AR048312A1 - Derivados de pirazolil-indolilo en calidad de activadores ppar - Google Patents
Derivados de pirazolil-indolilo en calidad de activadores pparInfo
- Publication number
- AR048312A1 AR048312A1 ARP050100858A ARP050100858A AR048312A1 AR 048312 A1 AR048312 A1 AR 048312A1 AR P050100858 A ARP050100858 A AR P050100858A AR P050100858 A ARP050100858 A AR P050100858A AR 048312 A1 AR048312 A1 AR 048312A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- alkoxy
- cycloalkyl
- alkynyl
- Prior art date
Links
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 title 1
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 title 1
- 239000012190 activator Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 15
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 239000001257 hydrogen Substances 0.000 abstract 8
- 150000002431 hydrogen Chemical class 0.000 abstract 7
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 5
- 125000003342 alkenyl group Chemical group 0.000 abstract 4
- 125000000304 alkynyl group Chemical group 0.000 abstract 4
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 108010015181 PPAR delta Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Composiciones farmacéuticas que contienen tales compuestos, un proceso para su obtencion y su utilizacion para el tratamiento y/o prevencion de enfermedades moduladas por agonistas de PPARdelta y/o PPARalfa. Reivindicacion 1: Compuestos de la formula (1), en la que: R1 es hidrogeno o alquilo C1-7; R2 y R3, con independencia entre sí, son hidrogeno, alquilo C1-7 o alcoxi C1-7; R4 y R5, con independencia entre sí, son hidrogeno, alquilo C1-7, cicloalquilo C3-7, halogeno, alcoxiC1-7- alquiloC1-7, alquenilo C2-7, alquinilo C2-7, fluoroalquilo C1-7, ciano-alquiloC1-7 o ciano; R6, R7, R8 y R9, con independencia entre sí, son hidrogeno, alquilo C1-7, cicloalquilo C3-7, halogeno, alcoxiC1-7-alquiloC1-7, alquenilo C2-7, alquinilo C2- 7, fluoroalquilo C1-7, ciano-alquiloC1-7 o ciano; y uno de R6, R7 y R8 es un grupo de formula (2), en la que: R10 es hidrogeno, alquilo C1-7, cicloalquilo C3-7, o fluoralquilo C1-7; R11 es hidrogeno, alquilo C1-7, o alcoxiC1-7-alquiloC1-7; uno de R12 o R13 es hidrogeno, alquilo C1-7, cicloalquilo C3-7, alcoxiC2-7-alquilo1-7, alquenilo C2-7, alquinilo C2-7 o fluoralquilo C1-7; y el otro es un par solitario; R14 es hidrogeno, alquilo C1-7, cicloalquilo C3-7, halogeno, alcoxiC1-7-alquiloC1-7, alquenilo C2-7, alquinilo C2-7 o fluoroalquilo C1-7; R15 es arilo o heteroarilo; y n es 1, 2 o 3; y todos los enantiomeros y sales y/o ésteres farmacéuticamente aceptables de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04100958 | 2004-03-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR048312A1 true AR048312A1 (es) | 2006-04-19 |
Family
ID=34917207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050100858A AR048312A1 (es) | 2004-03-09 | 2005-03-07 | Derivados de pirazolil-indolilo en calidad de activadores ppar |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7265149B2 (es) |
| EP (1) | EP1725546B1 (es) |
| JP (1) | JP4599395B2 (es) |
| CN (1) | CN100467463C (es) |
| AR (1) | AR048312A1 (es) |
| AT (1) | ATE410422T1 (es) |
| AU (1) | AU2005219536A1 (es) |
| BR (1) | BRPI0509440A (es) |
| CA (1) | CA2557789C (es) |
| DE (1) | DE602005010218D1 (es) |
| ES (1) | ES2314630T3 (es) |
| RU (1) | RU2375357C2 (es) |
| TW (1) | TW200540153A (es) |
| WO (1) | WO2005085235A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7405236B2 (en) * | 2004-08-16 | 2008-07-29 | Hoffman-La Roche Inc. | Indole derivatives comprising an acetylene group |
| RU2528406C2 (ru) * | 2008-11-21 | 2014-09-20 | Раквалиа Фарма Инк. | Новое производное пиразол-3-карбоксамида, обладающее антагонистической активностью в отношении рецептора 5-нт2в |
| CN113480522A (zh) * | 2021-08-19 | 2021-10-08 | 守恒(厦门)医疗科技有限公司 | 新型苯基吡唑类衍生物及其在降血糖药物中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9604242D0 (en) * | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| JP2005504778A (ja) * | 2001-08-29 | 2005-02-17 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 経口抗糖尿病剤 |
| US6867224B2 (en) * | 2002-03-07 | 2005-03-15 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods of preparation |
| US6875780B2 (en) * | 2002-04-05 | 2005-04-05 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods for their preparation |
| WO2003099793A1 (en) * | 2002-05-24 | 2003-12-04 | Takeda Pharmaceutical Company Limited | 1,2-azole derivatives with hypoglycemic and hypolipidemic activity |
| EP1581491A1 (en) | 2003-01-06 | 2005-10-05 | Eli Lilly And Company | Indole derivatives as ppar modulators |
-
2005
- 2005-02-28 RU RU2006135544/04A patent/RU2375357C2/ru not_active IP Right Cessation
- 2005-02-28 BR BRPI0509440-2A patent/BRPI0509440A/pt not_active IP Right Cessation
- 2005-02-28 AT AT05715587T patent/ATE410422T1/de active
- 2005-02-28 DE DE602005010218T patent/DE602005010218D1/de not_active Expired - Lifetime
- 2005-02-28 AU AU2005219536A patent/AU2005219536A1/en not_active Abandoned
- 2005-02-28 ES ES05715587T patent/ES2314630T3/es not_active Expired - Lifetime
- 2005-02-28 CN CNB2005800075312A patent/CN100467463C/zh not_active Expired - Fee Related
- 2005-02-28 WO PCT/EP2005/002074 patent/WO2005085235A1/en not_active Ceased
- 2005-02-28 CA CA2557789A patent/CA2557789C/en not_active Expired - Fee Related
- 2005-02-28 JP JP2007502232A patent/JP4599395B2/ja not_active Expired - Fee Related
- 2005-02-28 EP EP05715587A patent/EP1725546B1/en not_active Expired - Lifetime
- 2005-03-04 TW TW094106683A patent/TW200540153A/zh unknown
- 2005-03-07 AR ARP050100858A patent/AR048312A1/es unknown
- 2005-03-08 US US11/074,474 patent/US7265149B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7265149B2 (en) | 2007-09-04 |
| ATE410422T1 (de) | 2008-10-15 |
| CN100467463C (zh) | 2009-03-11 |
| EP1725546A1 (en) | 2006-11-29 |
| ES2314630T3 (es) | 2009-03-16 |
| US20050203160A1 (en) | 2005-09-15 |
| JP4599395B2 (ja) | 2010-12-15 |
| AU2005219536A1 (en) | 2005-09-15 |
| RU2375357C2 (ru) | 2009-12-10 |
| BRPI0509440A (pt) | 2007-09-04 |
| WO2005085235A1 (en) | 2005-09-15 |
| CN1930150A (zh) | 2007-03-14 |
| JP2007527880A (ja) | 2007-10-04 |
| DE602005010218D1 (de) | 2008-11-20 |
| TW200540153A (en) | 2005-12-16 |
| RU2006135544A (ru) | 2008-04-20 |
| CA2557789C (en) | 2012-12-11 |
| EP1725546B1 (en) | 2008-10-08 |
| CA2557789A1 (en) | 2005-09-15 |
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| FB | Suspension of granting procedure |