AR070454A1 - Pirrolopirimidincarboxamidas y composiciones farmaceuticas que las comprenden - Google Patents
Pirrolopirimidincarboxamidas y composiciones farmaceuticas que las comprendenInfo
- Publication number
- AR070454A1 AR070454A1 ARP090100594A ARP090100594A AR070454A1 AR 070454 A1 AR070454 A1 AR 070454A1 AR P090100594 A ARP090100594 A AR P090100594A AR P090100594 A ARP090100594 A AR P090100594A AR 070454 A1 AR070454 A1 AR 070454A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkoxy
- hydroxy
- optionally substituted
- alkyl
- group
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 11
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 10
- 239000001257 hydrogen Substances 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 150000002431 hydrogen Chemical class 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 3
- 150000001204 N-oxides Chemical class 0.000 abstract 3
- 125000004428 fluoroalkoxy group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- MALIONKMKPITBV-UHFFFAOYSA-N 2-(3-chloro-4-hydroxyphenyl)-n-[2-(4-sulfamoylphenyl)ethyl]acetamide Chemical group C1=CC(S(=O)(=O)N)=CC=C1CCNC(=O)CC1=CC=C(O)C(Cl)=C1 MALIONKMKPITBV-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000002590 phosphodiesterase V inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Son efectivos inhibidores de la fosfodiesterasa tipo 5. Reivindicacion 1: Compuesto de la formula (1) en donde R1 es -CH2-cicloalquilo C3-6 o alquilo C1-4 el cual está opcionalmente sustituido con R11, R11 es alcoxi C1-4 o hidroxi, R21 es hidrogeno, R22 es hidrogeno, halogeno, alquilo C1-4, alcoxi C1-4, hidroxi, fluoroalcoxi C1-4 o -C(O)-alquilo C1-4 o R21 y R22 se combinan para formar un grupo -O-CH2-O-, R23 es hidrogeno, halogeno, alquilo C1-4, alcoxi C1-4, hidroxi o fluoroalcoxi C1-4 o R22 y R23 se combinan para formar un grupo -O-CH2-O-, R24 es hidrogeno, Y es -(CH2)n-, n es 0 o 1, R3 es un anillo heterocíclico saturado de 4 a 7 miembros que contiene un átomo de nitrogeno y opcionalmente un átomo de oxígeno, estando dicho anillo heterocíclico opcionalmente sustituido con R4, o un grupo cicloalquilo C3-6 sustituido con R6, R4 es -C(O)-H, -C(O)-alquilo C1-4, en donde el grupo alquilo C1-4 está opcionalmente sustituido con R41, -C(O)-cicloalquilo C3-6, en donde el grupo cicloalquilo C3-6 está opcionalmente sustituido con R42, o -C(O)-O-alquilo C1-4, en donde el grupo alquilo C1-4 está opcionalmente sustituido con R43, R41 es alcoxi C1-4 o hidroxi, R42 es alcoxi C1-4 o hidroxi, R43 es alcoxi C1-4 o hidroxi, R6 es -NH-C(O)-R7, -C(O)-NR8R9 o NH2, R7 es hidrogeno, alquilo C1-4, el cual está opcionalmente sustituido con R71, cicloalquilo C3-6, el cual está opcionalmente sustituido con R72, o alcoxi C1-4, el cual está opcionalmente sustituido con R73, R71 es alcoxi C1-4 o hidroxi, R72 es alcoxi C1-4 o hidroxi, R73 es alcoxi C1-4 o hidroxi, R8 es H; R9 es alquilo C1-4, el cual está opcionalmente sustituido con R91, o cicloalquilo C3-6, el cual está opcionalmente sustituido con R92, R91 es alcoxi C1-4 o hidroxi, R92 es alcoxi C1-4 o hidroxi, una sal del mismo, un N-oxido del compuesto o la sal del mismo o un estereoisomero del compuesto, la sal, el N-oxido del compuesto o el N-oxido de la sal del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08102052 | 2008-02-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR070454A1 true AR070454A1 (es) | 2010-04-07 |
Family
ID=39855184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090100594A AR070454A1 (es) | 2008-02-27 | 2009-02-20 | Pirrolopirimidincarboxamidas y composiciones farmaceuticas que las comprenden |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8445501B2 (es) |
| EP (1) | EP2247594A1 (es) |
| JP (1) | JP5615187B2 (es) |
| KR (1) | KR20100136469A (es) |
| CN (1) | CN101959890B (es) |
| AR (1) | AR070454A1 (es) |
| AU (1) | AU2009218507B2 (es) |
| BR (1) | BRPI0907863A2 (es) |
| CA (1) | CA2711733A1 (es) |
| CO (1) | CO6341477A2 (es) |
| EA (1) | EA018331B1 (es) |
| EC (1) | ECSP10010425A (es) |
| IL (1) | IL207639A (es) |
| MX (1) | MX2010009276A (es) |
| MY (1) | MY152061A (es) |
| NZ (1) | NZ586486A (es) |
| SG (1) | SG188823A1 (es) |
| TW (1) | TW200944527A (es) |
| UA (1) | UA101018C2 (es) |
| WO (1) | WO2009106531A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG188117A1 (en) | 2008-06-19 | 2013-03-28 | Takeda Pharmaceutical | Heterocyclic compound and use thereof |
| EP2404896A1 (en) | 2009-03-05 | 2012-01-11 | Shionogi&Co., Ltd. | Cyclohexane derivative having npy y5 receptor antagonism |
| JP2013503132A (ja) * | 2009-08-26 | 2013-01-31 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | メチルピロロピリジンカルボキサミド |
| AR077898A1 (es) | 2009-08-26 | 2011-09-28 | Nycomed Gmbh | Metilpirrolopirimidincarboxamidas |
| CN103201244B (zh) * | 2010-08-26 | 2015-06-17 | 阿尔比马尔公司 | 用于制备1-溴代-2-(环丙基甲氧基)-5-氟代-4-甲氧基苯的方法 |
| MX2013014888A (es) | 2011-06-17 | 2014-02-27 | Takeda Gmbh | Novedosos derivados de ftalazinona-pirrolopirimidinacarboxamida. |
| US10527935B2 (en) * | 2016-12-31 | 2020-01-07 | Rohm And Haas Electronic Materials Llc | Radiation-sensitive compositions and patterning and metallization processes |
| JP2020097527A (ja) * | 2017-03-31 | 2020-06-25 | 武田薬品工業株式会社 | 複素環化合物 |
| JP7450842B2 (ja) | 2017-07-07 | 2024-03-18 | 蘇州旺山旺水生物医薬股▲ふん▼有限公司 | フェニルピリミドン化合物の塩、結晶多形並びにその医薬組成物及び使用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2754260B1 (fr) * | 1996-10-04 | 1998-10-30 | Adir | Nouveaux derives substitues de biphenyle ou de phenylpyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US6187777B1 (en) * | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
| US20050124623A1 (en) * | 2003-11-26 | 2005-06-09 | Bender John A. | Diazaindole-dicarbonyl-piperazinyl antiviral agents |
| AU2006221957A1 (en) * | 2005-03-09 | 2006-09-14 | Nycomed Gmbh | Amido-substituted 6-phenylphenanthridines |
-
2009
- 2009-02-20 AR ARP090100594A patent/AR070454A1/es unknown
- 2009-02-25 CN CN2009801072042A patent/CN101959890B/zh not_active Expired - Fee Related
- 2009-02-25 WO PCT/EP2009/052198 patent/WO2009106531A1/en not_active Ceased
- 2009-02-25 MY MYPI20103000 patent/MY152061A/en unknown
- 2009-02-25 EP EP09714992A patent/EP2247594A1/en not_active Withdrawn
- 2009-02-25 US US12/918,740 patent/US8445501B2/en not_active Expired - Fee Related
- 2009-02-25 AU AU2009218507A patent/AU2009218507B2/en not_active Ceased
- 2009-02-25 EA EA201001348A patent/EA018331B1/ru not_active IP Right Cessation
- 2009-02-25 UA UAA201011254A patent/UA101018C2/ru unknown
- 2009-02-25 NZ NZ586486A patent/NZ586486A/en not_active IP Right Cessation
- 2009-02-25 SG SG2013014634A patent/SG188823A1/en unknown
- 2009-02-25 MX MX2010009276A patent/MX2010009276A/es active IP Right Grant
- 2009-02-25 KR KR1020107021192A patent/KR20100136469A/ko not_active Ceased
- 2009-02-25 JP JP2010548092A patent/JP5615187B2/ja not_active Expired - Fee Related
- 2009-02-25 CA CA2711733A patent/CA2711733A1/en not_active Abandoned
- 2009-02-25 BR BRPI0907863A patent/BRPI0907863A2/pt not_active IP Right Cessation
- 2009-02-26 TW TW098106249A patent/TW200944527A/zh unknown
-
2010
- 2010-06-15 CO CO10071529A patent/CO6341477A2/es active IP Right Grant
- 2010-08-16 IL IL207639A patent/IL207639A/en not_active IP Right Cessation
- 2010-08-25 EC EC2010010425A patent/ECSP10010425A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20110021479A1 (en) | 2011-01-27 |
| CN101959890B (zh) | 2013-10-30 |
| ECSP10010425A (es) | 2010-09-30 |
| EA018331B1 (ru) | 2013-07-30 |
| BRPI0907863A2 (pt) | 2019-09-24 |
| SG188823A1 (en) | 2013-04-30 |
| EP2247594A1 (en) | 2010-11-10 |
| JP5615187B2 (ja) | 2014-10-29 |
| AU2009218507B2 (en) | 2014-02-13 |
| MY152061A (en) | 2014-08-15 |
| WO2009106531A1 (en) | 2009-09-03 |
| AU2009218507A1 (en) | 2009-09-03 |
| IL207639A (en) | 2013-09-30 |
| CA2711733A1 (en) | 2009-09-03 |
| NZ586486A (en) | 2012-06-29 |
| EA201001348A1 (ru) | 2011-04-29 |
| UA101018C2 (ru) | 2013-02-25 |
| JP2011513272A (ja) | 2011-04-28 |
| TW200944527A (en) | 2009-11-01 |
| IL207639A0 (en) | 2010-12-30 |
| CN101959890A (zh) | 2011-01-26 |
| MX2010009276A (es) | 2010-09-14 |
| CO6341477A2 (es) | 2011-11-21 |
| HK1153200A1 (en) | 2012-03-23 |
| US8445501B2 (en) | 2013-05-21 |
| KR20100136469A (ko) | 2010-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |