AR069281A2 - Composicion farmaceutica de liberacion sostenida y uso de la misma para preparar medicamentos - Google Patents

Composicion farmaceutica de liberacion sostenida y uso de la misma para preparar medicamentos

Info

Publication number
AR069281A2
AR069281A2 ARP080104921A ARP080104921A AR069281A2 AR 069281 A2 AR069281 A2 AR 069281A2 AR P080104921 A ARP080104921 A AR P080104921A AR P080104921 A ARP080104921 A AR P080104921A AR 069281 A2 AR069281 A2 AR 069281A2
Authority
AR
Argentina
Prior art keywords
pharmaceutical composition
same
sustained release
average molecular
molecular weight
Prior art date
Application number
ARP080104921A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22627919&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR069281(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR069281A2 publication Critical patent/AR069281A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Una composicion farmacéutica, que comprende fluvastatina o una sal farmacéuticamente aceptable de la misma, hidroxipropilmetilcelulosa y un polímero hidrofílico no ionico seleccionado del grupo formado hidroxietilcelulosa con un peso molecular promedio en numero de 90.000 a 1.300.000; hidroxipropilcelulosa con un peso molecular promedio en numero de 370.000 a 1.500.000; y poli(oxido de etileno) con un peso molecular promedio en numero de 100.000 a 500.000; y uso de la misma para preparar medicamentos. Reivindicacion 6: Una composicion farmacéutica de la reivindicacion 1, caracterizada porque comprende de 5 a 50 por ciento en peso de fluvastatina o una sal farmacéuticamente aceptable de la misma, basándose en el peso total de la composicion. Reivindicacion 12: Una composicion farmacéutica de la reivindicacion 1, caracterizada porque la proporcion en peso de hidroxipropilmetilcelulosa a polímero hidrofílico no ionico es de 10:1 a 3:1.
ARP080104921A 1998-10-14 2008-11-11 Composicion farmaceutica de liberacion sostenida y uso de la misma para preparar medicamentos AR069281A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17249198A 1998-10-14 1998-10-14

Publications (1)

Publication Number Publication Date
AR069281A2 true AR069281A2 (es) 2010-01-13

Family

ID=22627919

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP990105146A AR020780A1 (es) 1998-10-14 1999-10-12 Composicion farmaceutica de liberacion sostenida, y metodo para liberar un agente farmaceuticamente activo
ARP080104921A AR069281A2 (es) 1998-10-14 2008-11-11 Composicion farmaceutica de liberacion sostenida y uso de la misma para preparar medicamentos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP990105146A AR020780A1 (es) 1998-10-14 1999-10-12 Composicion farmaceutica de liberacion sostenida, y metodo para liberar un agente farmaceuticamente activo

Country Status (30)

Country Link
EP (1) EP1121116B1 (es)
JP (2) JP2002527388A (es)
KR (1) KR100517090B1 (es)
CN (1) CN1196481C (es)
AR (2) AR020780A1 (es)
AT (1) ATE382345T1 (es)
AU (1) AU765475B2 (es)
BR (1) BR9911648A (es)
CA (1) CA2346868C (es)
CO (1) CO5140079A1 (es)
CY (1) CY1107874T1 (es)
DE (1) DE69937891T2 (es)
DK (1) DK1121116T3 (es)
ES (1) ES2297936T3 (es)
HK (1) HK1040920B (es)
HU (1) HUP0104268A3 (es)
ID (1) ID29350A (es)
IL (2) IL142375A0 (es)
MY (1) MY121105A (es)
NO (1) NO327285B1 (es)
NZ (1) NZ511010A (es)
PE (1) PE20001110A1 (es)
PL (1) PL198850B1 (es)
PT (1) PT1121116E (es)
RU (1) RU2259826C2 (es)
SK (2) SK286595B6 (es)
TR (1) TR200101088T2 (es)
TW (1) TW577738B (es)
WO (1) WO2000021525A2 (es)
ZA (1) ZA200103001B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569461B1 (en) 1999-03-08 2003-05-27 Merck & Co., Inc. Dihydroxy open-acid and salts of HMG-CoA reductase inhibitors
US6242003B1 (en) * 2000-04-13 2001-06-05 Novartis Ag Organic compounds
ATE418979T2 (de) 2000-06-09 2009-01-15 Lek Pharmaceuticals Stabilisiertes arzneimittel und arzneizubereitung
ES2284709T3 (es) * 2000-09-29 2007-11-16 Solvay Pharmaceuticals B.V. Formulacion farmaceutica de liberacion sostenida independiente de la fuerza ionica.
US20060127474A1 (en) 2001-04-11 2006-06-15 Oskar Kalb Pharmaceutical compositions comprising fluvastatin
WO2004024184A1 (ja) * 2002-09-11 2004-03-25 Takeda Pharmaceutical Company Limited 徐放性製剤
JP2007523664A (ja) 2003-04-23 2007-08-23 フェリング ベスローテン フェンノートシャップ 医薬組成物用サシェ
US8987322B2 (en) 2003-11-04 2015-03-24 Circ Pharma Research And Development Limited Pharmaceutical formulations for carrier-mediated transport statins and uses thereof
DE102004062475A1 (de) * 2004-12-24 2006-07-06 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung
KR100582347B1 (ko) * 2004-12-30 2006-05-22 한미약품 주식회사 3-하이드록시-3-메틸글루타릴 조효소 a 환원효소 억제제및 고혈압 치료제의 복합제제 및 그의 제조방법
CA2615941A1 (en) * 2005-08-05 2007-02-15 Orbus Pharma Inc. Stabilized extended release pharmeceutical compositions comprising an hmg-coa reductase inhibitor
BRPI0708191A2 (pt) * 2006-02-24 2012-05-29 Teva Pharma " composições farmacêuticas de fluvastatina sódica "
RU2342144C1 (ru) * 2007-04-05 2008-12-27 Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") Фармацевтический состав, обладающий противосудорожным и психотропным действием
RU2356532C2 (ru) * 2007-06-01 2009-05-27 Открытое Акционерное Общество "Отечественные Лекарства" Фармацевтическая композиция проксодолола с контролируемым высвобождением
CN102805739B (zh) * 2012-04-10 2013-08-14 宋芸 氟伐他汀钠缓释包衣滴丸及其制备方法
EP2943186A1 (en) * 2013-01-09 2015-11-18 Edgemont Pharmaceuticals LLC Controlled release formulations of lorazepam
CN106344535B (zh) * 2016-08-29 2019-09-20 济南康和医药科技有限公司 一种氟伐他汀钠微孔渗透泵控释片及其制备方法
CN118593482A (zh) 2017-12-05 2024-09-06 赛诺维信制药公司 非外消旋混合物及其用途
WO2019113084A1 (en) 2017-12-05 2019-06-13 Sunovion Pharmaceuticals Inc. Crystal forms and production methods thereof
US11802103B2 (en) 2018-09-25 2023-10-31 Ponce De Leon Health Designated Activity Company Process of making calcium alpha-ketoglutarate
MX2021014774A (es) 2019-06-04 2022-02-03 Sunovion Pharmaceuticals Inc Formulaciones de liberacion modificada y usos de las mismas.
EP3980001B1 (en) * 2019-06-10 2025-08-27 Ponce de Leon Health Designated Activity Company Sustained-release compositions of alpha-ketoglutarate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4915954A (en) * 1987-09-03 1990-04-10 Alza Corporation Dosage form for delivering a drug at two different rates
CA2045428A1 (en) * 1990-06-26 1991-12-27 Alfred W. Alberts Method for enhancing the lowering of plasma cholesterol levels
ZA959221B (en) * 1994-11-02 1997-04-30 Janssen Pharmaceutica Nv Cisapride extended release
US5798375A (en) * 1995-07-03 1998-08-25 Sankyo Company, Limited Treatment of arteriosclerosis and xanthoma
GB9523752D0 (en) * 1995-11-21 1996-01-24 Pfizer Ltd Pharmaceutical formulations
DE69625046T2 (de) * 1995-12-22 2003-04-10 Kowa Co., Ltd. Pharmazeutische zusammensetzung stabilisiert mit einem basischen medium
SE9603667D0 (sv) * 1996-10-08 1996-10-08 Astra Ab Pharmaceutical compositions

Also Published As

Publication number Publication date
DE69937891T2 (de) 2008-12-11
CA2346868C (en) 2008-09-09
NZ511010A (en) 2003-10-31
SK286595B6 (sk) 2009-01-07
EP1121116B1 (en) 2008-01-02
HUP0104268A3 (en) 2002-06-28
ATE382345T1 (de) 2008-01-15
ZA200103001B (en) 2002-07-11
CA2346868A1 (en) 2000-04-20
JP4938383B2 (ja) 2012-05-23
NO20011695L (no) 2001-05-30
CO5140079A1 (es) 2002-03-22
NO327285B1 (no) 2009-06-02
RU2259826C2 (ru) 2005-09-10
PE20001110A1 (es) 2000-11-01
TR200101088T2 (tr) 2001-10-22
JP2006298945A (ja) 2006-11-02
ES2297936T3 (es) 2008-05-01
AU6090999A (en) 2000-05-01
CN1196481C (zh) 2005-04-13
HK1040920A1 (en) 2002-06-28
AU765475B2 (en) 2003-09-18
HK1040920B (zh) 2005-07-29
ID29350A (id) 2001-08-23
EP1121116A2 (en) 2001-08-08
KR20010080156A (ko) 2001-08-22
IL142375A (en) 2012-01-31
JP2002527388A (ja) 2002-08-27
CY1107874T1 (el) 2013-06-19
TW577738B (en) 2004-03-01
PT1121116E (pt) 2008-03-12
BR9911648A (pt) 2001-03-20
SK286596B6 (sk) 2009-01-07
CN1328454A (zh) 2001-12-26
HUP0104268A2 (hu) 2002-04-29
KR100517090B1 (ko) 2005-09-27
PL348109A1 (en) 2002-05-06
PL198850B1 (pl) 2008-07-31
DK1121116T3 (da) 2008-05-13
MY121105A (en) 2005-12-30
SK5092001A3 (en) 2001-09-11
DE69937891D1 (de) 2008-02-14
IL142375A0 (en) 2002-03-10
WO2000021525A2 (en) 2000-04-20
NO20011695D0 (no) 2001-04-04
AR020780A1 (es) 2002-05-29
WO2000021525A3 (en) 2000-08-10

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