AP553A - Use of insulin sensitizers for treating renal failure. - Google Patents

Use of insulin sensitizers for treating renal failure. Download PDF

Info

Publication number: AP553A
Authority: AP; ARIPO
Prior art keywords: formula; pharmaceutically acceptable; group; use according; insulin sensitiser
Prior art date: 1994-02-10

Application number

APAP/P/1995/000717A

Other languages

English (en)

Other versions

AP9500717A0 (en

Inventor

Robin Edwin Buckingham

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-02-10

Filing date

1995-02-08

Publication date

1996-11-06

1994-02-10 Priority claimed from GB9402624A external-priority patent/GB9402624D0/en

1994-05-21 Priority claimed from GB9410214A external-priority patent/GB9410214D0/en

1994-12-22 Priority claimed from GBGB9426019.7A external-priority patent/GB9426019D0/en

1995-02-08 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

1995-04-30 Publication of AP9500717A0 publication Critical patent/AP9500717A0/xx

1996-11-06 Application granted granted Critical

1996-11-06 Publication of AP553A publication Critical patent/AP553A/en

Links

229940122355 Insulin sensitizer Drugs 0.000 title 1
208000001647 Renal Insufficiency Diseases 0.000 title 1
201000006370 kidney failure Diseases 0.000 title 1
238000011282 treatment Methods 0.000 claims abstract description 27
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229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
239000000843 powder Substances 0.000 description 1
MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
229960004919 procaine Drugs 0.000 description 1
230000008569 process Effects 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
238000002731 protein assay Methods 0.000 description 1
238000000159 protein binding assay Methods 0.000 description 1
125000000714 pyrimidinyl group Chemical group 0.000 description 1
229960000948 quinine Drugs 0.000 description 1
230000004044 response Effects 0.000 description 1
239000000837 restrainer Substances 0.000 description 1
230000000630 rising effect Effects 0.000 description 1
230000001235 sensitizing effect Effects 0.000 description 1
AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
229940080313 sodium starch Drugs 0.000 description 1
229940032147 starch Drugs 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000000758 substrate Substances 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
229910021653 sulphate ion Inorganic materials 0.000 description 1
GFYHSKONPJXCDE-UHFFFAOYSA-N sym-collidine Natural products CC1=CN=C(C)C(C)=C1 GFYHSKONPJXCDE-UHFFFAOYSA-N 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
125000000335 thiazolyl group Chemical group 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
210000004926 tubular epithelial cell Anatomy 0.000 description 1
210000005239 tubule Anatomy 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
238000011680 zucker rat Methods 0.000 description 1
238000011684 zucker rat (obese) Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Obesity (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

APAP/P/1995/000717A 1994-02-10 1995-02-08 Use of insulin sensitizers for treating renal failure. AP553A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB9402624A GB9402624D0 (en)	1994-02-10	1994-02-10	Novel method
GB9410214A GB9410214D0 (en)	1994-05-21	1994-05-21	Novel method
GBGB9426019.7A GB9426019D0 (en)	1994-12-22	1994-12-22	Novel method

Publications (2)

Publication Number	Publication Date
AP9500717A0 AP9500717A0 (en)	1995-04-30
AP553A true AP553A (en)	1996-11-06

Family

ID=27267046

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
APAP/P/1995/000717A AP553A (en)	1994-02-10	1995-02-08	Use of insulin sensitizers for treating renal failure.

Country Status (11)

Country	Link
EP (1)	EP0777469A1 (ja)
JP (1)	JPH09512249A (ja)
CN (2)	CN1083715C (ja)
AP (1)	AP553A (ja)
AU (1)	AU700826B2 (ja)
CA (1)	CA2182986A1 (ja)
IL (1)	IL112590A (ja)
MX (1)	MX9603338A (ja)
SG (1)	SG47100A1 (ja)
TW (1)	TW475896B (ja)
WO (1)	WO1995021608A1 (ja)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5919782A (en) *	1996-05-06	1999-07-06	Dr. Reddy's Research Foundation	Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
ZA973848B (en) *	1996-05-06	1997-12-02	Reddy Research Foundation	Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them.
US5889025A (en) *	1996-05-06	1999-03-30	Reddy's Research Foundation	Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US6372750B2 (en)	1996-07-01	2002-04-16	Dr. Reddy's Research Foundation	Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
US5885997A (en) *	1996-07-01	1999-03-23	Dr. Reddy's Research Foundation	Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
USRE39266E1 (en) *	1996-07-01	2006-09-05	Dr. Reddy's Laboratories, Limited	Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US5985884A (en) *	1996-07-01	1999-11-16	Dr. Reddy's Research Foundation	Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6114526A (en) *	1996-07-01	2000-09-05	Dr. Reddy's Research Foundation	Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6011036A (en) *	1997-04-15	2000-01-04	Dr. Reddy's Research Foundation	Heterocyclic compounds having antidiabetic hypolipidemic antihypertensive properties process for their preparation and pharmaceutical compositions containing them
US6011031A (en) *	1997-05-30	2000-01-04	Dr. Reddy's Research Foundation	Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them
GB9711683D0 (en) *	1997-06-05	1997-08-06	Smithkline Beecham Plc	Composition
GB9726566D0 (en) *	1997-12-16	1998-02-11	Smithkline Beecham Plc	Novel pharmaceutical
US20020137940A1 (en)	1997-12-16	2002-09-26	Smithkline Beecham P.L.C.	5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical
GB9726563D0 (en) *	1997-12-16	1998-02-11	Smithkline Beecham Plc	Novel pharmaceutical
US7045519B2 (en)	1998-06-19	2006-05-16	Chiron Corporation	Inhibitors of glycogen synthase kinase 3
RS50114B (sr)	1999-04-23	2009-03-25	Smithkline Beecham P.L.C.,	Novi polimorfni oblik 5-/4-/2-(n-metil- n-(2-piridil)amino/ etoksi/benzil/ tiazolidin-2,4-dion, soli maleinske kiseline
BR0013375A (pt) *	1999-08-17	2002-07-23	Smithkline Beecham Plc	Composições farmacêuticas contendo derivados tiazolidinodiona e processo para sua preparação
US20040115626A1 (en) *	2000-05-25	2004-06-17	Masahide Goto	Human pgc-1 promoter
GB0019223D0 (en) *	2000-08-04	2000-09-27	Smithkline Beecham Plc	Novel pharmaceutical
US7767682B2 (en)	2005-03-03	2010-08-03	Glaxosmithkline Llc	Medicaments
WO2008134828A2 (en)	2007-05-04	2008-11-13	Katholieke Universiteit Leuven	Tissue degeneration protection
US20240180908A1 (en) *	2021-04-01	2024-06-06	Aclipse One, Inc.	Treatment of kidney diseases

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EP0842925A1 (en) *	1987-09-04	1998-05-20	Beecham Group Plc	Substituted thiazolidinedione derivatives
GB9023584D0 (en) *	1990-10-30	1990-12-12	Beecham Group Plc	Novel compounds
FR2680512B1 (fr) *	1991-08-20	1995-01-20	Adir	Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
JPH05310719A (ja) *	1992-04-28	1993-11-22	Terumo Corp	チアゾリジン−２，４−ジオン誘導体

1995
- 1995-02-07 SG SG1996007235A patent/SG47100A1/en unknown
- 1995-02-07 EP EP95907653A patent/EP0777469A1/en not_active Withdrawn
- 1995-02-07 WO PCT/EP1995/000441 patent/WO1995021608A1/en not_active Ceased
- 1995-02-07 MX MX9603338A patent/MX9603338A/es unknown
- 1995-02-07 CA CA002182986A patent/CA2182986A1/en not_active Abandoned
- 1995-02-07 JP JP7520956A patent/JPH09512249A/ja not_active Ceased
- 1995-02-07 AU AU15783/95A patent/AU700826B2/en not_active Ceased
- 1995-02-07 CN CN95192362A patent/CN1083715C/zh not_active Expired - Fee Related
- 1995-02-08 AP APAP/P/1995/000717A patent/AP553A/en active
- 1995-02-09 IL IL11259095A patent/IL112590A/en not_active IP Right Cessation
- 1995-02-10 TW TW084101155A patent/TW475896B/zh not_active IP Right Cessation
2001
- 2001-03-30 CN CN01112436A patent/CN1318372A/zh active Pending

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J.DIABET.COMPL., Vol. 4, no.2, 1990. pg 75-78 *

Also Published As

Publication number	Publication date
MX9603338A (es)	1997-03-29
CN1318372A (zh)	2001-10-24
CA2182986A1 (en)	1995-08-17
SG47100A1 (en)	1998-03-20
EP0777469A1 (en)	1997-06-11
AU1578395A (en)	1995-08-29
JPH09512249A (ja)	1997-12-09
CN1083715C (zh)	2002-05-01
TW475896B (en)	2002-02-11
CN1145027A (zh)	1997-03-12
AP9500717A0 (en)	1995-04-30
AU700826B2 (en)	1999-01-14
IL112590A (en)	2002-08-14
IL112590A0 (en)	1995-06-29
WO1995021608A1 (en)	1995-08-17

Publication	Publication Date	Title
AP553A (en)	1996-11-06	Use of insulin sensitizers for treating renal failure.
US5661168A (en)	1997-08-26	Hypoglycemic agents
KR100697582B1 (ko)	2007-03-22	케톤증 개선제
RU2190425C2 (ru)	2002-10-10	Способ и композиция для лечения и предупреждения гиперурикемии
NO314065B1 (no)	2003-01-27	Farmasöytisk sammensetning omfattende en insulinsensitivitetsenhancer og etbiguanid ved behandling av diabetes
EP0695183B1 (en)	2003-07-23	Use of thiazolidinediones for the treatment of atherosclerosis and eating disorders
CA2283319A1 (en)	1998-12-10	Use of thiazolidinedione derivatives in the treatment of polycystic ovary syndrome and gestational diabetes
CZ79396A3 (en)	1996-10-16	The use of thiazolidine derivatives for preparing a threapeutical preparation for treating deteriorated glucose tolerance in order to prevent or delay insulin-independent diabetes mellitus coming
EP0921798A1 (en)	1999-06-16	Novel treatment of leptine resistance
US20020156106A1 (en)	2002-10-24	Use of insulin sensitisers for treating renal diseases
US20020115699A1 (en)	2002-08-22	Method for treating renal disease
US20040266833A1 (en)	2004-12-30	Novel use of certain insulin sensitizers or ppar-gamma agonists
CZ32998A3 (cs)	1998-10-14	Výroba léčiva pro snížení množství exogenního insulinu
CZ7799A3 (cs)	2000-01-12	Farmaceutický prostředek proti leptinové rezistenci
NZ506200A (en)	2002-02-01	Use of a leptine sensitiser in combination with leptin to treat leptine resistance conditions (e.g. obesity)
HU224436B1 (hu)	2005-09-28	Az 5-[4-{2-[N-metil-N-(2-piridil)-amino]-etoxi}-benzil]-2,4-dioxotiazolidin alkalmazása vesebetegségek kezelésére szolgáló gyógyszerkészítmények előállítására
AU7217000A (en)	2001-02-22	Novel treatment of leptin resistance
HK1057164A (en)	2004-03-19	Use of thiazolidinediones for the treatment of atherosclerosis and eating disorders
KR20010079550A (ko)	2001-08-22	심장의 허혈후 손상을 감소시키기 위한 글루코즈 업테이크증진제의 용도
BG107384A (bg)	2003-09-30	ИЗПОЛЗВАНЕ НА PPARгама АГОНИСТ ЗА ПОЛУЧАВАНЕ НА МЕДИКАМЕНТ ЗА ЛЕЧЕНИЕ И ПРОФИЛАКТИКА НА СЪСТОЯНИЯ СВЪРЗАНИ СЪС СЪРДЕЧНА ИНСУЛИНОВА РЕЗИСТЕНТНОСТ
KR20010079551A (ko)	2001-08-22	아폽토시스를 감소시키기 위한 글루코즈 업테이크증진제의 용도
ZA200300283B (en)	2004-08-25	Treatment and prevention of cardiac insulin resistance associated conditions.
AU6662400A (en)	2001-01-11	Use of thiazolidinediones for the treatment of atherosclerosis and eating disorders