AR055100A1 - Benzimidazoles triciclicos y su uso como moduladores de receptores metabotropicos de glutamato - Google Patents

Benzimidazoles triciclicos y su uso como moduladores de receptores metabotropicos de glutamato

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Publication number
AR055100A1
AR055100A1 ARP060103273A ARP060103273A AR055100A1 AR 055100 A1 AR055100 A1 AR 055100A1 AR P060103273 A ARP060103273 A AR P060103273A AR P060103273 A ARP060103273 A AR P060103273A AR 055100 A1 AR055100 A1 AR 055100A1
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Argentina
Prior art keywords
alkylene
group
nr6r7
alkyl
independently selected
Prior art date
Application number
ARP060103273A
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English (en)
Inventor
Methvin Isaac
Malik Slassi
Ian Egle
Fupeng Ma
Original Assignee
Astrazeneca Ab
Nps Pharma Inc
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Publication date
Application filed by Astrazeneca Ab, Nps Pharma Inc filed Critical Astrazeneca Ab
Publication of AR055100A1 publication Critical patent/AR055100A1/es

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    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
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  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Reivindicacion 1: Un compuesto de formula (1): en donde A se selecciona del grupo formado por CR8R9, NR5, O, S, SO y SO2, B se selecciona del grupo formado por CH y N; D se selecciona del grupo formado por NH, N-C1-6-alquilo, y -(CR5R6)z-, en donde uno de los grupos -CR5R6- se puede reemplazar por -C(O)-, NH, o NC1-6-alquilo; L se selecciona del grupo formado por un enlace directo y -(CR5R6)w-, en donde cuando L es -(CR5R6)w; (i) B-L pueden ser insaturados, o dos átomos de carbono adyacentes pueden formar parte de un anillo ciclopropilo; o (ji) uno o dos grupos CR5R6 se puede reemplazar con O, S, o NR5; el resto de formula (2) representa un anillo seleccionado entre el grupo formado por azetidina y un anillo de 5 a 7 miembros, que pueden ser insaturados, en donde el anillo puede estar sustituido por uno o más R4; R1en cada caso, se selecciona del grupo formado por H, F, Cl, Br, I, OH, CN, nitro, C1-6-alquilo, OC1-6-alquilo, C1-6-alquilhalo, OC1-6-alquilhalo, C2-6-alquenilo, OC2-6-alquenilo, C2-6-alquinilo, OC2-6-alquinilo, C3-8-cicloalquilo, C1-6-alquilen-C3-8-cicloalquilo, OC0-6- alquilen-C3-8-cicloalquilo, arilo, heteroarilo, C1-6-alquilenoarilo, C1-6-alquilenoheteroarilo, OC1-6- alquilenoarilo, OC1-6- alquilenoheteroarilo, C1-6-alquilenoheterocicloalquilo, (CO) R5, (CO)OR5, C1-6-alquilenoOR5, OC2-6-alquilenoOR5, C1-6-alquileno (CO)R5, OC1-6-alquileno(CO)R5, C1-6-alquilenociano, OC2-6-alquilenociano, C0-6-alquilenoNR6R7, OC2-6-alquilenoNR6R7, C1-6- alquileno(CO)NR6R7, OC1-6-alquileno(CO) NR6R7, C0-6-alquilenoNR6(CO)R7, OC2-6-alquilenoNR6(CO)R7, C0-6-alquilenoNR6(CO)NR6R7, C0-6-alquilenoSO2R5, OC2-6-alquilenoSO2R5, C0--6-alquileno (SO2) NR6R7, OC2-6-alquileno (SO2)NR6R7, C0-6-alquilenoNR6 (SO2)R7, OC2-6-alquilenoNR6 (SO2)R7', C0-6- alquilenoNR6(SO2)NR6R7, OC2-6-alquilenoNR6(SO2)NR6R7, (CO)NR6R7 y SO3R5, en donde cualquier grupo cíclico puede estar también sustituido con uno o más grupos R2; R2 y R4, en cada caso, se seleccionan en forma independiente entre el grupo formado por H, F, Cl, Br, I, CN, nitro, hidroxi, oxo, C1-6-alquilo, OC1-6-alquilo, C1-6-alquilhalo, OC1-6-alquilhalo y C0-6-alquilenoNR5R6; R3 es un sistema de anillo de 5 a 12 miembros que es opcionalmente sustituido por hasta tres grupos R1, en donde el sistema de anillo puede contener uno o más heteroátomos seleccionados en forma independiente entre el grupo formado por N, O y S; R5 se selecciona del grupo formado por H, C1-6-alquilo, arilo, C3-8- cicloalquilo, C1-6-alquilenoarilo y C1-6-alquilen-C3-8-cicloalquilo, en donde cualquier grupo cíclico puede estar también sustituido con uno o más grupos R2 seleccionados en forma independiente; R6 y R7 se seleccionan en forma independiente entre el grupo formado por H, y C1-6- alquilo; R8 y R9 se seleccionan en forma independiente entre el grupo formado por H, -O-(CH2)2-O- y -O-(CH2)3-O-; m y n son enteros seleccionados en forma independiente entre el grupo formado por 0, 1, 2, 3 y 4, con la salvedad de que m y n no pueden ser simultáneamente 0; x y y son enteros seleccionados en forma independiente entre el grupo formado por 1, 2, y 3; y w y z'. son enteros seleccionados en forma independiente entre el grupo formado por 1, 2, 3, 4, 5, y 6; o una sal aceptable para uso farmacéutico, hidrato, solvato, isoforma, tautomero, isomero optico, o combinacion de los mismos.
ARP060103273A 2005-08-05 2006-07-28 Benzimidazoles triciclicos y su uso como moduladores de receptores metabotropicos de glutamato AR055100A1 (es)

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US (2) US20070032469A1 (es)
EP (1) EP1912989A2 (es)
JP (1) JP2009503069A (es)
KR (1) KR20080035576A (es)
CN (1) CN101268077A (es)
AR (1) AR055100A1 (es)
AU (1) AU2006279034A1 (es)
BR (1) BRPI0614168A2 (es)
CA (1) CA2616020A1 (es)
EC (1) ECSP088128A (es)
IL (1) IL188809A0 (es)
MX (1) MX2008001152A (es)
NO (1) NO20080475L (es)
RU (1) RU2008101923A (es)
TW (1) TW200745112A (es)
UY (1) UY29710A1 (es)
WO (1) WO2007018998A2 (es)

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MX2008001152A (es) 2008-04-02
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