AP9801234A0 - Cox-2 selective carprofenor treating pain and inflammation in dogs. - Google Patents

Cox-2 selective carprofenor treating pain and inflammation in dogs.

Info

Publication number: AP9801234A0
Authority: AP; ARIPO
Prior art keywords: cox; acids; activity; dogs; inhibition
Prior art date: 1997-05-05

Application number

APAP/P/1998/001234A

Other languages

English (en)

Inventor

Kristin Marie Lundy

Anthony Paul Ricketts

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-05

Filing date

1998-05-04

Publication date

1999-11-04

1998-05-04 Application filed by Pfizer filed Critical Pfizer

1999-11-04 Publication of AP9801234A0 publication Critical patent/AP9801234A0/en

Links

101150071146 COX2 gene Proteins 0.000 title abstract 3
101100114534 Caenorhabditis elegans ctc-2 gene Proteins 0.000 title abstract 3
101150000187 PTGS2 gene Proteins 0.000 title abstract 3
241000282472 Canis lupus familiaris Species 0.000 title abstract 2
230000004054 inflammatory process Effects 0.000 title abstract 2
206010061218 Inflammation Diseases 0.000 title 1
230000000694 effects Effects 0.000 abstract 4
230000005764 inhibitory process Effects 0.000 abstract 3
101100496968 Caenorhabditis elegans ctc-1 gene Proteins 0.000 abstract 2
SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
101100221647 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) cox-1 gene Proteins 0.000 abstract 2
101150062589 PTGS1 gene Proteins 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
150000007513 acids Chemical class 0.000 abstract 2
239000003112 inhibitor Substances 0.000 abstract 2
PLIKAWJENQZMHA-UHFFFAOYSA-N 4-aminophenol Chemical class NC1=CC=C(O)C=C1 PLIKAWJENQZMHA-UHFFFAOYSA-N 0.000 abstract 1
108010037464 Cyclooxygenase 1 Proteins 0.000 abstract 1
108010037462 Cyclooxygenase 2 Proteins 0.000 abstract 1
102100038277 Prostaglandin G/H synthase 1 Human genes 0.000 abstract 1
102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 abstract 1
235000011054 acetic acid Nutrition 0.000 abstract 1
PDODBKYPSUYQGT-UHFFFAOYSA-N acetic acid;1h-indene Chemical class CC(O)=O.C1=CC=C2CC=CC2=C1 PDODBKYPSUYQGT-UHFFFAOYSA-N 0.000 abstract 1
RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical class NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
239000008280 blood Substances 0.000 abstract 1
210000004369 blood Anatomy 0.000 abstract 1
PUXBGTOOZJQSKH-UHFFFAOYSA-N carprofen Chemical compound C1=C(Cl)C=C2C3=CC=C(C(C(O)=O)C)C=C3NC2=C1 PUXBGTOOZJQSKH-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
-1 heteroaryl acetic acids Chemical class 0.000 abstract 1
PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
230000001939 inductive effect Effects 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
229940058287 salicylic acid derivative anticestodals Drugs 0.000 abstract 1
150000003872 salicylic acid derivatives Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Medicinal Preparation (AREA)

APAP/P/1998/001234A 1997-05-05 1998-05-04 Cox-2 selective carprofenor treating pain and inflammation in dogs. AP9801234A0 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US4563597P	1997-05-05	1997-05-05

Publications (1)

Publication Number	Publication Date
AP9801234A0 true AP9801234A0 (en)	1999-11-04

Family

ID=21939053

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
APAP/P/1998/001234A AP9801234A0 (en)	1997-05-05	1998-05-04	Cox-2 selective carprofenor treating pain and inflammation in dogs.

Country Status (32)

Country	Link
EP (1)	EP0988034A1 (fr)
JP (1)	JP2000513020A (fr)
KR (2)	KR20040004406A (fr)
CN (1)	CN1255059A (fr)
AP (1)	AP9801234A0 (fr)
AR (2)	AR011726A1 (fr)
AU (1)	AU6932198A (fr)
BG (1)	BG103852A (fr)
BR (1)	BR9808720A (fr)
CA (1)	CA2288759A1 (fr)
DZ (1)	DZ2479A1 (fr)
EA (1)	EA003696B1 (fr)
GT (1)	GT199800063A (fr)
HR (1)	HRP980244A2 (fr)
HU (1)	HUP0001286A3 (fr)
ID (1)	ID21311A (fr)
IL (1)	IL132570A0 (fr)
IS (1)	IS5220A (fr)
MA (1)	MA26491A1 (fr)
NO (1)	NO995389L (fr)
NZ (1)	NZ500183A (fr)
OA (1)	OA11213A (fr)
PA (1)	PA8450601A1 (fr)
PE (1)	PE72599A1 (fr)
PL (1)	PL337003A1 (fr)
SK (1)	SK148199A3 (fr)
TN (1)	TNSN98059A1 (fr)
TW (1)	TW590773B (fr)
UY (1)	UY24989A1 (fr)
WO (1)	WO1998050033A1 (fr)
YU (1)	YU55899A (fr)
ZA (1)	ZA983722B (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6245797B1 (en)	1997-10-22	2001-06-12	Merck & Co., Inc.	Combination therapy for reducing the risks associated with cardio-and-cerebrovascular disease
US6506785B2 (en)	1998-05-22	2003-01-14	Pfizer, Inc.	Treating or preventing the early stages of degeneration of articular cartilage or subchondral bone in mammals using carprofen and derivatives
AU2003204888B2 (en) *	1998-05-22	2005-07-28	Pfizer Products Inc.	Treating or Preventing the Early Stages of Degeneration of Articular Cartilage or Subchondral Bone in Mammals Using Carprofen and Derivatives
EP1123091A1 (fr) *	1998-10-23	2001-08-16	Merck Frosst Canada & Co.	Produit de combinaison comprenant un ligand de prostaglandine de type e et un inhibiteur selectif de cox-2, et procedes d'utilisation dudit produit
ATE306263T1 (de) *	1999-03-10	2005-10-15	Searle Llc	Zusammensetzungen zur verabreichung eines cyclooxygenase-2-hemmers an tiere
AU1592901A (en) *	1999-11-11	2001-06-06	Eli Lilly And Company	Oncolytic combinations for the treatment of cancer
WO2001087343A2 (fr) *	2000-05-15	2001-11-22	Merck Frosst Canada & Co.	Polytherapie faisant appel a un inhibiteur selectif de cox-2 et a un inhibiteur de la thromboxane ainsi que des compositions contenant ceux-ci
MXPA02012344A (es)	2000-06-13	2004-02-26	Wyeth Corp	Composiciones y anti-inflamatorias que contienen inhibidores cox-2.
DE10032132A1 (de) *	2000-07-01	2002-01-17	Lohmann Therapie Syst Lts	Dermales Therapeutisches System enthaltend nichtsteroidale Antiphlogistika mit selektiver COX-2-Hemmung
WO2002012445A1 (fr)	2000-08-07	2002-02-14	Vanderbilt University	Detection de l'activite cox-2 et des metabolites d'anandamide
AU2002354901A1 (en) *	2001-07-16	2003-03-03	Edward Hogestatt	Compounds with analgesic, antipyretic and/or anti-inflammatory activity
ES2275218T3 (es)	2003-05-07	2007-06-01	Osteologix A/S	Sales de estroncio hidrosolubles para el tratamiento de afecciones de cartilagos y/o huesos.
JP2007500691A (ja) *	2003-07-31	2007-01-18	ファルマシア・アンド・アップジョン・カンパニー・エルエルシー	抗炎症剤の分散性製剤
BRPI0610316A2 (pt) *	2005-05-20	2010-06-15	Pfizer Ltd	combinações sinergìsticas de medicamentos atiinflamatórios não estereoidais com alfa-delta-ligantes
ES2393814T3 (es)	2007-04-04	2012-12-28	Sigmoid Pharma Limited	Una composición farmacéutica oral
CA2685118C (fr)	2007-04-26	2016-11-01	Sigmoid Pharma Limited	Fabrication de minicapsules multiples
ES2530049T3 (es)	2009-05-18	2015-02-26	Sigmoid Pharma Limited	Composición que comprende gotas de aceite
CN102573802A (zh)	2009-08-12	2012-07-11	希格默伊德药业有限公司	包含聚合物基质和油相的免疫调节组合物
GB201020032D0 (en)	2010-11-25	2011-01-12	Sigmoid Pharma Ltd	Composition
GB201212010D0 (en)	2012-07-05	2012-08-22	Sigmoid Pharma Ltd	Formulations
GB201319791D0 (en)	2013-11-08	2013-12-25	Sigmoid Pharma Ltd	Formulations
US12109218B2 (en)	2014-12-09	2024-10-08	Aratana Therapeutics, Inc.	Compositions of grapiprant and methods for using the same
PT3113774T (pt)	2014-03-06	2022-02-28	Elanco Animal Health Incorporated	Composições de grapiprant e métodos de utilização das mesmas
JP6716582B2 (ja)	2014-11-07	2020-07-01	サブリミティ・セラピューティクス・リミテッドＳｕｂｌｉｍｉｔｙＴｈｅｒａｐｅｕｔｉｃｓＬｉｍｉｔｅｄ	シクロスポリンを含む組成物
BR112017014750A2 (pt) *	2015-01-09	2018-06-19	Jaguar Animal Health	métodos para tratamento de diarreia em animais de estimação
CN115335046A (zh) *	2020-03-25	2022-11-11	思研（Sri）国际顾问与咨询公司	脂肪氧合酶抑制剂
US11116737B1 (en)	2020-04-10	2021-09-14	University Of Georgia Research Foundation, Inc.	Methods of using probenecid for treatment of coronavirus infections
KR102404883B1 (ko)	2020-11-30	2022-06-07	(주)이노보테라퓨틱스	벤즈브로마론을 포함하는 켈로이드 또는 비대흉터 예방 또는 치료용 약학 조성물

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3896145A (en) *	1972-07-24	1975-07-22	Hoffmann La Roche	Carbazoles
CA1319886C (fr) *	1987-02-03	1993-07-06	Alberto Ferro	Solutions de micelles mixtes

1998
- 1998-03-02 DZ DZ980089A patent/DZ2479A1/fr active
- 1998-04-30 TW TW087106689A patent/TW590773B/zh not_active IP Right Cessation
- 1998-05-01 WO PCT/IB1998/000662 patent/WO1998050033A1/fr not_active Ceased
- 1998-05-01 JP JP10547869A patent/JP2000513020A/ja active Pending
- 1998-05-01 SK SK1481-99A patent/SK148199A3/sk unknown
- 1998-05-01 HU HU0001286A patent/HUP0001286A3/hu unknown
- 1998-05-01 KR KR10-2003-7005258A patent/KR20040004406A/ko not_active Ceased
- 1998-05-01 AU AU69321/98A patent/AU6932198A/en not_active Abandoned
- 1998-05-01 BR BR9808720-7A patent/BR9808720A/pt not_active IP Right Cessation
- 1998-05-01 YU YU55899A patent/YU55899A/sh unknown
- 1998-05-01 CA CA002288759A patent/CA2288759A1/fr not_active Abandoned
- 1998-05-01 EA EA199900895A patent/EA003696B1/ru not_active IP Right Cessation
- 1998-05-01 EP EP98915041A patent/EP0988034A1/fr not_active Withdrawn
- 1998-05-01 CN CN98804845A patent/CN1255059A/zh active Pending
- 1998-05-01 NZ NZ500183A patent/NZ500183A/en unknown
- 1998-05-01 IL IL13257098A patent/IL132570A0/xx unknown
- 1998-05-01 ID IDP980651A patent/ID21311A/id unknown
- 1998-05-01 KR KR1019997010252A patent/KR20010012300A/ko not_active Ceased
- 1998-05-01 PL PL98337003A patent/PL337003A1/xx unknown
- 1998-05-04 PE PE1998000335A patent/PE72599A1/es not_active Application Discontinuation
- 1998-05-04 TN TNTNSN98059A patent/TNSN98059A1/fr unknown
- 1998-05-04 UY UY24989A patent/UY24989A1/es not_active Application Discontinuation
- 1998-05-04 ZA ZA9803722A patent/ZA983722B/xx unknown
- 1998-05-04 AP APAP/P/1998/001234A patent/AP9801234A0/en unknown
- 1998-05-04 MA MA25059A patent/MA26491A1/fr unknown
- 1998-05-04 GT GT199800063A patent/GT199800063A/es unknown
- 1998-05-05 HR HR60/045,635A patent/HRP980244A2/hr not_active Application Discontinuation
- 1998-05-05 PA PA19988450601A patent/PA8450601A1/es unknown
- 1998-05-05 AR ARP980102089A patent/AR011726A1/es unknown
1999
- 1999-10-19 IS IS5220A patent/IS5220A/is unknown
- 1999-11-02 OA OA9900242A patent/OA11213A/en unknown
- 1999-11-03 BG BG103852A patent/BG103852A/xx unknown
- 1999-11-04 NO NO995389A patent/NO995389L/no not_active Application Discontinuation
2003
- 2003-04-09 AR ARP030101251A patent/AR039628A2/es unknown

Also Published As

Publication number	Publication date
NO995389D0 (no)	1999-11-04
CA2288759A1 (fr)	1998-11-12
PE72599A1 (es)	1999-08-12
EA199900895A1 (ru)	2000-06-26
CN1255059A (zh)	2000-05-31
PL337003A1 (en)	2000-07-31
KR20040004406A (ko)	2004-01-13
HUP0001286A2 (hu)	2000-11-28
NO995389L (no)	2000-01-04
AR011726A1 (es)	2000-08-30
ID21311A (id)	1999-05-20
JP2000513020A (ja)	2000-10-03
IL132570A0 (en)	2001-03-19
HRP980244A2 (en)	1999-02-28
WO1998050033A1 (fr)	1998-11-12
KR20010012300A (ko)	2001-02-15
OA11213A (en)	2003-07-14
PA8450601A1 (es)	2000-05-24
UY24989A1 (es)	2001-10-25
NZ500183A (en)	2002-04-26
BR9808720A (pt)	2000-07-11
EP0988034A1 (fr)	2000-03-29
GT199800063A (es)	1999-10-26
BG103852A (en)	2000-06-30
HUP0001286A3 (en)	2000-12-28
TNSN98059A1 (fr)	2005-03-15
EA003696B1 (ru)	2003-08-28
ZA983722B (en)	1999-11-04
YU55899A (sh)	2003-08-29
IS5220A (is)	1999-10-19
TW590773B (en)	2004-06-11
AU6932198A (en)	1998-11-27
MA26491A1 (fr)	2004-12-20
AR039628A2 (es)	2005-03-02
DZ2479A1 (fr)	2003-02-01
SK148199A3 (en)	2001-09-11

Publication	Publication Date	Title
AP9801234A0 (en)	1999-11-04	Cox-2 selective carprofenor treating pain and inflammation in dogs.
NZ330860A (en)	1999-11-29	Method of inhibiting photoaging of skin
EE04416B1 (et)	2005-02-15	a1L- agonistide kasutamine uriiniinkontinentsuse raviks
EA200000825A1 (ru)	2001-02-26	Композиция, включающая ингибитор il-1 и полимер, контролирующий высвобождение
BG104476A (en)	2000-12-29	Therapeutical form for tolterodin with controlled release
ATE333874T1 (de)	2006-08-15	Konjugierte linolensäure zur behandlung von cyclooxygenase-2 vermittelten entzündungen und schmerzen
WO2000028980A3 (fr)	2000-07-27	Methode de traitement de la douleur
DE50014190D1 (de)	2007-05-03	Verwendung von phthalazin-derivaten zur behandlung neurodegenerativer krankheiten
NO985575L (no)	1999-02-01	FremgangsmÕter og preparater anvendelige for inhibering av <alfa>v<beta>5-mediert angiogenese
NO20014046L (no)	2001-08-20	Gabapentinderivater for forhindring og behandling av visceral smerte
PT944631E (pt)	2004-06-30	Novos derivados substituidos de pirazole para tratamento de doencas cardiovasculares
DE69613840D1 (de)	2001-08-16	Orale dosierungsform und verfahren zur behandlung von schmerzzuständen in dermundhöhle
IT8320064A0 (it)	1983-03-14	Inibitori dell'enzima che trasforma l'angiotensina, costituiti da acidi amminoalchilfosfinici e da acidi amminofosfinici sostituiti simili.
BG102918A (en)	1999-09-30	Biphenylsulphanomide inhibitors of the matrix metalloproteinase
AU3346095A (en)	1996-03-22	Use of 5-substituted pyridine and hexahydroquinoline-3 carboxylic acid derivatives for treating diseases of the central nervous system
AU8026200A (en)	2001-04-30	Treatment of heart disease with cox-2 inhibitors
IL143594A0 (en)	2002-04-21	Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors for the treatment of respiratory diseases
AU6330799A (en)	2000-04-17	Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders
AU8742198A (en)	1999-03-08	Use of cholinesterase inhibitor for treating diseases associated with pro teolytic enzyme activity
CO5021216A1 (es)	2001-03-27	Carprofeno selectivo para cox-2, para el tratamiento del dolor e inflamacion en perros
EE9700350A (et)	1998-10-15	COMT-inhibiitorite uus kasutamine ja diabeetiliste vaskulaarsete häirete ärahoidmise meetod
ATE286892T1 (de)	2005-01-15	Hydroxam- und carbonsäurederivate mit mmp- und tnf-hemmender aktivität
ATE232541T1 (de)	2003-02-15	Gallensauersälze mit physiologisch aktiven metalle und ihre verwendung zur therapeutischen behandlung
BR0213634A (pt)	2004-11-30	Sistema de liberação de droga com ação retardada para um agente antiespasmódico
FR2760363B1 (fr)	1999-12-17	Composition pour le traitement topique des affections de la peau et des phaneres