AR013696A1 - Amidas de acido isoquinolin-3-carboxilicos sustituidas, su preparacion y su empleo como medicamentos - Google Patents

Amidas de acido isoquinolin-3-carboxilicos sustituidas, su preparacion y su empleo como medicamentos

Info

Publication number: AR013696A1
Authority: AR; Argentina
Prior art keywords: isoquinolin; carboxylic acid; amidas; employment; medicines
Prior art date: 1997-10-20

Application number

ARP980105164A

Other languages

English (en)

Spanish (es)

Original Assignee

Hoechst Marion Roussel Deutchland Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-20

Filing date

1998-10-16

Publication date

2001-01-10

1998-10-16 Application filed by Hoechst Marion Roussel Deutchland Gmbh filed Critical Hoechst Marion Roussel Deutchland Gmbh

2001-01-10 Publication of AR013696A1 publication Critical patent/AR013696A1/es

Links

239000003814 drug Substances 0.000 title 1
KVMMIDQDXZOPAB-UHFFFAOYSA-N isoquinoline-3-carboxylic acid Chemical compound C1=CC=C2C=NC(C(=O)O)=CC2=C1 KVMMIDQDXZOPAB-UHFFFAOYSA-N 0.000 title 1
239000001257 hydrogen Substances 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 3
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 2
229910052801 chlorine Inorganic materials 0.000 abstract 2
239000000460 chlorine Substances 0.000 abstract 2
125000001309 chloro group Chemical group Cl* 0.000 abstract 2
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
229910052731 fluorine Inorganic materials 0.000 abstract 2
239000011737 fluorine Substances 0.000 abstract 2
125000004428 fluoroalkoxy group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
102000004079 Prolyl Hydroxylases Human genes 0.000 abstract 1
108010043005 Prolyl Hydroxylases Proteins 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
KKSZSACCVDIWIE-UHFFFAOYSA-N isoquinoline-3-carboxamide Chemical class C1=CC=C2C=NC(C(=O)N)=CC2=C1 KKSZSACCVDIWIE-UHFFFAOYSA-N 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000007863 steatosis Effects 0.000 abstract 1
231100000240 steatosis hepatitis Toxicity 0.000 abstract 1
125000005415 substituted alkoxy group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Cardiology (AREA)
Obesity (AREA)
Gastroenterology & Hepatology (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Hematology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Toxicology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

ARP980105164A 1997-10-20 1998-10-16 Amidas de acido isoquinolin-3-carboxilicos sustituidas, su preparacion y su empleo como medicamentos AR013696A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19746287A DE19746287A1 (de)	1997-10-20	1997-10-20	Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number	Publication Date
AR013696A1 true AR013696A1 (es)	2001-01-10

Family

ID=7846053

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ARP980105164A AR013696A1 (es)	1997-10-20	1998-10-16	Amidas de acido isoquinolin-3-carboxilicos sustituidas, su preparacion y su empleo como medicamentos

Country Status (24)

Country	Link
US (1)	US6093730A (2)
EP (2)	EP0911340B1 (2)
JP (2)	JP3782591B2 (2)
KR (1)	KR100618922B1 (2)
CN (1)	CN1117079C (2)
AR (1)	AR013696A1 (2)
AT (2)	ATE432940T1 (2)
AU (1)	AU755714B2 (2)
BR (1)	BR9804504B1 (2)
CA (2)	CA2250664A1 (2)
CZ (1)	CZ337298A3 (2)
DE (3)	DE19746287A1 (2)
DK (2)	DK1538160T3 (2)
ES (2)	ES2245471T3 (2)
HU (1)	HUP9802422A3 (2)
ID (1)	ID21115A (2)
IL (1)	IL126638A0 (2)
NO (1)	NO312365B1 (2)
NZ (1)	NZ332363A (2)
PL (1)	PL192354B1 (2)
PT (1)	PT911340E (2)
SG (1)	SG87776A1 (2)
TR (1)	TR199802106A2 (2)
ZA (1)	ZA989505B (2)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2001275014A1 (en) *	2000-05-30	2001-12-11	Neurogen Corporation	Imidazoloisoquinolines
US6762318B2 (en) *	2001-12-03	2004-07-13	Novo Nordisk A/S	Glucagon antagonists
CN102552263A (zh) *	2001-12-06	2012-07-11	法布罗根股份有限公司	提高内源性红细胞生成素(epo)的方法
US8318703B2 (en)	2001-12-06	2012-11-27	Fibrogen, Inc.	Methods for improving kidney function
EP2295060B1 (en)	2001-12-06	2018-10-31	Fibrogen, Inc.	Treatment or prevention of ischemic or hypoxic conditions
US8124582B2 (en) *	2002-12-06	2012-02-28	Fibrogen, Inc.	Treatment of diabetes
US7618940B2 (en)	2002-12-06	2009-11-17	Fibrogen, Inc.	Fat regulation
WO2005007192A2 (en) *	2003-06-06	2005-01-27	Fibrogen, Inc.	Cytoprotection through the use of hif hydroxylase inhibitors
US8614204B2 (en) *	2003-06-06	2013-12-24	Fibrogen, Inc.	Enhanced erythropoiesis and iron metabolism
CA2528232C (en)	2003-06-06	2010-05-25	Fibrogen, Inc.	Novel nitrogen-containing heteroaryl compounds and their use in increasing endogenous erythropoietin
US20060276477A1 (en) *	2005-06-06	2006-12-07	Fibrogen, Inc.	Treatment method for anemia
AU2006259352A1 (en)	2005-06-15	2006-12-28	Fibrogen, Inc.	Use of HIF 1alfa modulators for treatment of cancer
JP5202327B2 (ja) *	2005-12-09	2013-06-05	アムジエン・インコーポレーテツド	プロリルヒドロキシラーゼ阻害活性を示すキノロンベースの化合物、およびこの組成物、およびこの使用
EP2476669A1 (en)	2006-01-27	2012-07-18	Fibrogen, Inc.	Cyanoisoquinoline compounds and methods of use thereof
US7745461B1 (en)	2006-02-27	2010-06-29	Alcon Research, Ltd.	Method of treating dry eye disorders
WO2007101204A1 (en) *	2006-02-27	2007-09-07	Alcon Research, Ltd.	Method of treating glaucoma
WO2007114612A1 (en) *	2006-03-30	2007-10-11	Lg Electronics Inc.	A method and apparatus for decoding/encoding a video signal
CN103497184A (zh)	2006-04-04	2014-01-08	菲布罗根有限公司	作为hif调节剂的吡咯并吡啶和噻唑并吡啶化合物
BRPI0713350B1 (pt)	2006-06-26	2022-04-12	Akebia Therapeutics Inc	Composto, e, composição
EP2111399A2 (en)	2006-12-18	2009-10-28	Amgen Inc.	Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof
US8048892B2 (en)	2006-12-18	2011-11-01	Amgen Inc.	Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof
EP2142509B1 (en)	2007-04-18	2013-12-04	Amgen, Inc	Quinolones and azaquinolones that inhibit prolyl hydroxylase
EP2155680B1 (en)	2007-04-18	2013-12-04	Amgen, Inc	Indanone derivatives that inhibit prolyl hydroxylase
US8097620B2 (en)	2007-05-04	2012-01-17	Amgen Inc.	Diazaquinolones that inhibit prolyl hydroxylase activity
ES2389063T3 (es)	2007-05-04	2012-10-22	Amgen, Inc	Derivados de tienopiridina y tiazolopiridina que inhiben la actividad prolil hidroxilasa
US8962530B2 (en) *	2007-06-27	2015-02-24	Regents Of The University Of Colorado	Inflammatory bowel disease therapies
CN101497584B (zh) *	2008-01-29	2010-12-22	首都医科大学	异喹啉-3-甲酰氨基酸苄酯及其制备和应用
EP2294066B9 (en)	2008-04-28	2015-03-11	Janssen Pharmaceutica, N.V.	Benzoimidazoles as prolyl hydroxylase inhibitors
WO2010056767A1 (en)	2008-11-14	2010-05-20	Fibrogen, Inc.	Thiochromene derivatives as hip hydroxylase inhibitors
SI2455381T1 (sl) *	2009-07-17	2014-08-29	Japan Tobacco Inc.	Triazolopiridinova spojina in njeno delovanje kot zaviralec prolil-hidroksilaze in induktor produkcije eritropoietina
NO2686520T3 (2)	2011-06-06	2018-03-17
US9206134B2 (en) *	2011-07-22	2015-12-08	Beijing Betta Pharmaceuticals Co. Ltd.	Polymorphic forms of compounds as prolyl hydroxylase inhibitor, and uses thereof
US9273034B2 (en)	2011-10-25	2016-03-01	Janssen Pharmaceutica Nv	Meglumine salt formulations of 1-(5,6-dichloro-1H-benzo[D]imidazol-2-yl)-1H-pyrazole-4-carboxylic acid
AU2013229922B2 (en)	2012-03-09	2017-09-28	Kyntra Bio, Inc.	4 -hydroxy- isoquinoline compounds as HIF hydroxylase inhibitors
US8883823B2 (en)	2012-07-16	2014-11-11	Fibrogen, Inc.	Crystalline forms of a prolyl hydroxylase inhibitor
KR20210130849A (ko)	2012-07-16	2021-11-01	피브로겐, 인크.	프롤릴 하이드록실라제 억제제 [(4-하이드록시-1-메틸-7-페녹시-아이소퀴놀린-3-카보닐)-아미노]-아세트산의 결정형
EP2872487B1 (en)	2012-07-16	2017-04-26	Fibrogen, Inc.	Process for making isoquinoline compounds
US9822135B2 (en)	2012-10-30	2017-11-21	H. Lee Moffitt Cancer Center And Research Institute, Inc.	STAT3 dimerization inhibitors
CA2899024C (en)	2013-01-24	2022-01-04	Fibrogen, Inc.	Crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid
KR20210104173A (ko)	2013-06-06	2021-08-24	피브로겐, 인크.	Hif 하이드록실라제 억제자의 약학적 제형
SG10201910773VA (en)	2013-06-13	2020-01-30	Akebia Therapeutics Inc	Compositions and methods for treating anemia
AR099354A1 (es)	2013-11-15	2016-07-20	Akebia Therapeutics Inc	Formas sólidas de ácido {[5-(3-clorofenil)-3-hidroxipiridin-2-carbonil]amino}acético, composiciones, y sus usos
SMT202000516T1 (it)	2014-05-15	2020-11-10	Insmed Inc	Metodi per trattamento di infezioni micobatteriche polmonati non tubercolari
AU2016209126A1 (en)	2015-01-23	2017-08-10	Akebia Therapeutics, Inc.	Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
US11324734B2 (en)	2015-04-01	2022-05-10	Akebia Therapeutics, Inc.	Compositions and methods for treating anemia
US20180243271A1 (en) *	2015-05-28	2018-08-30	Japan Tobacco Inc.	Method for Treating or Preventing Diabetic Nephropathy
EP3319976B1 (en) *	2015-07-09	2021-09-01	Insmed Incorporated	Compositions and methods for treating lung diseases and lung injury
AR108326A1 (es)	2016-04-27	2018-08-08	Samumed Llc	Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
AR108325A1 (es) *	2016-04-27	2018-08-08	Samumed Llc	Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
CN111819190A (zh) *	2018-01-09	2020-10-23	康奈尔大学	器官纤维化的预防和治疗
EP3773505B1 (en)	2018-03-30	2026-04-29	Insmed Incorporated	Methods for continuous manufacture of liposomal drug products
WO2019213398A1 (en)	2018-05-02	2019-11-07	Insmed Incorporated	Methods for the manufacture of liposomal drug formulations
EP3790863A1 (en)	2018-05-09	2021-03-17	Akebia Therapeutics Inc.	Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid
EP3829623A4 (en) *	2018-08-03	2022-10-19	Cornell University	METHODS OF REDUCING ABNORMAL SCAR FORMATION
TWI865563B (zh)	2019-07-30	2024-12-11	德商拜耳動物保健有限公司	新穎異喹啉衍生物
US11524939B2 (en)	2019-11-13	2022-12-13	Akebia Therapeutics, Inc.	Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid
CN112979541B (zh) *	2019-12-17	2022-11-11	浙江大学	一种基于n-(3-羟基吡啶-2-羰基)甘氨酸的抗肿瘤药物增敏剂及其应用
CN116120340B (zh) *	2021-11-15	2023-10-31	艾立康药业股份有限公司	一种吡啶并噁嗪类化合物及其制备方法、组合物和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4015255A1 (de) *	1990-05-12	1991-11-14	Hoechst Ag	Oxalyl-aminosaeurederivate, verfahren zu ihrer herstellung und ihrer verwendung als arzneimittel zur inhibierung der prolyl-hydroxylase
EP0548883A1 (de) *	1991-12-24	1993-06-30	Hoechst Aktiengesellschaft	Substituierte Pyridin-N-oxide, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
TW352384B (en) *	1992-03-24	1999-02-11	Hoechst Ag	Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals
DE4233124A1 (de) *	1992-10-02	1994-04-07	Hoechst Ag	Acylsulfonamido- und Sulfonamidopyridin-2-carbonsäureester sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
ES2101420T3 (es) *	1993-11-02	1997-07-01	Hoechst Ag	Esteres-amidas de acidos carboxilicos heterociclicos sustituidos, su preparacion y su utilizacion como medicamentos.
EP0650961B1 (de) *	1993-11-02	1997-03-05	Hoechst Aktiengesellschaft	Substituierte heterocyclische Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
NZ270267A (en) *	1993-12-30	1997-03-24	Hoechst Ag	3-hydroxypyridin-2yl (and -quinolin-2-yl) carboxamide derivatives and pharmaceutical compositions
SE9400810D0 (sv) *	1994-03-10	1994-03-10	Pharmacia Ab	New use of Quinoline-3-carboxamide compounds
IL135495A (en) *	1995-09-28	2002-12-01	Hoechst Ag	Intermediate compounds for the preparation of quinoline-converted amines - 2 - carboxylic acid

1997
- 1997-10-20 DE DE19746287A patent/DE19746287A1/de not_active Withdrawn
1998
- 1998-10-16 NZ NZ332363A patent/NZ332363A/xx unknown
- 1998-10-16 EP EP98119591A patent/EP0911340B1/de not_active Expired - Lifetime
- 1998-10-16 AT AT05004047T patent/ATE432940T1/de active
- 1998-10-16 ID IDP981374A patent/ID21115A/id unknown
- 1998-10-16 PT PT98119591T patent/PT911340E/pt unknown
- 1998-10-16 ES ES98119591T patent/ES2245471T3/es not_active Expired - Lifetime
- 1998-10-16 DK DK05004047T patent/DK1538160T3/da active
- 1998-10-16 DE DE59814365T patent/DE59814365D1/de not_active Expired - Lifetime
- 1998-10-16 ES ES05004047T patent/ES2328156T3/es not_active Expired - Lifetime
- 1998-10-16 AT AT98119591T patent/ATE299148T1/de active
- 1998-10-16 DK DK98119591T patent/DK0911340T3/da active
- 1998-10-16 EP EP05004047A patent/EP1538160B1/de not_active Expired - Lifetime
- 1998-10-16 AR ARP980105164A patent/AR013696A1/es unknown
- 1998-10-16 DE DE59812907T patent/DE59812907D1/de not_active Expired - Lifetime
- 1998-10-18 IL IL12663898A patent/IL126638A0/xx unknown
- 1998-10-19 CA CA002250664A patent/CA2250664A1/en not_active Abandoned
- 1998-10-19 ZA ZA989505A patent/ZA989505B/xx unknown
- 1998-10-19 KR KR1019980043578A patent/KR100618922B1/ko not_active Expired - Lifetime
- 1998-10-19 JP JP29701198A patent/JP3782591B2/ja not_active Expired - Lifetime
- 1998-10-19 CZ CZ983372A patent/CZ337298A3/cs unknown
- 1998-10-19 BR BRPI9804504-0A patent/BR9804504B1/pt not_active IP Right Cessation
- 1998-10-19 AU AU89413/98A patent/AU755714B2/en not_active Expired
- 1998-10-19 TR TR1998/02106A patent/TR199802106A2/xx unknown
- 1998-10-19 US US09/174,558 patent/US6093730A/en not_active Expired - Lifetime
- 1998-10-19 HU HU9802422A patent/HUP9802422A3/hu unknown
- 1998-10-19 NO NO19984877A patent/NO312365B1/no not_active IP Right Cessation
- 1998-10-20 SG SG9804225A patent/SG87776A1/en unknown
- 1998-10-20 PL PL329274A patent/PL192354B1/pl unknown
- 1998-10-20 CA CA2251647A patent/CA2251647C/en not_active Expired - Lifetime
- 1998-10-20 CN CN98121000A patent/CN1117079C/zh not_active Expired - Lifetime
2005
- 2005-09-02 JP JP2005254578A patent/JP4691419B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU8941398A (en)	1999-05-06
KR19990037182A (ko)	1999-05-25
ES2328156T3 (es)	2009-11-10
CN1117079C (zh)	2003-08-06
TR199802106A3 (tr)	1999-05-21
DE59812907D1 (de)	2005-08-11
NO312365B1 (no)	2002-04-29
DE19746287A1 (de)	1999-04-22
NO984877L (no)	1999-04-21
HUP9802422A3 (en)	2002-02-28
EP0911340B1 (de)	2005-07-06
PL192354B1 (pl)	2006-10-31
PL329274A1 (en)	1999-04-26
CA2251647C (en)	2011-08-30
EP0911340A2 (de)	1999-04-28
ES2245471T3 (es)	2006-01-01
NZ332363A (en)	2000-04-28
HU9802422D0 (en)	1998-12-28
CZ337298A3 (cs)	1999-05-12
DE59814365D1 (de)	2009-07-16
BR9804504B1 (pt)	2009-01-13
JPH11302257A (ja)	1999-11-02
ID21115A (id)	1999-04-22
SG87776A1 (en)	2002-04-16
ATE432940T1 (de)	2009-06-15
BR9804504A (pt)	2001-05-22
ATE299148T1 (de)	2005-07-15
PT911340E (pt)	2005-09-30
TR199802106A2 (xx)	1999-05-21
EP1538160A1 (de)	2005-06-08
EP0911340A3 (de)	1999-07-07
HK1019605A1 (en)	2000-02-18
NO984877D0 (no)	1998-10-19
DK0911340T3 (da)	2005-11-07
AU755714B2 (en)	2002-12-19
JP3782591B2 (ja)	2006-06-07
CN1218802A (zh)	1999-06-09
JP4691419B2 (ja)	2011-06-01
DK1538160T3 (da)	2009-10-05
IL126638A0 (en)	1999-08-17
HUP9802422A2 (hu)	1999-08-30
US6093730A (en)	2000-07-25
EP1538160B1 (de)	2009-06-03
CA2251647A1 (en)	1999-04-20
KR100618922B1 (ko)	2007-04-25
ZA989505B (en)	1999-04-20
CA2250664A1 (en)	1999-04-20
JP2006056894A (ja)	2006-03-02

Publication	Publication Date	Title
AR013696A1 (es)	2001-01-10	Amidas de acido isoquinolin-3-carboxilicos sustituidas, su preparacion y su empleo como medicamentos
FI894540L (fi)	1989-09-26	Substituerade 2-oxindol-1 -karboxiamider.
EA199800579A1 (ru)	1998-12-24	Новые производные 5-амино-3-циано-4-этилсульфинил-1-фенилпиразола и их применение в качестве пестицидов
ES2127878T3 (es)	1999-05-01	Nuevos derivados de n-heteroarilamida como inhibidores de la acil coenzima a: la colesterol acetiltransferasa.
PE108099A1 (es)	1999-11-18	Acidos 5-alquil-2-arilaminofenilaceticos y sus derivados
ES2045180T3 (es)	1994-01-16	Nuevo procedimiento para la obtencion de 4-aciloxi-3-hidroxietil-azetidinonas.
ES2139933T3 (es)	2000-02-16	2,3-dihidro-1-(2,2,2-trifluoroetil)-2-oxo-5-fenil-1h-1,4-benzodiacepinas.
SE7707731L (sv)	1978-02-27	Sett att framstella nya piperidyl-indolderivat och salter derav
SE8600413L (sv)	1986-01-30	Nytt lekemedel och sett att framstella detsamma
EA200000094A1 (ru)	2000-06-26	Способ получения замещенного пергидроизоиндола
MX9304399A (es)	1994-02-28	Proceso novedoso para preparar [[2-bromoetil)-amino]metil]-2-nitro-1h-imidazol-1-etanol quiral y compuestos relacionados.
RO86081A (ro)	1985-02-25	Procedeu pentru prepararea unor derivati de benzamida
ES523166A0 (es)	1984-03-16	Procedimiento para la obtencion de imidas de acido maleico sustituidas.
MX9700938A (es)	1997-04-30	Preparacion de acidos sacarincarboxilicos y esteres de acido carboxilico.
ES555820A0 (es)	1987-08-16	Procedimiento para la obtencion de 1-aril-5-alcoxiiminoalquilamino-pirazoles
ES2016017A6 (es)	1990-10-01	Procedimiento para preparar derivados de acido 1,1-dioxocefem-4-carbotiolico.
CA1264753C (en)	1990-01-23	2-PYRIDYLCARBOXAMIDES
ZA842575B (en)	1984-11-28	2,2-dimethyl-3-(2-halogeno-vinyl)-cyclopropanecarboxylic acid esters,a process for their preparation and their use as agents for combating pests
ES2039364T3 (es)	1995-04-01	Derivados de n - ariltetrahidroftalimida y sus productos previos.
ES479444A1 (es)	1979-11-16	Un procedimiento para preparar derivados de pirrolidincarbo-xaldehido y piperidicarboxaldehido.
AR245439A1 (es)	1994-01-31	Preparacion de acidos (2-cloro, bromo o nitro)-4-(alquil sulfonil) benzoico e intermediarios.
PH18972A (en)	1985-11-26	Novel cyclopropanedcarboxylic acid derivatives,compositions and use
NO932158L (no)	1993-12-13	Nye benzyl- og benzhydrylalkoholer
ES2034537T3 (es)	1993-04-01	Procedimiento para la obtencion de derivados del acido 5-(n-3,4,5,6-tetrahidroftalimido)-canimico.
FI972189A0 (fi)	1997-05-22	Halogenoidut esterit, jotka ovat käyttökelpoisia välituotteina hyönteismyrkkyjen valmistamiseksi