AR045151A1 - Procedimiento para la sistensis de perindopril y de sus sales farmaceuticamente aceptables - Google Patents
Procedimiento para la sistensis de perindopril y de sus sales farmaceuticamente aceptablesInfo
- Publication number
- AR045151A1 AR045151A1 ARP040102693A ARP040102693A AR045151A1 AR 045151 A1 AR045151 A1 AR 045151A1 AR P040102693 A ARP040102693 A AR P040102693A AR P040102693 A ARP040102693 A AR P040102693A AR 045151 A1 AR045151 A1 AR 045151A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- compound
- perindopril
- procedure
- pharmaceutically acceptable
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 title abstract 2
- 229960002582 perindopril Drugs 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 6
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 238000010511 deprotection reaction Methods 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- -1 hydroxy, p-toluenesulfonyloxy, methanesulfonyloxy Chemical group 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 125000005951 trifluoromethanesulfonyloxy group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Procedimiento para la síntesis de perindopril de fórmula (1). Reivindicación 1: Procedimiento para la síntesis del compuesto de fórmula (1), y sus sales farmacéuticamente aceptables, caracterizado porque se hace reaccionar el compuesto de fórmula (2), en la cual R representa un átomo de hidrógeno o un grupo bencilo o alquilo (C1-6) lineal o ramificado, con un compuesto de fórmula (3) de configuración (R), en la cual G representa un átomo de cloro, de bromo o de yodo, o un grupo hidroxi, p-toluensulfoniloxi, metanosulfoniloxi o trifluorometanosulfoniloxi, en presencia de una base, para obtener un compuesto de fórmula (4), en la cual R y G son tal como se han definido anteriormente, que se somete a reacción con el compuesto de fórmula (5) de configuración (S), para obtener luego la desprotección, cuando fuere necesario, el compuesto de fórmula (1).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03291931A EP1367063B1 (fr) | 2003-07-31 | 2003-07-31 | Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR045151A1 true AR045151A1 (es) | 2005-10-19 |
Family
ID=29414890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040102693A AR045151A1 (es) | 2003-07-31 | 2004-07-29 | Procedimiento para la sistensis de perindopril y de sus sales farmaceuticamente aceptables |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7358372B2 (es) |
| EP (1) | EP1367063B1 (es) |
| JP (1) | JP4263743B2 (es) |
| KR (1) | KR100798560B1 (es) |
| CN (1) | CN100404548C (es) |
| AR (1) | AR045151A1 (es) |
| AT (1) | ATE337332T1 (es) |
| AU (1) | AU2004261439B2 (es) |
| BR (1) | BRPI0413169A (es) |
| CA (1) | CA2533005C (es) |
| CY (1) | CY1105791T1 (es) |
| DE (1) | DE60307721T2 (es) |
| DK (1) | DK1367063T3 (es) |
| EA (1) | EA008685B1 (es) |
| ES (1) | ES2271498T3 (es) |
| GE (1) | GEP20094740B (es) |
| MA (1) | MA27911A1 (es) |
| MX (1) | MXPA06001243A (es) |
| MY (1) | MY139443A (es) |
| NO (1) | NO333957B1 (es) |
| NZ (1) | NZ544879A (es) |
| PL (1) | PL211892B1 (es) |
| PT (1) | PT1367063E (es) |
| SI (1) | SI1367063T1 (es) |
| UA (1) | UA80905C2 (es) |
| WO (1) | WO2005012333A2 (es) |
| ZA (1) | ZA200600479B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI21800A (sl) * | 2004-05-14 | 2005-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze perindoprila |
| WO2016178591A2 (en) | 2015-05-05 | 2016-11-10 | Gene Predit, Sa | Genetic markers and treatment of male obesity |
| PH12018502155B1 (en) | 2016-04-20 | 2024-03-27 | Servier Lab | Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES8604144A1 (es) * | 1984-11-21 | 1986-01-16 | Farmhispania | Procedimiento para la obtencion del acido (2s, 3as, 7as)-1-((s)-1-etoxicarbonil-3-fenilpropil) alanil) exahidro-2-indolincarboxilico |
| FR2807431B1 (fr) * | 2000-04-06 | 2002-07-19 | Adir | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
| FR2827860B1 (fr) * | 2001-07-24 | 2004-12-10 | Servier Lab | Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril |
-
2003
- 2003-07-31 SI SI200330430T patent/SI1367063T1/sl unknown
- 2003-07-31 ES ES03291931T patent/ES2271498T3/es not_active Expired - Lifetime
- 2003-07-31 DE DE60307721T patent/DE60307721T2/de not_active Expired - Lifetime
- 2003-07-31 DK DK03291931T patent/DK1367063T3/da active
- 2003-07-31 AT AT03291931T patent/ATE337332T1/de active
- 2003-07-31 PT PT03291931T patent/PT1367063E/pt unknown
- 2003-07-31 EP EP03291931A patent/EP1367063B1/fr not_active Expired - Lifetime
-
2004
- 2004-07-29 CN CNB2004800212090A patent/CN100404548C/zh not_active Expired - Fee Related
- 2004-07-29 US US10/566,562 patent/US7358372B2/en not_active Expired - Fee Related
- 2004-07-29 PL PL379631A patent/PL211892B1/pl unknown
- 2004-07-29 JP JP2006521621A patent/JP4263743B2/ja not_active Expired - Fee Related
- 2004-07-29 MY MYPI20043053A patent/MY139443A/en unknown
- 2004-07-29 AR ARP040102693A patent/AR045151A1/es not_active Application Discontinuation
- 2004-07-29 UA UAA200602130A patent/UA80905C2/xx unknown
- 2004-07-29 WO PCT/FR2004/002035 patent/WO2005012333A2/fr not_active Ceased
- 2004-07-29 ZA ZA200600479A patent/ZA200600479B/en unknown
- 2004-07-29 GE GEAP20049261A patent/GEP20094740B/en unknown
- 2004-07-29 KR KR1020067001920A patent/KR100798560B1/ko not_active Expired - Fee Related
- 2004-07-29 BR BRPI0413169-0A patent/BRPI0413169A/pt active Search and Examination
- 2004-07-29 NZ NZ544879A patent/NZ544879A/en not_active IP Right Cessation
- 2004-07-29 MX MXPA06001243A patent/MXPA06001243A/es active IP Right Grant
- 2004-07-29 EA EA200600250A patent/EA008685B1/ru not_active IP Right Cessation
- 2004-07-29 CA CA2533005A patent/CA2533005C/fr not_active Expired - Fee Related
- 2004-07-29 AU AU2004261439A patent/AU2004261439B2/en not_active Ceased
-
2006
- 2006-01-17 MA MA28731A patent/MA27911A1/fr unknown
- 2006-02-24 NO NO20060922A patent/NO333957B1/no not_active IP Right Cessation
- 2006-11-16 CY CY20061101673T patent/CY1105791T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |