AR037097A1 - Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento - Google Patents

Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento

Info

Publication number
AR037097A1
AR037097A1 ARP020103736A ARP020103736A AR037097A1 AR 037097 A1 AR037097 A1 AR 037097A1 AR P020103736 A ARP020103736 A AR P020103736A AR P020103736 A ARP020103736 A AR P020103736A AR 037097 A1 AR037097 A1 AR 037097A1
Authority
AR
Argentina
Prior art keywords
substituted
cycloalkyl
phenyl
substituents
defined above
Prior art date
Application number
ARP020103736A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0124027A external-priority patent/GB0124027D0/en
Priority claimed from GB0124028A external-priority patent/GB0124028D0/en
Priority claimed from GB0124839A external-priority patent/GB0124839D0/en
Priority claimed from GB0127173A external-priority patent/GB0127173D0/en
Priority claimed from GB0127174A external-priority patent/GB0127174D0/en
Priority claimed from GB0127343A external-priority patent/GB0127343D0/en
Priority claimed from GB0211524A external-priority patent/GB0211524D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR037097A1 publication Critical patent/AR037097A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/51—Y being a hydrogen or a carbon atom
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/24—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by sulfur atoms to which a second hetero atom is attached
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C07D213/71—Sulfur atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
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    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
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    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
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    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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    • C07D451/06—Oxygen atoms
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    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
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    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
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Abstract

Un compuesto acilsulfonamidas de fórmula (1), en donde: R1 es haloalquilo C1-6, alquenilo C2-6, alquenilo C2-6 substituido por fenilo, no substituido o substituido por 1 hasta 5 sustituyentes, tienilo, piridina, benztiazolilo, cromanilo (esto es, 1,2-dihidrobenzopiranilo) o arilo C6-18, en donde los sustituyentes son seleccionados del grupo que consiste de halógeno, nitro, di-alquilamino C1-4, ciano, alquilo C1-6, haloalquilo C1-4, fenilcarbonilamino-alquilo C1-4 no sustituido, alcoxi C1-4, haloalcoxi C1-4, aminocarbonilo, di-alquilaminocarbonilo C1-4, alquilcarbonilo C1-4, alcoxicarbonilo C1-4, fenilo no sustituido, carboxilo y fenilcarbonilamino-alquilo C1-4 sustituido por fenilo o fenilo sustituido, en donde los sustituyentes fenilo son seleccionados del grupo que consiste de halógeno, nitro, di-alquilamino C1-4, ciano, alquilo C1-6, haloalquilo C1-4, alcoxi C1-4, haloalcoxi C1-4, aminocarbonilo, di-alquilaminocarbonilo C1-4, alquilcarbonilo C1-4, alcoxicarbonilo C1-4 y carboxilo, o R1 se selecciona del grupo de fórmulas (2); R2 se selecciona del grupo de fórmulas (3); R3 y R13 independientemente de cada uno son hidrógeno, hidroxi, halógeno, ciano, alquilo C1-4, alcoxi C1-4, fenilo o fenoxi, al menos uno de R4 y R5 junto con el átomo de carbono al cual están enlazados, R11 y R12 juntos con el átomo de carbono al cual están enlazados, independientemente de cada uno son un sustituido, sistema cicloalquilo de conexión, cicloalquilo C4-8, piperidina, tetrahidropiridina, o sistema heterocíclico de conexión, en donde los sustituyentes son seleccionados del grupo que consiste de alcoxicarbonilamino C1-6, alcoxicarbonil C1-6-(alquil C1-4)amino, alcoxicarbonil C1-6-(alquenil C2-4)amino, cicloalquilcarbonilamino C3-8, cicloalquilcarbonil C3-8-(alquil C1-4)amino, cicloalquilcarbonil C3-8-(alquenil C2-4)amino, alcoxicarboniloxi C1-6, fenil-alquilcarboniloxi C1-4, en donde fenilo está no sustituido o sustituido y en donde los sustituyentes son como se definió arriba por fenilo sustituido, fenilsulfonilo, en donde fenilo está no sustituido o sustituido y en donde los sustituyentes son como se definió arriba por fenilo sustituido, alquilo C4-8, por ejemplo, alquilo C5-8, hidroxialquilo C1-4, hidroxialquilo C1-4 sustituido por fenilo, en donde fenilo está no sustituido o sustituido y en donde los sustituyentes son como se definió arriba por fenilo sustituido, alcoxicarbonil C1-6-alquilo C1-4, cicloalcoxicarbonil C3-8-alquilo C1-4, alcoxicarbonilamino C1-6-alquilo C1-4, cicloalquilcarbonilamino C3-8-alquilo C1-4, fenilo o fenilo sustituido, en donde los sustituyentes son como se definió arriba por fenilo sustituido, heterociclilo que tiene 5 o 6 miembros en el anillo y 1 hasta 4 heteroátomos seleccionados de N, O, S, por ejemplo, oxadiazolilo, cicloalcoxicarbonilo C3-8, cicloalquil C3-8-alquilcarbonilo C1-4, en donde cicloalquilo está no sustituido o sustituido por hidroxi, fenilcarbonilo, en donde fenilo está no sustituido o sustituido y en donde los sustituyentes son como se definió arriba por fenilo sustituido, cicloalquilaminocarbonilo C3-8, cicloalquil C3-8-(alquil C1-4)aminocarbonilo, cicloalquil C3-8(alquenil C2-4)aminocarbonilo, y alcoxicarbonilo C1-8); R3, R8, R13 y R18 independientemente de cada uno son hidrógeno, hidroxi, halógeno, ciano, alquilo C1-4, alcoxi C1-4, fenilo o fenoxi, ya sea R8 o R18, respectivamente, independientemente de cada uno son hidrógeno, hidroxi, halógeno, ciano, alquilo C1-4, alcoxi C1-4, fenilo o fenoxi, y al menos uno de R9 y R10 junto con el átomo de carbono al cual están enlazados, R16 y R17 junto con el átomo de carbono al cual están enlazados, independientemente de cada uno tiene el significado de R4 y R5 junto con el átomo de carbono al cual están enlazados, como se definió arriba, o al menos uno de R9 y R10 juntos con el átomo de carbono al cual están enlazados, R16 y R17 juntos con el átomo de carbono al cual están enlazados, son cicloalquilo C3-8, y R8 o R18, respectivamente, independientemente de cada uno son un sustituido, sistema cicloalquilo de conexión, cicloalquilo C4-8, piperidina sustituida, tetrahidropiridina, o un sistema heterocíclico de conexión, en donde los sustituyentes son como se definió arriba para los grupos correspondientes, R6 y R15 independientemente de cada uno son haloalquilo C1-6, arilo C6-18 no sustituido o sustituido, en donde los sustituyentes arilo son como se definió arriba, o un sustituido, sistema cicloalquilo de conexión, cicloalquilo C4-8, piperidina, tetrahidropiridina, o sistema heterocíclico de conexión, en donde los sustituyentes son como se definió arriba para los grupos correspondientes o R6 y R15 independientemente de cada uno son amino sustituido por un sustituido sistema cicloalquilo de conexión, cicloalquilo C4-8, piperidina, tetrahidropiridina, o sistema heterocíclico de conexión, en donde los sustituyentes son como se definió arriba para el grupo correspondiente, R7 y R14 independientemente de cada uno son un sustituido sistema cicloalquilo de conexión, cicloalquilo C4-8, piperidina, tetrahidropiridina, o sistema heterocíclico de conexión, en donde los sustituyentes son como se definió arriba para los grupos correspondientes, o R7 y R14 independientemente de cada uno son amino sustituido por un sustituido sistema cicloalquilo de conexión, cicloalquilo C4-8, piperidina, tetrahidropiridina, o sistema heterocíclico de conexión, en donde los sustituyentes son como se definió arriba para el grupo correspondiente, m es 0, 1, 2, 3 ó 4, tal como 0 ó 1, n es 0, 1, 2, 3, ó 4, tal como 0 ó 1, y si m y/o n son diferentes a 0, entonces R1, si m es diferente a 0 y R2, n es diferente a 0, independientemente del otro tiene el significado como se define arriba, y adicionalmente puede ser piperazina sustituida, en donde los sustituyentes son como se definió arriba para piperidina sustituida; y un sistema cicloalquilo de conexión sustituido está sustituido como se definió arriba para un sistema cicloalquilo de conexión sustituido, y adicionalmente puede estar sustituido por oxo y/o alquilo C1-4; y si R1 es un sustituido sistema de anillo cicloalquilo de conexión, cicloalquilo C4-8, piperidina, tetrahidropiridina, o un sistema de anillo heterociclilo de conexión, en donde, los sustituyentes son como se definió arriba para los grupos correspondientes ,o si R1 es adicionalmente piperazina, si m es diferente a 0, entonces R2 tiene el significado como se definió arriba y adicionalmente puede ser haloalquilo C1-6, alquenilo C2-6 no sustituido, alquenilo C2-6 sustituido por fenilo, no sustituido o por 1 hasta 5 sustituyentes sustituido, tienilo, piridina, benztiazolilo, cromanilo (esta es, 1,2-dihidrobenzopiranilo) o arilo(C6-18), en donde los sustituyentes son como se definió arriba para los grupos correspondientes, y si m es 0, n es 0 y R2 es sustituido cicloalquilo C4-8 o un sistema de anillo sustituido de conexión en donde los sustituyentes son como se definieron arriba, entonces R1 es otro haloalquilo C1-6; composiciones farmacéuticas y el uso de dichos compuestos para la preparación de medicamentos para el tratamiento de padecimientos mediados por la acción de la sulfatasa esteroide.
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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1627871B1 (en) * 2003-05-21 2010-04-14 ASKA Pharmaceutical Co., Ltd. Cyclic aminophenyl sulfamate derivative
WO2005097738A1 (ja) * 2004-04-06 2005-10-20 Dainippon Sumitomo Pharma Co., Ltd. 新規スルホンアミド誘導体
WO2005117882A2 (en) * 2004-04-20 2005-12-15 Incyte Corporation Hydroxamic acid derivatives as metalloprotease inhibitors
DE102004035203A1 (de) 2004-07-21 2006-02-16 Bayer Healthcare Ag Substituierte Chinolone
WO2006073361A1 (en) * 2005-01-06 2006-07-13 Astrazeneca Ab Novel pyridine compounds
GB0505539D0 (en) * 2005-03-17 2005-04-27 Novartis Ag Organic compounds
GB0505541D0 (en) * 2005-03-17 2005-04-27 Novartis Ag Organic compounds
US7208526B2 (en) * 2005-05-20 2007-04-24 Hoffmann-La Roche Inc. Styrylsulfonamides
US20080312208A1 (en) * 2005-07-13 2008-12-18 Astrazeneca Ab Pyridine Analogues
WO2007051255A1 (en) * 2005-11-04 2007-05-10 The University Of Sydney Process for the preparation of compounds containing an azacyclic ring system
DE102006005861A1 (de) 2006-02-09 2007-08-23 Aicuris Gmbh & Co. Kg Substituierte Chinolone III
CA2698814A1 (en) 2007-09-17 2009-03-26 Preglem S.A. Treatment of oestrogen dependant conditions in pre-menopausal women
JP6929792B2 (ja) 2015-02-16 2021-09-01 ザ ユニバーシティ オブ クィーンズランド スルホニル尿素及び関連化合物並びにその使用
CN110914256A (zh) 2017-07-07 2020-03-24 英夫拉索姆有限公司 新颖磺酰胺羧酰胺化合物

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH402844A (de) 1960-05-25 1965-11-30 Ciba Geigy Verfahren zur Herstellung neuer Sulfonamide
US3534049A (en) 1968-04-12 1970-10-13 American Home Prod 1 - substituted - 3 - (1 - hydroxy - n - (arylsulfonyl)formimidoyl)pyridines and derivatives
IL33813A (en) 1969-02-14 1973-10-25 Sparamedica Ag Bornanocarboxamides and their salts,and their preparation
US3637845A (en) 1969-04-14 1972-01-25 Minnesota Mining & Mfg Fluoroalkanesulfonamides
US3707559A (en) 1971-05-14 1972-12-26 Searle & Co N-acyl phenylalanine amides
US3917692A (en) 1974-06-12 1975-11-04 Mead Johnson & Co Arylsulfonylcarbamoyl-1,3-dicarbonylalicyclic
GB1570536A (en) 1976-03-01 1980-07-02 Shell Int Research Insecticidal substituted acetamides
US4034091A (en) 1976-05-10 1977-07-05 Shell Oil Company N-(Arylsulfonyl)-2-nitro-2-(tetrahydro-2H-1,3-thiazin-2-ylidene)acetamides
GB1576120A (en) 1976-06-07 1980-10-01 Shell Int Research Method of treating rice
US4029791A (en) 1976-06-17 1977-06-14 Shell Oil Company N-(Arylsulfonyl)-2-nitro-2-(1-methyl-2-(1,3-diazacycloalkylidene)acetamides
CA1092606A (en) 1976-10-05 1980-12-30 Herbert Berger 1-(n-acylcarbamoyl)-2-cyano-aziridines and the preparation thereof
GB1593609A (en) 1978-01-31 1981-07-22 Christiaens Sa A Pyridine sulfonamides
AU527371B2 (en) 1980-09-16 1983-03-03 Torii & Co., Ltd. Amidine
DK101683A (da) 1982-03-12 1983-09-13 Duphar Int Res Phenylpiperazinderivater og fremgangsmaade til fremstilling heraf
US4743290A (en) 1986-04-21 1988-05-10 E. I. Du Pont De Nemours And Company Thiophenesulfonamide herbicides
US5085684A (en) 1988-05-09 1992-02-04 Bayer Aktiengesellschaft Herbicidal sulphonylaminocarbonyltriazolinones having substituents which are bonded via sulphur
US4880804A (en) 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
US5300480A (en) 1989-04-13 1994-04-05 Bayer Aktiengesellschaft Herbicidal sulphonylaminocarbonyltriazolinones having two substituents bonded via oxygen
US5057144A (en) 1988-05-09 1991-10-15 Bayer Aktiengesellschaft Sulphonylaminocarbonyltriazolinones
DE3826230A1 (de) 1988-08-02 1990-02-08 Hoechst Ag Heterocyclische n-acylsufonamide, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als herbizide oder wachstumsregulatoren
KR0138528B1 (en) 1988-12-14 1998-05-01 Shionogi Seiyaku Kk Preparation of 2,3-trans-1,4-bridged cyclohexane sulfonamide derivatives
EP0400835A1 (en) 1989-05-15 1990-12-05 Merck & Co. Inc. Substituted benzimidazoles as angiotensin II antagonists
IL94390A (en) 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
EP0412594B1 (en) 1989-07-28 1996-01-03 Merck & Co. Inc. Substituted triazolinones, triazolinethiones, and triazolinimines as angiotensin II antagonists
US5411980A (en) 1989-07-28 1995-05-02 Merck & Co., Inc. Substituted triazolinones, triazolinethiones, and triazolinimines as angiotensin II antagonists
DE3935277A1 (de) 1989-10-24 1991-05-02 Hoechst Ag Sulfonierte heterocyclische carboxamide, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als herbizide oder wachstumsregulatoren
US5256632A (en) 1990-05-30 1993-10-26 Bayer Aktiengesellschaft Herbicidal sulphonylated carboxamides
GB9015916D0 (en) 1990-07-19 1990-09-05 Schering Agrochemicals Ltd Herbicides
DE4029753A1 (de) 1990-09-20 1992-03-26 Basf Ag Sulfonamide
JP2896822B2 (ja) 1990-11-29 1999-05-31 キヤノン株式会社 非磁性一成分系現像剤、画像形成方法、画像形成装置、装置ユニット及びファクシミリ装置
DE4200954A1 (de) 1991-04-26 1992-10-29 Bayer Ag Heterocyclisch substituierte phenylessigsaeurederivate
GB2263637A (en) * 1992-01-28 1993-08-04 Merck & Co Inc Substituted imidazo-fused 6-membered carbocycle or heterocycle as neurotensin antagonists
US5204354A (en) 1992-02-14 1993-04-20 Merck & Co., Inc. Substituted quinazolinones as neurotensin antagonists useful in the treatment of CNS disorders
US5356926A (en) 1992-02-24 1994-10-18 Warner-Lambert Company 3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo [β]thiophene-2-carboxamides as inhibitors of cell adhesion
FR2694295B1 (fr) 1992-07-28 1994-09-02 Adir Nouveaux peptides dérivés de trifluoromethylcetones, leur procéde de préparation et les compositions pharmaceutiques qui les contiennent.
IL109431A (en) 1993-05-14 2001-01-11 Warner Lambert Co Pharmaceutical compositions containing n-acyl sulfamic acid esters (or thioesters), n-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters), for regulating plasma cholesterol concentration, and certain such novel compounds
DE4326344A1 (de) 1993-08-05 1995-02-09 Thomae Gmbh Dr K Carbonamide, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
AU7782694A (en) 1993-09-28 1995-04-18 Ciba-Geigy Ag Acylated sulphonamides as insecticides and acaricides
US5568872A (en) 1994-09-13 1996-10-29 Hinnant, Sr.; Wayne M. Eyeglass holder
DE4432860A1 (de) 1994-09-15 1996-03-21 Merck Patent Gmbh Imidazopyridine
WO1996009818A1 (en) 1994-09-27 1996-04-04 Merck & Co., Inc. Endothelin receptor antagonists for the treatment of emesis
JPH08208632A (ja) 1994-10-28 1996-08-13 Wakunaga Pharmaceut Co Ltd 新規スルホンアミド誘導体又はその塩及びこれを含有する血圧降下剤
AU1106195A (en) 1994-11-09 1996-06-06 Novo Nordisk A/S Heterocyclic compounds, their preparation and use
CA2188924C (en) 1995-02-28 2008-04-08 Hirokazu Annoura Arylpiperidine and arylpiperazine derivatives and drugs containing the same
AU5687396A (en) 1995-04-21 1996-11-07 Novarits Ag N-aroylamino acid amides as endothelin inhibitors
WO1996032937A1 (en) 1995-04-21 1996-10-24 Eli Lilly And Company Benzothiophenes with novel basic side chains
JP3133073B2 (ja) 1995-05-29 2001-02-05 ファイザー・インコーポレーテッド 成長ホルモンの放出を促進するジペプチド類
CN1192140A (zh) 1995-08-04 1998-09-02 沃尼尔·朗伯公司 氨基磺酸衍生物、酰基磺酰氨或磺酰基氨基甲酸酯在制备降低脂蛋白水平的药物中的用途
US5798356A (en) 1995-08-07 1998-08-25 Alcon Laboratories, Inc. Angiostatic compounds
DE19540737A1 (de) 1995-11-02 1997-05-07 Bayer Ag Substituierte Sulfonylamino(thio)carbonylverbindungen
GEP20032998B (en) 1996-04-12 2003-06-25 Searle & Co Substituted Benzenesulfonamide Derivatives as Prodrugs of Cox-2 Inhibitors
GB9609641D0 (en) 1996-05-09 1996-07-10 Pfizer Ltd Compounds useful in therapy
DE19650196A1 (de) 1996-12-04 1998-06-10 Bayer Ag Thienylsulfonylamino(thio)carbonylverbindungen
US6013662A (en) 1996-12-30 2000-01-11 Rhone-Poulenc Rorer S.A. Farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments
DE19710831A1 (de) 1997-03-15 1998-09-17 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
WO1998054207A1 (en) 1997-05-30 1998-12-03 Celltech Therapeutics Limited Anti-inflammatory tyrosine derivatives
GB9722287D0 (en) 1997-10-22 1997-12-17 Pfizer Ltd Compounds useful in therapy
GB9805520D0 (en) 1998-03-17 1998-05-13 Zeneca Ltd Chemical compounds
WO1999055661A1 (en) 1998-04-24 1999-11-04 Proteus Molecular Design Limited Aminomethyl-benzoic ester derivatives as tryptase inhibitors
GB9812523D0 (en) 1998-06-10 1998-08-05 Angeletti P Ist Richerche Bio Peptide inhibitors of hepatitis c virus ns3 protease
DE19845407B4 (de) 1998-10-02 2012-06-28 Arysta LifeScience North America Corp.(n.d.Ges.d.Staates Californien) Selektive Herbizide auf Basis eines substituierten Phenylsulfonylaminocarbonyl-triazolinons
IT1303249B1 (it) 1998-10-23 2000-11-06 Dompe Spa Alcune n-(2-aril-propionil)-solfonammidi e preparazionifarmaceutiche che le contengono.
US6117870A (en) 1998-11-12 2000-09-12 Fujirebio Kabushiki Kaisha Cyclic amide derivatives
UA74781C2 (en) 1999-04-02 2006-02-15 Abbott Lab Antiinflammatory and immumosuppressive compounds inhibiting cell adhesion
HRP20010795A2 (en) 1999-04-28 2003-02-28 Aventis Pharma Gmbh Di-aryl acid derivatives as ppar receptor ligands
AU5158100A (en) 1999-05-24 2000-12-12 Cor Therapeutics, Inc. Inhibitors of factor xa
EP1198231A1 (en) 1999-07-21 2002-04-24 American Home Products Corporation Bicyclic antagonists selective for the(alpha)v(beta)3 integrin
AU7447500A (en) 1999-09-30 2001-04-30 Mitsubishi Chemical Corporation Acylsulfonamide derivatives
JP4491866B2 (ja) 1999-09-30 2010-06-30 三菱化学株式会社 アシルスルホンアミド誘導体
IL139455A0 (en) 1999-11-08 2001-11-25 Pfizer Compounds for the treatment of female sexual dysfunction
GB2356139A (en) 1999-11-15 2001-05-16 Bayer Ag Use of substituted (quinolin-2-yl-methoxy)phenyl-acyl-sulphonamides and cyanamides for the treatment of diseases
US6160125A (en) 1999-12-27 2000-12-12 Bayer Corporation Process for the manufacture of sulfonylaminocarbonyl triazolinones in the presence of xylene as solvent
KR100704718B1 (ko) 1999-12-27 2007-04-09 바이엘 코포레이션 설포닐아미노카보닐 트리아졸리논 염의 제조방법
WO2001057037A1 (en) 2000-02-04 2001-08-09 Cor Therapeutics, Inc. Platelet adp receptor inhibitors
US6180125B1 (en) * 2000-02-18 2001-01-30 Colgate-Palmolive Company Low tack cosmetic composition sticks
TWI288745B (en) 2000-04-05 2007-10-21 Daiichi Seiyaku Co Ethylenediamine derivatives
DE10031825A1 (de) 2000-06-30 2002-01-10 Bayer Ag Selektive Herbizide auf Basis von Arylsulfonylaminocarbonyltriazolinonen
AU2001267878A1 (en) 2000-07-05 2002-01-14 Ajinomoto Co. Inc. Hypoglycemics
CA2369967A1 (en) 2001-02-12 2002-08-12 Joseph Anthony Cornicelli Methods of treating nuclear factor-kappa b mediated diseases and disorders

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KR100952770B1 (ko) 2010-04-14
BR0213131A (pt) 2004-09-21
CN1564811A (zh) 2005-01-12
CN100509774C (zh) 2009-07-08
PE20030548A1 (es) 2003-07-07
CA2458453A1 (en) 2003-04-17
JP2005504843A (ja) 2005-02-17
NZ532072A (en) 2007-02-23
KR20090123988A (ko) 2009-12-02
PL367411A1 (en) 2005-02-21
AU2002350490B2 (en) 2006-07-27
US20050059712A1 (en) 2005-03-17

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