AR048220A1 - Arreglo de dispositivos utilizables en la elaboracion de microcapsulas para la liberacion controlada de peptidos y procedimiento de elaboracion de dichas opcionalmente sustituido - Google Patents

Arreglo de dispositivos utilizables en la elaboracion de microcapsulas para la liberacion controlada de peptidos y procedimiento de elaboracion de dichas opcionalmente sustituido

Info

Publication number
AR048220A1
AR048220A1 ARP050100302A AR048220A1 AR 048220 A1 AR048220 A1 AR 048220A1 AR P050100302 A ARP050100302 A AR P050100302A AR 048220 A1 AR048220 A1 AR 048220A1
Authority
AR
Argentina
Prior art keywords
temperature
degree
aqueous phase
elaboration
peptides
Prior art date
Application number
Other languages
English (en)
Inventor
Graciela Enriquez
Graciela Haydee Marrone
Fernando Daniel Grassi
Cristina Beatriz Ramat
Original Assignee
Lkm S A Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lkm S A Lab filed Critical Lkm S A Lab
Priority to ARP050100302 priority Critical patent/AR048220A1/es
Priority to PCT/ES2006/000036 priority patent/WO2006082265A1/es
Priority to BRPI0606338-1A priority patent/BRPI0606338A2/pt
Priority to EP06708855.9A priority patent/EP1847261A4/en
Publication of AR048220A1 publication Critical patent/AR048220A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Un arreglo de dispositivos utilizable en la elaboracion de microcápsulas para la liberacion controlada de péptidos que optimiza el entrampamiento de los mismos, caracterizado porque comprende un recipiente encamisado cerrado que tiene incorporado un sistema que permite agitar y/o homogeneizar de manera controlada su contenido, donde dicho recipiente se comunica, mediante un dispositivo de inyeccion de un diámetro menor a 1 mm, con un segundo recipiente de características similares al anterior, que permite la realizacion de una segunda homogeneizacion, y porque dicho arreglo de dispositivos permite un control estricto de la temperatura y de la viscosidad de su contenido, en donde dicha temperatura se mantiene siempre menor o igual a 15 degree C y la viscosidad se mantiene dentro del rango comprendido entre 500 y 20000 cp. y porque mediante dicho control de la temperatura y de la viscosidad es posible controlar la distribucion de tamanos de las microesferas obtenidas. Reivindicacion 6: Un procedimiento para elaborar microcápsulas para la liberacion controlada de péptidos, caracterizado porque comprende: preparar una primera fase acuosa (W1) solubilizando un polímero en agua y solubilizar en dicha fase acuosa el péptido hidrofílico; preparar una fase orgánica (O) de un solvente adecuado y mediante la utilizacion del dispositivo de acuerdo con la reivindicacion 1; emulsionar la fase acuosa (W1), a una temperatura de alrededor de ente 2 degree C y 10 degree C, en la fase oleosa (O), para obtener una emulsion (W1/O); dispersar la emulsion obtenida en la etapa anterior en la fase acuosa del coloide protector (W2), a una temperatura comprendida en el rango de entre 15 degree C y 20 degree C, hasta obtener una emulsion W1/O/W2; para finalmente evaporar el solvente a una temperatura comprendida entre 25 degree C y 40 degree C y posterior centrifugacion y liofilizacion para luego obtener las micropartículas.
ARP050100302 2005-01-28 2005-01-28 Arreglo de dispositivos utilizables en la elaboracion de microcapsulas para la liberacion controlada de peptidos y procedimiento de elaboracion de dichas opcionalmente sustituido AR048220A1 (es)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ARP050100302 AR048220A1 (es) 2005-01-28 2005-01-28 Arreglo de dispositivos utilizables en la elaboracion de microcapsulas para la liberacion controlada de peptidos y procedimiento de elaboracion de dichas opcionalmente sustituido
PCT/ES2006/000036 WO2006082265A1 (es) 2005-01-28 2006-01-27 Conjunto de dispositivos utilizable en la elaboración de microcápsulas para la liberación controlada de péptidos
BRPI0606338-1A BRPI0606338A2 (pt) 2005-01-28 2006-01-27 arranjo de dispositivos utilizável na elaboração de microcápsulas para a liberação controlada de peptìdeos e que aperfeiçoa a captura dos mesmos
EP06708855.9A EP1847261A4 (en) 2005-01-28 2006-01-27 DEVICE SET FOR USE IN THE PRODUCTION OF CONTROLLED RELEASE MICRO-FILES OF PEPTIDES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ARP050100302 AR048220A1 (es) 2005-01-28 2005-01-28 Arreglo de dispositivos utilizables en la elaboracion de microcapsulas para la liberacion controlada de peptidos y procedimiento de elaboracion de dichas opcionalmente sustituido

Publications (1)

Publication Number Publication Date
AR048220A1 true AR048220A1 (es) 2006-04-12

Family

ID=36608832

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050100302 AR048220A1 (es) 2005-01-28 2005-01-28 Arreglo de dispositivos utilizables en la elaboracion de microcapsulas para la liberacion controlada de peptidos y procedimiento de elaboracion de dichas opcionalmente sustituido

Country Status (4)

Country Link
EP (1) EP1847261A4 (es)
AR (1) AR048220A1 (es)
BR (1) BRPI0606338A2 (es)
WO (1) WO2006082265A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101558083B1 (ko) * 2014-04-07 2015-10-07 에스케이케미칼주식회사 약물함유 고분자미립구 제조방법
US20200001263A1 (en) * 2018-06-28 2020-01-02 Cornell University Encapsulation System and Method

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5879712A (en) * 1995-06-07 1999-03-09 Sri International Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced
AR023940A1 (es) * 2000-05-03 2002-09-04 Eriochem Sa Procedimiento para la produccion de microcapsulas de liberacion prolongada de peptidos solubles en agua
PT103476B (pt) * 2006-05-10 2008-09-19 Univ De Coimbra Processo de produção e isolamento de micro- e nanopartículas poliméricas contendo macromoléculas de natureza hidrofílica e termolábil

Also Published As

Publication number Publication date
WO2006082265A1 (es) 2006-08-10
EP1847261A4 (en) 2013-09-25
BRPI0606338A2 (pt) 2009-11-17
EP1847261A1 (en) 2007-10-24

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