AR062123A1 - Dominio vhh monomerico derivado de anticuerpos de camelidos anti-vp6 dominio dimerico, metodo de inmunodeteccion de rotavirus, composiciones, metodos de prevencion y tratamiento de infecciones con rotavirus - Google Patents

Dominio vhh monomerico derivado de anticuerpos de camelidos anti-vp6 dominio dimerico, metodo de inmunodeteccion de rotavirus, composiciones, metodos de prevencion y tratamiento de infecciones con rotavirus

Info

Publication number
AR062123A1
AR062123A1 ARP070103331A ARP070103331A AR062123A1 AR 062123 A1 AR062123 A1 AR 062123A1 AR P070103331 A ARP070103331 A AR P070103331A AR P070103331 A ARP070103331 A AR P070103331A AR 062123 A1 AR062123 A1 AR 062123A1
Authority
AR
Argentina
Prior art keywords
rotavirus
domain
compositions
vhh
treatment methods
Prior art date
Application number
ARP070103331A
Other languages
English (en)
Original Assignee
Inst Nac De Tecnologia Agropec
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nac De Tecnologia Agropec filed Critical Inst Nac De Tecnologia Agropec
Priority to ARP070103331A priority Critical patent/AR062123A1/es
Priority to US12/670,409 priority patent/US8597651B2/en
Priority to CN200880108604.0A priority patent/CN101878227B/zh
Priority to AU2008281889A priority patent/AU2008281889B2/en
Priority to CA2694363A priority patent/CA2694363C/en
Priority to PCT/EP2008/059745 priority patent/WO2009016100A1/en
Priority to EP08786407A priority patent/EP2181122B1/en
Priority to ES08786407T priority patent/ES2386750T3/es
Priority to KR1020107003893A priority patent/KR101581184B1/ko
Priority to AT08786407T priority patent/ATE555129T1/de
Priority to RU2010107200/10A priority patent/RU2490275C2/ru
Priority to MX2010000994A priority patent/MX2010000994A/es
Priority to BRPI0815763-4A priority patent/BRPI0815763B1/pt
Priority to JP2010517406A priority patent/JP5384495B2/ja
Publication of AR062123A1 publication Critical patent/AR062123A1/es
Priority to IL203414A priority patent/IL203414A/en
Priority to ZA2010/00470A priority patent/ZA201000470B/en
Priority to US14/095,365 priority patent/US9371373B2/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/15—Reoviridae, e.g. calf diarrhea virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/14—Reoviridae, e.g. rotavirus, bluetongue virus, Colorado tick fever virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Dominio VNH monomérico derivado de anticuerpos de camélidos anti-Vp6, dominio dimérico, método de inmunodeteccion de rotavirus, composiciones, métodos de prevencion y tratamiento de infecciones con rotavirus, en donde dicho dominio puede ser cualquiera de las secuencias de aminoácidos mostradas en SEQ ID N° 1, SEQ ID N° 2, SEQ ID N° 3 o SEQ ID N° 4, y en donde dichos dominios se unen a la proteína Vp6 de rotavirus del grupo A.
ARP070103331A 2007-07-27 2007-07-27 Dominio vhh monomerico derivado de anticuerpos de camelidos anti-vp6 dominio dimerico, metodo de inmunodeteccion de rotavirus, composiciones, metodos de prevencion y tratamiento de infecciones con rotavirus AR062123A1 (es)

Priority Applications (17)

Application Number Priority Date Filing Date Title
ARP070103331A AR062123A1 (es) 2007-07-27 2007-07-27 Dominio vhh monomerico derivado de anticuerpos de camelidos anti-vp6 dominio dimerico, metodo de inmunodeteccion de rotavirus, composiciones, metodos de prevencion y tratamiento de infecciones con rotavirus
ES08786407T ES2386750T3 (es) 2007-07-27 2008-07-24 DominioVHH monomérico derivado de anticuerpos de camélidos anti-VP6, dominio dimérico, método de inmunización, método de detección de rotavirus, composición, métodos de prevención y tratamiento de infecciones por rotavirus
RU2010107200/10A RU2490275C2 (ru) 2007-07-27 2008-07-24 Мономерный домен vhh, полученный из анти-vp6-антител верблюдовых, димерный домен, способ иммунизации, способ выявления ротавирусов, композиция, способы профилактики и лечения ротавирусных инфекций
AU2008281889A AU2008281889B2 (en) 2007-07-27 2008-07-24 Monomeric VHH domain derived from anti-VP6 camelid antibodies, dimeric domain, immunisation method, rotavirus detection method, composition, prevention and treatment methods for rotavirus infections
CA2694363A CA2694363C (en) 2007-07-27 2008-07-24 Monomeric vhh domain derived from anti-vp6 camelid antibodies, dimeric domain, immunisation method, rotavirus detection method, composition, prevention and treatment methods for rotavirus infections
PCT/EP2008/059745 WO2009016100A1 (en) 2007-07-27 2008-07-24 Monomeric vhh domain derived from anti-vp6 camelid antibodies, dimeric domain, immunisation method, rotavirus detection method, composition, prevention and treatment methods for rotavirus infections
EP08786407A EP2181122B1 (en) 2007-07-27 2008-07-24 Monomeric vhh domain derived from anti-vp6 camelid antibodies, dimeric domain, immunisation method, rotavirus detection method, composition, prevention and treatment methods for rotavirus infections
US12/670,409 US8597651B2 (en) 2007-07-27 2008-07-24 Monomeric VHH domain derived from anti-VP6 camelid antibodies, dimeric domain, immunisation method, rotavirus detection method, composition, prevention and treatment methods for rotavirus infections
KR1020107003893A KR101581184B1 (ko) 2007-07-27 2008-07-24 항-브이피6 카멜리드 항체로부터 유래한 단량체 브이에이치에이치 도메인, 이합체 도메인, 면역화 방법, 로타바이러스 검출 방법, 조성물, 로타바이러스 감염의 예방 및 치료 방법
AT08786407T ATE555129T1 (de) 2007-07-27 2008-07-24 Aus anti-vp6-camelid-antikörpern gewonnene monomere vhh-domäne, dimere domäne, immunisierungsverfahren, verfahren zum nachweis von rotaviren, zusammensetzung, präventions- und behandlungsverfahren gegen rotavirusinfektionen
CN200880108604.0A CN101878227B (zh) 2007-07-27 2008-07-24 来源于抗-vp6骆驼科动物抗体的单体vhh结构域、二聚体结构域、免疫方法、轮状病毒检测方法、组合物、用于轮状病毒感染的预防和治疗方法
MX2010000994A MX2010000994A (es) 2007-07-27 2008-07-24 Dominio vhh monomerico derivado de anticuerpos de camelidos anti-vp6, dominio dimerico, metodo de inmunizacion, metodo de deteccion de rotavirus, composicion, metodos de prevencion y tratamiento de infecciones con rotavirus.
BRPI0815763-4A BRPI0815763B1 (pt) 2007-07-27 2008-07-24 Domínio vhh monomérico ou dimérico derivado de anticorpos anti-vp6 de camelídeo, método de produção do mesmo, método de imunodetecção de rotavírus, composição, plasmídeo, vetor de expressão recombinante, células transgênicas de microrganismos, anticorpos, kit para imunodetecção de rotavírus, e sequência de aminoácidos
JP2010517406A JP5384495B2 (ja) 2007-07-27 2008-07-24 抗ｖｐ６ラクダ抗体由来の単量体ｖｈｈドメイン、二量体ドメイン、免疫法、ロタウイルス検出法、組成物、ロタウイルス感染の予防及び治療方法
IL203414A IL203414A (en) 2007-07-27 2010-01-20 Monomeric vhh domain derived from anti-vp6 camelid antibodies, dimeric domain, immunisation method, rotavirus detection method, composition, prevention and treatment methods for rotavirus infections
ZA2010/00470A ZA201000470B (en) 2007-07-27 2010-01-21 Monomeric vhh domain derived from anti-vp6 camelid antibodies,dimeric domain,immunisation method,rotavirus detection method,composition,prevention and treatment methods for rotavirus infections
US14/095,365 US9371373B2 (en) 2007-07-27 2013-12-03 Monomeric VHH domain derived from anti-VP6 camelid antibodies, dimeric domain, immunisation method, composition, and treatment methods for rotavirus infections

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ARP070103331A AR062123A1 (es) 2007-07-27 2007-07-27 Dominio vhh monomerico derivado de anticuerpos de camelidos anti-vp6 dominio dimerico, metodo de inmunodeteccion de rotavirus, composiciones, metodos de prevencion y tratamiento de infecciones con rotavirus

Publications (1)

Publication Number Publication Date
AR062123A1 true AR062123A1 (es) 2008-10-15

Family

ID=39929432

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070103331A AR062123A1 (es) 2007-07-27 2007-07-27 Dominio vhh monomerico derivado de anticuerpos de camelidos anti-vp6 dominio dimerico, metodo de inmunodeteccion de rotavirus, composiciones, metodos de prevencion y tratamiento de infecciones con rotavirus

Country Status (16)

Country Link
US (2) US8597651B2 (es)
EP (1) EP2181122B1 (es)
JP (1) JP5384495B2 (es)
KR (1) KR101581184B1 (es)
CN (1) CN101878227B (es)
AR (1) AR062123A1 (es)
AT (1) ATE555129T1 (es)
AU (1) AU2008281889B2 (es)
BR (1) BRPI0815763B1 (es)
CA (1) CA2694363C (es)
ES (1) ES2386750T3 (es)
IL (1) IL203414A (es)
MX (1) MX2010000994A (es)
RU (1) RU2490275C2 (es)
WO (1) WO2009016100A1 (es)
ZA (1) ZA201000470B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR062123A1 (es) 2007-07-27 2008-10-15 Inst Nac De Tecnologia Agropec Dominio vhh monomerico derivado de anticuerpos de camelidos anti-vp6 dominio dimerico, metodo de inmunodeteccion de rotavirus, composiciones, metodos de prevencion y tratamiento de infecciones con rotavirus
EP2686347B1 (en) * 2011-03-16 2018-05-02 argenx BVBA Antibodies to cd70
CA2835606A1 (en) * 2011-04-07 2012-10-11 Synaptic Research, Llc Single chain antibodies for photosynthetic microorganisms and methods of use
SG10201805064SA (en) * 2011-06-23 2018-07-30 Ablynx Nv Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
CN102372779A (zh) * 2011-10-25 2012-03-14 李江伟 具有蒜氨酸酶活性的骆驼单域抗体及制备方法和应用
CN102766207B (zh) * 2012-07-18 2014-03-12 中国农业科学院兰州兽医研究所 抗猪圆环病毒2型的双峰驼重链单域抗体及其制备方法和用途
FR3007411B1 (fr) * 2013-06-21 2015-07-03 Agronomique Inst Nat Rech Anticorps monocatenaire a chaine lourde de camelide dirige contre la chromatine et utilisations
CN106282214A (zh) * 2016-08-03 2017-01-04 康众（北京）生物科技有限公司 一种快速获得纳米抗体的方法及其应用
CN109970860A (zh) * 2017-12-27 2019-07-05 信达生物制药(苏州)有限公司 三链抗体、其制备方法及其用途
JP7190674B2 (ja) * 2018-08-23 2022-12-16 パナソニックＩｐマネジメント株式会社 ノロウイルスに結合する抗体、複合体、それを用いた検出装置及び検出方法
JP7171737B2 (ja) * 2019-07-23 2022-11-15 源道隆（蘇州）医学科技有限公司 Ｓｆｔｓｖに結合可能なナノ抗体及びその使用
EP4620979A1 (en) 2022-11-14 2025-09-24 Cognano, Inc. Antibody and method for producing antibody
KR20240086721A (ko) * 2022-11-22 2024-06-19 (주)애드바이오텍 송아지 소화기성 질병의 예방 또는 치료용 단일 도메인 vhh 항체의 제조방법
CN121342963B (zh) * 2025-12-17 2026-04-21 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） 一种g6型牛轮状病毒纳米抗体及其应用
CN121362246B (zh) * 2025-12-17 2026-03-03 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） 一种g10型牛轮状病毒纳米抗体及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2129017C1 (ru) * 1998-03-20 1999-04-20 Московский научно-исследовательский институт эпидемиологии и микробиологии им.Г.Н.Габричевского Способ получения антиротавирусного иммуноглобулина
US20030104402A1 (en) * 2001-01-23 2003-06-05 University Of Rochester Methods of producing or identifying intrabodies in eukaryotic cells
KR100460709B1 (ko) * 2001-08-14 2004-12-09 네오바이오다임 주식회사 돼지 로타바이러스에 대한 단일클론 항체, 이를 생산하는 하이브리도마 세포주, 이를 이용한 면역 측정 방법 및 측정용 킷트
BRPI0516681A (pt) * 2004-11-25 2008-09-16 Unilever Nv sistema de entrega de anticorpos ao trato gastrointestinal, vetor de expressão, microorganismos transformados, método de entrega de anticorpos, imunoglobulinas de cadeia pesada e seu uso, produto alimentìcio e seu método de fabricação e utensìlio de distribuição
AR062123A1 (es) 2007-07-27 2008-10-15 Inst Nac De Tecnologia Agropec Dominio vhh monomerico derivado de anticuerpos de camelidos anti-vp6 dominio dimerico, metodo de inmunodeteccion de rotavirus, composiciones, metodos de prevencion y tratamiento de infecciones con rotavirus

Also Published As

Publication number Publication date
KR20100061652A (ko) 2010-06-08
AU2008281889B2 (en) 2013-10-03
US8597651B2 (en) 2013-12-03
BRPI0815763B1 (pt) 2021-08-10
CN101878227B (zh) 2014-08-27
US20100330068A1 (en) 2010-12-30
IL203414A (en) 2012-10-31
MX2010000994A (es) 2010-06-02
BRPI0815763A2 (pt) 2016-10-11
CN101878227A (zh) 2010-11-03
WO2009016100A1 (en) 2009-02-05
JP5384495B2 (ja) 2014-01-08
ES2386750T3 (es) 2012-08-29
CA2694363A1 (en) 2009-02-05
AU2008281889A1 (en) 2009-02-05
KR101581184B1 (ko) 2015-12-31
CA2694363C (en) 2016-01-26
US9371373B2 (en) 2016-06-21
JP2010534465A (ja) 2010-11-11
ATE555129T1 (de) 2012-05-15
EP2181122A1 (en) 2010-05-05
RU2490275C2 (ru) 2013-08-20
US20140178405A1 (en) 2014-06-26
RU2010107200A (ru) 2011-09-10
ZA201000470B (en) 2011-04-28
EP2181122B1 (en) 2012-04-25

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