AR072880A1 - Derivados nitrogenados de la pancratistatina - Google Patents

Derivados nitrogenados de la pancratistatina

Info

Publication number: AR072880A1
Authority: AR; Argentina
Prior art keywords: linear; branched; optionally substituted; links; hydrogen atom
Prior art date: 2008-07-28

Application number

ARP090102865A

Other languages

English (en)

Spanish (es)

Original Assignee

Pf Medicament

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-07-28

Filing date

2009-07-28

Publication date

2010-09-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40394438&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR072880(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-07-28 Application filed by Pf Medicament filed Critical Pf Medicament

2010-09-29 Publication of AR072880A1 publication Critical patent/AR072880A1/es

Links

QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical class [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 title 1
VREZDOWOLGNDPW-UHFFFAOYSA-N pancratistatine Natural products C1=C2C3C(O)C(O)C(O)C(O)C3NC(=O)C2=C(O)C2=C1OCO2 VREZDOWOLGNDPW-UHFFFAOYSA-N 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
125000003342 alkenyl group Chemical group 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 6
125000000304 alkynyl group Chemical group 0.000 abstract 6
229920006395 saturated elastomer Polymers 0.000 abstract 5
229930195734 saturated hydrocarbon Natural products 0.000 abstract 5
125000003710 aryl alkyl group Chemical group 0.000 abstract 4
125000001072 heteroaryl group Chemical group 0.000 abstract 4
125000000623 heterocyclic group Chemical group 0.000 abstract 4
239000000203 mixture Substances 0.000 abstract 3
125000003107 substituted aryl group Chemical group 0.000 abstract 3
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 abstract 2
239000004721 Polyphenylene oxide Substances 0.000 abstract 2
125000004103 aminoalkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229920000768 polyamine Polymers 0.000 abstract 2
229920000570 polyether Polymers 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
229910018828 PO3H2 Inorganic materials 0.000 abstract 1
229910006069 SO3H Inorganic materials 0.000 abstract 1
238000011319 anticancer therapy Methods 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/664—Amides of phosphorus acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Inorganic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ARP090102865A 2008-07-28 2009-07-28 Derivados nitrogenados de la pancratistatina AR072880A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0855161A FR2934266B1 (fr)	2008-07-28	2008-07-28	Derives azotes de la pancratistatine

Publications (1)

Publication Number	Publication Date
AR072880A1 true AR072880A1 (es)	2010-09-29

Family

ID=40394438

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ARP090102865A AR072880A1 (es)	2008-07-28	2009-07-28	Derivados nitrogenados de la pancratistatina

Country Status (24)

Country	Link
US (2)	US8415348B2 (fr)
EP (1)	EP2324031B1 (fr)
JP (1)	JP5666442B2 (fr)
KR (1)	KR20110036842A (fr)
CN (1)	CN102137867A (fr)
AR (1)	AR072880A1 (fr)
AU (1)	AU2009275929B2 (fr)
BR (1)	BRPI0916716A2 (fr)
CA (1)	CA2731901A1 (fr)
CL (1)	CL2011000168A1 (fr)
CO (1)	CO6341557A2 (fr)
ES (1)	ES2584165T3 (fr)
FR (1)	FR2934266B1 (fr)
GE (1)	GEP20135818B (fr)
HU (1)	HUE028098T2 (fr)
IL (1)	IL210868A0 (fr)
MA (1)	MA32588B1 (fr)
MX (1)	MX2011000956A (fr)
NZ (1)	NZ591298A (fr)
PL (1)	PL2324031T3 (fr)
RU (1)	RU2011106570A (fr)
TW (1)	TW201011031A (fr)
WO (1)	WO2010012714A1 (fr)
ZA (1)	ZA201101426B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8703792B2 (en)	2008-12-18	2014-04-22	Brock University	C-1 analogs of pancratistatin and 7-deoxypancratistatin and processes for their preparation
CN101805384B (zh) *	2010-04-26	2014-08-20	江苏省中国科学院植物研究所	一种新石蒜异喹诺酮类生物碱及其制备方法和用途
GB2498539A (en) *	2012-01-18	2013-07-24	Renesas Mobile Corp	Base station assisted asymmetric device-to-device communications
CN106543194A (zh) *	2015-09-22	2017-03-29	孙青*	水仙环素衍生物及其制备与在制备抗肿瘤药物中的应用
CN107007595B (zh) *	2015-12-01	2019-01-25	哈尔滨商业大学	水鬼蕉新碱a在制备抗炎药物中的应用
CN115677714B (zh) *	2022-11-01	2024-06-11	昆明医科大学	(+)-水鬼蕉碱制备中的中间体及其应用
CN115894507B (zh) *	2022-11-01	2024-06-07	昆明医科大学	(+)-水鬼蕉碱的合成方法及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4985436A (en) *	1984-02-17	1991-01-15	Arizona Board Of Regents	Composition of matter for inhibiting leukemias and sarcomas
US5529989A (en) *	1995-01-09	1996-06-25	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Pancratistatin prodrug
EP1585750B1 (fr) *	2002-12-09	2008-10-15	Arizona Board Of Regents	Promedicaments a base de narcistatine
WO2005007084A2 (fr) *	2003-06-20	2005-01-27	Arizona Board Of Regents A Body Corporate Of The State Of Arizone, Acting For And On Behalf Of Arizona State University	Promedicaments de phosphate cyclique de pancratistatine et promedicaments de phosphate cyclique de phenpanstatine
WO2005089736A2 (fr)	2004-03-05	2005-09-29	The Arizona Board Of Regents, On Behalf Of, Arizona State University	Methodes pour traiter des maladies inflammatoires et auto-immunes
US7709643B2 (en) *	2005-01-14	2010-05-04	Arizona Board of Regents, a body corporate of the State of Arizona, Acting for and on Behalf of the Arizona State University	Synthesis of sodium narcistatin and related compounds
WO2008043846A2 (fr) *	2006-10-13	2008-04-17	Unibioscreen Sa	Nouveaux dérivés d'isocarbostyryl alcaloïde
US8703792B2 (en) *	2008-12-18	2014-04-22	Brock University	C-1 analogs of pancratistatin and 7-deoxypancratistatin and processes for their preparation

2008
- 2008-07-28 FR FR0855161A patent/FR2934266B1/fr not_active Expired - Fee Related
2009
- 2009-07-27 TW TW098125189A patent/TW201011031A/zh unknown
- 2009-07-28 AU AU2009275929A patent/AU2009275929B2/en not_active Ceased
- 2009-07-28 WO PCT/EP2009/059715 patent/WO2010012714A1/fr not_active Ceased
- 2009-07-28 AR ARP090102865A patent/AR072880A1/es not_active Application Discontinuation
- 2009-07-28 MX MX2011000956A patent/MX2011000956A/es active IP Right Grant
- 2009-07-28 NZ NZ591298A patent/NZ591298A/en not_active IP Right Cessation
- 2009-07-28 US US13/055,947 patent/US8415348B2/en not_active Expired - Fee Related
- 2009-07-28 BR BRPI0916716A patent/BRPI0916716A2/pt not_active IP Right Cessation
- 2009-07-28 EP EP09781165.7A patent/EP2324031B1/fr active Active
- 2009-07-28 PL PL09781165.7T patent/PL2324031T3/pl unknown
- 2009-07-28 KR KR1020117004221A patent/KR20110036842A/ko not_active Withdrawn
- 2009-07-28 GE GEAP200912118A patent/GEP20135818B/en unknown
- 2009-07-28 RU RU2011106570/04A patent/RU2011106570A/ru not_active Application Discontinuation
- 2009-07-28 CN CN2009801342179A patent/CN102137867A/zh active Pending
- 2009-07-28 ES ES09781165.7T patent/ES2584165T3/es active Active
- 2009-07-28 HU HUE09781165A patent/HUE028098T2/en unknown
- 2009-07-28 CA CA2731901A patent/CA2731901A1/fr not_active Abandoned
- 2009-07-28 JP JP2011520466A patent/JP5666442B2/ja not_active Expired - Fee Related
2011
- 2011-01-25 IL IL210868A patent/IL210868A0/en unknown
- 2011-01-27 CL CL2011000168A patent/CL2011000168A1/es unknown
- 2011-02-23 ZA ZA2011/01426A patent/ZA201101426B/en unknown
- 2011-02-25 CO CO11023614A patent/CO6341557A2/es active IP Right Grant
- 2011-02-28 MA MA33648A patent/MA32588B1/fr unknown
2012
- 2012-12-26 US US13/727,101 patent/US8697064B2/en active Active

Also Published As

Publication number	Publication date
JP5666442B2 (ja)	2015-02-12
IL210868A0 (en)	2011-04-28
RU2011106570A (ru)	2012-09-10
US8415348B2 (en)	2013-04-09
JP2011529097A (ja)	2011-12-01
EP2324031A1 (fr)	2011-05-25
AU2009275929A1 (en)	2010-02-04
CO6341557A2 (es)	2011-11-21
TW201011031A (en)	2010-03-16
AU2009275929B2 (en)	2013-06-20
PL2324031T3 (pl)	2016-11-30
CN102137867A (zh)	2011-07-27
US20110123516A1 (en)	2011-05-26
HUE028098T2 (en)	2016-11-28
FR2934266A1 (fr)	2010-01-29
GEP20135818B (en)	2013-05-10
BRPI0916716A2 (pt)	2015-11-10
EP2324031B1 (fr)	2016-05-04
CL2011000168A1 (es)	2011-07-15
MX2011000956A (es)	2011-07-29
MA32588B1 (fr)	2011-08-01
ES2584165T3 (es)	2016-09-26
ZA201101426B (en)	2011-10-26
CA2731901A1 (fr)	2010-02-04
KR20110036842A (ko)	2011-04-11
US20130121986A1 (en)	2013-05-16
NZ591298A (en)	2011-12-22
FR2934266B1 (fr)	2010-09-17
US8697064B2 (en)	2014-04-15
WO2010012714A1 (fr)	2010-02-04

Legal Events

Date	Code	Title	Description
2014-12-03	FA	Abandonment or withdrawal

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AR076435A1 (es)	2011-06-08	Compuestos de indazoles sustituidos, composiciones farmaceuticas que los contienen y procesos de obtencion de los mismos
AR070828A1 (es)	2010-05-05	Derivados de azetidina y ciclobutano como inhibidores de jak
BR112014025564A8 (pt)	2018-01-16	composto heterocíclico contendo nitrogênio ou sal do mesmo
AR096979A1 (es)	2016-02-10	Derivados de pirrol, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
PE20090060A1 (es)	2009-01-18	ANALOGOS DE IMIDAZOLOPIRIMIDINA Y SU USO COMO INHIBIDORES DE PI3 CINASA Y mTOR
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