AR040683A1 - Composicion de tabletas de liberacion sostenida que comprende un agonista de los receptores de la dopamina - Google Patents
Composicion de tabletas de liberacion sostenida que comprende un agonista de los receptores de la dopaminaInfo
- Publication number
- AR040683A1 AR040683A1 AR20030102668A ARP030102668A AR040683A1 AR 040683 A1 AR040683 A1 AR 040683A1 AR 20030102668 A AR20030102668 A AR 20030102668A AR P030102668 A ARP030102668 A AR P030102668A AR 040683 A1 AR040683 A1 AR 040683A1
- Authority
- AR
- Argentina
- Prior art keywords
- sustained release
- chbr
- chcl
- chf
- chi
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title 2
- 239000000556 agonist Substances 0.000 title 1
- 229960003638 dopamine Drugs 0.000 title 1
- 239000007939 sustained release tablet Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 238000013268 sustained release Methods 0.000 abstract 2
- 239000012730 sustained-release form Substances 0.000 abstract 2
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 1
- UUFQTNFCRMXOAE-UHFFFAOYSA-N 1-methylmethylene Chemical compound C[CH] UUFQTNFCRMXOAE-UHFFFAOYSA-N 0.000 abstract 1
- -1 4-methylpiperazinyl Chemical group 0.000 abstract 1
- 101100167062 Caenorhabditis elegans chch-3 gene Proteins 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- 238000005299 abrasion Methods 0.000 abstract 1
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical class [H]N([H])C(*)=O 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229920001477 hydrophilic polymer Polymers 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Composición farmacéutica de liberación sostenida en forma de una tableta administrable por vía oral comprende como agente farmacéutico activo un compuesto de fórmula (1) o una sal farmacéuticamente aceptable del mismo, donde R1,R2 y R3 son iguales o distintos y son H, alquilo C1-6 (opcionalmente sustituido con fenilo), alquenilo o alquinilo C3-5 ó cicloalquilo C3-10, o donde R3 es el mismo que anteriormente y R1 y R2 están ciclados con el átomo de N ligado para formar grupos pirrolodinilo, piperidinilo, morfolinilo, 4-metilpiperazinilo o imidazolilo; X es H, F, Cl, Br, I, OH, alquilo o alcoxi C1-6, CN, carboxamida, carboxilo o (alquilo C1-6)carbonilo; A es CH, CH2, CHF, CHCl, CHBr, CHI, CHCH3, C=O, C=S, CSCH3, C=NH, CNH2, CNHCH3, CNHCOOCH3, CNHCN, SO2 o N; B es CH, CH2, CHF, CHCl, CHBr, CHI, C=O, N, NH o NCH3, y n es 0 ó 1; y D es CH, CH2, CHF, CHCl, CHBr, CHI, C=O, O, N, NH o NCH3. El agente está dispersado en una matriz que comprende un polímero hidrófilo y un almidón que tiene una resistencia a la tensión de al menos aproximadamente 0,15 KN cm-2 en una fracción sólida representativa de la tableta. La composición presenta propiedades de liberación sostenida eficaces para el tratamiento de la enfermedad de Parkinson. La tableta se recubre opcionalmente. Las tabletas tienen una mejor resistencia a la abrasión o al desgaste durante su fabricación, empaquetamiento y manejo.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39842702P | 2002-07-25 | 2002-07-25 | |
| US39844702P | 2002-07-25 | 2002-07-25 | |
| US47932703P | 2003-06-18 | 2003-06-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR040683A1 true AR040683A1 (es) | 2005-04-13 |
Family
ID=31192086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR20030102668A AR040683A1 (es) | 2002-07-25 | 2003-07-24 | Composicion de tabletas de liberacion sostenida que comprende un agonista de los receptores de la dopamina |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20050079217A1 (es) |
| EP (1) | EP1539165A1 (es) |
| JP (1) | JP2005537286A (es) |
| KR (1) | KR20050043894A (es) |
| CN (1) | CN1671388A (es) |
| AR (1) | AR040683A1 (es) |
| AU (1) | AU2003261265A1 (es) |
| BR (1) | BR0312891A (es) |
| CA (1) | CA2493179A1 (es) |
| MX (1) | MXPA05001055A (es) |
| TW (1) | TW200412961A (es) |
| WO (1) | WO2004011002A1 (es) |
| ZA (1) | ZA200500438B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9101155B2 (en) | 2003-07-11 | 2015-08-11 | Asahi Kasei Chemicals Corporation | Functional starch powder |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5273975A (en) * | 1989-06-09 | 1993-12-28 | The Upjohn Company | Heterocyclic amines having central nervous system activity |
| KR0167346B1 (ko) * | 1989-06-09 | 1999-01-15 | 로버트 에이. 아미테이지 | 중추신경계 활성을 갖는 헤테로사이클릭 아민 |
| WO1997004752A1 (en) * | 1995-07-26 | 1997-02-13 | Duramed Pharmaceuticals, Inc. | Pharmaceutical compositions of conjugated estrogens and methods for their use |
| CA2211778A1 (en) * | 1997-08-14 | 1999-02-14 | Francois Carriere | Preparation of pregelatinized high amylose starch and debranched starch useful as an excipient for controlled release of active agents |
| US6197339B1 (en) * | 1997-09-30 | 2001-03-06 | Pharmacia & Upjohn Company | Sustained release tablet formulation to treat Parkinson's disease |
| GB9802201D0 (en) * | 1998-02-03 | 1998-04-01 | Cerestar Holding Bv | Free-flowable directly compressible starch as binder,disintegrant and filler for compresion tablets and hard gelatine capsules |
| JP2002506031A (ja) * | 1998-03-11 | 2002-02-26 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | 組成物 |
| EP1169024B1 (en) * | 1999-03-31 | 2005-12-21 | Janssen Pharmaceutica N.V. | Pregelatinized starch in a controlled release formulation |
| AR031152A1 (es) * | 2000-10-31 | 2003-09-10 | Upjohn Co | Tratamientos nuevos para el sindrome de piernas inquietas |
-
2003
- 2003-07-24 AR AR20030102668A patent/AR040683A1/es not_active Application Discontinuation
- 2003-07-24 US US10/626,274 patent/US20050079217A1/en not_active Abandoned
- 2003-07-25 WO PCT/US2003/023403 patent/WO2004011002A1/en not_active Ceased
- 2003-07-25 MX MXPA05001055A patent/MXPA05001055A/es unknown
- 2003-07-25 EP EP03771888A patent/EP1539165A1/en not_active Withdrawn
- 2003-07-25 BR BR0312891-1A patent/BR0312891A/pt not_active IP Right Cessation
- 2003-07-25 CA CA002493179A patent/CA2493179A1/en not_active Abandoned
- 2003-07-25 AU AU2003261265A patent/AU2003261265A1/en not_active Abandoned
- 2003-07-25 KR KR1020057001263A patent/KR20050043894A/ko not_active Ceased
- 2003-07-25 CN CNA038178222A patent/CN1671388A/zh active Pending
- 2003-07-25 JP JP2004524865A patent/JP2005537286A/ja not_active Withdrawn
- 2003-07-25 TW TW092120417A patent/TW200412961A/zh unknown
-
2005
- 2005-01-17 ZA ZA200500438A patent/ZA200500438B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW200412961A (en) | 2004-08-01 |
| MXPA05001055A (es) | 2005-04-08 |
| US20050079217A1 (en) | 2005-04-14 |
| CA2493179A1 (en) | 2004-02-05 |
| AU2003261265A1 (en) | 2004-02-16 |
| CN1671388A (zh) | 2005-09-21 |
| KR20050043894A (ko) | 2005-05-11 |
| ZA200500438B (en) | 2006-08-30 |
| JP2005537286A (ja) | 2005-12-08 |
| BR0312891A (pt) | 2005-06-14 |
| WO2004011002A1 (en) | 2004-02-05 |
| EP1539165A1 (en) | 2005-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |