AR037565A1 - Formas de sales de amlodipina y procedimientos para prepararlas. - Google Patents

Formas de sales de amlodipina y procedimientos para prepararlas.

Info

Publication number
AR037565A1
AR037565A1 ARP020104445A ARP020104445A AR037565A1 AR 037565 A1 AR037565 A1 AR 037565A1 AR P020104445 A ARP020104445 A AR P020104445A AR P020104445 A ARP020104445 A AR P020104445A AR 037565 A1 AR037565 A1 AR 037565A1
Authority
AR
Argentina
Prior art keywords
forms
procedures
prepare
amlodipine besylate
amlodipine salts
Prior art date
Application number
ARP020104445A
Other languages
English (en)
Inventor
Gerrit J B Ettema
Hans J Hoorn
Jacobus M Lemmens
Original Assignee
Synthon Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Bv filed Critical Synthon Bv
Publication of AR037565A1 publication Critical patent/AR037565A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Se describen formas de besilato de amlodipina, que incluyen hidratos de besilato de amlodipina y novedosos anhidratos de besilato de amlodipina. Se describen un método para preparar diversas formas de besilato de amlodipina a partir de un medio acuoso así como el uso de las mismas como bloqueadores de canales de calcio.
ARP020104445A 2001-11-21 2002-11-20 Formas de sales de amlodipina y procedimientos para prepararlas. AR037565A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33174201P 2001-11-21 2001-11-21

Publications (1)

Publication Number Publication Date
AR037565A1 true AR037565A1 (es) 2004-11-17

Family

ID=23295188

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020104445A AR037565A1 (es) 2001-11-21 2002-11-20 Formas de sales de amlodipina y procedimientos para prepararlas.

Country Status (5)

Country Link
US (1) US6828339B2 (es)
EP (1) EP1448197A1 (es)
AR (1) AR037565A1 (es)
AU (1) AU2002343257A1 (es)
WO (1) WO2003043635A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1152013C (zh) * 2001-11-22 2004-06-02 张喜田 一类左旋氨氯地平盐的水合物及其制剂
AU2003225370A1 (en) * 2002-04-13 2003-11-03 Hanlim Pharmaceutical Co., Ltd. Amlodipine nicotinate and process for the preparation thereof
CA2525700C (en) * 2002-09-11 2009-11-24 Hanlim Pharmaceutical Co., Ltd. S-(-)-amlodipine nicotinate and process for the preparation thereof
JP2007528349A (ja) * 2003-01-27 2007-10-11 ハンミ ファーム． シーオー．， エルティーディー． 高い安定性を有する無定形アムロジピンカムシレート、その製造方法及びこれを含む経口投与用組成物
DE602005018387D1 (de) * 2004-10-06 2010-01-28 Eisai R&D Man Co Ltd Medizinische zusammensetzung, verfahren zu ihrer hdihydropyridin-verbindung in einer medizinischen zusammensetzung
RS53141B (sr) * 2004-11-05 2014-06-30 Boehringer Ingelheim International Gmbh Dvoslojna tableta koja sadrži telmisartan i amlodipin
WO2006059217A1 (en) * 2004-12-01 2006-06-08 Ranbaxy Laboratories Limited Stable solid dosage forms of amlodipine besylate and processes for their preparation
EP1863457A2 (en) * 2005-03-15 2007-12-12 Lupin Ltd. Pharmaceutical compositions of amlodipine and benazepril.
US20100016378A1 (en) * 2005-04-28 2010-01-21 Toshio Suzuki Method of preventing dihydropyridine compound from degradation
GT200600371A (es) * 2005-08-17 2007-03-21 Formas de dosis sólidas de valsartan y amlodipina y método para hacer las mismas
FR2894826B1 (fr) * 2005-12-21 2010-10-22 Servier Lab Nouvelle association d'un inhibiteur du courant if sinusal et d'un inhibiteur calcique et les compositions pharmaceutiques qui la contiennent
KR20100137520A (ko) 2008-03-20 2010-12-30 애버리 데니슨 코포레이션 작용기의 위치가 조절된 아크릴 중합체
WO2011146450A1 (en) 2010-05-19 2011-11-24 Avery Dennison Corporation Ordered architectures in acrylic polymers
KR101939108B1 (ko) 2011-10-14 2019-01-16 애버리 데니슨 코포레이션 조절된 구조 폴리머
CN104326970B (zh) * 2014-09-09 2016-04-13 石药集团欧意药业有限公司 左旋氨氯地平马来酸盐化合物及制备方法与含其药物制剂
CN110882249B (zh) 2019-11-08 2021-04-30 北京吾为尔创科技有限公司 含苯磺酸左氨氯地平水合物的组合物及其制备方法
CN119367310B (zh) * 2024-12-27 2025-04-18 成都硕德药业有限公司 一种比索洛尔氨氯地平复方片剂及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8608335D0 (en) * 1986-04-04 1986-05-08 Pfizer Ltd Pharmaceutically acceptable salts
SI9200344B (sl) * 1992-11-26 1998-06-30 Lek, Postopek za pripravo amlodipin benzensulfonata
HU221810B1 (hu) * 1997-08-12 2003-01-28 EGIS Gyógyszergyár Rt. Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei
PL189666B1 (pl) * 1998-04-09 2005-09-30 Adamed Sp Z Oo Sposób otrzymywania benzenosulfonianu amlodypiny
UA72768C2 (en) * 1999-07-05 2005-04-15 Richter Gedeon Vegyeszet A method for obtaining amilodipine benzenesulphonate
WO2002053535A2 (en) * 2000-12-29 2002-07-11 Bioorganics B.V. Process for making amlodipine, derivatives thereof, and precursors therefor
SI21233A (sl) 2002-05-31 2003-12-31 LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. Kristalni hidratni obliki amlodipin benzensulfonata visoke čistote, postopki za njuno pripravo in uporaba

Also Published As

Publication number Publication date
US6828339B2 (en) 2004-12-07
WO2003043635A1 (en) 2003-05-30
EP1448197A1 (en) 2004-08-25
US20030139455A1 (en) 2003-07-24
AU2002343257A1 (en) 2003-06-10

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Legal Events

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