AR059018A1 - Derivados de 6- fenil -1h- imidazo (4,5-c) piridina -4- carbonitrilo y su uso en el tratamiento de enfermedades relacionadas con catepsina s y/o catepsina k - Google Patents
Derivados de 6- fenil -1h- imidazo (4,5-c) piridina -4- carbonitrilo y su uso en el tratamiento de enfermedades relacionadas con catepsina s y/o catepsina kInfo
- Publication number
- AR059018A1 AR059018A1 ARP070100175A ARP070100175A AR059018A1 AR 059018 A1 AR059018 A1 AR 059018A1 AR P070100175 A ARP070100175 A AR P070100175A AR P070100175 A ARP070100175 A AR P070100175A AR 059018 A1 AR059018 A1 AR 059018A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- independently
- alkyloxy
- nitrogen
- attached
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 13
- 125000003545 alkoxy group Chemical group 0.000 abstract 6
- 125000005842 heteroatom Chemical group 0.000 abstract 6
- 229910052757 nitrogen Inorganic materials 0.000 abstract 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 6
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 6
- 229910052760 oxygen Inorganic materials 0.000 abstract 6
- 229910052717 sulfur Inorganic materials 0.000 abstract 6
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 5
- 125000000623 heterocyclic group Chemical group 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- PWCCDWCZFKPZBK-UHFFFAOYSA-N 6-phenyl-1h-imidazo[4,5-c]pyridine-4-carbonitrile Chemical class C=1C=2NC=NC=2C(C#N)=NC=1C1=CC=CC=C1 PWCCDWCZFKPZBK-UHFFFAOYSA-N 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- -1 quinuclidin-3- yl Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- RAHZWNYVWXNFOC-UHFFFAOYSA-N sulfur dioxide Inorganic materials O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Reivindicacion 1: Un derivado de 6-fenil-1H-imidazo[4,5-c]piridina-4-carbonitrilo, caracterizado porque tiene la formula general (1), donde R es un orto- o meta-sustituyente opcional seleccionado entre halogeno y C1-4 alquiloxi; R1 es C1-4 alquilo, C1-4 alquiloxi, halogeno o CF3; R2 es C1-4 alquilo, C1-4 alquiloxi, o halogeno; R3 es H o (CH2)n-NR5R6; R4 es H o C1-6 alquilo, opcionalmente sustituido con COOR7 o NR8R9; R5 y R6 son independientemente H, C3-8 cicloalquilo, quinuclidin-3- ilo, C2-6 alquenilo o C1-6 alquilo, opcionalmente sustituido con halogeno, CF3, C3-8 cicloalquilo, C6-10 arilo, un grupo heteroarilo de 5 o 6 miembros, OH, C1-6 alquiloxi, C6-10 ariloxi, COOR10, CONR11R12, NR13R14 o NR13SO2(C1-4)alquilo; o R5 y R6, junto con el nitrogeno al cual están unidos, forman un anillo heterocíclico saturado de 4-8 miembros que opcionalmente comprende además 1 o más heteroátomos seleccionados entre O, S, SO2 y NR15, estando el anillo opcionalmente sustituido con oxo, C1-4 alquilo, C3-8 cicloalquilo, NR16R17 o CONR18R19; R7 es H o C1-4) alquilo; R8 y R9 son independientemente H, C1-4 alquilo (opcionalmente sustituido con di(C1-4)alquilamino) o C3-8 cicloalquilo; o R8 y R9 forman, junto con el nitrogeno al cual están unidos, un anillo heterocíclico saturado de 4-8 miembros que opcionalmente comprende además un heteroátomo seleccionado entre O y S; R10 es H o C1-4 alquilo; R11 y R12 son independientemente H o C1-4 alquilo; o R11 y R12, junto con el nitrogeno al cual están unidos, forman un anillo heterocíclico saturado de 4-8 miembros que opcionalmente comprende además un heteroátomo seleccionado entre O y S; R13 y R14 son independientemente H o C1-4 alquilo; o R13 y R14, junto con el nitrogeno al cual están unidos, forman un anillo heterocíclico saturado de 4-8 miembros que opcionalmente comprende además un heteroátomo seleccionado entre O y S; R15 es H, C1-4 alquilo (opcionalmente sustituido con OH, C1-4 alquiloxi, di(C1- 4)alquilamino o CONR21R22), fenilo, piridilo, COR20 o CONR21R22; R16 y R17 son independientemente H o C1-4 alquilo; o R16 y R17, junto con el nitrogeno al cual están unidos, forman un. anillo heterocíclico saturado de 4-8 miembros que opcionalmente comprende además un heteroátomo seleccionado entre O y S; R18 y R19 son independientemente H o C1-4 alquilo; R20 es H, C1-4 alquilo, C3-8 cicloalquilo, C1-4 alquiloxi o furilo; R21 y R22 son independientemente H o C1-4 alquilo; o R21 y R22, junto con el nitrogeno al cual están unidos, forman un anillo heterocíclico saturado de 4-8 miembros que opcionalmente comprende además un heteroátomo seleccionado entre O y S; y n es 0 o1; o una sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06100357 | 2006-01-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR059018A1 true AR059018A1 (es) | 2008-03-05 |
Family
ID=35987201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070100175A AR059018A1 (es) | 2006-01-16 | 2007-01-16 | Derivados de 6- fenil -1h- imidazo (4,5-c) piridina -4- carbonitrilo y su uso en el tratamiento de enfermedades relacionadas con catepsina s y/o catepsina k |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1979351B1 (es) |
| JP (1) | JP5203968B2 (es) |
| KR (1) | KR20080098484A (es) |
| CN (1) | CN101374838B (es) |
| AR (1) | AR059018A1 (es) |
| AT (1) | ATE463496T1 (es) |
| AU (1) | AU2007204311B2 (es) |
| BR (1) | BRPI0706570A2 (es) |
| CA (1) | CA2635982A1 (es) |
| DE (1) | DE602007005775D1 (es) |
| EC (1) | ECSP088654A (es) |
| ES (1) | ES2342021T3 (es) |
| IL (1) | IL192133A0 (es) |
| NO (1) | NO20082791L (es) |
| NZ (1) | NZ569296A (es) |
| PE (1) | PE20080003A1 (es) |
| RU (1) | RU2400482C2 (es) |
| TW (1) | TW200734338A (es) |
| WO (1) | WO2007080191A1 (es) |
| ZA (1) | ZA200805566B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200911803A (en) * | 2007-07-16 | 2009-03-16 | Organon Nv | 6-phenyl-1H-imidazo [4,5-c] pyridine-4-carbonitrile derivatives |
| US7932251B2 (en) | 2007-07-16 | 2011-04-26 | N.V. Organon | 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives |
| EP2379564A1 (en) | 2008-12-19 | 2011-10-26 | Schering Corporation | Bicyclic heterocyclic derivatives and methods of use thereof |
| TW201035094A (en) | 2009-01-16 | 2010-10-01 | Organon Nv | 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives |
| US8026236B2 (en) | 2009-01-16 | 2011-09-27 | N.V. Organon | 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives |
| CN104284895B (zh) | 2012-04-17 | 2016-08-31 | 安斯泰来制药株式会社 | 含氮双环式芳香族杂环化合物 |
| EP3623371A1 (en) | 2014-12-16 | 2020-03-18 | Axovant Sciences GmbH | Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors |
| CA2988968A1 (en) | 2015-06-10 | 2016-12-15 | Forum Pharmaceuticals, Inc. | Aminobenzisoxazole compounds as agonists of a7-nicotinic acetylcholine receptors |
| WO2017027600A1 (en) | 2015-08-12 | 2017-02-16 | Forum Pharmaceuticals, Inc. | GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF α7-NICOTINIC ACETYLCHOLINE RECEPTORS |
| AU2020250933A1 (en) | 2019-04-05 | 2021-10-28 | Centre Hospitalier Régional Et Universitaire De Brest | Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning |
| CN116514813A (zh) * | 2021-12-31 | 2023-08-01 | 轩竹生物科技股份有限公司 | 酪氨酸激酶抑制剂及其中间体的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU566842A1 (ru) * | 1976-01-06 | 1977-07-30 | Донецкое Отделение Физико-Органической Химии Института Физической Химии Им.Л.В.Писаржевского Ан Украинской Сср | Способ получени замещенных имидазопиридинов |
| UA62972C2 (en) * | 1997-07-03 | 2004-01-15 | Application of imidazopyrimidins and imidazopyridins for the treatment of neural disorders | |
| DE19845153A1 (de) * | 1998-10-01 | 2000-04-06 | Merck Patent Gmbh | Imidazo[4,5]-pyridin-4-on-derivate |
| SE0201980D0 (sv) * | 2002-06-24 | 2002-06-24 | Astrazeneca Ab | Novel compounds |
| JPWO2005085210A1 (ja) * | 2004-03-10 | 2008-01-17 | 小野薬品工業株式会社 | ニトリル化合物およびその化合物を有効成分として含有する医薬組成物 |
-
2007
- 2007-01-04 TW TW096100360A patent/TW200734338A/zh unknown
- 2007-01-15 CA CA002635982A patent/CA2635982A1/en not_active Abandoned
- 2007-01-15 AT AT07703872T patent/ATE463496T1/de not_active IP Right Cessation
- 2007-01-15 CN CN2007800031597A patent/CN101374838B/zh not_active Expired - Fee Related
- 2007-01-15 NZ NZ569296A patent/NZ569296A/en unknown
- 2007-01-15 BR BRPI0706570-1A patent/BRPI0706570A2/pt not_active IP Right Cessation
- 2007-01-15 WO PCT/EP2007/050356 patent/WO2007080191A1/en not_active Ceased
- 2007-01-15 AU AU2007204311A patent/AU2007204311B2/en not_active Ceased
- 2007-01-15 PE PE2007000039A patent/PE20080003A1/es not_active Application Discontinuation
- 2007-01-15 DE DE602007005775T patent/DE602007005775D1/de active Active
- 2007-01-15 JP JP2008549884A patent/JP5203968B2/ja not_active Expired - Fee Related
- 2007-01-15 EP EP07703872A patent/EP1979351B1/en active Active
- 2007-01-15 KR KR1020087016682A patent/KR20080098484A/ko not_active Withdrawn
- 2007-01-15 RU RU2008133588/04A patent/RU2400482C2/ru not_active IP Right Cessation
- 2007-01-15 ES ES07703872T patent/ES2342021T3/es active Active
- 2007-01-16 AR ARP070100175A patent/AR059018A1/es unknown
-
2008
- 2008-06-12 IL IL192133A patent/IL192133A0/en unknown
- 2008-06-20 NO NO20082791A patent/NO20082791L/no not_active Application Discontinuation
- 2008-06-25 ZA ZA200805566A patent/ZA200805566B/xx unknown
- 2008-07-30 EC EC2008008654A patent/ECSP088654A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200805566B (en) | 2009-04-29 |
| PE20080003A1 (es) | 2008-01-30 |
| AU2007204311A1 (en) | 2007-07-19 |
| BRPI0706570A2 (pt) | 2011-04-05 |
| WO2007080191A1 (en) | 2007-07-19 |
| NO20082791L (no) | 2008-10-14 |
| EP1979351B1 (en) | 2010-04-07 |
| TW200734338A (en) | 2007-09-16 |
| DE602007005775D1 (en) | 2010-05-20 |
| NZ569296A (en) | 2010-04-30 |
| RU2400482C2 (ru) | 2010-09-27 |
| CN101374838A (zh) | 2009-02-25 |
| KR20080098484A (ko) | 2008-11-10 |
| AU2007204311A8 (en) | 2008-07-31 |
| RU2008133588A (ru) | 2010-02-27 |
| CA2635982A1 (en) | 2007-07-19 |
| AU2007204311B2 (en) | 2011-07-14 |
| EP1979351A1 (en) | 2008-10-15 |
| ES2342021T3 (es) | 2010-06-30 |
| IL192133A0 (en) | 2008-12-29 |
| ECSP088654A (es) | 2008-08-29 |
| JP2009523717A (ja) | 2009-06-25 |
| JP5203968B2 (ja) | 2013-06-05 |
| ATE463496T1 (de) | 2010-04-15 |
| CN101374838B (zh) | 2013-04-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |