AR110384A1 - Proceso para la fabricación de derivados de diazepina - Google Patents
Proceso para la fabricación de derivados de diazepinaInfo
- Publication number
- AR110384A1 AR110384A1 ARP170103540A ARP170103540A AR110384A1 AR 110384 A1 AR110384 A1 AR 110384A1 AR P170103540 A ARP170103540 A AR P170103540A AR P170103540 A ARP170103540 A AR P170103540A AR 110384 A1 AR110384 A1 AR 110384A1
- Authority
- AR
- Argentina
- Prior art keywords
- manufacture
- compound
- formula
- derivatives
- diazepin
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- LRANPJDWHYRCER-UHFFFAOYSA-N 1,2-diazepine Chemical class N1C=CC=CC=N1 LRANPJDWHYRCER-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 125000002576 diazepinyl group Chemical class N1N=C(C=CC=C1)* 0.000 abstract 1
- JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 abstract 1
- 229940011051 isopropyl acetate Drugs 0.000 abstract 1
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La solicitud se refiere a un proceso para la fabricación de derivados de diazepina. Reivindicación 1: Un proceso para la fabricación de un compuesto de fórmula (1), que comprende las siguientes etapas: (a) la reacción de un compuesto de fórmula (2), que tiene una relación enantiomérica de al menos 70:30 con un ácido para llegar al compuesto de fórmula (1); y (b) la cristalización del compuesto de fórmula (1) obtenido en la etapa (a) a partir de acetato de isopropilo; en donde R¹ es alquilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2016110279 | 2016-12-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR110384A1 true AR110384A1 (es) | 2019-03-27 |
Family
ID=60857055
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170103540A AR110384A1 (es) | 2016-12-16 | 2017-12-15 | Proceso para la fabricación de derivados de diazepina |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20190284202A1 (es) |
| EP (1) | EP3555059A1 (es) |
| JP (1) | JP2020502148A (es) |
| KR (1) | KR20190092429A (es) |
| CN (1) | CN110088095A (es) |
| AR (1) | AR110384A1 (es) |
| AU (1) | AU2017376583A1 (es) |
| BR (1) | BR112019008435A2 (es) |
| CA (1) | CA3041949A1 (es) |
| IL (1) | IL267305A (es) |
| MX (1) | MX2019006956A (es) |
| TW (1) | TW201827420A (es) |
| WO (1) | WO2018109053A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111094263A (zh) * | 2017-09-14 | 2020-05-01 | 豪夫迈·罗氏有限公司 | 可用于制造药物的新化合物 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994006802A1 (fr) | 1992-09-18 | 1994-03-31 | Yoshitomi Pharmaceutical Industries, Ltd. | Compose de thienodiazepine et son utilisation medicinale |
| DE69717160T2 (de) | 1996-09-13 | 2003-05-08 | Mitsubishi Pharma Corp., Osaka | Thienotriazolodiazepinverbindungen und ihre medizinischen anwendungen |
| US6323214B1 (en) | 1997-10-29 | 2001-11-27 | Medco Research, Inc | Allosteric adenosine receptor modulators |
| GB0722340D0 (en) | 2007-11-14 | 2007-12-27 | Univ Leiden | Sphingosine-1-phosphate (S1P) receptor compounds |
| PL2902030T3 (pl) * | 2010-05-14 | 2017-07-31 | Dana-Farber Cancer Institute, Inc. | Związki tienotriazolodiazepinowe do leczenia nowotworu |
| MX354217B (es) | 2010-05-14 | 2018-02-19 | Dana Farber Cancer Inst Inc | Composiciones y metodos para el tratamiento de leucemia. |
| CN103180318B (zh) * | 2010-05-14 | 2017-05-10 | 达那-法伯癌症研究所 | 雄性避孕组合物以及使用方法 |
| JP5715241B2 (ja) * | 2010-05-14 | 2015-05-07 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | 新生物、炎症性疾患、およびその他の障害を治療するための組成物および方法 |
| SG11201607108XA (en) | 2014-02-28 | 2016-09-29 | Tensha Therapeutics Inc | Treatment of conditions associated with hyperinsulinaemia |
| JP6333996B2 (ja) | 2014-04-09 | 2018-05-30 | カイノス・メディスン・インコーポレイテッドＫａｉｎｏｓ Ｍｅｄｉｃｉｎｅ， Ｉｎｃ． | がんを予防または治療するための、ブロモドメイン阻害化合物およびそれを含む医薬組成物 |
-
2017
- 2017-12-14 KR KR1020197016490A patent/KR20190092429A/ko not_active Ceased
- 2017-12-14 BR BR112019008435A patent/BR112019008435A2/pt not_active Application Discontinuation
- 2017-12-14 CN CN201780078025.5A patent/CN110088095A/zh active Pending
- 2017-12-14 JP JP2019532001A patent/JP2020502148A/ja active Pending
- 2017-12-14 MX MX2019006956A patent/MX2019006956A/es unknown
- 2017-12-14 AU AU2017376583A patent/AU2017376583A1/en not_active Abandoned
- 2017-12-14 EP EP17822227.9A patent/EP3555059A1/en not_active Withdrawn
- 2017-12-14 WO PCT/EP2017/082729 patent/WO2018109053A1/en not_active Ceased
- 2017-12-14 CA CA3041949A patent/CA3041949A1/en not_active Abandoned
- 2017-12-15 AR ARP170103540A patent/AR110384A1/es unknown
- 2017-12-15 TW TW106144100A patent/TW201827420A/zh unknown
-
2019
- 2019-06-07 US US16/434,438 patent/US20190284202A1/en not_active Abandoned
- 2019-06-13 IL IL267305A patent/IL267305A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20190092429A (ko) | 2019-08-07 |
| AU2017376583A1 (en) | 2019-05-16 |
| CN110088095A (zh) | 2019-08-02 |
| CA3041949A1 (en) | 2018-06-21 |
| US20190284202A1 (en) | 2019-09-19 |
| BR112019008435A2 (pt) | 2019-07-09 |
| TW201827420A (zh) | 2018-08-01 |
| MX2019006956A (es) | 2019-08-01 |
| WO2018109053A1 (en) | 2018-06-21 |
| IL267305A (en) | 2019-08-29 |
| EP3555059A1 (en) | 2019-10-23 |
| JP2020502148A (ja) | 2020-01-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |