AP747A - Pharmaceutical compositions in the form of a tablet containing famciclovir. - Google Patents

Pharmaceutical compositions in the form of a tablet containing famciclovir. Download PDF

Info

Publication number: AP747A
Authority: AP; ARIPO
Prior art keywords: famciclovir; tablet; percentage; lactose; pharmaceutical
Prior art date: 1996-01-16

Application number

APAP/P/1997/000911A

Other languages

English (en)

Other versions

AP9700911A0 (en

Inventor

Michael John Greenway

Jennifer Mary Slater

Original Assignee

Novartis Int Pharmaceutical Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-01-16

Filing date

1997-01-02

Publication date

1999-05-03

1997-01-02 Application filed by Novartis Int Pharmaceutical Ltd filed Critical Novartis Int Pharmaceutical Ltd

1997-01-31 Publication of AP9700911A0 publication Critical patent/AP9700911A0/xx

1999-05-03 Application granted granted Critical

1999-05-03 Publication of AP747A publication Critical patent/AP747A/en

Links

229960004396 famciclovir Drugs 0.000 title claims abstract description 24
GGXKWVWZWMLJEH-UHFFFAOYSA-N famcyclovir Chemical compound N1=C(N)N=C2N(CCC(COC(=O)C)COC(C)=O)C=NC2=C1 GGXKWVWZWMLJEH-UHFFFAOYSA-N 0.000 title claims abstract description 24
239000008194 pharmaceutical composition Substances 0.000 title description 2
239000004480 active ingredient Substances 0.000 claims abstract description 7
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 10
239000000546 pharmaceutical excipient Substances 0.000 claims description 10
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 8
239000000203 mixture Substances 0.000 claims description 6
235000019359 magnesium stearate Nutrition 0.000 claims description 5
229940080313 sodium starch Drugs 0.000 claims description 5
229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 4
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 4
229960004977 anhydrous lactose Drugs 0.000 claims description 4
239000001863 hydroxypropyl cellulose Substances 0.000 claims description 4
235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 4
229960001375 lactose Drugs 0.000 claims description 4
239000008101 lactose Substances 0.000 claims description 4
238000000034 method Methods 0.000 claims description 4
239000000470 constituent Substances 0.000 claims description 2
238000002360 preparation method Methods 0.000 claims description 2
238000007906 compression Methods 0.000 description 5
230000006835 compression Effects 0.000 description 5
JNTOCHDNEULJHD-UHFFFAOYSA-N Penciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(CCC(CO)CO)C=N2 JNTOCHDNEULJHD-UHFFFAOYSA-N 0.000 description 2
230000000840 anti-viral effect Effects 0.000 description 2
239000011248 coating agent Substances 0.000 description 2
238000000576 coating method Methods 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
239000008187 granular material Substances 0.000 description 2
229960001179 penciclovir Drugs 0.000 description 2
241000700721 Hepatitis B virus Species 0.000 description 1
241000700588 Human alphaherpesvirus 1 Species 0.000 description 1
241000701074 Human alphaherpesvirus 2 Species 0.000 description 1
241000701085 Human alphaherpesvirus 3 Species 0.000 description 1
229920000168 Microcrystalline cellulose Polymers 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
235000010980 cellulose Nutrition 0.000 description 1
239000003814 drug Substances 0.000 description 1
238000007580 dry-mixing Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000012458 free base Substances 0.000 description 1
-1 hydroxypropyl Chemical group 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
239000012453 solvate Chemical class 0.000 description 1
239000007916 tablet composition Substances 0.000 description 1
241001529453 unidentified herpesvirus Species 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Virology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

APAP/P/1997/000911A 1996-01-16 1997-01-02 Pharmaceutical compositions in the form of a tablet containing famciclovir. AP747A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9600847.9A GB9600847D0 (en)	1996-01-16	1996-01-16	Pharmaceuticals

Publications (2)

Publication Number	Publication Date
AP9700911A0 AP9700911A0 (en)	1997-01-31
AP747A true AP747A (en)	1999-05-03

Family

ID=10787105

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
APAP/P/1997/000911A AP747A (en)	1996-01-16	1997-01-02	Pharmaceutical compositions in the form of a tablet containing famciclovir.
APAP/P/1998/001298A AP1114A (en)	1996-01-16	1997-01-13	Indole compounda as anti-inflammatory/analgesic agents.

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
APAP/P/1998/001298A AP1114A (en)	1996-01-16	1997-01-13	Indole compounda as anti-inflammatory/analgesic agents.

Country Status (37)

Country	Link
US (1)	US6765007B1 (fr)
EP (1)	EP0874632B1 (fr)
JP (2)	JP4711360B2 (fr)
KR (1)	KR100338829B1 (fr)
CN (1)	CN1132582C (fr)
AP (2)	AP747A (fr)
AR (1)	AR005456A1 (fr)
AT (1)	ATE220910T1 (fr)
AU (1)	AU713090B2 (fr)
BG (1)	BG63488B1 (fr)
BR (1)	BR9706982A (fr)
CY (1)	CY2390B1 (fr)
CZ (1)	CZ287205B6 (fr)
DE (1)	DE69714215T2 (fr)
DK (1)	DK0874632T3 (fr)
DZ (1)	DZ2159A1 (fr)
EA (1)	EA001946B1 (fr)
EG (1)	EG23684A (fr)
ES (1)	ES2180922T3 (fr)
GB (1)	GB9600847D0 (fr)
HU (1)	HU225472B1 (fr)
IL (1)	IL124913A0 (fr)
MX (1)	MX9805713A (fr)
MY (1)	MY127527A (fr)
NO (1)	NO315689B1 (fr)
NZ (1)	NZ326769A (fr)
OA (1)	OA10812A (fr)
PE (1)	PE35498A1 (fr)
PL (1)	PL187291B1 (fr)
PT (1)	PT874632E (fr)
SK (1)	SK282132B6 (fr)
TR (1)	TR199800954T2 (fr)
TW (1)	TW434016B (fr)
UA (1)	UA63897C2 (fr)
UY (2)	UY24437A1 (fr)
WO (1)	WO1997025990A1 (fr)
ZA (1)	ZA97310B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20100136106A1 (en) *	2005-06-08	2010-06-03	Gary Liversidge	Modified Release Famciclovir Compositions
AU2010265863C1 (en)	2009-06-26	2012-11-01	Taris Biomedical Llc	Implantable drug delivery devices and methods of making the same
JP2015063521A (ja) *	2013-09-02	2015-04-09	科研製薬株式会社	高い薬物含有率を有する錠剤及びその製造方法
CN104434852B (zh) *	2013-09-18	2018-11-20	北京韩美药品有限公司	泛昔洛韦直压片及其制备方法
CN112587491B (zh) *	2021-01-03	2022-08-23	迪沙药业集团有限公司	一种泛昔洛韦片组合物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2671970A1 (fr) *	1991-01-30	1992-07-31	Wellcome Found	Comprimes dispersables dans l'eau.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3421800C1 (de) *	1984-06-12	1986-04-17	Maschinen und Werkzeugbau Michael Brümmer GmbH, 8804 Dinkelsbühl	Elastische Walze zum Behandeln einer thermoplastischen Folie
EP0182024B1 (fr) *	1984-09-20	1991-04-03	Beecham Group Plc	Dérivés de purine et leur utilisation pharmaceutique
RU2126255C1 (ru)	1991-05-15	1999-02-20	Йель Юниверсити	Способ получения противоопухолевого эффекта у млекопитающих
GB9303157D0 (en) *	1993-02-17	1993-03-31	Scotia Holdings Plc	Treatment of a group of related disorders
IL111138A (en)	1993-10-05	1997-04-15	Smithkline Beecham Plc	Pharmaceutical compositions comprising penciclovir and/or its bioprecursor and/or its derivatives for the treatment and prophylaxis of post-herpetic neuralgia
JP3702594B2 (ja) *	1997-08-07	2005-10-05	株式会社明電舎	パラメータ調節方法及び装置

1996
- 1996-01-16 GB GBGB9600847.9A patent/GB9600847D0/en active Pending
1997
- 1997-01-02 AP APAP/P/1997/000911A patent/AP747A/en active
- 1997-01-10 UY UY24437A patent/UY24437A1/es not_active IP Right Cessation
- 1997-01-13 WO PCT/EP1997/000195 patent/WO1997025990A1/fr not_active Ceased
- 1997-01-13 NZ NZ326769A patent/NZ326769A/xx not_active IP Right Cessation
- 1997-01-13 IL IL12491397A patent/IL124913A0/xx not_active IP Right Cessation
- 1997-01-13 UA UA98063199A patent/UA63897C2/uk unknown
- 1997-01-13 CN CN97191703A patent/CN1132582C/zh not_active Expired - Lifetime
- 1997-01-13 HU HU9901021A patent/HU225472B1/hu unknown
- 1997-01-13 SK SK956-98A patent/SK282132B6/sk not_active IP Right Cessation
- 1997-01-13 AT AT97901539T patent/ATE220910T1/de active
- 1997-01-13 EA EA199800573A patent/EA001946B1/ru not_active IP Right Cessation
- 1997-01-13 KR KR1019980705371A patent/KR100338829B1/ko not_active Expired - Lifetime
- 1997-01-13 TR TR1998/00954T patent/TR199800954T2/xx unknown
- 1997-01-13 PL PL97327922A patent/PL187291B1/pl unknown
- 1997-01-13 JP JP52569297A patent/JP4711360B2/ja not_active Expired - Lifetime
- 1997-01-13 DE DE69714215T patent/DE69714215T2/de not_active Expired - Lifetime
- 1997-01-13 DK DK97901539T patent/DK0874632T3/da active
- 1997-01-13 AP APAP/P/1998/001298A patent/AP1114A/en active
- 1997-01-13 ES ES97901539T patent/ES2180922T3/es not_active Expired - Lifetime
- 1997-01-13 BR BR9706982A patent/BR9706982A/pt not_active IP Right Cessation
- 1997-01-13 CZ CZ19982254A patent/CZ287205B6/cs not_active IP Right Cessation
- 1997-01-13 US US09/101,926 patent/US6765007B1/en not_active Expired - Lifetime
- 1997-01-13 AU AU15418/97A patent/AU713090B2/en not_active Expired
- 1997-01-13 PT PT97901539T patent/PT874632E/pt unknown
- 1997-01-13 EP EP97901539A patent/EP0874632B1/fr not_active Expired - Lifetime
- 1997-01-14 AR ARP970100130A patent/AR005456A1/es active IP Right Grant
- 1997-01-14 TW TW086100335A patent/TW434016B/zh not_active IP Right Cessation
- 1997-01-14 EG EG4697A patent/EG23684A/xx active
- 1997-01-15 MY MYPI97000137A patent/MY127527A/en unknown
- 1997-01-15 DZ DZ970004A patent/DZ2159A1/fr active
- 1997-01-15 ZA ZA9700310A patent/ZA97310B/xx unknown
- 1997-01-15 PE PE1997000022A patent/PE35498A1/es not_active IP Right Cessation
- 1997-05-16 UY UY24556A patent/UY24556A1/es not_active IP Right Cessation
1998
- 1998-07-15 BG BG102638A patent/BG63488B1/bg unknown
- 1998-07-15 MX MX9805713A patent/MX9805713A/es unknown
- 1998-07-15 NO NO19983259A patent/NO315689B1/no not_active IP Right Cessation
- 1998-07-16 OA OA9800116A patent/OA10812A/en unknown
2003
- 2003-11-28 CY CY0300085A patent/CY2390B1/xx unknown
2008
- 2008-11-19 JP JP2008295818A patent/JP2009091362A/ja active Pending

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2671970A1 (fr) *	1991-01-30	1992-07-31	Wellcome Found	Comprimes dispersables dans l'eau.

Also Published As

Publication number	Publication date
ATE220910T1 (de)	2002-08-15
DE69714215T2 (de)	2003-01-23
HK1016473A1 (en)	1999-11-05
PE35498A1 (es)	1998-08-07
JP2000503311A (ja)	2000-03-21
TR199800954T2 (xx)	1998-10-21
CZ287205B6 (en)	2000-10-11
HUP9901021A2 (hu)	1999-08-30
SK95698A3 (en)	1999-01-11
UY24556A1 (es)	2001-08-27
PL327922A1 (en)	1999-01-04
CN1132582C (zh)	2003-12-31
KR100338829B1 (ko)	2002-07-18
DK0874632T3 (da)	2002-11-11
NO983259L (no)	1998-07-15
NO983259D0 (no)	1998-07-15
AR005456A1 (es)	1999-06-23
AU1541897A (en)	1997-08-11
BG102638A (bg)	1999-07-30
CZ225498A3 (cs)	1998-12-16
TW434016B (en)	2001-05-16
HUP9901021A3 (en)	2000-08-28
EA001946B1 (ru)	2001-10-22
AP9801298A0 (en)	1998-09-30
ES2180922T3 (es)	2003-02-16
KR19990077229A (ko)	1999-10-25
HU225472B1 (en)	2006-12-28
CY2390B1 (en)	2004-09-10
ZA97310B (en)	1997-10-23
PL187291B1 (pl)	2004-06-30
DZ2159A1 (fr)	2002-12-01
OA10812A (en)	2003-01-29
MY127527A (en)	2006-12-29
GB9600847D0 (en)	1996-03-20
NO315689B1 (no)	2003-10-13
NZ326769A (en)	2000-05-26
UA63897C2 (en)	2004-02-16
SK282132B6 (sk)	2001-11-06
EP0874632A1 (fr)	1998-11-04
UY24437A1 (es)	1997-06-06
CN1208350A (zh)	1999-02-17
JP2009091362A (ja)	2009-04-30
BG63488B1 (bg)	2002-03-29
AP9700911A0 (en)	1997-01-31
EA199800573A1 (ru)	1999-02-25
AP1114A (en)	2002-10-18
DE69714215D1 (de)	2002-08-29
BR9706982A (pt)	1999-07-20
EP0874632B1 (fr)	2002-07-24
MX9805713A (es)	1998-10-31
WO1997025990A1 (fr)	1997-07-24
JP4711360B2 (ja)	2011-06-29
IL124913A0 (en)	1999-01-26
US6765007B1 (en)	2004-07-20
AU713090B2 (en)	1999-11-25
EG23684A (en)	2007-05-09
PT874632E (pt)	2002-10-31

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