AR070077A1 - Compuestos de n- fenil - imidazo (1,2-a) piridin -2- carboxamidas, su preparacion y su aplicacion en terapeutica - Google Patents
Compuestos de n- fenil - imidazo (1,2-a) piridin -2- carboxamidas, su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- AR070077A1 AR070077A1 ARP080105782A ARP080105782A AR070077A1 AR 070077 A1 AR070077 A1 AR 070077A1 AR P080105782 A ARP080105782 A AR P080105782A AR P080105782 A ARP080105782 A AR P080105782A AR 070077 A1 AR070077 A1 AR 070077A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- atom
- alkoxy
- halogen
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 5
- 125000004429 atom Chemical group 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 229910003827 NRaRb Inorganic materials 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- RBLDNKGJSKNMKB-UHFFFAOYSA-N 5-n-(2-methoxyethyl)pyridine-2,5-diamine Chemical compound COCCNC1=CC=C(N)N=C1 RBLDNKGJSKNMKB-UHFFFAOYSA-N 0.000 abstract 1
- NSNGLRIDOAXXQV-UHFFFAOYSA-N 5-n-ethylpyridine-2,5-diamine Chemical compound CCNC1=CC=C(N)N=C1 NSNGLRIDOAXXQV-UHFFFAOYSA-N 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000030886 Traumatic Brain injury Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004666 alkoxyiminoalkyl group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 hydroxyiminoalkyl Chemical group 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 201000006152 substance dependence Diseases 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Medicamento, composicion farmacéutica, compuestos intermedios 5-etilaminopiridin-2-amina, 5-(2-metoxietilamino)piridin-2-amina, utilizacion en terapéutica, en enfermedades neurodegenerativas, traumatismos cerebrales y epilepsia, enfermedades psiquiátricas, inflamatorias, osteoporosis, tumores malignos, esquizofrenia, depresion, dependencia a sustancias. Reivindicacion 1: Compuestos de formula (1) en la que: X representa un grupo fenilo eventualmente sustituido por uno o varios grupos elegidos independientemente unos de otros entre los átomos o grupos siguientes: halogeno, alcoxi C1-6, alquilo C1-6, NRaRb, pudiendo estar sustituidos eventualmente los grupos alquilo y alcoxi por uno o varios átomos de halogeno; R1 representa un átomo de hidrogeno, un átomo de halogeno, un grupo alcoxi C1-6, alquilo C1-6, amino, un grupo NRcRd, pudiendo estar sustituidos eventualmente los grupos alquilo y alcoxi por uno o varios átomos de halogeno, un grupo hidroxi, amino, o alcoxi C1-6; R2 representa uno de los grupo siguientes: un grupo NRcRd, -N=CH-NRaRb, nitro, hidroxiiminoalquilo, alcoxiiminoalquilo, alquil C1-6tio, alquil C1-6sulfinilo, alquil C1-6sulfonilo, -SO2-NR5R6, (alquil C1-6)3sililetinilo, R3 representa un átomo de hidrogeno, un grupo alquilo C1-6, alcoxi C1-6 o un átomo de halogeno; R4 representa un átomo de hidrogeno, un grupo alquilo C1-4, alcoxi C1-4 o un átomo de fluor; R5 y R6, iguales o diferentes, representan un átomo de H o un grupo alquilo C1-6; Ra y Rb representan, independientemente uno de otro, un átomo de H, un grupo alquilo C1-6 o forman con el átomo de N que los soporta un ciclo de 4 a 7 eslabones; Rc representa un átomo de H y Rd representa un átomo de H o un grupo alquilo C1-6, estando dicho alquilo eventualmente sustituido por un grupo alcoxi C1-6; en estado de base o de sal de adicion de ácido.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0800008A FR2925906B1 (fr) | 2008-01-02 | 2008-01-02 | COMPOSES DE N-PHENYL-IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR070077A1 true AR070077A1 (es) | 2010-03-10 |
Family
ID=39743816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080105782A AR070077A1 (es) | 2008-01-02 | 2008-12-31 | Compuestos de n- fenil - imidazo (1,2-a) piridin -2- carboxamidas, su preparacion y su aplicacion en terapeutica |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20100317620A1 (es) |
| EP (1) | EP2225245B1 (es) |
| JP (1) | JP2011509251A (es) |
| KR (1) | KR20100103544A (es) |
| CN (1) | CN101910175A (es) |
| AR (1) | AR070077A1 (es) |
| AT (1) | ATE529426T1 (es) |
| AU (1) | AU2008353144A1 (es) |
| BR (1) | BRPI0821426A2 (es) |
| CA (1) | CA2710811A1 (es) |
| CL (1) | CL2008003931A1 (es) |
| CO (1) | CO6321242A2 (es) |
| EA (1) | EA201070819A1 (es) |
| FR (1) | FR2925906B1 (es) |
| IL (1) | IL206666A0 (es) |
| MA (1) | MA32036B1 (es) |
| TW (1) | TW200934778A (es) |
| UY (1) | UY31592A1 (es) |
| WO (1) | WO2009115651A2 (es) |
| ZA (1) | ZA201004520B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2925900B1 (fr) * | 2008-01-02 | 2011-03-04 | Sanofi Aventis | DERIVES DE N-PHENYL-IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
| WO2014103801A1 (ja) * | 2012-12-28 | 2014-07-03 | 株式会社新日本科学 | イミダゾピリジン誘導体を有効成分として含むｏｃｔ３活性阻害剤又はｏｃｔ３検出剤 |
| CN103350373B (zh) * | 2013-06-14 | 2017-10-17 | 肇庆市正海机械设备制造有限公司 | 一种磨刀机及磨刀方法 |
| WO2020172324A1 (en) * | 2019-02-19 | 2020-08-27 | The Regents Of The University Of California | Nurr1 receptor modulators |
| EP4596548A1 (en) * | 2024-02-05 | 2025-08-06 | Ludwig-Maximilians-Universität | Nurr1 modulators |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2638161B1 (fr) * | 1988-10-24 | 1991-01-11 | Centre Nat Rech Scient | Nouvelles benzoyl-2 imidazo (1,2-a) pyridines et leurs sels, leur procede de preparation, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
| WO2005030704A1 (en) * | 2003-09-24 | 2005-04-07 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| US7544803B2 (en) * | 2004-01-23 | 2009-06-09 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| EP1742935B1 (en) * | 2004-04-13 | 2010-02-24 | Icagen, Inc. | Polycyclic pyrazines as potassium ion channel modulators |
| FR2903107B1 (fr) * | 2006-07-03 | 2008-08-22 | Sanofi Aventis Sa | Derives d'imidazopyridine-2-carboxamides, leur preparation et leur application en therapeutique |
| FR2903108B1 (fr) * | 2006-07-03 | 2008-08-29 | Sanofi Aventis Sa | Utilisation de derives d'imidazo[1,2-a] pyridine-2-carboxamides en therapeutique. |
| FR2925900B1 (fr) * | 2008-01-02 | 2011-03-04 | Sanofi Aventis | DERIVES DE N-PHENYL-IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
-
2008
- 2008-01-02 FR FR0800008A patent/FR2925906B1/fr not_active Expired - Fee Related
- 2008-12-30 UY UY31592A patent/UY31592A1/es not_active Application Discontinuation
- 2008-12-30 CL CL2008003931A patent/CL2008003931A1/es unknown
- 2008-12-31 EP EP08873376A patent/EP2225245B1/fr active Active
- 2008-12-31 TW TW097151690A patent/TW200934778A/zh unknown
- 2008-12-31 EA EA201070819A patent/EA201070819A1/ru unknown
- 2008-12-31 AT AT08873376T patent/ATE529426T1/de not_active IP Right Cessation
- 2008-12-31 CA CA2710811A patent/CA2710811A1/fr not_active Abandoned
- 2008-12-31 KR KR1020107014643A patent/KR20100103544A/ko not_active Withdrawn
- 2008-12-31 AR ARP080105782A patent/AR070077A1/es unknown
- 2008-12-31 WO PCT/FR2008/001839 patent/WO2009115651A2/fr not_active Ceased
- 2008-12-31 JP JP2010541088A patent/JP2011509251A/ja not_active Withdrawn
- 2008-12-31 CN CN2008801238397A patent/CN101910175A/zh active Pending
- 2008-12-31 BR BRPI0821426-3A patent/BRPI0821426A2/pt not_active IP Right Cessation
- 2008-12-31 AU AU2008353144A patent/AU2008353144A1/en not_active Abandoned
-
2010
- 2010-06-25 ZA ZA2010/04520A patent/ZA201004520B/en unknown
- 2010-06-28 IL IL206666A patent/IL206666A0/en unknown
- 2010-07-01 US US12/828,384 patent/US20100317620A1/en not_active Abandoned
- 2010-07-02 CO CO10080864A patent/CO6321242A2/es not_active Application Discontinuation
- 2010-07-27 MA MA33050A patent/MA32036B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2225245A2 (fr) | 2010-09-08 |
| WO2009115651A3 (fr) | 2010-02-25 |
| ZA201004520B (en) | 2011-09-28 |
| CO6321242A2 (es) | 2011-09-20 |
| IL206666A0 (en) | 2010-12-30 |
| ATE529426T1 (de) | 2011-11-15 |
| EP2225245B1 (fr) | 2011-10-19 |
| BRPI0821426A2 (pt) | 2015-06-16 |
| CN101910175A (zh) | 2010-12-08 |
| UY31592A1 (es) | 2009-08-03 |
| JP2011509251A (ja) | 2011-03-24 |
| EA201070819A1 (ru) | 2010-12-30 |
| TW200934778A (en) | 2009-08-16 |
| CL2008003931A1 (es) | 2010-01-22 |
| US20100317620A1 (en) | 2010-12-16 |
| FR2925906A1 (fr) | 2009-07-03 |
| MA32036B1 (fr) | 2011-01-03 |
| WO2009115651A2 (fr) | 2009-09-24 |
| CA2710811A1 (fr) | 2009-09-24 |
| AU2008353144A1 (en) | 2009-09-24 |
| KR20100103544A (ko) | 2010-09-27 |
| FR2925906B1 (fr) | 2010-08-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |