AR044495A1 - Amidas sustituidas de acido carboxilico, su preparacion y su uso como medicamentos - Google Patents

Amidas sustituidas de acido carboxilico, su preparacion y su uso como medicamentos

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Publication number
AR044495A1
AR044495A1 ARP030104741A ARP030104741A AR044495A1 AR 044495 A1 AR044495 A1 AR 044495A1 AR P030104741 A ARP030104741 A AR P030104741A AR P030104741 A ARP030104741 A AR P030104741A AR 044495 A1 AR044495 A1 AR 044495A1
Authority
AR
Argentina
Prior art keywords
group
alkyl
substituted
amino
membered
Prior art date
Application number
ARP030104741A
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English (en)
Inventor
Bauer Eckhart Dr
James Gillard
Dahmann Georg Dr
Gerlach Kai Dr
Handschuh Sandra Ruth Dr
Nar Herbert Dr
Pfau Roland Dr
Priepke Henning Dr
Wienen Wolfgang Dr
Schuler-Metz Annette Mario Dr
Original Assignee
Boehringer Ingelheim Pharma
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Publication date
Priority claimed from DE2002159407 external-priority patent/DE10259407A1/de
Priority claimed from DE10335545A external-priority patent/DE10335545A1/de
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of AR044495A1 publication Critical patent/AR044495A1/es

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Abstract

Amidas substituidas de ácido carboxílico de fórmula general (1) en la que R1 representa un grupo amino, alquilamino C1-5, cicloalquilamino C3-7 o un grupo (fenilalquilo C1-3)-amino que en su caso pueden estar substituidos en el átomo de nitrógeno amínico adicionalmente con un grupo fenilcarbonilo o fenilsulfonilo o con un grupo en su caso substituido en la parte alquilo con un grupo hidroxi, un grupo alquiloxi C1-3 o un grupo carboxi un grupo que puede transformarse in vivo en un grupo carboxi un grupo alquilo C1-5 o alquilcarbonilo C1-5 substituido con amino, alquilamino C1-3, di-(alquil C1-3)-amino o un grupo cicloalquilenimino de 4 a 7 miembros, en donde en el grupo alquilo C1-5 substituido indicado precedentemente, dos heteroátomos están separados entre sí por al menos dos átomos de carbono, un grupo cicloalquileniminocarbonilo o cicloalquileniminosulfonilo de 4 a 7 miembros, en donde la parte cicloalquilenimino de la estructura carbonada puede estar substituida con un átomo de flúor, cloro o bromo, uno o dos grupos alquilo C1-3, alquenilo C2-3, alquinilo C2-3, hidroxi-alquilo C1-3, alquiloxi C1-3-alquilo, fenilalquilo C1-3, difenilalquilo C1-3, heteroarilalquilo C1-3, aminoalquilo C1-3, cicloalquilamino C3- 6-alquilo C1-3, fenilamino-alquilo C1-3, alquilamino C1-5-alquilo C1-3, di-(alquil C1-5)-amino-alquilo C1-3, N-(cicloalquil C3-6)-alquilamino C1-3-alquilo C1-3, un grupo cicloalquileniminoalquilo C1-3 de 4 a 7 miembros, N-(alquilcarbonil C1- 3)alquilamino C1-3-alquilo C1-3, un grupo carboxi-alquilo C1-3, alquiloxicarbonil C1-3alquilo C1-3, aminocarbonilalquilo C1-3, alquilaminocarbonil C1-3alquilo C1-3, di-(alquil C1-3)-aminocarbonilalquilo C1-3, un grupo cicloalquileniminocarbonilalquilo C1-3 de 4 a 7 miembros, un grupo alquiloxicarbonilamino C1-5-alquilo C1-3, alquilcarbonilamino C1-3-alquilo C1-3, alquilsulfonilamino C1-3-alquilo C1-3, aminocarbonilamino-alquilo C1-3, alquilaminocarbonilamino C1-3- alquilo C1-3, di-(alquil C1-3)-aminocarbonilamino-alquilo C1-3, carboxi, alquiloxicarbonilo C1-3, benciloxicarbonilo, alquilcarbonilo C1-3, aminocarbonilo, alquilamino C1-3-carbonilo, di-(alquil C1-3)-aminocarbonilo, N-(cicloalquil C3-7)- alquilaminocarbonilo C1-5, N-(fenilalquil C1-3)-alquilaminocarbonilo C1-5, un grupo cicloalquileniminocarbonilo de 4 a 7 miembros, un grupo aminocarbonil C1-3-alquilaminocarbonilo C1-3, hidroxi, alquiloxi C1-3, aliloxi, propargiloxi, benciloxi, amino, alquilamino C1-3, di-(alquil C1-3)-amino, un grupo cicloalquilenimino C1-3, trifluormetilcarbonilamino, un grupo mono, di o trifluormetilamino, un grupo fenilo o un grupo heteroarilo de 5 a 6 miembros con la condición de que en la substitución de un grupo metileno adyacente al grupo imino, dos heteroátomos estén separados entre sí por al menos dos átomos de carbono, y/o un grupo metileno puede estar substituido en posición 3 de un grupo cicloalquilenimino de 5 miembros con un átomo de azufre, un grupo sulfinilo o sulfonilo o un grupo metileno puede estar substituido en posición 4 de un grupo cicloalquilenimino de 6 a 7 miembros con un átomo de oxígeno o azufre, un grupo carbonilo, sulfinilo o sulfonilo o con un grupo NH eventualmente substituido con un grupo alquilo C1-3, hidroxi, formilo o alquilcarbonilo C1-3, en donde un grupo metileno adyacente al grupo NH indicado precedentemente eventualmente substituido puede estar substituido con un grupo carbonilo, sulfinilo o sulfonilo, con la condición de que en la substitución de los radicales cicloalquilenimino de 6 a 7 miembros indicados anteriormente, en los que un grupo metileno se substituyó con un átomo de oxígeno o azufre, con un grupo sulfinilo o sulfonilo, dos heteroátomos estén separados entre sí por al menos dos átomos de carbono, un grupo cicloalquileniminocarbonilo o cicloalquileniminosulfonilo de 5 a 7 miembros substituido eventualmente con uno o dos grupos alquilo C1-3, amino-alquilo C1-3, alquilamino C1-3-alquilo C1-3, di-(alquil C1-3)-amino-alquilo C1-3, un grupo cicloalquilenimino-alquilo C1-3 de 4 a 7 miembros, cicloalquilamino C1-6-alquilo C1-3, fenilo, fenilalquilo C1-3, heteroarilo, heteroarilalquilo C1-3, aminocarbonilo, alquilaminocarbonilo C1-3, di-(alquil C1-3)-aminocarbonilo o con grupos cicloalquileniminocarbonilo de 4 a 7 miembros, en donde el enlace doble no está ligado al nitrógeno y puede condensarse con un grupo heteroarilo de 5 a 6 miembros, un grupo aminocarbonilo o aminosulfonilo eventualmente substituido con uno o dos grupos alquilo C1-5, alquenilo C2-3, alquinilo C2-3, cicloalquilo C3-6 o grupos cicloalquilenimino de 5 a 7 miembros, en donde los substituyentes pueden ser iguales o diferentes y en cada caso uno de los grupos alquilo C1-5 puede estar substituido con uno o dos grupos hidroxi-alquilo C1-3, alcoxi C1-3-alquilo C1-3, benciloxi-alquilo C1-3, amino-alquilo C1-3, alquilamino C1-3-alquilo C1-3, di-(alquil C1-3)-amino-alquilo C1- 3, un grupo cicloalquilenimino C1-3-alquilo C1-3 de 4 a 7 miembros, un grupo alquiloxicarbonilamino C1-5-alquilo C1-3, cicloalquilamino C3-6-alquilo C1-3, aminocarbonilo, alquilamino C1-3-carbonilo, N-(cicloalquil C3-6)-alquilaminocarbonilo C1-3, N- (fenilalquil C1-3)-alquilaminocarbonilo C1-5, di-(alquil C1-3)-aminocarbonilo o un grupo cicloalquileniminocarbonilo de 4 a 7 miembros, un grupo alquilcarbonilo C1-7 o cicloalquilcarbonilo C3-7, en donde el grupo metileno puede estar substituido en la posición 2, 3 o 4 en un grupo cicloalquilcarbonilo C3-7 con un átomo de oxígeno o azufre, un grupo carbonilo, sulfinilo, sulfonilo o un grupo NH , en el cual el átomo de hidrógeno del grupo NH puede estar substituido con un grupo alquilo C1-3 o alquilcarbonilo C1-3, un grupo fenilcarbonilo o heteroarilcarbonilo, pueden estar substituidos en la parte fenilo o heteroarilo con un átomo de flúor, cloro o bromo, con un grupo trifluormetilo, alquilo C1-3, amino-alquilo C1-3, alquilamino C1-3- alquilo C1-3, di-(alquil C1-3)-amino-alquilo C1-3, cicloalquilenimino-alquilo C1-3 de 4 a 7 miembros o un grupo alcoxi C1-3, un grupo alquilo C1-3 monosubstituido eventualmente substituido con un grupo amino, alquilamino C1-3, di-(alquil C1-3)- amino, hidroxi, fenilo, heteroarilo o un grupo cicloalquilenimino de 4 a 7 miembros, en donde la parte fenilo puede estar substituida con un átomo de flúor, cloro o bromo, con un grupo trifluormetilo, alquilo C1-3, amino-alquilo C1-3, alquilamino C1- 3-alquilo C1-3, di-(alquil C1-3)-amino-alquilo C1-3, cicloalquilenimino-alquilo C1-3 de 4 a 7 miembros o un grupo alcoxi C1-3, y/o un grupo -CH2-CH2- de un grupo cicloalquilenimino de 5 a 7 miembros puede estar substituido con un grupo -NH-CO-, -CO- NH-, -CO-N(CH3)- o un grupo -N(CH3)-CO- o un grupo metileno adyacente al átomo de nitrógeno de un grupo cicloalquilenimino de 5 a 7 miembros puede estar substituido con un grupo carbonilo, o un grupo del grupo de fórmulas (2), en las cuales la parte heterocíclica en cada caso puede estar substituido un átomo de hidrógeno con un grupo alquilo C1-3, alquiloxicarbonilo C1-3, alquiloxicarbonilamino C1-5-alquilo C1-3, metilsulfonilmetilo, amino-alquilo C1-3, alquilamino C1-3-alquilo C1-3, di-(alquil C1-3)-amino-alquilo C1-3, un grupo cicloalquileniminoalquilo C1-3 de 4 a 7 miembros, morfolin-4-il-alquilo C1-3, piperazinil-alquilo C1-3, N-(alquil C1-3)-piperazin-4-il-alquilo C1-3, aminocarbonilo, alquilaminocarbonilo C1-3 o di-(alquil C1-3)- aminocarbonilo y m significa 1 o 2, R2 un átomo de hidrógeno, flúor, cloro o bromo, un grupo alquilo C1-3, en el cual los átomos de hidrógeno pueden estar substituidos total o parcialmente con un átomo de flúor, un grupo alquenilo C2-3, alquinilo C2- 3, alcoxi C1-3, un grupo mono, di o trifluorometoxi, R3 un átomo de hidrógeno o un grupo alquilo C1-3, R4 un átomo de hidrógeno o un grupo alquenilo C2-3 o alquinilo C2-3 o un grupo alquilo C1-5 lineal o ramificado, que eventualmente puede estar substituido con un átomo de flúor, un grupo mono, di o trifluorometilo, un grupo nitrilo, un grupo hidroxi, un grupo alquiloxi C1-3, en el cual los átomos de hidrógeno pueden estar total o parcialmente substituidos con un átomo de flúor, un grupo aliloxi, propargiloxi, benciloxi, alquilcarboniloxi C1-5, alquiloxicarboniloxi C1-5, carboxi-alquiloxi C1-3, alquiloxicarbonil C1-5-alquiloxi C1-3, alquiloxicarbonilamino C1-8, cloro-alquilaminocarbonilamino C1-3, mercapto, alquilsulfanilo C1-3, alquilsulfinilo C1-3, alquilsulfonilo C1-3, alquilcarbonilamino-alquilsulfanilo C1-3, alquilcarbonilamino-alquilsulfinilo C1-3, alquilcarbonilamino-alquilsulfonilo C1-3, carboxi, alquiloxicarbonilo C1-3, aliloxicarbonilo, propargiloxicarbonilo, benciloxicarbonilo, aminocarbonilo, alquilaminocarbonilo, di-(alquil)-aminocarbonilo, aminosulfonilo, amino, alquilamino C1-3, di-(alquil C1-3)-amino, alquilcarbonilamino C1-5, alquilsulfonilamino C1-3, N-(alquilsulfonilo C1-3)-alquilamino C1-3, cicloalquilcarbonilamino C3-6, aminocarbonilamino, alquilaminocarbonilamino C1-3, di-(alquil C1-3)-carbonilamino, un grupo cicloalquileniminocarbonilamino de 4 a 7 miembros, benciloxicarbonilamino, fenilcarbonilamino heteroarilo o un grupo guanidino, un grupo de la fórmula general -(CH2)o-N(R11)-C(O)-A, en la cual o es uno de los números 2, 3, 4 ó 5, R11 es un átomo de hidrógeno o un grupo alquilo C1-3 y A es un grupo heteroarilo o un grupo cicloalquilo C5-7, en el cual el grupo metino puede estar substituido en posición 1 con un átomo de nitrógeno y/o un grupo metileno puede estar substituido con un átomo de oxígeno o azufre, un grupo -NH-, -N(OH)-, -N(alquil C1-3)-, -N(alquilcarbonil C1-3)-, o -N(heteroarilo)- y/o un grupo metileno adyacente a un grupo -NH-, -N(OH)-, -N(alquil C1-3)-, -N(alquilcarbonil C1-3)-, o -N(heteroarilo)- puede estar adicionalmente substituido con un grupo carbonilo, sulfinilo o sulfonilo, un grupo cicloalquileniminocarbonilalquilo C1-3 de 4 a 7 miembros, en donde un grupo metileno de la parte cicloalquilenimino puede estar substituido con un grupo alquilo C1-3 eventualmente substituido con un
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Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10260730A1 (de) * 2002-12-23 2004-07-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue substituierte stickstoffhaltige Heterobicyclen, deren Herstellung und deren Verwendung als Arzneimittel
US7371743B2 (en) * 2004-02-28 2008-05-13 Boehringer Ingelheim International Gmbh Carboxylic acid amides, the preparation thereof and their use as medicaments
US7795448B2 (en) 2004-05-06 2010-09-14 Cytokinetics, Incorporated Imidazoyl-benzamide anti-cancer agents
US7618981B2 (en) * 2004-05-06 2009-11-17 Cytokinetics, Inc. Imidazopyridinyl-benzamide anti-cancer agents
US7504413B2 (en) 2004-05-06 2009-03-17 Cytokinetics, Inc. N-(4-(imidazo[1,2A]pyridin-YL)phenethyl)benzamide inhibitors of the mitotic kinesin CENP-E for treating certain cellular proliferation diseases
DE102004027821A1 (de) * 2004-06-08 2006-01-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Benzimidazole, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
US7453002B2 (en) * 2004-06-15 2008-11-18 Bristol-Myers Squibb Company Five-membered heterocycles useful as serine protease inhibitors
KR20070057965A (ko) 2004-09-21 2007-06-07 신타 파마슈티칼스 코프. 염증 및 면역 관련 용도를 위한 화합물
GEP20104994B (en) * 2005-02-25 2010-05-25 Serenex Inc Tetrahydroindolone and tetrahydroindazolone derivatives
US20070185184A1 (en) * 2005-09-16 2007-08-09 Serenex, Inc. Carbazole derivatives
CA2642931A1 (en) * 2006-02-27 2007-09-07 Serenex, Inc. Cyclohexylamino, benzene, pyridine, and pyridazine derivatives
AR066379A1 (es) * 2007-05-02 2009-08-12 Boehringer Ingelheim Int Amidas de acido carboxilico su preparacion y su uso como medicamentos
DE102007028407A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028406A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028319A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
EP2220079A2 (en) 2007-11-15 2010-08-25 Boehringer Ingelheim International GmbH Substituted amides, manufacturing and use thereof as medicaments
US8278313B2 (en) 2008-03-11 2012-10-02 Abbott Laboratories Macrocyclic spiro pyrimidine derivatives
US8436005B2 (en) 2008-04-03 2013-05-07 Abbott Laboratories Macrocyclic pyrimidine derivatives
US8278302B2 (en) 2009-04-08 2012-10-02 Boehringer Ingelheim International Gmbh Substituted piperidines as CCR3 antagonists
EA024099B1 (ru) 2010-09-13 2016-08-31 Оцука Фармасьютикал Ко., Лтд. Гетероциклические соединения для лечения или профилактики расстройств, вызываемых ослабленной нейротрансмиссией серотонина, норэпинефрина или допамина
AR097279A1 (es) 2013-08-09 2016-03-02 Actelion Pharmaceuticals Ltd Derivados de benzimidazolil-metil urea como agonistas del receptor de alx
JP6166996B2 (ja) * 2013-09-27 2017-07-19 株式会社日本ファインケム ヒドラジノアリールカルボン酸類の製造方法
GEAP201814220A (en) 2013-12-24 2018-03-12 Oncotartis Inc Benzamide and nicotinamide compounds and methods of using same
EP3134406A1 (en) * 2014-04-24 2017-03-01 Dart Neuroscience (Cayman) Ltd Substituted 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole and 4,5,6,7-tetrahydro-2h-pyrazolo [4,3-c]pyridine compounds as glyt1 inhibitors
EP3215500A1 (en) 2014-11-05 2017-09-13 Dart NeuroScience (Cayman) Ltd. Substituted azetidinyl compounds as glyt1 inhibitors
AU2017269256B2 (en) * 2016-05-23 2021-02-25 The Rockefeller University Aminoacylindazole immunomodulators for treatment of autoimmune diseases
US11472794B2 (en) * 2018-01-15 2022-10-18 UCB Biopharma SRL Fused imidazole derivatives as IL-17 modulators
KR102267662B1 (ko) * 2019-11-19 2021-06-22 한국화학연구원 벤즈아미드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
CA3132034A1 (en) * 2020-01-17 2021-07-22 Boris Slavinovich Farber Benzimidazole derivatives, their salts, compositions exhibiting antigeriatric action
CN114262322B (zh) * 2020-09-16 2026-01-06 中国科学院上海有机化学研究所 一类细胞程序性坏死抑制剂及其制备方法和用途
KR102733257B1 (ko) * 2021-05-17 2024-11-26 에이치케이이노엔 주식회사 벤즈아미드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
CN113773260B (zh) * 2021-08-26 2023-09-22 华南师范大学 一种类共价有机材料及其制备方法和应用

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6087380A (en) 1949-11-24 2000-07-11 Boehringer Ingelheim Pharma Kg Disubstituted bicyclic heterocycles, the preparations and the use thereof as pharmaceutical compositions
DE4007535A1 (de) * 1990-03-09 1991-09-12 Hoechst Ag Wasserunloesliche azofarbmittel, ihre herstellung und verwendung
NZ290008A (en) * 1994-06-29 1998-08-26 Smithkline Beecham Corp Vitronectin receptor antagonists, comprising a fibrinogen antagonist analogue linked to a heterocycle
ES2191922T3 (es) * 1997-01-23 2003-09-16 Yamanouchi Pharma Co Ltd Nuevos derivados de amida y sus composiciones medicinales.
PE121699A1 (es) * 1997-02-18 1999-12-08 Boehringer Ingelheim Pharma Heterociclos biciclicos disustituidos como inhibidores de la trombina
US6414008B1 (en) 1997-04-29 2002-07-02 Boehringer Ingelheim Pharma Kg Disubstituted bicyclic heterocycles, the preparation thereof, and their use as pharmaceutical compositions
WO2000077027A2 (en) 1999-06-14 2000-12-21 Tularik Limited Serine protease inhibitors
US6114532A (en) 1998-02-03 2000-09-05 Boehringer Ingelheim Pharma Kg Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals
EP1060166A1 (de) 1998-02-03 2000-12-20 Boehringer Ingelheim Pharma KG 5-gliedrige benzokondensierte heterocyclen als antithrombotika
TWI248435B (en) * 1998-07-04 2006-02-01 Boehringer Ingelheim Pharma Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions
US6248770B1 (en) 1998-07-09 2001-06-19 Boehringer Ingelheim Pharma Kg Benzimidazoles having antithrombotic activity
US6747023B1 (en) 1998-08-11 2004-06-08 Daiichi Pharmaceutical Co., Ltd. Sulfonyl derivatives
CA2348267A1 (en) 1998-10-29 2000-05-11 Henry H. Gu Novel inhibitors of impdh enzyme
WO2000059905A1 (en) * 1999-04-02 2000-10-12 Neurogen Corporation ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS
AU5283700A (en) 1999-05-24 2000-12-12 Cor Therapeutics, Inc. Inhibitors of factor xa
JP2003502314A (ja) 1999-06-14 2003-01-21 イーライ・リリー・アンド・カンパニー 化合物
US6451832B2 (en) 1999-12-23 2002-09-17 Boehringer Ingelheim Pharma Kg Benzimidazoles with antithrombotic activity
DE19962329A1 (de) 1999-12-23 2001-06-28 Boehringer Ingelheim Pharma Benzimidazole, deren Herstellung und deren Verwendung als Arzneimittel
TWI290136B (en) 2000-04-05 2007-11-21 Daiichi Seiyaku Co Ethylenediamine derivatives
GB0030306D0 (en) 2000-12-13 2001-01-24 Lilly Co Eli Compounds
GB0030304D0 (en) 2000-12-13 2001-01-24 Lilly Co Eli Compounds
GB0030305D0 (en) 2000-12-13 2001-01-24 Lilly Co Eli Compounds
US20040082786A1 (en) 2000-09-29 2004-04-29 Bing-Yan Zhu Piperazine based inhibitors of factor xa
DE10111842A1 (de) 2001-03-13 2002-09-19 Boehringer Ingelheim Pharma Antithrombotische Carbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel
US20020183519A1 (en) 2001-03-13 2002-12-05 Herbert Nar Antithrombotic carboxylic acid amides
US7429597B2 (en) 2002-12-23 2008-09-30 Boehringer Ingelheim Pharma Gmbh & Co., Kg Substituted nitrogen-containing heterobicycles, the preparation thereof and their use as pharmaceutical compositions
US7371743B2 (en) 2004-02-28 2008-05-13 Boehringer Ingelheim International Gmbh Carboxylic acid amides, the preparation thereof and their use as medicaments
DE102004027821A1 (de) * 2004-06-08 2006-01-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Benzimidazole, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel

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