AT241900B - Process for the production of a veterinary preparation for the control of lungworm infections in sheep and cattle - Google Patents
Process for the production of a veterinary preparation for the control of lungworm infections in sheep and cattleInfo
- Publication number
- AT241900B AT241900B AT864961A AT864961A AT241900B AT 241900 B AT241900 B AT 241900B AT 864961 A AT864961 A AT 864961A AT 864961 A AT864961 A AT 864961A AT 241900 B AT241900 B AT 241900B
- Authority
- AT
- Austria
- Prior art keywords
- infections
- lungworm
- production
- cattle
- sheep
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 6
- 238000002360 preparation method Methods 0.000 title description 8
- 208000015181 infectious disease Diseases 0.000 title description 6
- 241000243789 Metastrongyloidea Species 0.000 title description 5
- 238000004519 manufacturing process Methods 0.000 title description 4
- 241000283690 Bos taurus Species 0.000 title description 3
- 241001494479 Pecora Species 0.000 title description 3
- VEPOHXYIFQMVHW-XOZOLZJESA-N 2,3-dihydroxybutanedioic acid (2S,3S)-3,4-dimethyl-2-phenylmorpholine Chemical compound OC(C(O)C(O)=O)C(O)=O.C[C@H]1[C@@H](OCCN1C)c1ccccc1 VEPOHXYIFQMVHW-XOZOLZJESA-N 0.000 claims description 7
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims description 7
- 230000009974 thixotropic effect Effects 0.000 claims description 6
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims description 2
- UGMCXQCYOVCMTB-UHFFFAOYSA-K dihydroxy(stearato)aluminium Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[Al](O)O UGMCXQCYOVCMTB-UHFFFAOYSA-K 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 description 4
- 239000000243 solution Substances 0.000 description 3
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 2
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 238000000265 homogenisation Methods 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Description
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Verfahren zur Herstellung eines Veterinärpräparates für die Bekämpfung von Lungenwurminfektionen bei Schafen und Rindern
In der österr. Patentschrift Nr. 236691 ist ein Verfahren zur Bekämpfung von Lungenwurminfektionen bei Schafen und Rindern beschrieben worden. Gemäss dieser Erfindung werden die Infektionen mit einem phenazinenthaltenden Präparat bekämpft.
Die Erfindung bezieht sich auf ein Verfahren zur Herstellung von phenazinhaltigen Veterinärpräparaten, welche für die Bekämpfung von Lungenwurminfektionen geeignet sind, in Form von Dispersionen bzw. Injektionsflüssigkeiten.
Weil das Phenazin in Wasser schlecht lösbar ist, was bei der Herstellung von Injektionsflüssigkeiten Schwierigkeiten bereiten kann, wird die Herstellung einer thixotropen Injektionsflüssigkeit bevorzugt.
Eine solche Flüssigkeit lässt sich dadurch herstellen, dass 0, 1-15 Gew.-Teilen Phenazin 85-99, 9 Gew. Teile einer thixotropen Lösung von 1 bis 5 Gew.-Teilen eines Aluminiumsalzes einer aliphatischen Carbonsäure mit 14 - 20 Kohlenstoffatomen und 95-99 Gew.-Teile eines Esters eines aliphatischen Alkohols mit 1 - 6 Kohlenstoffatomen und einer aliphatischen Carbonsäure mit 14 - 20 Kohlenstoffatomen zugesetzt werden, wonach dieses Gemisch homogenisiert und sterilisiert wird.
Beispiel : 15 g pulveriges Phenazin wurden mit einer thixotropen Lösung von 3 g Aluminiummonostearat in 97 g Isopropylmyristat zu 100 ml angefüllt. Nach Sterilisierung ist die thixotrope Flüssigkeit zur Verwendung für Injektionen fertig.
PATENTANSPRÜCHE :
1. Verfahren zur Herstellung eines zur Bekämpfung von Lungenwurmlarven der infektiösen Stufe geeigneten Veterinärpräparates, in Form von Dispersionen bzw. Injektionsflüssigkeiten, dadurch gekennzeichnet, dass feingemahlenes Phenazin in einer Menge von 0,1 bis 15 Gew.-Teilen mit 85 bis 99 9 Gew.-Teilen einer thixotropen Lösung von 1 bis 5 Gew.-Teilen eines Aluminiumsalzes einer aliphatischen Carbonsäure mit 14 - 20 Kohlenstoffatomen und 95-99 Gew.-Teilen eines Esters eines aliphatischen Alkohols mit 1-6 Kohlenstoffatomen und einer aliphatischen Carbonsäure mit 14-20 Kohlenstoffatomen gemischt und das erzeugte Präparat, gegebenenfalls nach Homogenisierung, sterilisiert wird.
**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.
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Process for the production of a veterinary preparation for the control of lungworm infections in sheep and cattle
In the Austrian patent specification No. 236691 a method for controlling lungworm infections in sheep and cattle has been described. According to this invention, the infections are combated with a preparation containing phenazine.
The invention relates to a process for the production of veterinary preparations containing phenazine, which are suitable for combating lungworm infections, in the form of dispersions or injection liquids.
Because the phenazine is poorly soluble in water, which can cause difficulties in the preparation of injection liquids, the preparation of a thixotropic injection liquid is preferred.
Such a liquid can be prepared by adding 0.1-15 parts by weight of phenazine 85-99.9 parts by weight of a thixotropic solution of 1 to 5 parts by weight of an aluminum salt of an aliphatic carboxylic acid with 14-20 carbon atoms and 95 -99 parts by weight of an ester of an aliphatic alcohol with 1-6 carbon atoms and an aliphatic carboxylic acid with 14-20 carbon atoms are added, after which this mixture is homogenized and sterilized.
Example: 15 g of powdery phenazine were made up to 100 ml with a thixotropic solution of 3 g of aluminum monostearate in 97 g of isopropyl myristate. After sterilization, the thixotropic liquid is ready to be used for injections.
PATENT CLAIMS:
1. A process for the production of a veterinary preparation suitable for combating lungworm larvae of the infectious stage, in the form of dispersions or injection liquids, characterized in that finely ground phenazine in an amount of 0.1 to 15 parts by weight with 85 to 99 9 wt. Parts of a thixotropic solution of 1 to 5 parts by weight of an aluminum salt of an aliphatic carboxylic acid having 14-20 carbon atoms and 95-99 parts by weight of an ester of an aliphatic alcohol having 1-6 carbon atoms and an aliphatic carboxylic acid having 14-20 carbon atoms mixed and the preparation produced, optionally after homogenization, is sterilized.
** WARNING ** End of DESC field may overlap beginning of CLMS **.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL252142 | 1960-05-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT241900B true AT241900B (en) | 1965-08-10 |
Family
ID=19752385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT864961A AT241900B (en) | 1960-05-30 | 1960-08-03 | Process for the production of a veterinary preparation for the control of lungworm infections in sheep and cattle |
Country Status (1)
| Country | Link |
|---|---|
| AT (1) | AT241900B (en) |
-
1960
- 1960-08-03 AT AT864961A patent/AT241900B/en active
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