AR089703A1 - Derivados de arilamida que tienen propiedades antiandrogenicas - Google Patents
Derivados de arilamida que tienen propiedades antiandrogenicasInfo
- Publication number
- AR089703A1 AR089703A1 ARP130100091A ARP130100091A AR089703A1 AR 089703 A1 AR089703 A1 AR 089703A1 AR P130100091 A ARP130100091 A AR P130100091A AR P130100091 A ARP130100091 A AR P130100091A AR 089703 A1 AR089703 A1 AR 089703A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivatives
- arilamide
- trifluoromethyl
- hydrogen
- formula
- Prior art date
Links
- 230000002280 anti-androgenic effect Effects 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Los derivados de arilamida de la fórmula (1) tienen propiedades antiandrogénicas. La presente también se refiere a los compuestos de la fórmula (1) para utilizar como un medicamento y a composiciones farmacéuticas que los comprenden y a su preparación. Reivindicación 1: Un derivado de arilamida que tiene la fórmula (1) y estereoisómeros y sales farmacéuticamente aceptables de los mismos; donde R² es halo o trifluorometilo; y R⁸ y R⁹ se seleccionan del grupo que consta de hidrógeno, halo y trifluorometilo, siempre que al menos uno de R⁸ y R⁹ sea distinto de hidrógeno; y R¹¹ es alquilo C₃₋₅ ramificado o cicloalquilo C₃₋₆; siempre que cuando R¹¹ es isopentilo, R² es trifluorometilo y R⁹ es hidrógeno, luego R⁸ no es flúor.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20125041 | 2012-01-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR089703A1 true AR089703A1 (es) | 2014-09-10 |
Family
ID=47678880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130100091A AR089703A1 (es) | 2012-01-13 | 2013-01-11 | Derivados de arilamida que tienen propiedades antiandrogenicas |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR089703A1 (es) |
| TW (1) | TW201332953A (es) |
| WO (1) | WO2013104831A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016079521A1 (en) * | 2014-11-20 | 2016-05-26 | University College Cardiff Consultants Limited | Androgen receptor modulators and their use as anti-cancer agents |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE28864T1 (de) | 1982-07-23 | 1987-08-15 | Ici Plc | Amide-derivate. |
| KR20090030345A (ko) | 2006-07-19 | 2009-03-24 | 더 오하이오 스테이트 유니버시티 리서치 파운데이션 | 선택적인 안드로겐 수용체 모듈레이터, 그 유사체와 유도체, 및 그의 용도 |
| ITBO20090078A1 (it) | 2009-02-13 | 2010-08-14 | Consiglio Nazionale Ricerche | Composti per il trattamento del tumore alla prostata e procedimenti per la loro sintesi |
| EP2424853B1 (en) | 2009-04-10 | 2018-09-19 | Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori (I.R.S.T.) S.R.L. | Non-steroidal compounds for androgen receptor modulation, processes for the preparation and uses thereof |
| FI20105806A0 (fi) * | 2010-07-15 | 2010-07-15 | Medeia Therapeutics Ltd | Uudet aryyliamidijohdannaiset, joilla on antiandrogeenisia ominaisuuksia |
-
2013
- 2013-01-11 AR ARP130100091A patent/AR089703A1/es unknown
- 2013-01-11 TW TW102101024A patent/TW201332953A/zh unknown
- 2013-01-11 WO PCT/FI2013/050028 patent/WO2013104831A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013104831A1 (en) | 2013-07-18 |
| TW201332953A (zh) | 2013-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |