AP812A - A vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminium phosphate. - Google Patents

A vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminium phosphate. Download PDF

Info

Publication number: AP812A
Authority: AP; ARIPO
Prior art keywords: vaccine; polysaccharide; conjugate; protein; antigen
Prior art date: 1995-06-23

Application number

APAP/P/1997/001159A

Other languages

English (en)

Other versions

AP9701159A0 (en

Inventor

Julien Peetermans

Pierre Hauser

Original Assignee

Smithkline Biologicals S A

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-23

Filing date

1996-06-19

Publication date

2000-02-24

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27451299&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP812(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-06-23 Priority claimed from GBGB9512827.8A external-priority patent/GB9512827D0/en

1995-07-01 Priority claimed from GBGB9513443.3A external-priority patent/GB9513443D0/en

1995-12-15 Priority claimed from GBGB9525657.4A external-priority patent/GB9525657D0/en

1996-03-22 Priority claimed from GBGB9606032.2A external-priority patent/GB9606032D0/en

1996-06-19 Application filed by Smithkline Biologicals S A filed Critical Smithkline Biologicals S A

1998-01-31 Publication of AP9701159A0 publication Critical patent/AP9701159A0/xx

2000-02-24 Application granted granted Critical

2000-02-24 Publication of AP812A publication Critical patent/AP812A/en

Links

229960005486 vaccine Drugs 0.000 title claims abstract description 51
239000000427 antigen Substances 0.000 title claims abstract description 24
108091007433 antigens Proteins 0.000 title claims abstract description 24
102000036639 antigens Human genes 0.000 title claims abstract description 24
239000000203 mixture Substances 0.000 title claims abstract description 22
229910000147 aluminium phosphate Inorganic materials 0.000 title claims abstract description 17
ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 title claims abstract description 16
229940001007 aluminium phosphate Drugs 0.000 title claims abstract description 16
150000004676 glycans Chemical class 0.000 title claims description 32
229920001282 polysaccharide Polymers 0.000 title claims description 32
239000005017 polysaccharide Substances 0.000 title claims description 32
208000015181 infectious disease Diseases 0.000 claims abstract description 6
239000003814 drug Substances 0.000 claims abstract description 3
206010013023 diphtheria Diseases 0.000 claims description 11
238000000034 method Methods 0.000 claims description 11
229960000814 tetanus toxoid Drugs 0.000 claims description 11
108010078791 Carrier Proteins Proteins 0.000 claims description 10
102000014914 Carrier Proteins Human genes 0.000 claims description 10
102000004169 proteins and genes Human genes 0.000 claims description 9
108090000623 proteins and genes Proteins 0.000 claims description 9
206010043376 Tetanus Diseases 0.000 claims description 8
241000606768 Haemophilus influenzae Species 0.000 claims description 7
201000005702 Pertussis Diseases 0.000 claims description 5
208000002672 hepatitis B Diseases 0.000 claims description 5
230000004224 protection Effects 0.000 claims description 5
241000709721 Hepatovirus A Species 0.000 claims description 4
229940047650 haemophilus influenzae Drugs 0.000 claims description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
101710116435 Outer membrane protein Proteins 0.000 claims description 3
208000000474 Poliomyelitis Diseases 0.000 claims description 3
229960003983 diphtheria toxoid Drugs 0.000 claims description 3
239000008215 water for injection Substances 0.000 claims description 3
244000052769 pathogen Species 0.000 claims 2
230000001717 pathogenic effect Effects 0.000 claims 2
230000001268 conjugating effect Effects 0.000 claims 1
238000009472 formulation Methods 0.000 abstract description 12
230000002265 prevention Effects 0.000 abstract description 3
201000010099 disease Diseases 0.000 abstract description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 2
238000004519 manufacturing process Methods 0.000 abstract description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 9
238000010168 coupling process Methods 0.000 description 6
238000005859 coupling reaction Methods 0.000 description 6
239000000047 product Substances 0.000 description 6
230000008878 coupling Effects 0.000 description 5
238000002347 injection Methods 0.000 description 5
239000007924 injection Substances 0.000 description 5
239000011780 sodium chloride Substances 0.000 description 5
229910019142 PO4 Inorganic materials 0.000 description 4
241000700159 Rattus Species 0.000 description 4
229960000074 biopharmaceutical Drugs 0.000 description 4
229940001442 combination vaccine Drugs 0.000 description 4
229960004443 hemophilus influenzae b vaccines Drugs 0.000 description 4
229940029583 inactivated polio vaccine Drugs 0.000 description 4
230000004044 response Effects 0.000 description 4
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
108010060123 Conjugate Vaccines Proteins 0.000 description 3
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
229940031670 conjugate vaccine Drugs 0.000 description 3
230000021615 conjugation Effects 0.000 description 3
ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 3
229940045808 haemophilus influenzae type b Drugs 0.000 description 3
208000005252 hepatitis A Diseases 0.000 description 3
229940124736 hepatitis-B vaccine Drugs 0.000 description 3
230000003053 immunization Effects 0.000 description 3
238000002649 immunization Methods 0.000 description 3
230000005847 immunogenicity Effects 0.000 description 3
238000002156 mixing Methods 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
230000009467 reduction Effects 0.000 description 3
238000006722 reduction reaction Methods 0.000 description 3
238000001179 sorption measurement Methods 0.000 description 3
241000588832 Bordetella pertussis Species 0.000 description 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
229940124914 Havrix Drugs 0.000 description 2
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
230000004913 activation Effects 0.000 description 2
WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 2
229910021502 aluminium hydroxide Inorganic materials 0.000 description 2
150000001718 carbodiimides Chemical class 0.000 description 2
238000009833 condensation Methods 0.000 description 2
230000005494 condensation Effects 0.000 description 2
239000004643 cyanate ester Substances 0.000 description 2
230000000694 effects Effects 0.000 description 2
238000002523 gelfiltration Methods 0.000 description 2
230000036039 immunity Effects 0.000 description 2
239000008101 lactose Substances 0.000 description 2
230000002829 reductive effect Effects 0.000 description 2
239000000243 solution Substances 0.000 description 2
238000003786 synthesis reaction Methods 0.000 description 2
150000003568 thioethers Chemical class 0.000 description 2
QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
ALEBYBVYXQTORU-UHFFFAOYSA-N 6-hydrazinyl-6-oxohexanoic acid Chemical compound NNC(=O)CCCCC(O)=O ALEBYBVYXQTORU-UHFFFAOYSA-N 0.000 description 1
206010002091 Anaesthesia Diseases 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 1
238000002965 ELISA Methods 0.000 description 1
229940124884 Engerix-B Drugs 0.000 description 1
239000004471 Glycine Substances 0.000 description 1
229940124915 Infanrix Drugs 0.000 description 1
229940124909 PedvaxHIB Drugs 0.000 description 1
JVWLUVNSQYXYBE-UHFFFAOYSA-N Ribitol Natural products OCC(C)C(O)C(O)CO JVWLUVNSQYXYBE-UHFFFAOYSA-N 0.000 description 1
PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
239000012506 Sephacryl® Substances 0.000 description 1
230000001154 acute effect Effects 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
230000002411 adverse Effects 0.000 description 1
HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
125000003277 amino group Chemical group 0.000 description 1
230000037005 anaesthesia Effects 0.000 description 1
229940031567 attenuated vaccine Drugs 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
238000001212 derivatisation Methods 0.000 description 1
238000011026 diafiltration Methods 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
229960005097 diphtheria vaccines Drugs 0.000 description 1
230000006806 disease prevention Effects 0.000 description 1
238000005538 encapsulation Methods 0.000 description 1
230000036541 health Effects 0.000 description 1
SYECJBOWSGTPLU-UHFFFAOYSA-N hexane-1,1-diamine Chemical compound CCCCCC(N)N SYECJBOWSGTPLU-UHFFFAOYSA-N 0.000 description 1
230000002163 immunogen Effects 0.000 description 1
230000002480 immunoprotective effect Effects 0.000 description 1
239000002502 liposome Substances 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000012263 liquid product Substances 0.000 description 1
229920002521 macromolecule Polymers 0.000 description 1
239000012528 membrane Substances 0.000 description 1
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
229940031348 multivalent vaccine Drugs 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
229940066827 pertussis vaccine Drugs 0.000 description 1
229960005323 phenoxyethanol Drugs 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
238000011552 rat model Methods 0.000 description 1
238000006268 reductive amination reaction Methods 0.000 description 1
HEBKCHPVOIAQTA-ZXFHETKHSA-N ribitol Chemical compound OC[C@H](O)[C@H](O)[C@H](O)CO HEBKCHPVOIAQTA-ZXFHETKHSA-N 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
125000006850 spacer group Chemical group 0.000 description 1
239000011550 stock solution Substances 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
229960002766 tetanus vaccines Drugs 0.000 description 1
-1 tetrafluoroborate Chemical compound 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
108700012359 toxins Proteins 0.000 description 1
238000000108 ultra-filtration Methods 0.000 description 1
238000002255 vaccination Methods 0.000 description 1

Classifications

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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Virology (AREA)
Mycology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Microbiology (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Biotechnology (AREA)
Gastroenterology & Hepatology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

APAP/P/1997/001159A 1995-06-23 1996-06-19 A vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminium phosphate. AP812A (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
GBGB9512827.8A GB9512827D0 (en)	1995-06-23	1995-06-23	Vaccines
GBGB9513443.3A GB9513443D0 (en)	1995-07-01	1995-07-01	Vaccines
GBGB9525657.4A GB9525657D0 (en)	1995-12-15	1995-12-15	Vaccines
GBGB9606032.2A GB9606032D0 (en)	1996-03-22	1996-03-22	Vaccines
PCT/EP1996/002690 WO1997000697A1 (en)	1995-06-23	1996-06-19	A vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminium phosphate

Publications (2)

Publication Number	Publication Date
AP9701159A0 AP9701159A0 (en)	1998-01-31
AP812A true AP812A (en)	2000-02-24

Family

ID=27451299

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
APAP/P/1997/001159A AP812A (en)	1995-06-23	1996-06-19	A vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminium phosphate.

Country Status (35)

Country	Link
EP (2)	EP0833662B2 (de)
JP (2)	JP4850987B2 (de)
KR (1)	KR100425929B1 (de)
CN (1)	CN1146444C (de)
AP (1)	AP812A (de)
AR (1)	AR003006A1 (de)
AT (2)	ATE199831T1 (de)
AU (1)	AU696338B2 (de)
BG (1)	BG62720B1 (de)
BR (1)	BRPI9609414B8 (de)
CA (1)	CA2222455C (de)
CY (1)	CY2297B1 (de)
CZ (1)	CZ288908B6 (de)
DE (2)	DE69637950D1 (de)
DK (2)	DK1082965T3 (de)
DZ (1)	DZ2055A1 (de)
EA (1)	EA199700413A1 (de)
EG (1)	EG25924A (de)
ES (2)	ES2157447T5 (de)
GR (1)	GR3036088T3 (de)
HU (1)	HU224514B1 (de)
IL (1)	IL122588A (de)
MA (1)	MA23918A1 (de)
MY (1)	MY114786A (de)
NO (1)	NO325169B1 (de)
NZ (1)	NZ312132A (de)
OA (1)	OA10646A (de)
PE (1)	PE11298A1 (de)
PL (1)	PL184872B1 (de)
PT (2)	PT1082965E (de)
SI (2)	SI0833662T2 (de)
SK (1)	SK176197A3 (de)
TR (1)	TR199701682T1 (de)
TW (1)	TW467746B (de)
WO (1)	WO1997000697A1 (de)

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1996
- 1996-06-19 EP EP96922871A patent/EP0833662B2/de not_active Expired - Lifetime
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- 1996-06-19 PL PL96324242A patent/PL184872B1/pl unknown
- 1996-06-19 DE DE69637950T patent/DE69637950D1/de not_active Expired - Lifetime
- 1996-06-19 AT AT96922871T patent/ATE199831T1/de active
- 1996-06-19 AT AT00203874T patent/ATE433329T1/de active
- 1996-06-19 TR TR97/01682T patent/TR199701682T1/xx unknown
- 1996-06-19 AU AU63591/96A patent/AU696338B2/en not_active Expired
- 1996-06-19 EP EP00203874A patent/EP1082965B1/de not_active Expired - Lifetime
- 1996-06-19 HU HU9900061A patent/HU224514B1/hu active IP Right Grant
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- 1996-06-19 KR KR1019970709651A patent/KR100425929B1/ko not_active Expired - Lifetime
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- 1996-06-22 EG EG57496A patent/EG25924A/xx active
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- 1997-12-23 BG BG102146A patent/BG62720B1/bg unknown
2001
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2002
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2008
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Also Published As

Publication number	Publication date
PL324242A1 (en)	1998-05-11
DE69612198T2 (de)	2001-11-08
BG102146A (en)	1998-10-30
KR100425929B1 (ko)	2004-05-31
CY2297B1 (en)	2003-07-04
BRPI9609414B8 (pt)	2021-05-25
MX9710521A (es)	1998-08-30
IL122588A (en)	2001-12-23
NO976035L (no)	1998-02-16
OA10646A (en)	2002-09-18
DE69637950D1 (de)	2009-07-23
DE69612198D1 (de)	2001-04-26
DZ2055A1 (fr)	2002-10-20
AP9701159A0 (en)	1998-01-31
SK176197A3 (en)	1998-07-08
ES2325301T3 (es)	2009-09-01
AR003006A1 (es)	1998-05-27
ES2157447T5 (es)	2011-04-29
CZ418997A3 (cs)	1998-06-17
DE69612198T3 (de)	2011-08-18
ATE433329T1 (de)	2009-06-15
EA199700413A1 (ru)	1998-08-27
GR3036088T3 (en)	2001-09-28
JPH11507935A (ja)	1999-07-13
ATE199831T1 (de)	2001-04-15
TW467746B (en)	2001-12-11
EP0833662B2 (de)	2011-01-26
KR19990028336A (ko)	1999-04-15
MA23918A1 (fr)	1996-12-31
JP4850987B2 (ja)	2012-01-11
AU6359196A (en)	1997-01-22
HK1009764A1 (en)	1999-06-11
IL122588A0 (en)	1998-06-15
HUP9900061A3 (en)	2000-03-28
BR9609414B1 (pt)	2013-11-19
EP0833662B1 (de)	2001-03-21
BR9609414A (pt)	1999-05-18
WO1997000697A1 (en)	1997-01-09
DK1082965T3 (da)	2009-07-27
SI0833662T1 (en)	2001-12-31
PT1082965E (pt)	2009-07-01
NO325169B1 (no)	2008-02-11
ES2157447T3 (es)	2001-08-16
BG62720B1 (bg)	2000-06-30
DK0833662T3 (da)	2001-07-09
EP1082965A1 (de)	2001-03-14
SI0833662T2 (sl)	2011-06-30
CZ288908B6 (cs)	2001-09-12
EG25924A (en)	2012-10-22
PL184872B1 (pl)	2003-01-31
EP0833662A1 (de)	1998-04-08
NO976035D0 (no)	1997-12-22
EP1082965B1 (de)	2009-06-10
DK0833662T4 (da)	2011-02-28
CA2222455C (en)	2013-05-28
MY114786A (en)	2003-01-31
CN1188418A (zh)	1998-07-22
HUP9900061A1 (hu)	1999-04-28
JP2008120833A (ja)	2008-05-29
CN1146444C (zh)	2004-04-21
PT833662E (pt)	2001-09-28
SI1082965T1 (sl)	2009-08-31
TR199701682T1 (xx)	1998-06-22
CA2222455A1 (en)	1997-01-09
PE11298A1 (es)	1998-03-20
HK1037516A1 (en)	2002-02-15
AU696338B2 (en)	1998-09-10
HU224514B1 (hu)	2005-10-28
NZ312132A (en)	1999-04-29

Publication	Publication Date	Title
CA2222455C (en)	2013-05-28	A vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminium phosphate
JP4233113B2 (ja)	2009-03-04	多糖類抗原−キャリア蛋白接合体および遊離キャリア蛋白を有してなるワクチン
US6756040B2 (en)	2004-06-29	Vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminum phosphate
EP0928198B1 (de)	2004-07-07	Bordetella pertussis aussermembran proteinfragmente enthaltende impfstoffzusammensetzung
HK1009764B (en)	2002-02-08	A vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminium phosphate
HK1037516B (en)	2010-01-22	A vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminium phosphate
MXPA97010521A (en)	1998-11-12	A composition of vaccines including an antigen conjugated of polysaccharid adsorbided in alumi phosphate