AR096789A1 - Derivados de péptidos similares a glp-1 y usos de los mismos - Google Patents

Derivados de péptidos similares a glp-1 y usos de los mismos

Info

Publication number: AR096789A1
Authority: AR; Argentina
Prior art keywords: derivatives; glp; same; side chains; analogs
Prior art date: 2013-07-04

Application number

ARP140102467A

Other languages

English (en)

Spanish (es)

Inventor

Wenzel Torne Christian

Reedtz-Runge Steffen

Kofoed Jacob

Sauerberg Per

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-07-04

Filing date

2014-07-02

Publication date

2016-02-03

2014-07-02 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2016-02-03 Publication of AR096789A1 publication Critical patent/AR096789A1/es

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Hematology (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Toxicology (AREA)
Genetics & Genomics (AREA)
Addiction (AREA)
Dermatology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Psychiatry (AREA)

ARP140102467A 2013-07-04 2014-07-02 Derivados de péptidos similares a glp-1 y usos de los mismos AR096789A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP13175094		2013-07-04

Publications (1)

Publication Number	Publication Date
AR096789A1 true AR096789A1 (es)	2016-02-03

Family

ID=48703344

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ARP140102467A AR096789A1 (es)	2013-07-04	2014-07-02	Derivados de péptidos similares a glp-1 y usos de los mismos

Country Status (11)

Country	Link
US (2)	US9498534B2 (2)
EP (1)	EP3016975B1 (2)
JP (2)	JP6139712B2 (2)
KR (1)	KR20160029079A (2)
CN (1)	CN105377884B (2)
AR (1)	AR096789A1 (2)
AU (1)	AU2014286234A1 (2)
BR (1)	BR112015032875A2 (2)
CA (1)	CA2916311A1 (2)
MX (1)	MX2015016875A (2)
WO (1)	WO2015000942A1 (2)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP6475233B2 (ja)	2013-06-20	2019-02-27	ノヴォノルディスクアー／エス	Ｇｌｐ−１誘導体及びその使用
EP3016975B1 (en) *	2013-07-04	2019-01-16	Novo Nordisk A/S	Derivatives of glp-1 like peptides, and uses thereof
JP6730278B2 (ja)	2014-11-27	2020-07-29	ノヴォノルディスクアー／エス	Ｇｌｐ−１誘導体及びその使用
WO2016097108A1 (en)	2014-12-17	2016-06-23	Novo Nordisk A/S	Glp-1 derivatives and uses thereof
AU2016270373A1 (en)	2015-06-05	2018-01-04	Vertex Pharmaceuticals Incorporated	Triazoles for the treatment of demyelinating diseases
CN108697768B (zh)	2015-12-23	2022-07-22	约翰霍普金斯大学	长效glp-1r激动剂作为神经系统病状和神经退行性病状的治疗方法
US10946074B2 (en)	2016-03-03	2021-03-16	Novo Nordisk A/S	GLP-1 derivatives and uses thereof
ES2828526T3 (es)	2016-11-07	2021-05-26	Novo Nordisk As	Esteres activos DCHBS de compuestos PEG y sus usos
WO2018106646A1 (en)	2016-12-06	2018-06-14	Vertex Pharmaceuticals Incorporated	Aminotriazoles for the treatment of demyelinating diseases
WO2018106641A1 (en)	2016-12-06	2018-06-14	Vertex Pharmaceuticals Incorporated	Pyrazoles for the treatment of demyelinating diseases
WO2018106643A1 (en)	2016-12-06	2018-06-14	Vertex Pharmaceuticals Incorporated	Heterocyclic azoles for the treatment of demyelinating diseases
CN108976147B (zh) *	2017-05-31	2021-02-12	首都医科大学	氨基正己酰氨基甲环酰氨基正己酰碱性氨基酸，其合成，活性和应用
CN109248323B (zh) *	2017-07-14	2023-09-08	杭州先为达生物科技有限公司	酰化的glp-1衍生物
CA3068956A1 (en)	2017-07-19	2019-01-24	Novo Nordisk A/S	Bifunctional compounds
KR102665710B1 (ko)	2017-08-24	2024-05-14	노보 노르디스크 에이/에스	Glp-1 조성물 및 그 용도
JP7359358B2 (ja) *	2017-11-30	2023-10-11	グリアファームエスエー	神経疾患の予防及び治療に使用するためのポリケチド化合物及びその誘導体
MX2020010505A (es)	2018-04-05	2021-01-15	Sun Pharmaceutical Ind Ltd	Analogos novedosos de glp-1.
CN110386974B (zh) *	2018-04-19	2022-12-09	杭州先为达生物科技有限公司	Glp-1衍生物及其治疗用途
CN113214381B (zh) *	2018-04-19	2024-01-19	杭州先为达生物科技股份有限公司	酰化的glp-1衍生物
WO2019200594A1 (zh)	2018-04-19	2019-10-24	杭州先为达生物科技有限公司	酰化的glp-1衍生物
DE112018007827T5 (de) *	2018-07-12	2021-03-25	Mitsubishi Electric Corporation	Halbleitervorrichtung
EP4085077A4 (en)	2019-12-31	2024-01-17	Beijing QL Biopharmaceutical Co., Ltd.	Fusion proteins of glp-1 and gdf15 and conjugates thereof
CN113728013B (zh)	2020-01-11	2022-06-14	北京质肽生物医药科技有限公司	Glp-1和fgf21的融合蛋白的缀合物
JP7761567B2 (ja) *	2020-02-18	2025-10-28	ノヴォノルディスクアー／エス	医薬製剤
CN114729060B (zh)	2020-09-30	2022-11-25	北京质肽生物医药科技有限公司	多肽缀合物和使用方法
CN116490212A (zh) *	2020-11-06	2023-07-25	诺和诺德股份有限公司	Glp-1前药及其用途
CN114685644A (zh) *	2020-12-29	2022-07-01	苏州康宁杰瑞生物科技有限公司	一种人glp-1多肽变体及其应用
WO2023284822A1 (en)	2021-07-14	2023-01-19	Beijing Ql Biopharmaceutical Co., Ltd.	Fusion polypeptides for metabolic disorders
EP4323413A4 (en)	2022-03-30	2025-10-15	Beijing Ql Biopharmaceutical Co Ltd	LIQUID PHARMACEUTICAL COMPOSITIONS OF POLYPEPTIDE CONJUGATES AND METHODS OF USE THEREOF
JP2026502943A (ja)	2022-12-30	2026-01-27	アルギファルマエーエス	経口投与されるポリペプチド治療剤の全身バイオアベイラビリティを高める組成物および方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6458924B2 (en) *	1996-08-30	2002-10-01	Novo Nordisk A/S	Derivatives of GLP-1 analogs
WO1999043706A1 (en) *	1998-02-27	1999-09-02	Novo Nordisk A/S	Derivatives of glp-1 analogs
CZ20013018A3 (cs)	1999-03-17	2002-02-13	Novo Nordisk A/S	Způsob pro acylování aminoskupiny peptidu nebo proteinu a sloučenina
EP1076066A1 (en) *	1999-07-12	2001-02-14	Zealand Pharmaceuticals A/S	Peptides for lowering blood glucose levels
AU1269501A (en)	1999-11-12	2001-05-30	Novo Nordisk A/S	Use of glp-1 agonists for the inhibition of beta cell degeneration
GB0020551D0 (en)	2000-08-22	2000-10-11	Birkett David	Sprinkler system
JP2006520818A (ja)	2003-03-19	2006-09-14	イーライリリーアンドカンパニー	ポリエチレングリコール結合ｇｌｐ−１化合物
TWI362392B (en)	2005-03-18	2012-04-21	Novo Nordisk As	Acylated glp-1 compounds
CA2608311C (en)	2005-05-13	2012-11-27	Eli Lilly And Company	Glp-1 pegylated compounds
US20110144010A1 (en)	2007-06-01	2011-06-16	Novo Nordisk A/S	Spontaneously Dispersible Preconcentrates Including a Peptide Drug in a Solid or Semisolid Carrier
EP2190872B1 (en)	2007-09-05	2018-03-14	Novo Nordisk A/S	Glucagon-like peptide-1 derivatives and their pharmaceutical use
WO2009030771A1 (en)	2007-09-05	2009-03-12	Novo Nordisk A/S	Peptides derivatized with a-b-c-d- and their therapeutical use
US20100317057A1 (en)	2007-12-28	2010-12-16	Novo Nordisk A/S	Semi-recombinant preparation of glp-1 analogues
ES2401965T3 (es)	2009-02-19	2013-04-25	Novo Nordisk A/S	Modificación de Factor VIII
JP6006118B2 (ja) *	2009-12-16	2016-10-12	ノヴォノルディスクアー／エス	Ｇｌｐ−１アナログ及び誘導体
JP6039569B2 (ja)	2010-11-09	2016-12-07	ノヴォノルディスクアー／エス	二重アシル化されたｇｌｐ−１誘導体
PL2696687T3 (pl)	2011-04-12	2017-06-30	Novo Nordisk A/S	Pochodne podwójnie acylowanej GLP-1
EP3016975B1 (en) *	2013-07-04	2019-01-16	Novo Nordisk A/S	Derivatives of glp-1 like peptides, and uses thereof

2014
- 2014-07-02 EP EP14734816.3A patent/EP3016975B1/en active Active
- 2014-07-02 CA CA2916311A patent/CA2916311A1/en not_active Withdrawn
- 2014-07-02 BR BR112015032875A patent/BR112015032875A2/pt not_active Application Discontinuation
- 2014-07-02 JP JP2015563070A patent/JP6139712B2/ja active Active
- 2014-07-02 AU AU2014286234A patent/AU2014286234A1/en not_active Abandoned
- 2014-07-02 AR ARP140102467A patent/AR096789A1/es unknown
- 2014-07-02 WO PCT/EP2014/064033 patent/WO2015000942A1/en not_active Ceased
- 2014-07-02 CN CN201480038380.6A patent/CN105377884B/zh active Active
- 2014-07-02 KR KR1020167002151A patent/KR20160029079A/ko not_active Withdrawn
- 2014-07-02 MX MX2015016875A patent/MX2015016875A/es unknown
- 2014-07-02 US US14/322,077 patent/US9498534B2/en active Active
2016
- 2016-09-28 US US15/278,501 patent/US10010614B2/en active Active
2017
- 2017-02-09 JP JP2017022249A patent/JP6687557B2/ja active Active

Also Published As

Publication number	Publication date
US10010614B2 (en)	2018-07-03
CA2916311A1 (en)	2015-01-08
JP2016528163A (ja)	2016-09-15
EP3016975A1 (en)	2016-05-11
CN105377884A (zh)	2016-03-02
US9498534B2 (en)	2016-11-22
AU2014286234A1 (en)	2015-12-17
US20170007707A1 (en)	2017-01-12
MX2015016875A (es)	2016-04-07
CN105377884B (zh)	2021-07-20
EP3016975B1 (en)	2019-01-16
KR20160029079A (ko)	2016-03-14
JP2017105819A (ja)	2017-06-15
WO2015000942A1 (en)	2015-01-08
JP6687557B2 (ja)	2020-04-22
JP6139712B2 (ja)	2017-05-31
BR112015032875A2 (pt)	2017-11-07
US20150011462A1 (en)	2015-01-08

Legal Events

Date	Code	Title	Description
2017-04-07	FB	Suspension of granting procedure

Publication	Publication Date	Title
AR096789A1 (es)	2016-02-03	Derivados de péptidos similares a glp-1 y usos de los mismos
CO2020003478A2 (es)	2020-04-13	Inhibidores de la ectonucleótido pirofosfatasa-fosfodiesterasa 1 (enpp-1) y usos de los mismos
MX2015016564A (es)	2016-04-15	Derivados de peptido similar al glucaton tipo 1 (glp-1) y uso de los mismos.
MX392572B (es)	2025-03-24	Compuestos del péptido yy (pyy) selectivos y sus usos.
MY181181A (en)	2020-12-21	Fgf21 derivatives and uses thereof
GT201500049A (es)	2016-02-15	Proteinas de fusiòn para el tratamiento de un sìndrome metàbolico
ECSP19021223A (es)	2019-04-30	Derivado de glucagon, conjugado del mismo, composición que comprende el mismo y uso terapéutico del mismo
CR20160006A (es)	2016-03-15	Derivados de pirrolamida sustituidos con glioxamida y su uso como medicamentos para el tratamiento de la hepatitis b
UY37505A (es)	2018-06-29	Conjugados que comprenden un agonista dual de glp-1/glucagón, un conector y ácido hialurónico
MX2018015252A (es)	2019-04-25	Inhibidores de la interaccion de menina-leucemia de linaje mixto.
BR112017012342A2 (pt)	2018-02-27	compostos inibitórios de bcl-xl e conjugados de anticorpo-fármaco incluindo os mesmos
CL2015002835A1 (es)	2016-05-20	Nuevos derivados de piridina
BR112018012707A2 (pt)	2019-01-29	inibidores da interação de menin-mll
UY36186A (es)	2016-01-29	Ácidos grasos novedosos y su uso en la conjugación con biomoléculas
CR20160237A (es)	2016-07-21	Derivados de la carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b
HRP20190388T1 (hr)	2019-04-19	Eksendin-4 derivati kao peptidni dvostruki agonisti receptora glp-1 / glukagona
PE20180449A1 (es)	2018-03-05	Derivado de glucagon y una composicion que comprende un conjugado de accion prolongada del mismo
CR20170129A (es)	2017-05-22	Uso de un agonista dual del receptor de glp-1/glucagón de acción prolongada para el tratamiento de la enfermedad del hígado graso no alcohólico
MX2016001971A (es)	2016-10-26	Composiciones farmaceuticas parenterales acuosas estables de peptidos insulinotropicos.
MX2018001723A (es)	2018-05-17	Conjugados farmaco-multiligando y usos de los mismos.
CL2018003319A1 (es)	2019-02-01	Compuestos de mic-1 y usos de estos.
CO2017006898A2 (es)	2017-10-10	Formulación de relación fija de insulina glargina/lixisenatida
AR095527A1 (es)	2015-10-21	Formulaciones de polipéptido fc-factor ix
BR112017021190A2 (pt)	2018-09-25	composição farmacêutica e o uso da mesma
EA201790495A1 (ru)	2017-09-29	Фармацевтические композиции длительного действия