-09-14
WO2011043568A3 (fr) 2011-09-29
MA33880B1 (fr) 2013-01-02
CO6430501A2 (es) 2012-04-30
ZA201202544B (en) 2012-12-29
BR112012007828B1 (pt) 2021-01-12
ECSP12011793A (es) 2012-05-30
HK1170224A1 (zh) 2013-02-22
KR101751325B1 (ko) 2017-06-27
EA201270520A1 (ru) 2012-10-30
AP2012006191A0 (en) 2012-04-30
WO2011043568A2 (fr) 2011-04-14
IL218669A0 (en) 2012-05-31
BR112012007828B8 (pt) 2021-05-25
MY162813A (en) 2017-07-31
CA2774133C (fr) 2019-06-25
ES2599829T3 (es) 2017-02-03
SG179186A1 (en) 2012-05-30
EA021025B1 (ru) 2015-03-31
JP5702392B2 (ja) 2015-04-15
US20120184582A1 (en) 2012-07-19
CN102574839B (zh) 2015-11-25
JP2013507355A (ja) 2013-03-04
TW201118077A (en) 2011-06-01
AR078504A1 (es) 2011-11-09
EP2467378B1 (fr) 2016-07-27
US8729273B2 (en) 2014-05-20
TWI423962B (zh) 2014-01-21
AU2010304091A1 (en) 2012-04-19
TR201203989T1 (tr) 2012-09-21
CA2774133A1 (fr) 2011-04-14

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