AR048376A1 - C- glicosidos heterociclos fusionados sustituidos - Google Patents

C- glicosidos heterociclos fusionados sustituidos

Info

Publication number
AR048376A1
AR048376A1 ARP040102728A ARP040102728A AR048376A1 AR 048376 A1 AR048376 A1 AR 048376A1 AR P040102728 A ARP040102728 A AR P040102728A AR P040102728 A ARP040102728 A AR P040102728A AR 048376 A1 AR048376 A1 AR 048376A1
Authority
AR
Argentina
Prior art keywords
substituted
glycycles
glycycle
fusioned
absent
Prior art date
Application number
ARP040102728A
Other languages
English (en)
Original Assignee
Janssen Pharmaceutica Nv
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv, Tanabe Seiyaku Co filed Critical Janssen Pharmaceutica Nv
Publication of AR048376A1 publication Critical patent/AR048376A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06—Heterocyclic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente se refiere a composiciones que contienen estos compuestos, y métodos para utilizarlos, por ejemplo para el tratamiento o rofilaxis de la diabetes y el Síndrome X. Reivindicacion 1: Un compuesto de la formula (1) en la cual: una de las líneas punteadas entre NR1 y X o entre X e Y está presente, o ambas están ausentes; dos de V. M y W son H y el tercero es como se muestra en la formula (2), R1 es H, alquilo C1-4, cuando la línea punteada entre NR1 y X está presente, R1 está ausente; X es N, C=O, CH; o C-Q-Z. Y es N-Q-Z o C-Q-Z, cuando X es N, C=O o CH; Y es CH, cuando X es C-Q-Z; Q=-(CH2)n-, donde n = 1 o 2; P = H, acilo C1-7 o (alcoxi C1-6)carbonilo; Z cestá sustituido o sin sustituir, y se selecciona de cicloalquilo C3-7, fenilo, heteroarilo de 5 o 6 miembros que presentan 1 o 2 heteroátomos independientemente seleccionados de N, O y S, un biarilo, biciclilo fusionado de 9 o 10 miembros y un heterobiciclilo fusionado, donde dicho heterobiciclilo fusionado presenta entre 1 y 4 heteroátomos independientemente seleccionados de N, O y S; o una sal aceptable desde el punto de vista farmacéutico del mismo.
ARP040102728A 2003-08-01 2004-07-30 C- glicosidos heterociclos fusionados sustituidos AR048376A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US49153403P 2003-08-01 2003-08-01
US49152303P 2003-08-01 2003-08-01
US51921003P 2003-11-12 2003-11-12
US57973004P 2004-06-15 2004-06-15

Publications (1)

Publication Number Publication Date
AR048376A1 true AR048376A1 (es) 2006-04-26

Family

ID=34120044

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040102728A AR048376A1 (es) 2003-08-01 2004-07-30 C- glicosidos heterociclos fusionados sustituidos

Country Status (9)

Country Link
US (4) US7094763B2 (es)
EP (1) EP1679965A4 (es)
AR (1) AR048376A1 (es)
AU (1) AU2004261660A1 (es)
CA (1) CA2549015A1 (es)
EA (1) EA009768B1 (es)
IL (1) IL175489A0 (es)
TW (1) TW200521131A (es)
WO (1) WO2005012318A2 (es)

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AU2004261660A1 (en) 2005-02-10
CA2549015A1 (en) 2005-02-10
US20100004160A1 (en) 2010-01-07
US7094763B2 (en) 2006-08-22
US20090105162A1 (en) 2009-04-23
US7482330B2 (en) 2009-01-27
EP1679965A2 (en) 2006-07-19
IL175489A0 (en) 2009-02-11
EA200601552A1 (ru) 2007-02-27
WO2005012318A3 (en) 2005-12-15
EA009768B1 (ru) 2008-04-28
US7816328B2 (en) 2010-10-19

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