AR048197A1 - Metodos para tratar la esquizofrenia y/o anomalias de glucorregulacion - Google Patents
Metodos para tratar la esquizofrenia y/o anomalias de glucorregulacionInfo
- Publication number
- AR048197A1 AR048197A1 ARP050101275A ARP050101275A AR048197A1 AR 048197 A1 AR048197 A1 AR 048197A1 AR P050101275 A ARP050101275 A AR P050101275A AR P050101275 A ARP050101275 A AR P050101275A AR 048197 A1 AR048197 A1 AR 048197A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- halogen
- hydrogen
- glucorregulation
- independently hydrogen
- Prior art date
Links
- 201000000980 schizophrenia Diseases 0.000 title abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 10
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 150000002431 hydrogen Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical group 0.000 abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 230000005856 abnormality Effects 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 239000000164 antipsychotic agent Substances 0.000 abstract 2
- -1 benzyloxy, hydroxy Chemical group 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente proporciona composiciones farmacéuticas para tratar la esquizofrenia y/o anomalías de glucorregulacion en un paciente que lo necesite, que comprende una cantidad terapéuticamente eficaz de un compuesto de formula (1), en la que: M es 0, 1 o 2; n es 0, 1 o 2; p es 0 o 1; cada R es independientemente hidrogeno, halogeno, trifluorometilo, alquilo C1-6, alcoxi C1-6, benciloxi, hidroxi, nitro o amino; cada R1 es independientemente hidrogeno, alquilo C1-6, alquenilo C1-6, alcanoilo C1-6, halogeno, ciano, -C(O)-alquiloC1-6, -alquilenC1-6-CN, -alquilenC1-6-NR'R'' en el que R' y R'' son cada uno independientemente hidrogeno o alquilo C1-6, -alquilenC1-6-OC(O)-alquiloC1-6, o -CH(OH)R4 en el que R4 es hidrogeno o alquilo C1-6; R2 es hidrogeno, alquilo C1-6 opcionalmente sustituido con halogeno, hidroxi o benciloxi, alquenilo C1-6, alquinilo C1-6, -CO2-alquiloC1-6, o -R5-NR'R'' en el que R5 es alquileno C1-6, alquenileno C1-6 o alquinileno C1-6 y R' y R'' son cada uno independientemente hidrogeno, alquilo C1-6 o alternativamente el grupo -NR'R'' como un solo grupo es 1-pirrolidinilo; y R3 es hidrogeno, nitro, amino, halogeno, alcoxi C1-6, hidroxi o alquilo C1-6; o una de sus sales farmacéuticamente aceptable, y el uso de dichos compuestos para la fabricacion de un medicamento. Composiciones farmacéuticas para tratar la esquizofrenia en un ser humano que evita la propension concomitante de anomalías de glucorregulacion asociadas con la administracion de agentes antipsicoticos para administrar a dicho ser humano que comprende i) una cantidad terapéuticamente eficaz de un compuesto o una de sus sales farmacéuticamente aceptable, y ii) una cantidad terapéuticamente eficaz del agente antipsicotico y el uso de dichos compuestos para la fabricacion de un medicamento.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55845104P | 2004-04-01 | 2004-04-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR048197A1 true AR048197A1 (es) | 2006-04-05 |
Family
ID=34978926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050101275A AR048197A1 (es) | 2004-04-01 | 2005-03-31 | Metodos para tratar la esquizofrenia y/o anomalias de glucorregulacion |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20070129403A1 (es) |
| EP (2) | EP1734959B1 (es) |
| JP (1) | JP2007531730A (es) |
| KR (1) | KR20070010161A (es) |
| CN (1) | CN1946399A (es) |
| AR (1) | AR048197A1 (es) |
| AT (1) | ATE446754T1 (es) |
| AU (1) | AU2005231446A1 (es) |
| BR (1) | BRPI0509512A (es) |
| CA (1) | CA2561162A1 (es) |
| CL (1) | CL2009001605A1 (es) |
| CY (1) | CY1109734T1 (es) |
| DE (1) | DE602005017373D1 (es) |
| DK (1) | DK1734959T3 (es) |
| DO (1) | DOP2005000050A (es) |
| ES (1) | ES2334241T3 (es) |
| GT (1) | GT200500063A (es) |
| IL (1) | IL178168A0 (es) |
| MX (1) | MXPA06011222A (es) |
| PA (1) | PA8628601A1 (es) |
| PL (1) | PL1734959T3 (es) |
| PT (1) | PT1734959E (es) |
| SI (1) | SI1734959T1 (es) |
| SV (1) | SV2006002069A (es) |
| TW (1) | TW200602040A (es) |
| WO (1) | WO2005097122A2 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR053710A1 (es) | 2005-04-11 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos espiroheterociclicos y sus usos como agentes terapeuticos |
| AR056968A1 (es) | 2005-04-11 | 2007-11-07 | Xenon Pharmaceuticals Inc | Compuestos espiro-oxindol y composiciones farmacéuticas |
| US20110294842A9 (en) * | 2006-10-12 | 2011-12-01 | Xenon Pharmaceuticals Inc. | Spiro (furo [3, 2-c] pyridine-3-3' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain |
| WO2008060789A2 (en) | 2006-10-12 | 2008-05-22 | Xenon Pharmaceuticals Inc. | Use of spiro-oxindole compounds as therapeutic agents |
| CA2741024A1 (en) | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| JO3032B1 (ar) | 2008-10-17 | 2016-09-05 | Xenon Pharmaceuticals Inc | مركبات سبيرو – اوكسندول وإستعمالاتها كعوامل علاجية. |
| WO2010068750A2 (en) * | 2008-12-11 | 2010-06-17 | Board Of Trustees Of Leland Stanford Junior University | Compositons and method for treatment of mood and cognitive impairments |
| EP2437744B1 (en) * | 2009-06-03 | 2015-06-03 | Marquette University | Modulation of kcnq potassium channel activity for treatment of psychiatric disorders and the symptoms thereof |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| KR20120099429A (ko) | 2009-10-14 | 2012-09-10 | 제논 파마슈티칼스 인크. | 스피로-옥스인돌 화합물의 합성 방법 |
| WO2011106729A2 (en) | 2010-02-26 | 2011-09-01 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents |
| US11090297B2 (en) | 2013-06-21 | 2021-08-17 | Prilenia Neurotherapeutics Ltd. | Pridopidine for treating huntington's disease |
| CN103512972A (zh) * | 2013-07-29 | 2014-01-15 | 上海交通大学 | 精神分裂症的生物标志物及其使用方法和应用 |
| WO2016127068A1 (en) | 2015-02-05 | 2016-08-11 | Teva Pharmaceuticals International Gmbh | Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound |
| KR101759122B1 (ko) | 2015-08-07 | 2017-07-18 | 계명대학교 산학협력단 | 오렉신 a를 함유하는 당뇨병 치료용 약학 조성물 |
| EP4516356A3 (en) | 2016-08-24 | 2025-05-14 | Prilenia Neurotherapeutics Ltd. | Use of pridopidine for treating functional decline |
| EP3941352A1 (en) | 2019-03-19 | 2022-01-26 | Cambridge Cognition Limited | Method and uses of diagnosing and recommending treatment for a psychotic disorder |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0287982B1 (en) * | 1987-04-24 | 1994-12-07 | Hoechst-Roussel Pharmaceuticals Incorporated | N-(Pyridinyl)-1H-indol-1-amines, a process for their preparation and their use as medicaments |
| US4970218A (en) | 1987-04-24 | 1990-11-13 | Hoechst-Roussel Pharmaceuticals Inc. | N-(pyridinyl)-1H-indol-1-amines |
| US4880822A (en) * | 1987-04-24 | 1989-11-14 | Hoechst-Roussel Pharmaceuticals, Inc. | N-(pyridinyl)-1H-indol-1-amines |
| US5102891A (en) * | 1990-07-23 | 1992-04-07 | Hoechst-Roussel Pharmaceuticals Inc. | 1-(substituted pyridinylamino)-1H-indol-5-yl substituted carbamates |
| US5214038A (en) * | 1991-04-15 | 1993-05-25 | Hoechst-Roussel Pharmaceuticals Inc. | 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof |
| US5356910A (en) * | 1993-07-19 | 1994-10-18 | Hoechst-Roussel Pharmaceuticals Inc. | Use of N-(pyridinyl)-1H-indol-1-amines for the treatment of obsessive-compulsive disorder |
| DE69621617T2 (de) * | 1995-07-27 | 2003-01-02 | Aventis Pharmaceuticals Inc., Bridgewater | Verwendung von substituierten und nichtsubstituierten n-(pyrrol-1-yl)pyridinaminen als antikonvulsiva |
| EP0876379A1 (en) | 1996-01-17 | 1998-11-11 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives, their preparation and use |
| IL128332A0 (en) | 1996-08-30 | 2000-01-31 | Novo Nordisk As | GLP-1 derivatives |
| DE19726167B4 (de) | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
| RU2215004C2 (ru) | 1997-07-16 | 2003-10-27 | Ново Нордиск А/С | Конденсированное производное 1,2,4-тиадиазина, фармацевтическая композиция и способ получения лекарственного препарата |
| GB0119435D0 (en) * | 2001-02-15 | 2001-10-03 | Aventis Pharm Prod Inc | Method of treating of demyelinating diseases or conditions |
-
2005
- 2005-03-22 GT GT200500063A patent/GT200500063A/es unknown
- 2005-03-30 DO DO2005000050A patent/DOP2005000050A/es unknown
- 2005-03-31 AR ARP050101275A patent/AR048197A1/es not_active Application Discontinuation
- 2005-04-01 PT PT05732721T patent/PT1734959E/pt unknown
- 2005-04-01 KR KR1020067022972A patent/KR20070010161A/ko not_active Ceased
- 2005-04-01 ES ES05732721T patent/ES2334241T3/es not_active Expired - Lifetime
- 2005-04-01 SI SI200530883T patent/SI1734959T1/sl unknown
- 2005-04-01 SV SV2005002069A patent/SV2006002069A/es unknown
- 2005-04-01 PL PL05732721T patent/PL1734959T3/pl unknown
- 2005-04-01 EP EP05732721A patent/EP1734959B1/en not_active Expired - Lifetime
- 2005-04-01 MX MXPA06011222A patent/MXPA06011222A/es active IP Right Grant
- 2005-04-01 JP JP2007506313A patent/JP2007531730A/ja not_active Abandoned
- 2005-04-01 PA PA20058628601A patent/PA8628601A1/es unknown
- 2005-04-01 EP EP09012248A patent/EP2138176A1/en not_active Withdrawn
- 2005-04-01 AT AT05732721T patent/ATE446754T1/de not_active IP Right Cessation
- 2005-04-01 AU AU2005231446A patent/AU2005231446A1/en not_active Abandoned
- 2005-04-01 CN CNA2005800121147A patent/CN1946399A/zh active Pending
- 2005-04-01 TW TW094110410A patent/TW200602040A/zh unknown
- 2005-04-01 BR BRPI0509512-3A patent/BRPI0509512A/pt not_active IP Right Cessation
- 2005-04-01 CA CA002561162A patent/CA2561162A1/en not_active Abandoned
- 2005-04-01 WO PCT/US2005/011107 patent/WO2005097122A2/en not_active Ceased
- 2005-04-01 DE DE602005017373T patent/DE602005017373D1/de not_active Expired - Lifetime
- 2005-04-01 DK DK05732721.5T patent/DK1734959T3/da active
-
2006
- 2006-09-18 IL IL178168A patent/IL178168A0/en unknown
- 2006-09-29 US US11/536,808 patent/US20070129403A1/en not_active Abandoned
-
2009
- 2009-07-17 CL CL2009001605A patent/CL2009001605A1/es unknown
-
2010
- 2010-01-11 CY CY20101100028T patent/CY1109734T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GT200500063A (es) | 2005-10-14 |
| SI1734959T1 (sl) | 2010-02-26 |
| ATE446754T1 (de) | 2009-11-15 |
| PL1734959T3 (pl) | 2010-03-31 |
| US20070129403A1 (en) | 2007-06-07 |
| CY1109734T1 (el) | 2014-09-10 |
| CN1946399A (zh) | 2007-04-11 |
| DE602005017373D1 (de) | 2009-12-10 |
| EP1734959A2 (en) | 2006-12-27 |
| ES2334241T3 (es) | 2010-03-08 |
| IL178168A0 (en) | 2006-12-31 |
| CA2561162A1 (en) | 2005-10-20 |
| DOP2005000050A (es) | 2005-11-30 |
| WO2005097122A2 (en) | 2005-10-20 |
| EP2138176A1 (en) | 2009-12-30 |
| MXPA06011222A (es) | 2007-01-16 |
| PA8628601A1 (es) | 2006-05-16 |
| PT1734959E (pt) | 2009-12-24 |
| JP2007531730A (ja) | 2007-11-08 |
| AU2005231446A1 (en) | 2005-10-20 |
| WO2005097122A3 (en) | 2006-02-02 |
| EP1734959B1 (en) | 2009-10-28 |
| SV2006002069A (es) | 2006-05-24 |
| TW200602040A (en) | 2006-01-16 |
| CL2009001605A1 (es) | 2009-11-27 |
| KR20070010161A (ko) | 2007-01-22 |
| DK1734959T3 (da) | 2010-03-08 |
| BRPI0509512A (pt) | 2007-09-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |