AP352A - Benzopyran and related LTB4 antagonists. - Google Patents

Benzopyran and related LTB4 antagonists. Download PDF

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Publication number
AP352A
AP352A APAP/P/1992/000449A AP9200449A AP352A AP 352 A AP352 A AP 352A AP 9200449 A AP9200449 A AP 9200449A AP 352 A AP352 A AP 352A
Authority
AP
ARIPO
Prior art keywords
formula
alkyl
carboxy
compound
phenyl
Prior art date
Application number
APAP/P/1992/000449A
Other languages
English (en)
Other versions
AP9200449A0 (en
Inventor
Kevin Koch
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AP9200449A0 publication Critical patent/AP9200449A0/xx
Application granted granted Critical
Publication of AP352A publication Critical patent/AP352A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
APAP/P/1992/000449A 1992-01-23 1992-11-20 Benzopyran and related LTB4 antagonists. AP352A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82441292A 1992-01-23 1992-01-23

Publications (2)

Publication Number Publication Date
AP9200449A0 AP9200449A0 (en) 1993-01-31
AP352A true AP352A (en) 1994-08-10

Family

ID=25241346

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1992/000449A AP352A (en) 1992-01-23 1992-11-20 Benzopyran and related LTB4 antagonists.

Country Status (36)

Country Link
US (2) US5552435A (de)
EP (1) EP0623123B1 (de)
JP (1) JP2765757B2 (de)
KR (2) KR0124802B1 (de)
CN (1) CN1041311C (de)
AP (1) AP352A (de)
AT (1) ATE152108T1 (de)
AU (1) AU666896B2 (de)
BG (1) BG62331B1 (de)
BR (1) BR9207061A (de)
CA (1) CA2126752C (de)
CZ (1) CZ282400B6 (de)
DE (1) DE69219364T2 (de)
DK (1) DK0623123T3 (de)
EG (1) EG20202A (de)
FI (1) FI943474L (de)
GR (1) GR3023657T3 (de)
HU (1) HU221194B1 (de)
IL (1) IL104386A (de)
IS (1) IS1795B (de)
MX (1) MX9300312A (de)
MY (1) MY109144A (de)
NO (1) NO306508B1 (de)
NZ (1) NZ245735A (de)
OA (1) OA11456A (de)
PH (1) PH30346A (de)
PL (1) PL171003B1 (de)
PT (1) PT101183B (de)
RO (1) RO112031B1 (de)
RU (1) RU2114110C1 (de)
SG (1) SG49813A1 (de)
SK (1) SK280451B6 (de)
TW (1) TW213907B (de)
WO (1) WO1993015067A1 (de)
YU (1) YU48949B (de)
ZA (1) ZA93486B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2084547B1 (es) * 1993-07-12 1997-01-16 Pfizer Antagonistas benzopiranicos y relacionados de leucotrieno b4.
NZ285154A (en) * 1994-10-13 1998-11-25 Pfizer Optionally heterocyclically substituted benzopyran and benzo-fused derivatives, preparation and use as leukotriene antagonists
RU2128655C1 (ru) * 1994-10-13 1999-04-10 Пфайзер Инк. Бензопирановые и бензоконденсированные соединения, промежуточные соединения, фармацевтическая композиция и способ ингибирования
DK0925292T3 (da) * 1996-09-16 2004-01-12 Pfizer Fremgangsmåder og mellemprodukter til fremstilling af substituerede chromanolderivater
US6416733B1 (en) 1996-10-07 2002-07-09 Bristol-Myers Squibb Pharma Company Radiopharmaceuticals for imaging infection and inflammation
IL121931A (en) * 1996-10-17 2000-02-17 Pfizer Pharmaceutical compositions for preventing allograft rejection
EP0963755A3 (de) * 1998-04-16 2001-03-14 Pfizer Products Inc. Verwendung von Benzopyrane zur Verhinderung von Abstossungsreaktionen allogener Transplantate
US6436987B1 (en) * 2000-06-08 2002-08-20 Pfizer Inc. Crystalline forms of (3S-trans)-2-[3,4-dihydro-4-hydroxy-3-(phenylmethyl)-2H-1-benzopyran-7-yl]-4-(trifluoromethyl)-benzoic acid
CA2427911A1 (en) 2000-11-03 2002-05-10 Bristol Myers Squibb Company Simultaneous dual isotope imaging of cardiac perfusion and cardiac inflammation
MXPA03006876A (es) * 2001-01-30 2003-11-13 Pfizer Prod Inc Intermedios y procedimientos para preparar derivados de cromanol sustituido.
AU4239302A (en) * 2001-06-28 2003-01-02 Pfizer Products Inc. Benzoic acid substituted benzopyrans for the treatment of atherosclerosis
JP2008506768A (ja) * 2004-07-22 2008-03-06 ファルマシア コーポレーション Ｃｏｘ−２選択的阻害剤とｌｔｂ４受容体アンタゴニストを組み合わせて用いる炎症および疼痛を治療するための組成物
EP3383389B1 (de) * 2015-11-30 2021-04-28 Merck Sharp & Dohme Corp. Arylacylsulfonamide als blt1-antagonisten
WO2017095722A1 (en) 2015-11-30 2017-06-08 Merck Sharp & Dohme Corp. Aryl acylsulfonamides as blt1 antagonists
EP3383868B1 (de) 2015-11-30 2022-10-05 Merck Sharp & Dohme LLC Arylsulfonamide als blt1-antagonisten
WO2017095725A1 (en) 2015-11-30 2017-06-08 Merck Sharp & Dohme Corp. Aryl sulfonamides as blt1 antagonists

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2309282A1 (de) * 1973-02-24 1974-08-29 Hoechst Ag Verfahren zur herstellung von 4-hydroxy-thiochromanen
EP0313295A2 (de) * 1987-10-19 1989-04-26 Pfizer Inc. Substituierte Tetraline, Chromane und verwandte Verbindungen für die Behandlung von Asthma, Arthritis und verwandte Krankheiten
EP0391625A1 (de) * 1989-04-07 1990-10-10 Pfizer Inc. Substituierte Chromane für die Behandlung von Asthma, Arthritis und ähnlichen Krankheiten
EP0404440A2 (de) * 1989-06-22 1990-12-27 Pfizer Inc. Substituierte Sulfonamide und verwandte Verbindungen zur Behandlung von Asthma, Arthritis und verwandten Krankheiten
EP0441515A1 (de) * 1990-02-07 1991-08-14 Pfizer Inc. Tetralin- und Chromanderivate zur Behandlung von Asthma, Arthritis und ähnlichen Krankheiten
US5059609A (en) * 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2745305A1 (de) * 1977-10-07 1979-04-19 Bayer Ag Insektizide und akarizide mittel
US4565882A (en) * 1984-01-06 1986-01-21 G. D. Searle & Co. Substituted dihydrobenzopyran-2-carboxylates
CA1320490C (en) * 1987-01-12 1993-07-20 Darrel M. Gapinski Anti-inflammatory agents
JPS63292977A (ja) * 1987-05-25 1988-11-30 片山　晋 スキ−用のビンディング固定板
ES2098547T3 (es) * 1992-01-23 1997-05-01 Pfizer Benzopirano y otros antagonistas de ltb4 relacionados.
SG65570A1 (en) * 1992-02-25 1999-06-22 Recordati Chem Pharm Heterobicyclic compounds
FR2693196B1 (fr) * 1992-07-03 1994-12-23 Lipha Dérivés de benzopyranone ou de benzothiopyranone, procédé de préparation et composition pharmaceutique les contenant.

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2309282A1 (de) * 1973-02-24 1974-08-29 Hoechst Ag Verfahren zur herstellung von 4-hydroxy-thiochromanen
EP0313295A2 (de) * 1987-10-19 1989-04-26 Pfizer Inc. Substituierte Tetraline, Chromane und verwandte Verbindungen für die Behandlung von Asthma, Arthritis und verwandte Krankheiten
US5059609A (en) * 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
EP0391625A1 (de) * 1989-04-07 1990-10-10 Pfizer Inc. Substituierte Chromane für die Behandlung von Asthma, Arthritis und ähnlichen Krankheiten
EP0404440A2 (de) * 1989-06-22 1990-12-27 Pfizer Inc. Substituierte Sulfonamide und verwandte Verbindungen zur Behandlung von Asthma, Arthritis und verwandten Krankheiten
EP0441515A1 (de) * 1990-02-07 1991-08-14 Pfizer Inc. Tetralin- und Chromanderivate zur Behandlung von Asthma, Arthritis und ähnlichen Krankheiten

Also Published As

Publication number Publication date
PL171003B1 (pl) 1997-02-28
NO942759D0 (no) 1994-07-22
HK1000245A1 (en) 1998-02-13
IS3969A (is) 1993-07-24
KR0124802B1 (ko) 1997-11-25
US5552435A (en) 1996-09-03
KR950700273A (ko) 1995-01-16
RU2114110C1 (ru) 1998-06-27
FI943474A0 (fi) 1994-07-22
JPH07502536A (ja) 1995-03-16
NZ245735A (en) 1995-04-27
ZA93486B (en) 1994-07-22
BG62331B1 (bg) 1999-08-31
PT101183B (pt) 1999-09-30
SK84494A3 (en) 1995-05-10
SG49813A1 (en) 1998-06-15
IL104386A (en) 2001-05-20
DK0623123T3 (da) 1997-10-13
BG98867A (bg) 1995-03-31
YU3393A (sh) 1996-07-24
TW213907B (de) 1993-10-01
PT101183A (pt) 1994-03-31
CZ282400B6 (cs) 1997-07-16
CN1041311C (zh) 1998-12-23
FI943474A7 (fi) 1994-07-22
YU48949B (sh) 2003-01-31
DE69219364D1 (de) 1997-05-28
CZ176294A3 (en) 1995-02-15
BR9207061A (pt) 1995-12-26
AU3065092A (en) 1993-09-01
MY109144A (en) 1996-12-31
EP0623123A1 (de) 1994-11-09
HU9401979D0 (en) 1994-09-28
NO942759L (no) 1994-07-22
MX9300312A (es) 1993-07-31
IS1795B (is) 2001-12-18
ATE152108T1 (de) 1997-05-15
DE69219364T2 (de) 1997-08-07
CA2126752C (en) 2000-05-16
US5684046A (en) 1997-11-04
NO306508B1 (no) 1999-11-15
PH30346A (en) 1997-04-02
HUT68790A (en) 1995-07-28
FI943474L (fi) 1994-07-22
JP2765757B2 (ja) 1998-06-18
SK280451B6 (sk) 2000-02-14
AP9200449A0 (en) 1993-01-31
AU666896B2 (en) 1996-02-29
EP0623123B1 (de) 1997-04-23
EG20202A (en) 1997-10-30
RU94035964A (ru) 1997-05-27
GR3023657T3 (en) 1997-09-30
HU221194B1 (en) 2002-08-28
IL104386A0 (en) 1993-05-13
WO1993015067A1 (en) 1993-08-05
OA11456A (en) 2003-11-18
CA2126752A1 (en) 1993-08-05
CN1075318A (zh) 1993-08-18
RO112031B1 (ro) 1997-04-30

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