AT124745B - Process for the preparation of the mono- or di [β-oxyäthylamine] salt of 3-acetylamino-4-oxybenzolaric acid (1). - Google Patents
Process for the preparation of the mono- or di [β-oxyäthylamine] salt of 3-acetylamino-4-oxybenzolaric acid (1).Info
- Publication number
- AT124745B AT124745B AT124745DA AT124745B AT 124745 B AT124745 B AT 124745B AT 124745D A AT124745D A AT 124745DA AT 124745 B AT124745 B AT 124745B
- Authority
- AT
- Austria
- Prior art keywords
- salt
- acetylamino
- mono
- acid
- preparation
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title claims description 10
- 238000000034 method Methods 0.000 title claims description 3
- 238000002360 preparation method Methods 0.000 title claims description 3
- 239000002253 acid Substances 0.000 title description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
- 239000012736 aqueous medium Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 235000019621 digestibility Nutrition 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
<Desc/Clms Page number 1>
Verfahren zur Darstellung des Mono- oder Di-[ss-oxyäthylamin]-Salzes der 3-Acetyl- amino-4-oxybenzolarsinsäure-(1).
EMI1.1
Salze bildet, die gegenüber den bislang bekannten Salzen dieser Säure den Vorzug grösserer Bekömmlich- keit und Haltbarkeit in Lösung zeigen und daher für die medizinische Praxis, vor allem bei der Behandlung von Kindern, Vorteile bieten. Je nachdem, ob man ein oder zwei Mol. Äthanolamin je Mol. Arsinsäure verwendet, bilden sich Mono-oder Di-[ss-oxyäthylamin]-Salze. Es ist nicht erforderlich, die entstandenen Salze erst zu isolieren, man kann vielmehr auch die durch Zusammengeben der Komponenten in wässerigem Medium erhaltenen Lösungen unmittelbar zum Gebrauch verwenden. Um die Stabilität der Lösungen zu erhöhen, ist es zweckmässig, den Lösungen geringe Mengen Natriumsulfit zuzusetzen.
Beispiel : 275 3-Acetylamino-4-oxybenzolarsinsäure- (1) werden mit 220 em3 Wasser angeteigt und 61 g ss-Oxyäthylamin, in 20 cm3 Wasser gelöst, zugesetzt. Nachdem durch Aufkochen gelöst wurde, setzt man 9 g Entfärbungskohle zu und filtriert. Das Filtrat (350 ein3) wird mit 70 ein3 Aceton versetzt und dann unter Rühren 350 cm Alkohol zugegeben. Das entstandene Salz kristallisiert nach kurzer Zeit aus ; nach dem Absaugen und Waschen mit Alkohol und Äther wird es im Vakuum getrocknet. Das Produkt bildet ein weisses kristallinisches Pulver, welches in 1, 5-2 Teilen Wasser von 350 C leicht, in Aceton, Äther und Benzin schwer löslich ist.
Verwendet man unter Einhaltung der gleichen Bedingungen 122 g ss-Oxyäthylamin, so erhält man das entsprechende Di-[ss-oxyäthylamin]-Salz.
**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.
<Desc / Clms Page number 1>
Process for the preparation of the mono- or di- [ss-oxyethylamine] salt of 3-acetylamino-4-oxybenzolaric acid (1).
EMI1.1
Forms salts which, compared to the previously known salts of this acid, have the advantage of greater digestibility and shelf life in solution and therefore offer advantages for medical practice, especially in the treatment of children. Depending on whether one or two moles of ethanolamine is used per mole of arsic acid, mono- or di- [β-oxyethylamine] salts are formed. It is not necessary first to isolate the resulting salts; rather, the solutions obtained by combining the components in an aqueous medium can also be used directly for use. To increase the stability of the solutions, it is advisable to add small amounts of sodium sulfite to the solutions.
Example: 275 3-acetylamino-4-oxybenzolaric acid- (1) are made into a paste with 220 cubic meters of water and 61 g of β-oxyethylamine, dissolved in 20 cm3 of water, are added. After it has been dissolved by boiling, 9 g of decolorizing charcoal are added and the mixture is filtered. The filtrate (350 in3) is treated with 70 in3 acetone and then 350 cm of alcohol is added with stirring. The resulting salt crystallizes out after a short time; after suctioning off and washing with alcohol and ether, it is dried in vacuo. The product forms a white crystalline powder, which is easily soluble in 1.5-2 parts of water at 350 C, and sparingly soluble in acetone, ether and petrol.
If 122 g of β-oxyethylamine are used while maintaining the same conditions, the corresponding di- [β-oxyethylamine] salt is obtained.
** WARNING ** End of DESC field may overlap beginning of CLMS **.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE124745X | 1929-06-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT124745B true AT124745B (en) | 1931-10-10 |
Family
ID=29277424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT124745D AT124745B (en) | 1929-06-14 | 1930-05-14 | Process for the preparation of the mono- or di [β-oxyäthylamine] salt of 3-acetylamino-4-oxybenzolaric acid (1). |
Country Status (1)
| Country | Link |
|---|---|
| AT (1) | AT124745B (en) |
-
1930
- 1930-05-14 AT AT124745D patent/AT124745B/en active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE527715C (en) | Process for the preparation of easily soluble salts of 3-acetylamino-4-oxybenzene-1-arsic acid | |
| AT117232B (en) | Process for the preparation of salts of antimonic acid and its derivatives. | |
| AT153203B (en) | Process for the preparation of water-soluble mercury compounds. | |
| AT117056B (en) | Process for the preparation of cellulose ethers. | |
| AT206580B (en) | ||
| AT120431B (en) | Process for the production of double compounds of urea with sodium iodine. | |
| DE723790C (en) | Process for the production of water-soluble compounds of 4-aminobenzene sulfonamides | |
| AT100734B (en) | Process for the preparation of sodium tribismutyl tartrate. | |
| AT160687B (en) | Process for the preparation of aminobenzenesulfonic acid amide compounds. | |
| DE495103C (en) | Process for the preparation of compounds of the ª † -aminoglycomonoaether and their derivatives | |
| AT70938B (en) | Process for the preparation of durable compounds of hydrogen peroxide with organic substances. | |
| AT262017B (en) | Process for the production of an acidic, iodine-containing, disinfecting cleaning agent | |
| AT133143B (en) | Process for the preparation of readily soluble sodium salts of 4-oxy-3-acylaminobenzolaric acids (1) or their substitution products. | |
| AT111255B (en) | Process for the preparation of bile acid salts of the natural or synthetic china alkaloids. | |
| AT158406B (en) | Process for the preparation of sulfonic acids of higher molecular weight acylated aliphatic amino ethers or their alkali salts. | |
| AT59697B (en) | Process for the preparation of a new yohimbine salt. | |
| DE560218C (en) | Process for the preparation of arsenic compounds | |
| DE607535C (en) | Process for the preparation of sulfonic acids of the diaminodiphenyl series | |
| AT150477B (en) | Process for the preparation of guaiacol compounds. | |
| AT147483B (en) | Process for the preparation of compounds of methyl N-methyltetrahydronicotinate. | |
| AT131132B (en) | Process for the preparation of 2-oxyacetic acid benzimidazolar acids. | |
| AT153205B (en) | Process for the preparation of 3,5-diiodo-4-oxyacetophenone. | |
| CH149249A (en) | Process for the preparation of the mono-oxy-ethylamine salt of 3-acetylamino-4-oxybenzene-arsic acid. | |
| DE1051103B (en) | Process for the production of an alkali, alkaline earth and halogen-free salt substitute | |
| CH141693A (en) | Process for preparing a mixture of B and γ-phenylazo-a, a-diaminopyridine. |