AP902A - Furan and thiophenenecarbothioamide derivatives, their preparation and their use as inhibitors of the replication of HIV-1 and HIV-1 mutants - Google Patents

Furan and thiophenenecarbothioamide derivatives, their preparation and their use as inhibitors of the replication of HIV-1 and HIV-1 mutants Download PDF

Info

Publication number: AP902A
Authority: AP; ARIPO
Prior art keywords: hiv; methyl; compound; reaction mixture; recited
Prior art date: 1995-11-30

Application number

APAP/P/1998/001245A

Other languages

English (en)

Other versions

AP9801245A0 (en

Inventor

Walter Gerhard Brouwer

Ewa Maria Osika

Benjamin James Pierce

Original Assignee

Uniroyal Chem Co Inc

Uniroyal Chemical Co /Uniroyal Chemical Cie

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-30

Filing date

1996-11-15

Publication date

2000-11-23

1996-11-15 Application filed by Uniroyal Chem Co Inc, Uniroyal Chemical Co /Uniroyal Chemical Cie filed Critical Uniroyal Chem Co Inc

1998-06-30 Publication of AP9801245A0 publication Critical patent/AP9801245A0/xx

2000-11-23 Application granted granted Critical

2000-11-23 Publication of AP902A publication Critical patent/AP902A/en

Links

241000713772 Human immunodeficiency virus 1 Species 0.000 title claims abstract description 35
230000010076 replication Effects 0.000 title claims abstract description 11
238000002360 preparation method Methods 0.000 title description 13
239000003112 inhibitor Substances 0.000 title description 6
YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 title description 4
150000001875 compounds Chemical class 0.000 claims abstract description 57
238000000034 method Methods 0.000 claims description 13
239000000203 mixture Substances 0.000 claims description 10
239000003937 drug carrier Substances 0.000 claims description 7
208000031886 HIV Infections Diseases 0.000 claims description 6
239000008194 pharmaceutical composition Substances 0.000 claims description 4
230000002401 inhibitory effect Effects 0.000 claims description 3
239000003814 drug Substances 0.000 claims 6
238000004519 manufacturing process Methods 0.000 claims 6
239000000126 substance Substances 0.000 claims 6
102100034343 Integrase Human genes 0.000 abstract description 16
108010092799 RNA-directed DNA polymerase Proteins 0.000 abstract description 16
208000030507 AIDS Diseases 0.000 abstract description 5
238000000338 in vitro Methods 0.000 abstract description 3
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201000010099 disease Diseases 0.000 abstract description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 2
238000001727 in vivo Methods 0.000 abstract description 2
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208000011580 syndromic disease Diseases 0.000 abstract description 2
230000001225 therapeutic effect Effects 0.000 abstract description 2
-1 ester compounds Chemical class 0.000 description 50
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239000000758 substrate Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
JRMUNVKIHCOMHV-UHFFFAOYSA-M tetrabutylammonium bromide Chemical compound [Br-].CCCC[N+](CCCC)(CCCC)CCCC JRMUNVKIHCOMHV-UHFFFAOYSA-M 0.000 description 1
238000011282 treatment Methods 0.000 description 1
239000008096 xylene Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Furan Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

APAP/P/1998/001245A 1995-11-30 1996-11-15 Furan and thiophenenecarbothioamide derivatives, their preparation and their use as inhibitors of the replication of HIV-1 and HIV-1 mutants AP902A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/565,493 US5696151A (en)	1995-11-30	1995-11-30	Compounds useful for the inhibition of the replication of HIV-1 and HIV-1 mutants
PCT/US1996/018394 WO1997019940A1 (en)	1995-11-30	1996-11-15	Furan- and thiophenecarbothioamide derivatives, their preparation and their use as inhibitors of the replication of hiv-1 and hiv-1 mutants

Publications (2)

Publication Number	Publication Date
AP9801245A0 AP9801245A0 (en)	1998-06-30
AP902A true AP902A (en)	2000-11-23

Family

ID=24258853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
APAP/P/1998/001245A AP902A (en)	1995-11-30	1996-11-15	Furan and thiophenenecarbothioamide derivatives, their preparation and their use as inhibitors of the replication of HIV-1 and HIV-1 mutants

Country Status (20)

Country	Link
US (1)	US5696151A (de)
EP (1)	EP0874839B1 (de)
JP (1)	JP3027771B2 (de)
KR (1)	KR100505841B1 (de)
CN (1)	CN1098847C (de)
AP (1)	AP902A (de)
AT (1)	ATE224382T1 (de)
AU (1)	AU704086B2 (de)
BR (1)	BR9611838A (de)
CA (1)	CA2237194C (de)
DE (1)	DE69623819T2 (de)
DK (1)	DK0874839T3 (de)
ES (1)	ES2183986T3 (de)
HU (1)	HU223660B1 (de)
NZ (1)	NZ324118A (de)
OA (1)	OA10864A (de)
PT (1)	PT874839E (de)
TW (1)	TW448169B (de)
WO (1)	WO1997019940A1 (de)
ZA (1)	ZA969490B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6143780A (en) *	1999-09-17	2000-11-07	Uniroyal Chemical Company, Inc.	N-arylmethylthioanilide compounds useful for the inhibition of the replication of HIV
US6017947A (en) *	1999-09-17	2000-01-25	Brouwer; Walter Gerhard	Heterocyclic carbodithioperoxyimidic compounds useful for the inhibition of the replication of HIV
US6498254B1 (en) *	2001-10-29	2002-12-24	Uniroyal Chemical Company, Inc.	Antiretroviral compounds and compositions
US7064139B2 (en) *	2001-10-29	2006-06-20	Uniroyal Chemical Company, Inc.	Method for treating retroviral infections
DE102008015033A1 (de)	2008-03-17	2009-09-24	Aicuris Gmbh & Co. Kg	Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung
DE102008015032A1 (de)	2008-03-17	2009-09-24	Aicuris Gmbh & Co. Kg	Substituierte Pyrazolamide und ihre Verwendung
DE102008062878A1 (de) *	2008-12-17	2010-06-24	Aicuris Gmbh & Co. Kg	Substituierte Furancarboxamide und ihre Verwendung
DE102008062863A1 (de)	2008-12-17	2010-06-24	Aicuris Gmbh & Co. Kg	Substituierte (Thiophenyl-carbonyl)imidazolidinone und ihre Verwendung
CN101987842A (zh) *	2009-07-31	2011-03-23	上海开拓者医药发展有限公司	一种2-甲基噻吩衍生物的制备方法
WO2016012424A1 (en) *	2014-07-24	2016-01-28	Bayer Cropscience Aktiengesellschaft	Fungicidal pyrazole derivatives

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1991005761A1 (en) *	1989-10-16	1991-05-02	Uniroyal Chemical Ltd./Uniroyal Chemical Ltee	Treatment of hiv infections and compounds useful therein

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5968910A (en) *	1994-11-30	1999-10-19	Jan M. R. Balzarini	Compositions containing two or three inhibitors of different HIV reverse transcriptases

1995
- 1995-11-30 US US08/565,493 patent/US5696151A/en not_active Expired - Lifetime
1996
- 1996-11-08 TW TW085113662A patent/TW448169B/zh not_active IP Right Cessation
- 1996-11-12 ZA ZA969490A patent/ZA969490B/xx unknown
- 1996-11-15 CA CA002237194A patent/CA2237194C/en not_active Expired - Lifetime
- 1996-11-15 AU AU11199/97A patent/AU704086B2/en not_active Expired
- 1996-11-15 AP APAP/P/1998/001245A patent/AP902A/en active
- 1996-11-15 NZ NZ324118A patent/NZ324118A/xx not_active IP Right Cessation
- 1996-11-15 AT AT96942010T patent/ATE224382T1/de active
- 1996-11-15 BR BR9611838A patent/BR9611838A/pt active Search and Examination
- 1996-11-15 PT PT96942010T patent/PT874839E/pt unknown
- 1996-11-15 EP EP96942010A patent/EP0874839B1/de not_active Expired - Lifetime
- 1996-11-15 HU HU9901990A patent/HU223660B1/hu active IP Right Grant
- 1996-11-15 ES ES96942010T patent/ES2183986T3/es not_active Expired - Lifetime
- 1996-11-15 KR KR10-1998-0703958A patent/KR100505841B1/ko not_active Expired - Lifetime
- 1996-11-15 CN CN96198705A patent/CN1098847C/zh not_active Expired - Lifetime
- 1996-11-15 WO PCT/US1996/018394 patent/WO1997019940A1/en not_active Ceased
- 1996-11-15 DK DK96942010T patent/DK0874839T3/da active
- 1996-11-15 DE DE69623819T patent/DE69623819T2/de not_active Expired - Lifetime
- 1996-11-15 JP JP9520533A patent/JP3027771B2/ja not_active Expired - Lifetime
1998
- 1998-05-29 OA OA9800070A patent/OA10864A/en unknown

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1991005761A1 (en) *	1989-10-16	1991-05-02	Uniroyal Chemical Ltd./Uniroyal Chemical Ltee	Treatment of hiv infections and compounds useful therein

Also Published As

Publication number	Publication date
DE69623819T2 (de)	2003-05-28
CN1203596A (zh)	1998-12-30
AU1119997A (en)	1997-06-19
ZA969490B (en)	1997-06-02
EP0874839A1 (de)	1998-11-04
HUP9901990A2 (en)	2000-07-28
DE69623819D1 (de)	2002-10-24
OA10864A (en)	2003-02-18
KR19990071682A (ko)	1999-09-27
HUP9901990A3 (en)	2000-08-28
CN1098847C (zh)	2003-01-15
CA2237194C (en)	2006-06-13
HU223660B1 (hu)	2004-11-29
US5696151A (en)	1997-12-09
AP9801245A0 (en)	1998-06-30
BR9611838A (pt)	1999-03-09
CA2237194A1 (en)	1997-06-05
NZ324118A (en)	1999-02-25
ES2183986T3 (es)	2003-04-01
EP0874839B1 (de)	2002-09-18
JPH11504657A (ja)	1999-04-27
WO1997019940A1 (en)	1997-06-05
DK0874839T3 (da)	2003-01-27
TW448169B (en)	2001-08-01
AU704086B2 (en)	1999-04-15
PT874839E (pt)	2003-02-28
ATE224382T1 (de)	2002-10-15
JP3027771B2 (ja)	2000-04-04
KR100505841B1 (ko)	2005-12-14
HK1016601A1 (en)	1999-11-05

Publication	Publication Date	Title
JP6181747B2 (ja)	2017-08-16	カテコールｏ−メチルトランスフェラーゼ活性阻害化合物
AP902A (en)	2000-11-23	Furan and thiophenenecarbothioamide derivatives, their preparation and their use as inhibitors of the replication of HIV-1 and HIV-1 mutants
MX2007003641A (es)	2007-08-14	Nuevos inhibidores de histona deacetilasas.
EP0322004B1 (de)	1992-01-15	Zyklische entzündungshemmende Derivate von Di-tert-butylphenol-Verbindungen
EP1220848B1 (de)	2003-11-19	N-arylmethylthioanilid-derivate für die hemmung der hiv-replikation
CA1239402A (en)	1988-07-19	Dithio compounds, pharmaceutical preparations containing them and their use
EP0087629A2 (de)	1983-09-07	Entzündungshemmende und/oder Schmerzstillende 2,3-Diaryl-5-halo thiophene
CA1097684A (fr)	1981-03-17	PROCEDE DE PREPARATION D'ACIDES.gamma.ARYL .gamma.OXO ISOVALERIQUES
CN113402414A (zh)	2021-09-17	一种苯甲酸衍生物及其制法和药物用途
WO2005037760A1 (ja)	2005-04-28	新規フェノール誘導体およびそれらを有効成分とする抗トリパノソーマ予防・治療剤
CN116332903B (zh)	2024-11-12	一种具有苯并[b]硒吩结构的二聚化合物及其用途
IE45905B1 (en)	1982-12-29	Substituted furan and thiophen alkyl ketones
JPH08151341A (ja)	1996-06-11	スーパーオキシド産生阻害剤および１−ナフトール誘導体
NL8400217A (nl)	1984-08-16	Derivaten van acrylzuur die een heterocyclische, zuurstofhoudende, groep bevatten als geneesmiddel, nieuwe, industriele produkten en bereidingswerkwijzen.
JPH04261178A (ja)	1992-09-17	肝障害の予防・治療剤