AT206591B - Process for the production of 6 β-methyl-3-oxo-Δ <4> -steroids of the androstane and pregnane series - Google Patents

Process for the production of 6 β-methyl-3-oxo-Δ <4> -steroids of the androstane and pregnane series

Info

Publication number
AT206591B
AT206591B AT363256A AT363256A AT206591B AT 206591 B AT206591 B AT 206591B AT 363256 A AT363256 A AT 363256A AT 363256 A AT363256 A AT 363256A AT 206591 B AT206591 B AT 206591B
Authority
AT
Austria
Prior art keywords
methyl
androstane
oxo
steroids
production
Prior art date
Application number
AT363256A
Other languages
German (de)
Original Assignee
British Drug Houses Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Drug Houses Ltd filed Critical British Drug Houses Ltd
Application granted granted Critical
Publication of AT206591B publication Critical patent/AT206591B/en

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  • Steroid Compounds (AREA)

Description

  

   <Desc/Clms Page number 1> 
 



   Verfahren zur Herstellung. von neuen   6 ss -Methyl-3-oxo-A -steroiden   der   Androstan-und   Pregnanreihe 
Die Erfindung betrifft ein Verfahren zur Herstellung von neuen   6ss-Methyl-3-oxo-#4-steroiden   der   Androstan-und Pregnanreihe,   welche auf Grund ihrer biologischen Wirksamkeit (z. B. anabole und androgene Aktivität oder gestagene Eigenschaften) oder als Zwischenprodukte bei der Herstellung von Verbin- 
 EMI1.1 
 
 EMI1.2 
 
 EMI1.3 
 -Methyl-3-oxo-A" -steroidePregnanreihe der allgemeinen Formel   II   
 EMI1.4 
 mit Mangandioxyd oxydiert. 



     Beispiel : 6ss-Methyltestosteron.-600   mg 6ss-Methylandrost-4-en-3ss, 17ss-diolwerdeninl20ml trockenem Benzol 3 Tage lang mit 4 g frisch hergestelltem Mangandioxyd geschüttelt. Anschliessend wird das anorganische Material abfiltriert und mehrmals mit warmem Benzol gewaschen. Das Filtrat und die 

 <Desc/Clms Page number 2> 

 Waschflüssigkeiten werden vereinigt und mit verdünnter Salzsäure, verdünnter wässeriger   Natriumcarbo-   natlösung sowie schliesslich mit Wasser gewaschen. Der nach dem Trocknen und nach Abdampfen des Lösungsmittels verbleibende Rückstand wird aus Aceton/Hexan umkristallisiert, wobei 17ss-Hydroxy-6ss- 
 EMI2.1 
 



   - Methyltestosteron) inPATENTANSPRUCH : 
Verfahren zur Herstellung von neuen   6ss-Methyl-3-oxo#4-steroiden der Androstan- und Pregnan-   reihe der allgemeinen Formel 
 EMI2.2 
 dadurch gekennzeicnnet, dass man ein 3ss-Hydroxy-6 ss-methyl-A-steroid der Androstan-und Pregnanreihe der allgemeinen Formel 
 EMI2.3 
 

**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.



   <Desc / Clms Page number 1>
 



   Method of manufacture. of new 6 ss -methyl-3-oxo-A -steroids of the androstane and pregnane series
The invention relates to a process for the production of new 6ss-methyl-3-oxo- # 4-steroids of the androstane and pregnane series, which because of their biological effectiveness (e.g. anabolic and androgenic activity or gestagenic properties) or as intermediates the production of connections
 EMI1.1
 
 EMI1.2
 
 EMI1.3
 -Methyl-3-oxo-A "-steroid Pregnane series of the general formula II
 EMI1.4
 oxidized with manganese dioxide.



     Example: 6ss-Methyltestosteron.-600 mg 6ss-Methylandrost-4-en-3ss, 17ss-diol are shaken in 20ml dry benzene for 3 days with 4g freshly made manganese dioxide. The inorganic material is then filtered off and washed several times with warm benzene. The filtrate and the

 <Desc / Clms Page number 2>

 Wash liquids are combined and washed with dilute hydrochloric acid, dilute aqueous sodium carbonate solution and finally with water. The residue remaining after drying and evaporation of the solvent is recrystallized from acetone / hexane, 17ss-hydroxy-6ss-
 EMI2.1
 



   - methyltestosterone) in PATENT CLAIM:
Process for the production of new 6ss-methyl-3-oxo # 4-steroids of the androstane and pregnan series of the general formula
 EMI2.2
 characterized in that one is a 3ss-hydroxy-6ss-methyl-A-steroid of the androstane and pregnane series of the general formula
 EMI2.3
 

** WARNING ** End of DESC field may overlap beginning of CLMS **.

Claims (1)

mit Hilfe von Mangandioxyd oxydiert. **WARNUNG** Ende CLMS Feld Kannt Anfang DESC uberlappen**. oxidized with the help of manganese dioxide. ** WARNING ** End of CLMS field may overlap beginning of DESC **.
AT363256A 1955-06-20 1956-06-18 Process for the production of 6 β-methyl-3-oxo-Δ <4> -steroids of the androstane and pregnane series AT206591B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB206591X 1955-06-20

Publications (1)

Publication Number Publication Date
AT206591B true AT206591B (en) 1959-12-10

Family

ID=10149524

Family Applications (1)

Application Number Title Priority Date Filing Date
AT363256A AT206591B (en) 1955-06-20 1956-06-18 Process for the production of 6 β-methyl-3-oxo-Δ <4> -steroids of the androstane and pregnane series

Country Status (1)

Country Link
AT (1) AT206591B (en)

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