AR018199A1 - 2-quinolinas nh- u o-sustituidas, procedimiento para su preparacion, una composicion farmaceutica que los comprende y el uso de las mismas para lafabricacion de un medicamento - Google Patents
2-quinolinas nh- u o-sustituidas, procedimiento para su preparacion, una composicion farmaceutica que los comprende y el uso de las mismas para lafabricacion de un medicamentoInfo
- Publication number
- AR018199A1 AR018199A1 ARP990101937A ARP990101937A AR018199A1 AR 018199 A1 AR018199 A1 AR 018199A1 AR P990101937 A ARP990101937 A AR P990101937A AR P990101937 A ARP990101937 A AR P990101937A AR 018199 A1 AR018199 A1 AR 018199A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally substituted
- mono
- aryl
- amino
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- -1 cyano, hydroxy Chemical group 0.000 abstract 4
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 102000003960 Ligases Human genes 0.000 abstract 1
- 108090000364 Ligases Proteins 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 125000005018 aryl alkenyl group Chemical group 0.000 abstract 1
- 125000005418 aryl aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
2-Quinolinas-NH u O-sustituidas, que comprenden un compuestos de formula (I), en la cual: R1 es arilo opcionalmente sustituido o heteroariloopcionalmente sustituido; R2 es hidrogeno, alquilo C1-6, aril-alquilo C1-4, aril-alquenilo C2-4 o alquil C1-6-carbonilo; R3 se selecciona de halo, ciano,hidroxi, alquilo C1-6 (sustituido opcionalmente con halo, hidroxi, amino, mono o perfluoro-alquilo C1-3, carboxi o alcoxi C1-6-carbonilo), cicloalquiloC3-7, alcoxi C1-6 amino, mono- o di- alquil amino C1-6,acilamino, carboxi, alcoxi C1-6-carbonilo, carboxi-alquiloxi C1-6, alquiltio C1-6, alquilsulfiniloC1-6, alquilsulfonilo C1-6, sulfamoilo, mono- y di- alquil C1-6-sulfamoilo, carbamoilo, mono- ydi- alquil C1-6- carbamoilo, y heterocíclico; m es 0 o unnumero entero de 1 a 3; X es CHR4 (en cuya formula R4 es hidrogeno, alquilo C1-6 o arilo), alquileno C2-4, alquenileno C3-4, o CO; Y es un grupoenlazador que tiene de 2 a 6 grupos metileno en cadena lineal y en el cual uno o más grupos metileno pueden tener uno o más sustituyentesalquilo C1-6, alcoxi C1-6 o alquilidenilo C1-6, y en cuya cadena los átomos de C 1,2 o 1,3 pueden estar enlazados por un puente alquileno C2-3 oalquenileno C3; R1 y X o R1 y R2 pueden estar unidos por una cadena de polimetileno para formar un anillo de 5 a 7 miembros, sustituido opcinalmentecon alquilo C1-6; X y R2, X e Y o Y y R2 pueden estar unidos por una cadena polimetileno para formar un anillo de 4 a 7 miembros, sustituido opcionalmentecon alquilo C1-6; Z esNH u O; y sus sales, preferiblemente sus sales farmacéuticamente aceptables, que son inhibidores de la enzima bactrianametionil-ARNt sintetasa de S aureus y son utiles en el tratamiento de infecciones bacterianas. Además se describe un procedimientopara su preparacion,una composicion farmacéutica que los comprende y el uso de las mismas para la fabricacion de un medicamento.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9809050.9A GB9809050D0 (en) | 1998-04-29 | 1998-04-29 | Novel compounds |
| GBGB9824571.5A GB9824571D0 (en) | 1998-11-09 | 1998-11-09 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR018199A1 true AR018199A1 (es) | 2001-10-31 |
Family
ID=26313554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990101937A AR018199A1 (es) | 1998-04-29 | 1999-04-27 | 2-quinolinas nh- u o-sustituidas, procedimiento para su preparacion, una composicion farmaceutica que los comprende y el uso de las mismas para lafabricacion de un medicamento |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6320051B1 (es) |
| EP (1) | EP1084110A1 (es) |
| JP (1) | JP2002513005A (es) |
| KR (1) | KR20010043131A (es) |
| CN (1) | CN1307565A (es) |
| AR (1) | AR018199A1 (es) |
| AU (1) | AU3523599A (es) |
| BR (1) | BR9909994A (es) |
| CA (1) | CA2330564A1 (es) |
| CO (1) | CO5080763A1 (es) |
| HU (1) | HUP0103093A3 (es) |
| IL (1) | IL138906A0 (es) |
| NO (1) | NO20005400D0 (es) |
| PL (1) | PL343680A1 (es) |
| TR (1) | TR200003170T2 (es) |
| WO (1) | WO1999055677A1 (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040014121A1 (en) * | 1996-04-18 | 2004-01-22 | Smithkline Beecham Corporation | Novel compounds |
| GB9822241D0 (en) * | 1998-10-12 | 1998-12-09 | Smithkline Beecham Plc | Novel compounds |
| GB9827467D0 (en) * | 1998-12-15 | 1999-02-10 | Zeneca Ltd | Chemical compounds |
| EP1466603A3 (en) * | 1999-05-05 | 2004-10-20 | Merck & Co., Inc. | Novel catechols as antimicrobial agents |
| US6348482B1 (en) * | 1999-05-05 | 2002-02-19 | Merck & Co., Inc. | Catechols as antimicrobial agents |
| WO2000071524A1 (en) * | 1999-05-19 | 2000-11-30 | Smithkline Beecham Plc | 2-nh-pyridones and pyrimidones as mrs inhibitors |
| GB9911594D0 (en) * | 1999-05-19 | 1999-07-21 | Smithkline Beecham Plc | Novel compounds |
| AU2002239506A1 (en) * | 2000-12-11 | 2002-06-24 | Smith Kline Beecham Corporation | Urotensin-ii receptor antagonists |
| EP1351688A4 (en) * | 2000-12-11 | 2006-01-04 | Smithkline Beecham Corp | UROTENSIN-II RECEPTOR ANTAGONISTS |
| US6818655B2 (en) | 2001-01-26 | 2004-11-16 | Smithkline Beecham Corporation | Urotensin-II receptor antagonists |
| SE0202134D0 (sv) * | 2002-07-08 | 2002-07-08 | Astrazeneca Ab | Therapeutic agents |
| PT1572215E (pt) | 2002-12-20 | 2009-12-09 | Glaxo Group Ltd | Derivados de benzo[d]azepina para o tratamento de perturbações neurológicas |
| WO2004078119A2 (en) | 2003-03-03 | 2004-09-16 | Replidyne Inc. | Substituted thiophenes with antibacterial activity |
| GB0304809D0 (en) * | 2003-03-03 | 2003-04-09 | Glaxo Group Ltd | Novel compounds |
| WO2005009336A2 (en) * | 2003-05-01 | 2005-02-03 | Replidyne, Inc. | Antibacterial methods and compositions |
| US20070185079A1 (en) * | 2004-01-07 | 2007-08-09 | Astrazeneca Ab | Therapeutic agents I |
| JO3077B1 (ar) * | 2005-07-28 | 2017-03-15 | Janssen Pharmaceutica Nv | مشتقات كوينولين مضادة للبكتيريا |
| FR2902100A1 (fr) * | 2006-06-13 | 2007-12-14 | Sanofi Aventis Sa | Molecules duales contenant un derive peroxydique, leur synthese et leurs applications en therapeutique |
| US7994192B2 (en) | 2006-09-26 | 2011-08-09 | Crestone, Inc. | Substituted thienopyridone compounds with antibacterial activity |
| US8658670B2 (en) | 2006-09-26 | 2014-02-25 | Crestone, Inc. | Methods and compounds for treatment of clostridium based infection |
| US7973050B2 (en) | 2006-09-26 | 2011-07-05 | Crestone, Inc. | Enantiomeric compounds with antibacterial activity |
| WO2008039639A2 (en) * | 2006-09-26 | 2008-04-03 | Crestone, Inc. | Substituted thienopyridone compounds with antibacterial activity |
| CN101652140B (zh) * | 2006-09-26 | 2013-07-10 | 克莱斯通公司 | 具有抗菌活性的对映体化合物 |
| US8697720B2 (en) | 2006-09-26 | 2014-04-15 | Crestone, Inc. | Substituted phenylether-thienopyridone compounds with antibacterial activity |
| CN104546857B (zh) * | 2013-10-18 | 2017-01-04 | 北京北科德源生物医药科技有限公司 | 化合物naphthoylenequinazolone的抗菌用途 |
| CN110475777B (zh) | 2017-03-30 | 2022-04-15 | 豪夫迈·罗氏有限公司 | 用于治疗和预防细菌感染的新吡啶并[2,3-b]吲哚化合物 |
| CN112870196B (zh) * | 2019-11-11 | 2022-02-18 | 山东畜牧兽医职业学院 | 一种治疗耐药性微生物菌的组合物 |
| EP4153565B1 (en) * | 2020-05-20 | 2026-02-18 | F. Hoffmann-La Roche AG | Benzylpyridinium reagent for mass spectrometry |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4005205A (en) * | 1974-04-24 | 1977-01-25 | Smith Kline & French Laboratories Limited | Compositions and methods for inhibiting H2 histamine receptors |
| GB8332091D0 (en) * | 1983-12-01 | 1984-01-11 | Smith Kline French Lab | Chemical compounds |
| KR950005301B1 (ko) * | 1990-09-04 | 1995-05-23 | 주식회사대웅제약 | 신규한 퀴놀론 카르복실산 유도체 |
| KR960007566A (ko) | 1994-08-19 | 1996-03-22 | 김정규 | 신규한 퀴놀릴아민 유도체, 그의 제조방법 및 항부정맥제로서의 용도 |
-
1999
- 1999-04-15 CN CN99807809A patent/CN1307565A/zh active Pending
- 1999-04-15 JP JP2000545837A patent/JP2002513005A/ja active Pending
- 1999-04-15 IL IL13890699A patent/IL138906A0/xx unknown
- 1999-04-15 CA CA002330564A patent/CA2330564A1/en not_active Abandoned
- 1999-04-15 US US09/674,102 patent/US6320051B1/en not_active Expired - Fee Related
- 1999-04-15 BR BR9909994-2A patent/BR9909994A/pt not_active Application Discontinuation
- 1999-04-15 AU AU35235/99A patent/AU3523599A/en not_active Abandoned
- 1999-04-15 WO PCT/EP1999/002648 patent/WO1999055677A1/en not_active Ceased
- 1999-04-15 TR TR2000/03170T patent/TR200003170T2/xx unknown
- 1999-04-15 KR KR1020007012024A patent/KR20010043131A/ko not_active Withdrawn
- 1999-04-15 EP EP99916927A patent/EP1084110A1/en not_active Withdrawn
- 1999-04-15 HU HU0103093A patent/HUP0103093A3/hu unknown
- 1999-04-15 PL PL99343680A patent/PL343680A1/xx unknown
- 1999-04-27 AR ARP990101937A patent/AR018199A1/es unknown
- 1999-04-29 CO CO99025654A patent/CO5080763A1/es unknown
-
2000
- 2000-10-26 NO NO20005400A patent/NO20005400D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1307565A (zh) | 2001-08-08 |
| EP1084110A1 (en) | 2001-03-21 |
| JP2002513005A (ja) | 2002-05-08 |
| AU3523599A (en) | 1999-11-16 |
| US6320051B1 (en) | 2001-11-20 |
| BR9909994A (pt) | 2000-12-26 |
| KR20010043131A (ko) | 2001-05-25 |
| PL343680A1 (en) | 2001-08-27 |
| NO20005400L (no) | 2000-10-26 |
| NO20005400D0 (no) | 2000-10-26 |
| WO1999055677A1 (en) | 1999-11-04 |
| CO5080763A1 (es) | 2001-09-25 |
| IL138906A0 (en) | 2001-11-25 |
| HUP0103093A3 (en) | 2002-03-28 |
| HUP0103093A2 (hu) | 2002-02-28 |
| CA2330564A1 (en) | 1999-11-04 |
| TR200003170T2 (tr) | 2001-01-22 |
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