AR092702A1 - Enzima hialuronano-liasa, metodo para producirla, su uso y metodo para preparar un hialuronano con un peso molecular bajo - Google Patents
Enzima hialuronano-liasa, metodo para producirla, su uso y metodo para preparar un hialuronano con un peso molecular bajoInfo
- Publication number
- AR092702A1 AR092702A1 ARP130103474A ARP130103474A AR092702A1 AR 092702 A1 AR092702 A1 AR 092702A1 AR P130103474 A ARP130103474 A AR P130103474A AR P130103474 A ARP130103474 A AR P130103474A AR 092702 A1 AR092702 A1 AR 092702A1
- Authority
- AR
- Argentina
- Prior art keywords
- enzyme
- molecular weight
- low molecular
- prepare
- hialuronano
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title abstract 4
- 108090000790 Enzymes Proteins 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 229920002674 hyaluronan Polymers 0.000 abstract 3
- 241000123205 Fistulina Species 0.000 abstract 2
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 abstract 2
- 229940099552 hyaluronan Drugs 0.000 abstract 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 1
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 abstract 1
- 241000233866 Fungi Species 0.000 abstract 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 abstract 1
- 102000004317 Lyases Human genes 0.000 abstract 1
- 108090000856 Lyases Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 229940097043 glucuronic acid Drugs 0.000 abstract 1
- 230000002440 hepatic effect Effects 0.000 abstract 1
- 229960003160 hyaluronic acid Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/12—Disaccharides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/02—Carbon-oxygen lyases (4.2) acting on polysaccharides (4.2.2)
- C12Y402/02001—Hyaluronate lyase (4.2.2.1)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Cosmetics (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Enzima que puede degradar el ácido hialurónico y que es producida por hongos del género Fistulina (especialmente por Fistulina hepática). La degradación se basa en un mecanismo propio de una liasa, es decir, en la formación de enlaces dobles entre los carbonos 4 y 5 del ácido glucurónico. Proceso para preparar y purificar dicha enzima. Posible uso práctico de dicha enzima, particularmente en la preparación de un hialuronano con un peso molecular bajo o de composiciones cosméticas o farmacéuticas. Método para preparar un hialuronano con un peso molecular bajo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZ20120664A CZ2012664A3 (cs) | 2012-09-27 | 2012-09-27 | Enzym hyaluronan-lyáza, zpusob jeho výroby, pouzití a zpusob prípravy nízkomolekulárního hyaluronanu |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR092702A1 true AR092702A1 (es) | 2015-04-29 |
Family
ID=49518625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130103474A AR092702A1 (es) | 2012-09-27 | 2013-09-27 | Enzima hialuronano-liasa, metodo para producirla, su uso y metodo para preparar un hialuronano con un peso molecular bajo |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20150344926A1 (es) |
| EP (1) | EP2900816A1 (es) |
| JP (1) | JP2015530099A (es) |
| KR (1) | KR20150063057A (es) |
| AR (1) | AR092702A1 (es) |
| BR (1) | BR112015005957A2 (es) |
| CZ (1) | CZ2012664A3 (es) |
| RU (1) | RU2015113473A (es) |
| WO (1) | WO2014048406A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3596224A1 (en) * | 2017-03-16 | 2020-01-22 | Contipro a.s. | Method of determination of hyaluronic acid |
| CN114457061A (zh) * | 2022-02-21 | 2022-05-10 | 中国海洋大学 | 一种透明质酸裂解酶及其应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3728223A (en) | 1971-10-08 | 1973-04-17 | Amano Pharma Co Ltd | Production of hyaluronidase from a strain of streptomyces |
| CH628088A5 (en) | 1975-09-17 | 1982-02-15 | Dresden Arzneimittel | Process for obtaining streptococcal metabolic products |
| JPS6033474B2 (ja) | 1978-05-11 | 1985-08-02 | 藤沢薬品工業株式会社 | 新規なヒアルロニダ−ゼｂｍｐ−８２３１およびその製造法 |
| JPS5968402A (ja) | 1982-10-08 | 1984-04-18 | 日本通運株式会社 | Ｐｃ桁の布設用門構吊上機 |
| JPS62104579A (ja) | 1985-10-30 | 1987-05-15 | Kyowa Hakko Kogyo Co Ltd | ヒアルロニダ−ゼの製造法 |
| NL9700003A (nl) * | 1993-09-28 | 1997-07-01 | House Foods Corp | Werkwijze voor het inoculeren van Fistulina hepatica. |
| AU758575C (en) | 1998-04-30 | 2003-11-20 | Maruha Corporation | Compounds having glucuronic acid derivative and glucosamine derivative in structure thereof, method for producing the compounds, and uses of the compounds |
| ATE245452T1 (de) * | 1998-12-23 | 2003-08-15 | Esparma Gmbh | Hyaluronatlyase als penetrationsförderer in topischen mitteln |
| US6902548B1 (en) | 2001-03-19 | 2005-06-07 | Ed Schuler | Use of Streptomyces hyalurolyticus enzyme in ophthalmic treatments |
| US20070202570A1 (en) * | 2006-02-24 | 2007-08-30 | Kikkoman Corporation | Enzyme composition, low molecular weight hyaluronan and process for preparing the same |
| RU2471867C2 (ru) | 2007-06-19 | 2013-01-10 | Тамара П. Уваркина | Гиалуронидаза и способ ее применения |
| US20120219554A2 (en) | 2009-05-14 | 2012-08-30 | Fidia Farmaceutici S.P.A. | Extracellular yaluronidase from streptomyces koganeiensis |
-
2012
- 2012-09-27 CZ CZ20120664A patent/CZ2012664A3/cs not_active IP Right Cessation
-
2013
- 2013-09-26 BR BR112015005957A patent/BR112015005957A2/pt not_active IP Right Cessation
- 2013-09-26 US US14/430,731 patent/US20150344926A1/en not_active Abandoned
- 2013-09-26 KR KR1020157008026A patent/KR20150063057A/ko not_active Withdrawn
- 2013-09-26 EP EP13786150.6A patent/EP2900816A1/en not_active Withdrawn
- 2013-09-26 RU RU2015113473A patent/RU2015113473A/ru not_active Application Discontinuation
- 2013-09-26 JP JP2015533449A patent/JP2015530099A/ja not_active Withdrawn
- 2013-09-26 WO PCT/CZ2013/000116 patent/WO2014048406A1/en not_active Ceased
- 2013-09-27 AR ARP130103474A patent/AR092702A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20150344926A1 (en) | 2015-12-03 |
| JP2015530099A (ja) | 2015-10-15 |
| CZ304140B6 (cs) | 2013-11-13 |
| CZ2012664A3 (cs) | 2013-11-13 |
| KR20150063057A (ko) | 2015-06-08 |
| EP2900816A1 (en) | 2015-08-05 |
| BR112015005957A2 (pt) | 2017-07-04 |
| WO2014048406A1 (en) | 2014-04-03 |
| RU2015113473A (ru) | 2016-11-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |