AR080778A1 - Conjunto de microagujas que comprenden proteoglicano - Google Patents

Conjunto de microagujas que comprenden proteoglicano

Info

Publication number
AR080778A1
AR080778A1 ARP110100885A ARP110100885A AR080778A1 AR 080778 A1 AR080778 A1 AR 080778A1 AR P110100885 A ARP110100885 A AR P110100885A AR P110100885 A ARP110100885 A AR P110100885A AR 080778 A1 AR080778 A1 AR 080778A1
Authority
AR
Argentina
Prior art keywords
microneedles
proteoglycan
skin
microagujas
understand
Prior art date
Application number
ARP110100885A
Other languages
English (en)
Inventor
Takuya Hamabuchi
Fumio Kamiyama
Ying-Shu Quan
Takao Taki
Kazuhide Ohta
Kazuyoshi Kawai
Tadayoshi Takemoto
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of AR080778A1 publication Critical patent/AR080778A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/16Emollients or protectives, e.g. against radiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/87Application Devices; Containers; Packaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91Injection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023Drug applicators using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046Solid microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053Methods for producing microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cosmetics (AREA)

Abstract

Un objeto de la presente invencion es proveer un nuevo conjunto de microagujas que tiene (1) la resistencia para soportar la insercion en la capa superficial de la piel y/o el estrato corneo, (2) la finura y flexibilidad para no causar dolor o sangrado en la capa superficial de la piel y/o el estrato corneo en el sitio de insercion de las microagujas y (3) solubilidad o biodegradabilidad de las partes de las microagujas que se encuentran debajo de la piel. El conjunto de microagujas se produce formando microagujas usando proteoglicano como un material de base.
ARP110100885A 2010-03-19 2011-03-18 Conjunto de microagujas que comprenden proteoglicano AR080778A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2010065089 2010-03-19

Publications (1)

Publication Number Publication Date
AR080778A1 true AR080778A1 (es) 2012-05-09

Family

ID=44649352

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110100885A AR080778A1 (es) 2010-03-19 2011-03-18 Conjunto de microagujas que comprenden proteoglicano

Country Status (18)

Country Link
US (1) US9539418B2 (es)
EP (1) EP2548608B1 (es)
JP (1) JP5800799B2 (es)
KR (1) KR101813735B1 (es)
CN (2) CN105107083B (es)
AR (1) AR080778A1 (es)
AU (1) AU2011228020A1 (es)
BR (1) BR112012023693A2 (es)
CA (1) CA2792927A1 (es)
CO (1) CO6620002A2 (es)
EA (1) EA201290928A1 (es)
ES (1) ES2663095T3 (es)
MX (1) MX2012010681A (es)
NZ (1) NZ602692A (es)
PH (1) PH12012501734A1 (es)
SG (1) SG183913A1 (es)
TW (1) TW201138881A (es)
WO (1) WO2011115272A1 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9149496B2 (en) 2007-05-10 2015-10-06 Cormatrix Cardiovascular, Inc. ECM Constructs for treating damaged biological tissue
JP5990913B2 (ja) * 2012-01-31 2016-09-14 凸版印刷株式会社 針状体の製造方法
BR112015005073B1 (pt) * 2012-09-13 2021-06-01 Amir Avraham Aplicador configurado para a administração de uma composição de melhoria de pele para uma pele e/ou subcútis de um sujeito, uso de um, microagulha e método para manufaturar uma microagulha
US12161831B2 (en) 2012-09-13 2024-12-10 Avraham Amir Microneedles and compositions for skin augmentation
USD726316S1 (en) * 2013-10-23 2015-04-07 Claire A. Marquez Micro-needling tattoo head
WO2015073919A1 (en) * 2013-11-14 2015-05-21 University Medical Pharmaceuticals Corporation Microneedles for therapeutic agent delivery with improved mechanical properties
WO2015108510A1 (en) * 2014-01-15 2015-07-23 Cormatrix Cardiovascular, Inc. Ecm constructs for treating damaged biological tissue
US20160279401A1 (en) 2015-03-27 2016-09-29 Allergan, Inc. Dissolvable microneedles for skin treatment
CN104888343A (zh) * 2015-05-07 2015-09-09 北京化工大学 一种高分子实心微针及其批量制备方法
CN104826228B (zh) * 2015-05-25 2017-12-29 成都凤磐生物科技有限公司 用于皮肤修复与保养的生物贴
US20170209553A1 (en) * 2016-01-22 2017-07-27 Transderm, Inc. Delivery of botulinum with microneedle arrays
JP2017145226A (ja) * 2016-02-19 2017-08-24 日本写真印刷株式会社 マイクロニードルシート
JP7020399B2 (ja) * 2016-03-25 2022-02-16 凸版印刷株式会社 経皮投与デバイス
US11241563B2 (en) 2016-12-22 2022-02-08 Johnson & Johnson Consumer Inc. Microneedle arrays and methods for making and using
AU2018222745B2 (en) 2017-02-17 2021-02-18 Allergan, Inc. Microneedle array with active ingredient
KR101993706B1 (ko) * 2017-06-13 2019-06-28 기 수 한 스탬프형 유체주입장치
KR20190005478A (ko) 2017-07-07 2019-01-16 경상대학교산학협력단 마이크로니들 디바이스
KR102139335B1 (ko) 2017-11-24 2020-07-29 주식회사 엘지생활건강 니들 팁에 코팅부를 보유하는 마이크로니들을 제조하는 방법 및 장치
SG10201800072YA (en) * 2018-01-03 2019-08-27 Micropoint Tech Pte Ltd Microneedle Patches Comprising Corticosteroid
EP3813792A2 (en) 2018-06-29 2021-05-05 Johnson & Johnson Consumer Inc. Three-dimensional microfluidics devices for the delivery of actives
KR102075103B1 (ko) * 2018-09-28 2020-02-10 주식회사 코씨드바이오팜 홍어 발효 추출물을 유효성분으로 함유하는 화장료 조성물
CN109675185A (zh) * 2019-01-02 2019-04-26 浙江大学 一种苯硼酸水凝胶基糖敏微针贴及其制备方法
JP1664598S (es) * 2019-09-19 2020-07-27
JP1664599S (es) * 2019-09-19 2020-07-27
JP1664520S (es) * 2019-09-19 2020-07-27
JP2021049141A (ja) * 2019-09-25 2021-04-01 富士フイルム株式会社 マイクロニードルアレイ、支持部材、マイクロニードルアレイの製造方法及びマイクロニードルアレイユニット
KR102368260B1 (ko) * 2020-01-09 2022-03-02 연세대학교 산학협력단 마이크로니들 어플리케이터
JP2021143146A (ja) * 2020-03-11 2021-09-24 コスメディ製薬株式会社 天然保湿因子含有貼付型化粧料
JP2023523952A (ja) 2020-04-28 2023-06-08 ティコナ・エルエルシー マイクロニードルアセンブリ
CN111939458A (zh) * 2020-08-25 2020-11-17 四川大学 一种具有超薄柔性背衬层的微针贴片及其制备方法
CN113197838B (zh) * 2021-03-31 2022-08-23 浙江大学 一种无酶糖敏微针贴及其温和制备方法
CN114366700B (zh) * 2022-01-19 2023-10-03 华工新颜(深圳)科技有限公司 一种祛眼袋的梅片龙脑香可溶性微针眼贴及其制备方法
CN115737530B (zh) * 2022-11-21 2024-09-27 西南交通大学 基于光动力灭菌且兼具抗氧化作用的微针及其制备和应用
KR20240098635A (ko) * 2022-12-21 2024-06-28 (주) 디에스테크 마이크로 구조체의 제조 방법 및 이에 따른 마이크로 구조체
TW202515631A (zh) * 2023-10-05 2025-04-16 日商大石膏盛堂股份有限公司 微針陣列

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7799766B2 (en) 1998-04-08 2010-09-21 Theta Biomedical Consulting & Development Co., Inc. Composition for treating hormonally-dependent cancers
EP1086214B1 (en) * 1998-06-10 2009-11-25 Georgia Tech Research Corporation Microneedle devices and methods of their manufacture
JP2001247602A (ja) * 2000-03-02 2001-09-11 Mitsuo Takai 鮭由来のコンドロイチン硫酸
JP2003299497A (ja) * 2002-02-05 2003-10-21 Masayoshi Kachi ムコ多糖類及びその製造方法
JP3756838B2 (ja) 2002-04-09 2006-03-15 日本メナード化粧品株式会社 皮膚外用剤
US7803787B2 (en) 2002-10-16 2010-09-28 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treating connective tissue damage by transmucosal administration
JP4913030B2 (ja) * 2005-01-31 2012-04-11 株式会社バイオセレンタック 経皮吸収製剤、経皮吸収製剤保持シート、及び経皮吸収製剤保持用具
EP1935438A4 (en) 2005-09-16 2011-10-19 St Marianna University School Of Medicine BIOLOGICAL MATERIAL FOR REGENERATIVE MEDICINE
JP2007131548A (ja) 2005-11-08 2007-05-31 Hirosaki Univ プロテオグリカンの新規医薬用途
RU2401839C2 (ru) * 2006-02-14 2010-10-20 Кусиро Индастриал Текнолоджи Сентер Способ получения протеогликана
US20090182306A1 (en) * 2006-07-21 2009-07-16 Georgia Tech Research Corporation Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal
WO2008020632A1 (en) * 2006-08-18 2008-02-21 Toppan Printing Co., Ltd. Microneedle and microneedle patch
KR101555391B1 (ko) 2007-11-21 2015-09-23 가부시키가이샤 바이오세렌택 체표 적용 제제 및 체표 적용 제제 보유 시트
JP5252623B2 (ja) * 2008-01-22 2013-07-31 国立大学法人弘前大学 プロテオグリカンの抽出方法
JP5267910B2 (ja) 2008-02-28 2013-08-21 コスメディ製薬株式会社 マイクロニードルアレイ
HRP20190691T1 (hr) * 2008-03-27 2019-07-12 Purdue Research Foundation Sintetički peptidoglikani koji vezuju kolagen, priprema, i postupci upotrebe
JP2009254756A (ja) * 2008-04-14 2009-11-05 Kosumedei Seiyaku Kk マイクロニードルアレイ
JP4427691B2 (ja) * 2008-04-14 2010-03-10 コスメディ製薬株式会社 マイクロニードルアレイ
JP2009254765A (ja) 2008-04-15 2009-11-05 Yoshisuke Watanabe 物干し装置
CA2729404C (en) 2008-06-30 2016-09-27 Hisamitsu Pharmaceutical Co., Inc. Microneedle device and method for enhancing the efficacy of influenza vaccine using microneedle device
US8858912B2 (en) * 2008-10-31 2014-10-14 The Invention Science Fund I, Llc Frozen compositions and methods for piercing a substrate
JP2011012050A (ja) * 2009-06-03 2011-01-20 Bioserentack Co Ltd 多孔性基盤を用いたマイクロニードル・アレイとその製造方法
EP2338557A1 (en) * 2009-12-23 2011-06-29 Debiotech S.A. Soluble microneedle

Also Published As

Publication number Publication date
CN102811763B (zh) 2015-11-25
CN102811763A (zh) 2012-12-05
SG183913A1 (en) 2012-10-30
JPWO2011115272A1 (ja) 2013-07-04
WO2011115272A1 (ja) 2011-09-22
NZ602692A (en) 2013-12-20
AU2011228020A1 (en) 2012-09-27
CN105107083B (zh) 2018-04-24
EP2548608B1 (en) 2018-01-31
TW201138881A (en) 2011-11-16
CA2792927A1 (en) 2011-09-22
US20130012882A1 (en) 2013-01-10
PH12012501734A1 (en) 2018-01-17
JP5800799B2 (ja) 2015-10-28
EP2548608A1 (en) 2013-01-23
MX2012010681A (es) 2012-10-09
US9539418B2 (en) 2017-01-10
EA201290928A1 (ru) 2013-04-30
EP2548608A4 (en) 2013-10-09
KR20130007615A (ko) 2013-01-18
CO6620002A2 (es) 2013-02-15
ES2663095T3 (es) 2018-04-11
KR101813735B1 (ko) 2017-12-29
CN105107083A (zh) 2015-12-02
BR112012023693A2 (pt) 2017-10-03

Similar Documents

Publication Publication Date Title
AR080778A1 (es) Conjunto de microagujas que comprenden proteoglicano
AR075442A1 (es) Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia
DOP2019000005A (es) 3-metil pirazinas 2,5-disustituidas y 3-metil pirazinas 2,5,6-trisustituidas como inhibidores alostéricos de shp2
GT201300243A (es) Derivados de ácido 3-fenilpropiónico ramificados y su uso
ECSP14010763A (es) Compuestos de ester boronato y composiciones farmaceuticas de los mismos
MX2017012321A (es) Parche de microagujas para administrar un ingrediente activo a la piel.
CL2014000050A1 (es) Composicion farmaceutica en forma de solucion que comprende apomorfina, un codisolvente micible en agua, un antioxidante y agua, en la que el ph es superior a 4; procedimiento para fabricarla; y su uso como solucion inyectable en el tratamiento de la enfermedad de parkinson.
PE20121798A1 (es) Un material de soporte para cuidado de heridas y/o otras aplicaciones de sanacion de tejidos
UY34918A (es) Nuevos ácidos 5-aminotetrahidroquinolin-2-carboxílicos y su uso
MX2018008597A (es) Composiciones inyectables de melfalan que comprenden un derivado de ciclodextrina y metodos de fabricacion y uso de las mismas.
CO6382089A2 (es) Compuestos,composiciones y metodos para el tratamiento de enfermadades causadas por un b-amiloide y sinucleinopatias
AR106364A1 (es) Derivados de insulina y sus usos médicos
BR112012028773A2 (pt) composições farmacêuticas compreendendo hidromorfona e naloxona
BR112017013273A2 (pt) emplastro em gel
UY38355A (es) Composiciones farmacéuticas semisólidas de base oleosa conteniendo pirfenidona para su aplicación en la reparación tisular
ECSP12012102A (es) Proceso para producir un extracto de alérgenos
BRPI1011610A2 (pt) êmbolo para um corpo oco medicinal e corpo oco medicinal
ES2535498T8 (es) Alfa derivados de ácidos grasos cis-monoinsaturados para ser usados como medicamento
BR112014013860A8 (pt) palmilha para suportar o pé de uma pessoa
UY31252A1 (es) Derivados de macrolidos utiles en el tratamiento de la malaria
PE20121537A1 (es) Combinacion de teobromina con un descongestivo
BR112015025362A2 (pt) método de fabricação de uma base de suporte para instrumentos médicos
NI201200103A (es) NUEVOS DERIVADOS ( HETEROCICLO - TETRAHIDRO - PIRIDIN ) - ( PIPERAZINIL ) - 1 - ALCANONA Y ( HETEROCICLO - DIHIDRO - PIRROLIDIN ) - ( PIPERAZINIL ) - 1 - ALCANONA Y SU UTILIZACIÓN COMO INHIBIDORES DE p75
AR076910A1 (es) Un agente cosmetico de despigmentacion que comprende un carbohidrato de delta -tocoferilo
CL2015003249A1 (es) Hoja para aplicación cutánea que contiene vitamina e o un éster de la misma

Legal Events

Date Code Title Description
FA Abandonment or withdrawal