AR240796A2 - Procedimiento para la preparacion de alcoholes aromaticos tio substituidos y compuesto intermediarioutilizado en el mismo - Google Patents
Procedimiento para la preparacion de alcoholes aromaticos tio substituidos y compuesto intermediarioutilizado en el mismoInfo
- Publication number
- AR240796A2 AR240796A2 AR29743584A AR29743584A AR240796A2 AR 240796 A2 AR240796 A2 AR 240796A2 AR 29743584 A AR29743584 A AR 29743584A AR 29743584 A AR29743584 A AR 29743584A AR 240796 A2 AR240796 A2 AR 240796A2
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- carboxyl
- formula
- group
- conh2
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 230000001681 protective effect Effects 0.000 abstract 2
- -1 CARBOXYL Chemical class 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- OHSJPLSEQNCRLW-UHFFFAOYSA-N triphenylmethyl radical Chemical class C1=CC=CC=C1[C](C=1C=CC=CC=1)C1=CC=CC=C1 OHSJPLSEQNCRLW-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
- C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
- C07C17/2635—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions involving a phosphorus compound, e.g. Wittig synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/35—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction
- C07C17/354—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction by hydrogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/18—Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part
- C07C33/20—Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part monocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/28—Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings
- C07C33/30—Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings monocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
Abstract
UN PROCEDIMIENTO PARA LA PREPARACION DE ALCOHOLES AROMATICOS TIO-SUBSTITUIDOS DE FORMULA (I), EN LA CUAL R1 ES UN GRUPO ALQUENILO CONTENIDO DE 1 A 4 DOBLES LIGADURAS, QUE ESTA OPCIONALMENTE SUBSTITUIDO POR UN GRUPO FENILO; R2 ES FENILO O FENILO SUBSTITUIDO CON 2-, 3- O 4-CARBOXILO, O ALQUILO SUBSTITUIDO POR CARBOXILO, NITRILO, TETRAZOLILO, UN GRUPO -CONH2 O UN RESIDUO AMINOACIDO DE CISTEINA, CISTEINILGLICINA O GLUTATION; Y R3, R4 Y R5 SON SELECCIONADOS CADA UNO DE HIDROGENO, 3-NITRILO, 3-CARBOXILO, 3-ALCOXI-CARBONILO, 3-TETRAZOL Y 3-CONH2. SE HACE REACCIONAR UN COMPUESTO DE FORMULA (II), CON UN TIOL DE FORMULA R2SH, ESTANDO LOS GRUPOS R2 A R5 OPCIONALMENTE PROTEGIDOS POR GRUPOS PROTECTORES CONVENCIONALES, ELEGIDOS ENTRE TRIFENILMETILO Y ALQUILO, CUANDO ES DESEABLE; SEGUIDO OPCIONALMENTE POR ELIMINACION DE CUALESQUIERA GRUPOS PROTECTORES POR TRATAMIENTO CON UN ACIDO O BASE MINERALES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB838320943A GB8320943D0 (en) | 1983-08-03 | 1983-08-03 | Organic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AR240796A2 true AR240796A2 (es) | 1991-02-28 |
| AR240796A1 AR240796A1 (es) | 1991-02-28 |
Family
ID=10546748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR297435A AR240796A1 (es) | 1983-08-03 | 1984-08-02 | Procedimiento para la preparacion de alcoholes aromaticos tio substituidos y compuesto intermediario utilizado en el mismo |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US4665189A (es) |
| EP (2) | EP0134111B1 (es) |
| JP (1) | JPS6064954A (es) |
| KR (1) | KR920005382B1 (es) |
| AR (1) | AR240796A1 (es) |
| AT (2) | ATE58899T1 (es) |
| AU (1) | AU575575B2 (es) |
| CA (2) | CA1297632C (es) |
| CY (1) | CY1539A (es) |
| DE (2) | DE3475516D1 (es) |
| DK (1) | DK167008B1 (es) |
| EG (1) | EG16349A (es) |
| ES (1) | ES534825A0 (es) |
| FI (1) | FI81084C (es) |
| GB (2) | GB8320943D0 (es) |
| GR (1) | GR80015B (es) |
| HK (1) | HK51090A (es) |
| HU (2) | HU199457B (es) |
| IE (1) | IE57691B1 (es) |
| IL (1) | IL72539A (es) |
| MY (1) | MY102762A (es) |
| NZ (1) | NZ209050A (es) |
| PH (1) | PH21029A (es) |
| PL (1) | PL144336B1 (es) |
| PT (1) | PT79002B (es) |
| SG (1) | SG28590G (es) |
| SU (1) | SU1402256A3 (es) |
| ZA (1) | ZA845923B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5143931A (en) * | 1982-06-24 | 1992-09-01 | Smithkline Beecham Corporation | Leukotriene antagonists containing tetrazolyl groups |
| AU573774B2 (en) * | 1984-02-02 | 1988-06-23 | Vanguard, Inc. | Sailboat traveler track |
| GB8432144D0 (en) * | 1984-12-20 | 1985-01-30 | Lilly Industries Ltd | Organic compounds |
| GB8502258D0 (en) * | 1985-01-30 | 1985-02-27 | Lilly Industries Ltd | Organic compounds |
| US4939279A (en) * | 1985-04-19 | 1990-07-03 | Smithkline Beecham Corporation | Leukotriene antagonists |
| US4874792A (en) * | 1985-04-19 | 1989-10-17 | Smithkline Beckman Corporation | Thiophenyl Alkanoic acids useful as leukotriene antagonists |
| US4937253A (en) * | 1985-04-19 | 1990-06-26 | Smithkline Beecham Corporation | Ester prodrugs |
| EP0358240B1 (en) * | 1985-04-19 | 1993-06-09 | Smithkline Beecham Corporation | Intermediates for the preparation of leukotriene antagonists |
| GB8530222D0 (en) * | 1985-12-07 | 1986-01-15 | Lilly Industries Ltd | Organic compounds |
| US4785004A (en) * | 1985-12-23 | 1988-11-15 | Ciba-Geigy Corporation | Aromatic thioethers |
| GB8709547D0 (en) * | 1987-04-22 | 1987-05-28 | Lilly Industries Ltd | Organic compounds |
| GB8709546D0 (en) * | 1987-04-22 | 1987-05-28 | Lilly Industries Ltd | Pharmaceutical use of organic compounds |
| US5314918A (en) * | 1987-06-24 | 1994-05-24 | Smithkline Beecham Corporation | Leukotriene antagonists |
| PT87616B (pt) * | 1987-06-24 | 1992-09-30 | Smithkline Beecham Corp | Processo de preparacao de antagonistas do leucotrieno e de composicoes farmaceuticas |
| GB8725260D0 (en) * | 1987-10-28 | 1987-12-02 | Lilly Industries Ltd | Organic compounds |
| AU610528B2 (en) * | 1987-10-29 | 1991-05-23 | Smithkline Beckman Corporation | Leukotriene antagonists |
| GB8807016D0 (en) * | 1988-03-24 | 1988-04-27 | Lilly Industries Ltd | Organic compounds & their pharmaceutical use |
| US5149717A (en) * | 1988-03-29 | 1992-09-22 | Ciba-Geigy Corporation | Alkanophenones useful for treating allergies |
| EP0360246B1 (en) * | 1988-09-21 | 1994-03-30 | G.D. Searle & Co. | 3-Oxiranyl benzoic acids and derivatives thereof |
| US4954513A (en) * | 1988-12-23 | 1990-09-04 | Smithkline Beecham Corporation | Leukotriene antagonists |
| US4954520A (en) * | 1989-01-19 | 1990-09-04 | G. D. Searle & Co. | 1,3-dioxolane derivatives useful in the treatment of inflammation |
| EP0419410A3 (en) * | 1989-09-19 | 1991-08-14 | Ciba-Geigy Ag | Alkanophenones |
| HU9401975D0 (en) * | 1990-08-01 | 1994-09-28 | Smithkline Beecham Corp | New intermediates for producing 2 -hydroxy-3-sulfido-3-phenyl-propionic acids |
| MY118813A (en) | 1997-02-12 | 2005-01-31 | Smithkline Beecham Corp | Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids |
| US6369226B1 (en) * | 1999-06-21 | 2002-04-09 | Agouron Pharmaceuticals, Inc. | Substituted benzamide inhibitors of rhinovirus 3C protease |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3649679A (en) * | 1968-08-15 | 1972-03-14 | Lilly Co Eli | Substituted phenylalkanoic acid derivatives ii |
| GB1520812A (en) * | 1975-10-02 | 1978-08-09 | Lafon Labor | Benzhydrylsulphinyl derivatives |
| US4513005A (en) * | 1981-06-18 | 1985-04-23 | Lilly Industries Limited | SRS-A antagonists |
| CA1255329A (en) * | 1984-10-19 | 1989-06-06 | Mitsuru Tanemura | Benzoic acid derivatives |
| US4755524A (en) * | 1986-01-31 | 1988-07-05 | G. D. Searle & Co. | Novel phenolic thioethers as inhibitors of 5-lipoxygenase |
-
1983
- 1983-08-03 GB GB838320943A patent/GB8320943D0/en active Pending
-
1984
- 1984-07-26 CA CA000459715A patent/CA1297632C/en not_active Expired - Fee Related
- 1984-07-30 PT PT79002A patent/PT79002B/pt not_active IP Right Cessation
- 1984-07-30 NZ NZ209050A patent/NZ209050A/xx unknown
- 1984-07-30 US US06/635,863 patent/US4665189A/en not_active Ceased
- 1984-07-30 AU AU31304/84A patent/AU575575B2/en not_active Ceased
- 1984-07-30 IL IL72539A patent/IL72539A/xx not_active IP Right Cessation
- 1984-07-31 GB GB08419526A patent/GB2144422B/en not_active Expired
- 1984-07-31 DE DE8484305203T patent/DE3475516D1/de not_active Expired
- 1984-07-31 AT AT86106093T patent/ATE58899T1/de active
- 1984-07-31 EP EP84305203A patent/EP0134111B1/en not_active Expired
- 1984-07-31 ZA ZA845923A patent/ZA845923B/xx unknown
- 1984-07-31 PH PH31052A patent/PH21029A/en unknown
- 1984-07-31 EP EP86106093A patent/EP0201823B1/en not_active Expired - Lifetime
- 1984-07-31 PL PL1984249009A patent/PL144336B1/pl unknown
- 1984-07-31 AT AT84305203T patent/ATE39110T1/de not_active IP Right Cessation
- 1984-07-31 DE DE8686106093T patent/DE3483722D1/de not_active Expired - Fee Related
- 1984-07-31 DK DK371384A patent/DK167008B1/da not_active IP Right Cessation
- 1984-08-01 FI FI843043A patent/FI81084C/fi not_active IP Right Cessation
- 1984-08-01 HU HU884449A patent/HU199457B/hu not_active IP Right Cessation
- 1984-08-01 EG EG490/84A patent/EG16349A/xx active
- 1984-08-01 SU SU843777634A patent/SU1402256A3/ru active
- 1984-08-01 IE IE1989/84A patent/IE57691B1/en not_active IP Right Cessation
- 1984-08-01 HU HU842937A patent/HU196956B/hu not_active IP Right Cessation
- 1984-08-02 KR KR1019840004617A patent/KR920005382B1/ko not_active Expired
- 1984-08-02 AR AR297435A patent/AR240796A1/es active
- 1984-08-02 ES ES534825A patent/ES534825A0/es active Granted
- 1984-08-02 JP JP59163458A patent/JPS6064954A/ja active Granted
- 1984-08-02 GR GR80015A patent/GR80015B/el unknown
-
1987
- 1987-09-22 MY MYPI87001855A patent/MY102762A/en unknown
-
1989
- 1989-11-01 US US07/430,697 patent/USRE33300E/en not_active Expired - Lifetime
- 1989-11-01 US US07/430,105 patent/US4963578A/en not_active Expired - Lifetime
-
1990
- 1990-04-10 SG SG285/90A patent/SG28590G/en unknown
- 1990-06-05 CA CA000615758A patent/CA1301181C/en not_active Expired - Fee Related
- 1990-06-28 HK HK510/90A patent/HK51090A/xx unknown
- 1990-11-16 CY CY1539A patent/CY1539A/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR240796A2 (es) | Procedimiento para la preparacion de alcoholes aromaticos tio substituidos y compuesto intermediarioutilizado en el mismo | |
| ES2054826T3 (es) | Peptidos con actividad inhibidora de colagenasa. | |
| AR241018A2 (es) | "n-(ciclopropil-triazinil-y-pirimidinil)-n'- (bencensulfonil) ureas con accion herbicida, procedimiento para su preparacion, intermediarios y composiciones que las contienen" | |
| LU90838I2 (fr) | Zometa-acide zol-dronique et ses sels pharmaceutiquement acceptables | |
| ES2070175T3 (es) | Derivados de acido 4-oxoquinolino-3-carboxilico, su preparacion y su uso. | |
| ES8500727A1 (es) | Procedimiento para la obtencion de derivados de feniletilamina | |
| AR246512A1 (es) | Procedimiento para la produccion de 2,2,6,6-tetraalquil-4-piperidilaminas. | |
| MX166753B (es) | Mejoras a composicion que contiene nitrogeno y fosforo para lubricantes a base de agua | |
| ATE73168T1 (de) | Reaktionsprodukte von alkenylsuccinverbindungen mit aromatischen aminen und diese enthaltende schmiermittelzusammensetzungen. | |
| ZA848389B (en) | The use of corrosion inhibitors in aqueous systems | |
| ES8705394A1 (es) | Procedimiento para la obtencion de imidazoles sustituidos | |
| ES8706148A1 (es) | Un procedimiento para preparar nuevos derivados de carbapenem. | |
| PT77081A (en) | Process for the manufacture of novel muramyl peptides | |
| ES8502086A1 (es) | Procedimiento para la obtencion de derivados de feniletilamina | |
| AR240813A2 (es) | N-fenilsulfonil-n'-pirimidinilureas, procedimiento para su preparacion, composiciones que las contienen e intermediarios para uso exclusivo en dicho procedimiento | |
| FI901696A0 (fi) | Framstaellning av substituerad eten. | |
| ES8206506A1 (es) | Procedimiento de preparacion de amino alcosi furanos o tio- fenos. | |
| ES8504680A1 (es) | Un procedimiento para la preparacion de derivados de benzamida | |
| DK0635021T3 (da) | Fremgangsmåde til fremstilling af derivater af bis(aminomethyl)phosphinsyre | |
| MX9304445A (es) | Diazabicicloalquenos novedosos y procedimientos para su preparacion. | |
| ES8505654A1 (es) | Procedimiento para preparar derivados de piridilaminoeteno | |
| ES8600232A1 (es) | Procedimiento para preparar bencenos sustituidos. |