AR080102A1 - Compuestos de aril-bencil-amina y su utilizacion en el tratamiento de trastornos mediados por las interacciones de los linfocitos - Google Patents

Compuestos de aril-bencil-amina y su utilizacion en el tratamiento de trastornos mediados por las interacciones de los linfocitos

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Publication number
AR080102A1
AR080102A1 ARP110100336A ARP110100336A AR080102A1 AR 080102 A1 AR080102 A1 AR 080102A1 AR P110100336 A ARP110100336 A AR P110100336A AR P110100336 A ARP110100336 A AR P110100336A AR 080102 A1 AR080102 A1 AR 080102A1
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AR
Argentina
Prior art keywords
carbon atoms
halogen
alkyl
optionally substituted
alkoxy
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ARP110100336A
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English (en)
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Novartis Ag
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Publication date
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Publication of AR080102A1 publication Critical patent/AR080102A1/es

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    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
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Abstract

Compuestos de aril-bencil-amina sustituida, a procesos para su produccion, a su uso como productos farmacéuticos, y a composiciones farmacéuticas que los comprenden. Reivindicacion 1: Un compuesto de la formula (1), o una sal farmacéuticamente aceptable del mismo; en donde: R1 es hidrogeno, halogeno, o alquilo de 1 a 6 átomos de carbono opcionalmente sustituido por halogeno; R2 es halogeno, alquilo de 1 a 6 átomos de carbono opcionalmente sustituido por halogeno, ciano, o alcoxilo de 1 a 6 átomos de carbono opcionalmente sustituido por halogeno; o R1 y R2, junto con los átomos de carbono con los que están unidos, forman un anillo de arilo con 6 a 10 átomos de carbono, el cual puede estar opcionalmente sustituido por 1 a 4 sustituyentes seleccionados a partir de ciano, alquilo de 1 a 4 átomos de carbono opcionalmente sustituido por halogeno, alcoxilo de 1 a 4 átomos de carbono opcionalmente sustituido por halogeno, y halogeno; R3 es hidrogeno, halogeno, o alquilo de 1 a 6 átomos de carbono opcionalmente sustituido por halogeno; R4 es hidrogeno, cicloalquilo de 3 a 6 átomos de carbono, o alquilo de 1 a 6 átomos de carbono opcionalmente sustituido por halogeno; R5 es hidrogeno o alquilo de 1 a 6 átomos de carbono; R6 y R7 se seleccionan independientemente a partir de H y alquilo de 1 a 6 átomos de carbono, o pueden formar, junto con el átomo de carbono con el que están unidos, un anillo carbocíclico saturado de 3 a 7 miembros; R8 y R9 se seleccionan independientemente a partir de H y alquilo de 1 a 6 átomos de carbono, o R8 y R9 pueden formar, junto con los átomos con los que están unidos, un anillo heterocíclico de 4 a 7 miembros, opcionalmente sustituido una o más veces por alquilo de 1 a 6 átomos de carbono opcionalmente sustituido por halogeno, trifluoro-metilo, hidroxilo, o amino; n = 1, 2, 3 o 4; R10 es hidrogeno, alquilo de 1 a 6 átomos de carbono, amino, hidroxilo o alcoxilo de 1 a 6 átomos de carbono; R se selecciona a partir de H; fenilo que está opcionalmente sustituido por alquilo de 1 a 6 átomos de carbono, alcoxilo de 1 a 6 átomos de carbono, halogeno o hidroxilo; y alquilo de 1 a 6 átomos de carbono opcionalmente sustituido por alcoxilo de 1 a 6 átomos de carbono, halogeno, hidroxilo, o fenilo opcionalmente sustituido por alquilo de 1 a 6 átomos de carbono, alcoxilo de 1 a 6 átomos de carbono, halogeno o hidroxilo, X1, X2, X3 y X4, se seleccionan cada uno independientemente a partir de N o CR11, R11 en cada caso se selecciona independientemente a partir de H, halogeno, ciano, alcoxilo de 1 a 6 átomos de carbono, alquilo de 1 a 6 átomos de carbono opcionalmente sustituido por halogeno, o -SO2-alqujlo de 1 a 6 átomos de carbono; e Y representa independientemente en cada presentacion CR12R13, en donde R12 y R13 se seleccionan independientemente a partir de H y alquilo de 1 a 6 átomos de carbono.
ARP110100336A 2010-02-02 2011-02-01 Compuestos de aril-bencil-amina y su utilizacion en el tratamiento de trastornos mediados por las interacciones de los linfocitos AR080102A1 (es)

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US (1) US8791100B2 (es)
EP (1) EP2531487B1 (es)
JP (1) JP5876419B2 (es)
CN (1) CN102741227B (es)
AR (1) AR080102A1 (es)
ES (1) ES2504090T3 (es)
TW (1) TW201130811A (es)
UY (1) UY33214A (es)
WO (1) WO2011095452A1 (es)

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WO2011095452A1 (en) 2011-08-11
US8791100B2 (en) 2014-07-29
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ES2504090T3 (es) 2014-10-08
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