AR044105A1 - 4-OXO- (PHENYL -3 - REPLACED -1,4- DIHYDRO - 1, 8- NAFTIRIDIN - 3- CARBOXAMIDS AS INHIBITORS OF PHOSPHODIESTERASE-4 - Google Patents

4-OXO- (PHENYL -3 - REPLACED -1,4- DIHYDRO - 1, 8- NAFTIRIDIN - 3- CARBOXAMIDS AS INHIBITORS OF PHOSPHODIESTERASE-4

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Publication number
AR044105A1
AR044105A1 ARP040101425A AR044105A1 AR 044105 A1 AR044105 A1 AR 044105A1 AR P040101425 A ARP040101425 A AR P040101425A AR 044105 A1 AR044105 A1 AR 044105A1
Authority
AR
Argentina
Prior art keywords
phosphodiesterase
inhibitors
naftiridin
carboxamids
dihydro
Prior art date
Application number
Other languages
Spanish (es)
Original Assignee
Merck Frosst Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc
Priority to ARP040101425 priority Critical patent/AR044105A1/en
Publication of AR044105A1 publication Critical patent/AR044105A1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Los compuestos representados por la fórmula (1), compuestos y sus sales farmacéuticamente aceptables, inhibidores de la fosfodiesterasa 4 útiles en el tratamiento del asma y de la inflamación, y son útiles para la mejora de la capacidad cognitiva. Reivindicación 1: Un compuesto representado por la fórmula (1), o una de sus sales farmacéuticamente aceptables, en la que: Y se selecciona de un resto de grupo de fórmula (2); R1 es ciclopropilo o -CH2-CF3; R2 es H, F o Cl; R3 es H o CH3; y R4 es H o CH3.The compounds represented by the formula (1), compounds and their pharmaceutically acceptable salts, phosphodiesterase 4 inhibitors useful in the treatment of asthma and inflammation, and are useful for the improvement of cognitive ability. Claim 1: A compound represented by the formula (1), or a pharmaceutically acceptable salt thereof, wherein: Y is selected from a group moiety of formula (2); R1 is cyclopropyl or -CH2-CF3; R2 is H, F or Cl; R3 is H or CH3; and R4 is H or CH3.

ARP040101425 2004-04-27 2004-04-27 4-OXO- (PHENYL -3 - REPLACED -1,4- DIHYDRO - 1, 8- NAFTIRIDIN - 3- CARBOXAMIDS AS INHIBITORS OF PHOSPHODIESTERASE-4 AR044105A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ARP040101425 AR044105A1 (en) 2004-04-27 2004-04-27 4-OXO- (PHENYL -3 - REPLACED -1,4- DIHYDRO - 1, 8- NAFTIRIDIN - 3- CARBOXAMIDS AS INHIBITORS OF PHOSPHODIESTERASE-4

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ARP040101425 AR044105A1 (en) 2004-04-27 2004-04-27 4-OXO- (PHENYL -3 - REPLACED -1,4- DIHYDRO - 1, 8- NAFTIRIDIN - 3- CARBOXAMIDS AS INHIBITORS OF PHOSPHODIESTERASE-4

Publications (1)

Publication Number Publication Date
AR044105A1 true AR044105A1 (en) 2005-08-24

Family

ID=42778141

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040101425 AR044105A1 (en) 2004-04-27 2004-04-27 4-OXO- (PHENYL -3 - REPLACED -1,4- DIHYDRO - 1, 8- NAFTIRIDIN - 3- CARBOXAMIDS AS INHIBITORS OF PHOSPHODIESTERASE-4

Country Status (1)

Country Link
AR (1) AR044105A1 (en)

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