AP9901659A0 - Quinoline-2-carboxylic acid derivatives and its use as excitatory amino acids antagonist. - Google Patents
Quinoline-2-carboxylic acid derivatives and its use as excitatory amino acids antagonist.Info
- Publication number
- AP9901659A0 AP9901659A0 APAP/P/1999/001659A AP9901659A AP9901659A0 AP 9901659 A0 AP9901659 A0 AP 9901659A0 AP 9901659 A AP9901659 A AP 9901659A AP 9901659 A0 AP9901659 A0 AP 9901659A0
- Authority
- AP
- ARIPO
- Prior art keywords
- antagonist
- carboxylic acid
- amino acids
- quinoline
- excitatory amino
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 239000003257 excitatory amino acid Substances 0.000 title abstract 2
- 230000002461 excitatory amino acid Effects 0.000 title abstract 2
- LOAUVZALPPNFOQ-UHFFFAOYSA-N quinaldic acid Chemical class C1=CC=CC2=NC(C(=O)O)=CC=C21 LOAUVZALPPNFOQ-UHFFFAOYSA-N 0.000 title 1
- LNYJXORXZWTJDA-UHFFFAOYSA-N 4-[2-(4-acetamidoanilino)-2-oxoethylidene]-5,7-dichloro-2,3-dihydro-1h-quinoline-2-carboxylic acid Chemical compound C1=CC(NC(=O)C)=CC=C1NC(=O)C=C1C2=C(Cl)C=C(Cl)C=C2NC(C(O)=O)C1 LNYJXORXZWTJDA-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9706294.7A GB9706294D0 (en) | 1997-03-26 | 1997-03-26 | Heterocyclic compound |
| PCT/EP1998/001700 WO1998042673A1 (en) | 1997-03-26 | 1998-03-24 | Quinoline-2-carboxylic acid derivative and its use as excitatory amino acids antagonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AP9901659A0 true AP9901659A0 (en) | 1999-09-30 |
Family
ID=10809909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| APAP/P/1999/001659A AP9901659A0 (en) | 1997-03-26 | 1998-03-24 | Quinoline-2-carboxylic acid derivatives and its use as excitatory amino acids antagonist. |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0971896A1 (is) |
| JP (1) | JP2001518901A (is) |
| KR (1) | KR20010005567A (is) |
| CN (1) | CN1257482A (is) |
| AP (1) | AP9901659A0 (is) |
| AU (1) | AU731394B2 (is) |
| BR (1) | BR9808424A (is) |
| CA (1) | CA2284710A1 (is) |
| EA (1) | EA199900755A1 (is) |
| GB (1) | GB9706294D0 (is) |
| HU (1) | HUP0001661A3 (is) |
| ID (1) | ID24306A (is) |
| IL (1) | IL131919A0 (is) |
| IS (1) | IS5186A (is) |
| NO (1) | NO994679L (is) |
| NZ (1) | NZ337793A (is) |
| PL (1) | PL335865A1 (is) |
| TR (1) | TR199902315T2 (is) |
| WO (1) | WO1998042673A1 (is) |
| YU (1) | YU47699A (is) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9917822D0 (en) * | 1999-07-29 | 1999-09-29 | Imperial College | Nmda antagonist |
| DE10132725A1 (de) | 2001-07-05 | 2006-08-03 | Grünenthal GmbH | Substituierte γ-Lactonverbindungen |
| DE10137487A1 (de) * | 2001-08-03 | 2003-03-27 | Gruenenthal Gmbh | Substituierte 5,6,6a,11b-Tetrahydro-7-oxa-6-aza- benzo[c]fluoren-6-carbonsäurederivate |
| DE10306202A1 (de) | 2003-02-13 | 2004-08-26 | Grünenthal GmbH | Arzneimittel enthaltend substituierte 2-Aryl-Aminoessigsäure-Verbindungen und/oder substituierte 2-Heteroaryl-Aminoessigsäure-Verbindungen |
| JP4360891B2 (ja) | 2003-12-09 | 2009-11-11 | アルパイン株式会社 | 放送受信機能を備えた電子装置およびその装置における電子番組ガイドの表示方法 |
| RU2451014C2 (ru) * | 2005-07-22 | 2012-05-20 | Мотида Фармасьютикал Ко., Лтд. | Новое производное гетероциклиден ацетамида |
| KR101136183B1 (ko) * | 2005-07-22 | 2012-04-17 | 모찌다 세이야쿠 가부시끼가이샤 | 신규 헤테로시클리덴 아세트아미드 유도체 |
| US9737531B2 (en) | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| JP7305560B2 (ja) | 2017-06-12 | 2023-07-10 | グリテック， エルエルシー | Ｎｍｄａアンタゴニスト及びｄ２／５ｈｔ２ａ又は選択的５ｈｔ２ａアンタゴニストによるうつ病の治療 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0386839B1 (en) * | 1989-03-08 | 1997-01-15 | Merck Sharp & Dohme Ltd. | Tetrahydroquinoline derivatives useful for neurodegenerative disorders |
| AU708148B2 (en) * | 1995-09-29 | 1999-07-29 | Glaxo Wellcome S.P.A. | Tetrahydroquinolines as NMDA antagonists |
| GB9617305D0 (en) * | 1996-08-17 | 1996-09-25 | Glaxo Wellcome Spa | Heterocyclic compounds |
-
1997
- 1997-03-26 GB GBGB9706294.7A patent/GB9706294D0/en active Pending
-
1998
- 1998-03-24 KR KR1019997008630A patent/KR20010005567A/ko not_active Withdrawn
- 1998-03-24 IL IL13191998A patent/IL131919A0/xx unknown
- 1998-03-24 ID IDW991108A patent/ID24306A/id unknown
- 1998-03-24 JP JP54323498A patent/JP2001518901A/ja active Pending
- 1998-03-24 HU HU0001661A patent/HUP0001661A3/hu unknown
- 1998-03-24 EP EP98919133A patent/EP0971896A1/en not_active Withdrawn
- 1998-03-24 CN CN98805302A patent/CN1257482A/zh active Pending
- 1998-03-24 WO PCT/EP1998/001700 patent/WO1998042673A1/en not_active Ceased
- 1998-03-24 AP APAP/P/1999/001659A patent/AP9901659A0/en unknown
- 1998-03-24 AU AU72094/98A patent/AU731394B2/en not_active Ceased
- 1998-03-24 NZ NZ337793A patent/NZ337793A/en unknown
- 1998-03-24 YU YU47699A patent/YU47699A/sh unknown
- 1998-03-24 PL PL98335865A patent/PL335865A1/xx unknown
- 1998-03-24 TR TR1999/02315T patent/TR199902315T2/xx unknown
- 1998-03-24 CA CA002284710A patent/CA2284710A1/en not_active Abandoned
- 1998-03-24 BR BR9808424-0A patent/BR9808424A/pt not_active IP Right Cessation
- 1998-03-24 EA EA199900755A patent/EA199900755A1/ru unknown
-
1999
- 1999-09-17 IS IS5186A patent/IS5186A/is unknown
- 1999-09-24 NO NO994679A patent/NO994679L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL131919A0 (en) | 2001-03-19 |
| YU47699A (sh) | 2001-12-26 |
| NO994679D0 (no) | 1999-09-24 |
| TR199902315T2 (xx) | 2000-05-22 |
| HUP0001661A3 (en) | 2001-12-28 |
| ID24306A (id) | 2000-07-13 |
| HUP0001661A2 (hu) | 2000-09-28 |
| AU731394B2 (en) | 2001-03-29 |
| BR9808424A (pt) | 2000-05-23 |
| JP2001518901A (ja) | 2001-10-16 |
| NO994679L (no) | 1999-11-24 |
| GB9706294D0 (en) | 1997-05-14 |
| NZ337793A (en) | 2001-02-23 |
| PL335865A1 (en) | 2000-05-22 |
| KR20010005567A (ko) | 2001-01-15 |
| EA199900755A1 (ru) | 2000-08-28 |
| WO1998042673A1 (en) | 1998-10-01 |
| CN1257482A (zh) | 2000-06-21 |
| IS5186A (is) | 1999-09-17 |
| EP0971896A1 (en) | 2000-01-19 |
| CA2284710A1 (en) | 1998-10-01 |
| AU7209498A (en) | 1998-10-20 |
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