AR098145A1 - Compuestos derivados de piridilo bicíclicos fusionados como inhibidores de fgfr4 - Google Patents

Compuestos derivados de piridilo bicíclicos fusionados como inhibidores de fgfr4

Info

Publication number: AR098145A1
Authority: AR; Argentina
Prior art keywords: alkyl; ring; substituted; alkoxy; saturated
Prior art date: 2013-10-25

Application number

ARP140103960A

Other languages

English (en)

Spanish (es)

Inventor

Buschmann Nicole

Alec Fairhurst Robin

Furet Pascal

Knpfel Thomas

Leblanc Catherine

Liao Lv

Mah Robert

Nimsgern Pierre

Ripoche Sebastien

Xiong Jing

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-10-25

Filing date

2014-10-22

Publication date

2016-05-04

2014-10-22 Application filed by Novartis Ag filed Critical Novartis Ag

2016-05-04 Publication of AR098145A1 publication Critical patent/AR098145A1/es

Links

150000001875 compounds Chemical class 0.000 title abstract 4
102100027844 Fibroblast growth factor receptor 4 Human genes 0.000 title 1
101000917134 Homo sapiens Fibroblast growth factor receptor 4 Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 14
125000005842 heteroatom Chemical group 0.000 abstract 7
229910052760 oxygen Inorganic materials 0.000 abstract 7
125000004432 carbon atom Chemical group C* 0.000 abstract 6
229910052739 hydrogen Inorganic materials 0.000 abstract 6
239000001257 hydrogen Substances 0.000 abstract 6
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
229910052799 carbon Inorganic materials 0.000 abstract 5
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
229910052717 sulfur Inorganic materials 0.000 abstract 5
229910052736 halogen Inorganic materials 0.000 abstract 4
150000002367 halogens Chemical class 0.000 abstract 4
229920006395 saturated elastomer Polymers 0.000 abstract 4
125000006583 (C1-C3) haloalkyl group Chemical group 0.000 abstract 3
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 3
125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 3
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 3
125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 2
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
125000001963 4 membered heterocyclic group Chemical group 0.000 abstract 2
125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 abstract 2
-1 NRY1RY2 Chemical group 0.000 abstract 2
125000004103 aminoalkyl group Chemical group 0.000 abstract 2
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
125000006698 (C1-C3) dialkylamino group Chemical group 0.000 abstract 1
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
239000013543 active substance Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000002619 bicyclic group Chemical group 0.000 abstract 1
BVCRERJDOOBZOH-UHFFFAOYSA-N bicyclo[2.2.1]heptanyl Chemical group C1C[C+]2CC[C-]1C2 BVCRERJDOOBZOH-UHFFFAOYSA-N 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
125000004438 haloalkoxy group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000005113 hydroxyalkoxy group Chemical group 0.000 abstract 1
201000007270 liver cancer Diseases 0.000 abstract 1
208000014018 liver neoplasm Diseases 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000004621 quinuclidinyl group Chemical group N12C(CC(CC1)CC2)* 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Landscapes

Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

ARP140103960A 2013-10-25 2014-10-22 Compuestos derivados de piridilo bicíclicos fusionados como inhibidores de fgfr4 AR098145A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CN2013086003		2013-10-25

Publications (1)

Publication Number	Publication Date
AR098145A1 true AR098145A1 (es)	2016-05-04

Family

ID=53491699

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ARP140103960A AR098145A1 (es)	2013-10-25	2014-10-22	Compuestos derivados de piridilo bicíclicos fusionados como inhibidores de fgfr4

Country Status (4)

Country	Link
AR (1)	AR098145A1 (fr)
MA (1)	MA39054B1 (fr)
TW (2)	TWI690528B (fr)
UY (1)	UY35792A (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0906472D0 (en) *	2009-04-15	2009-05-20	Astex Therapeutics Ltd	New compounds
GB201118656D0 (en) *	2011-10-28	2011-12-07	Astex Therapeutics Ltd	New compounds

2014
- 2014-10-22 AR ARP140103960A patent/AR098145A1/es unknown
- 2014-10-23 UY UY0001035792A patent/UY35792A/es not_active Application Discontinuation
- 2014-10-24 MA MA39054A patent/MA39054B1/fr unknown
- 2014-10-24 TW TW108124006A patent/TWI690528B/zh active
- 2014-10-24 TW TW103136873A patent/TWI673268B/zh active

Also Published As

Publication number	Publication date
UY35792A (es)	2015-05-29
TW201605853A (zh)	2016-02-16
MA39054B1 (fr)	2018-09-28
MA39054A1 (fr)	2018-02-28
TWI673268B (zh)	2019-10-01
TW201938560A (zh)	2019-10-01
TWI690528B (zh)	2020-04-11

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Legal Events

Date	Code	Title	Description
2021-04-29	FB	Suspension of granting procedure