AR076596A1 - Medicamento para la administracion oral que contiene al menos un estrogeno y/o al menos un gestageno y al menos una cepa de bacterias probioticas - Google Patents
Medicamento para la administracion oral que contiene al menos un estrogeno y/o al menos un gestageno y al menos una cepa de bacterias probioticasInfo
- Publication number
- AR076596A1 AR076596A1 ARP100101772A ARP100101772A AR076596A1 AR 076596 A1 AR076596 A1 AR 076596A1 AR P100101772 A ARP100101772 A AR P100101772A AR P100101772 A ARP100101772 A AR P100101772A AR 076596 A1 AR076596 A1 AR 076596A1
- Authority
- AR
- Argentina
- Prior art keywords
- microg
- gestagen
- probiotic bacteria
- strain
- daily dose
- Prior art date
Links
- 241000894006 Bacteria Species 0.000 title abstract 4
- 239000006041 probiotic Substances 0.000 title abstract 3
- 230000000529 probiotic effect Effects 0.000 title abstract 3
- 235000018291 probiotics Nutrition 0.000 title abstract 3
- 239000000583 progesterone congener Substances 0.000 title abstract 3
- UDPGUMQDCGORJQ-UHFFFAOYSA-N (2-chloroethyl)phosphonic acid Chemical compound OP(O)(=O)CCCl UDPGUMQDCGORJQ-UHFFFAOYSA-N 0.000 title 1
- 238000004690 coupled electron pair approximation Methods 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 6
- 229940079593 drug Drugs 0.000 abstract 4
- 229940011871 estrogen Drugs 0.000 abstract 2
- 239000000262 estrogen Substances 0.000 abstract 2
- 238000001794 hormone therapy Methods 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 abstract 1
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 abstract 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 abstract 1
- 208000004926 Bacterial Vaginosis Diseases 0.000 abstract 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 208000004483 Dyspareunia Diseases 0.000 abstract 1
- RSEPBGGWRJCQGY-RBRWEJTLSA-N Estradiol valerate Chemical compound C1CC2=CC(O)=CC=C2[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CCCC)[C@@]1(C)CC2 RSEPBGGWRJCQGY-RBRWEJTLSA-N 0.000 abstract 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 241000186660 Lactobacillus Species 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- IMONTRJLAWHYGT-ZCPXKWAGSA-N Norethindrone Acetate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](C#C)(OC(=O)C)[C@@]1(C)CC2 IMONTRJLAWHYGT-ZCPXKWAGSA-N 0.000 abstract 1
- 208000037009 Vaginitis bacterial Diseases 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 230000001332 colony forming effect Effects 0.000 abstract 1
- 229960000978 cyproterone acetate Drugs 0.000 abstract 1
- UWFYSQMTEOIJJG-FDTZYFLXSA-N cyproterone acetate Chemical compound C1=C(Cl)C2=CC(=O)[C@@H]3C[C@@H]3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 UWFYSQMTEOIJJG-FDTZYFLXSA-N 0.000 abstract 1
- 201000003146 cystitis Diseases 0.000 abstract 1
- 229960004976 desogestrel Drugs 0.000 abstract 1
- RPLCPCMSCLEKRS-BPIQYHPVSA-N desogestrel Chemical compound C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 RPLCPCMSCLEKRS-BPIQYHPVSA-N 0.000 abstract 1
- AZFLJNIPTRTECV-FUMNGEBKSA-N dienogest Chemical compound C1CC(=O)C=C2CC[C@@H]([C@H]3[C@@](C)([C@](CC3)(O)CC#N)CC3)C3=C21 AZFLJNIPTRTECV-FUMNGEBKSA-N 0.000 abstract 1
- 229960003309 dienogest Drugs 0.000 abstract 1
- METQSPRSQINEEU-UHFFFAOYSA-N dihydrospirorenone Natural products CC12CCC(C3(CCC(=O)C=C3C3CC33)C)C3C1C1CC1C21CCC(=O)O1 METQSPRSQINEEU-UHFFFAOYSA-N 0.000 abstract 1
- 229960004845 drospirenone Drugs 0.000 abstract 1
- METQSPRSQINEEU-HXCATZOESA-N drospirenone Chemical compound C([C@]12[C@H]3C[C@H]3[C@H]3[C@H]4[C@@H]([C@]5(CCC(=O)C=C5[C@@H]5C[C@@H]54)C)CC[C@@]31C)CC(=O)O2 METQSPRSQINEEU-HXCATZOESA-N 0.000 abstract 1
- 206010013990 dysuria Diseases 0.000 abstract 1
- 229960005309 estradiol Drugs 0.000 abstract 1
- 229930182833 estradiol Natural products 0.000 abstract 1
- 229960004766 estradiol valerate Drugs 0.000 abstract 1
- 229960002568 ethinylestradiol Drugs 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 229960004400 levonorgestrel Drugs 0.000 abstract 1
- IMSSROKUHAOUJS-MJCUULBUSA-N mestranol Chemical compound C1C[C@]2(C)[C@@](C#C)(O)CC[C@H]2[C@@H]2CCC3=CC(OC)=CC=C3[C@H]21 IMSSROKUHAOUJS-MJCUULBUSA-N 0.000 abstract 1
- 229960001390 mestranol Drugs 0.000 abstract 1
- 229960001652 norethindrone acetate Drugs 0.000 abstract 1
- 229960000417 norgestimate Drugs 0.000 abstract 1
- KIQQMECNKUGGKA-NMYWJIRASA-N norgestimate Chemical compound O/N=C/1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(OC(C)=O)C#C)[C@@H]4[C@@H]3CCC2=C\1 KIQQMECNKUGGKA-NMYWJIRASA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 235000013406 prebiotics Nutrition 0.000 abstract 1
- 230000006641 stabilisation Effects 0.000 abstract 1
- 238000011105 stabilization Methods 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 229940078964 tibolone 2.5 mg Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Pregnancy & Childbirth (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente se refiere a un medicamento para la administracion oral que contiene al menos un estrogeno y/o un gestágeno así como al menos una cepa de bacterias probioticas, como, por ejemplo, especies de lactobacilos. El medicamento se usa ya sea para la anticoncepcion oral o para la terapia hormonal (HT) , en donde es, en este caso, puede servir al mismo tiempo para la estabilizacion del ambiente vaginal y, con ello, para la prevencion de enfermedades infecciosas, tales como, por ejemplo, micosis vaginales, vaginosis bacterianas y/o inflamaciones de la vejiga (cistitis bacterianas) o la prevencion de síntomas urogenitales, por ejemplo, dispareunia y disuria. La presente se refiere también a composiciones farmacéuticas, a las unidades de dosis que contienen un medicamento descrito previamente, así como otras unidades de dosis que contienen exclusivamente una cepa de bacterias probioticas. Reivindicacion 7: Medicamento de acuerdo con la reivindicacion 1, caracterizado porque como dosis diaria de un gestágeno están contenidos: drospirenona 0,5 - 5 mg, levonorgestrel 30 - 250 microg, norgestimato 180 - 250 microg, acetato de noretisterona 0,5 - 1 mg, acetato de ciproterona 1 - 2 mg, desogestrel 20 - 150 microg, dienogest 1 - 3 mg, gestodeno 60 - 75 microg, tibolona 2,5 mg. Reivindicacion 9: Medicamento de acuerdo con la reivindicacion 1, caracterizado porque como dosis diaria de un estrogeno están contenidos: etinilestradiol 10 - 50 microg, estradiol 1 - 4 mg, valerato de estradiol 1 - 4 mg, mestranol 50 microg. Reivindicacion 11: Medicamento de acuerdo con la reivindicacion 1, caracterizado porque como dosis diaria de cepa de bacterias prebiotica están contenidas 109 a 1011 KBE (Kolonie Bildende Einheiten, 'unidades formadoras de colonias').
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009022947 | 2009-05-22 | ||
| DE102009023632 | 2009-05-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR076596A1 true AR076596A1 (es) | 2011-06-22 |
Family
ID=42617521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100101772A AR076596A1 (es) | 2009-05-22 | 2010-05-21 | Medicamento para la administracion oral que contiene al menos un estrogeno y/o al menos un gestageno y al menos una cepa de bacterias probioticas |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20120189599A1 (es) |
| EP (1) | EP2432474A1 (es) |
| JP (1) | JP2012527413A (es) |
| CN (1) | CN102438628A (es) |
| AR (1) | AR076596A1 (es) |
| CA (1) | CA2762640A1 (es) |
| TW (1) | TW201109019A (es) |
| UY (1) | UY32650A (es) |
| WO (1) | WO2010133314A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2992861B1 (fr) | 2012-07-09 | 2014-10-17 | Probionov | Utilisation de thiosulfate pour potentialiser l'effet anti-pathogene des lactobacilles |
| CN104178437B (zh) * | 2013-11-08 | 2016-08-24 | 苏州欧赛微科生物医药科技有限公司 | 一种卷曲乳杆菌及其在妇科疾病中的应用 |
| CN104546870B (zh) * | 2015-01-27 | 2018-01-12 | 唐凡兰 | 一种避孕药 |
| KR101867768B1 (ko) * | 2016-08-12 | 2018-06-15 | 한국식품연구원 | 락토바실러스 아시도필루스를 포함하는 갱년기 예방 또는 치료용 조성물 |
| EP3427745A1 (en) | 2017-07-12 | 2019-01-16 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | New probiotic composition for prevention of bacterial vaginosis |
| SG11202007163WA (en) * | 2018-02-07 | 2020-08-28 | Estetra Sprl | Contraceptive composition with reduced cardiovascular effects |
| KR102107443B1 (ko) * | 2018-08-31 | 2020-05-07 | (주)바이오리듬 | 여성 갱년기 증상 예방 또는 치료용 유산균 프로바이오틱스 제제 |
| KR20220026201A (ko) * | 2020-08-25 | 2022-03-04 | 고려대학교 산학협력단 | 락토바실러스 퍼멘텀을 포함하는 갱년기 예방 또는 치료용 조성물 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4905300A (en) * | 1999-05-25 | 2000-12-12 | Andrew W. Bruce | Oral administration of lactobacillus for the maintenance of health in women |
| KR100400411B1 (ko) * | 2000-09-09 | 2003-10-01 | 주식회사 바이오프로젠 | 질염 치료용 생균제제 |
| US7829079B2 (en) * | 2002-03-28 | 2010-11-09 | Christian Hansen A/S | Lactobacillus iners for the enhancement of urogenital health |
| US7759105B2 (en) * | 2003-08-29 | 2010-07-20 | Cobb & Company, Llp | Probiotic composition useful for dietary augmentation and/or combating disease states and adverse physiological conditions |
| CN101028289A (zh) * | 2006-03-01 | 2007-09-05 | 大连森佰澳科技有限公司 | 调整菌群预防或治疗细菌性阴道病的益生菌制剂及工艺 |
-
2010
- 2010-05-14 CA CA2762640A patent/CA2762640A1/en not_active Abandoned
- 2010-05-14 US US13/322,131 patent/US20120189599A1/en not_active Abandoned
- 2010-05-14 CN CN2010800219540A patent/CN102438628A/zh active Pending
- 2010-05-14 JP JP2012511177A patent/JP2012527413A/ja not_active Withdrawn
- 2010-05-14 WO PCT/EP2010/002965 patent/WO2010133314A1/de not_active Ceased
- 2010-05-14 EP EP10722604A patent/EP2432474A1/de not_active Withdrawn
- 2010-05-21 AR ARP100101772A patent/AR076596A1/es unknown
- 2010-05-21 TW TW099116393A patent/TW201109019A/zh unknown
- 2010-05-21 UY UY0001032650A patent/UY32650A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TW201109019A (en) | 2011-03-16 |
| JP2012527413A (ja) | 2012-11-08 |
| UY32650A (es) | 2010-12-31 |
| CN102438628A (zh) | 2012-05-02 |
| EP2432474A1 (de) | 2012-03-28 |
| US20120189599A1 (en) | 2012-07-26 |
| WO2010133314A1 (de) | 2010-11-25 |
| CA2762640A1 (en) | 2010-11-25 |
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