AT256847B - Process for the production of new sulfonamides - Google Patents
Process for the production of new sulfonamidesInfo
- Publication number
- AT256847B AT256847B AT455565A AT455565A AT256847B AT 256847 B AT256847 B AT 256847B AT 455565 A AT455565 A AT 455565A AT 455565 A AT455565 A AT 455565A AT 256847 B AT256847 B AT 256847B
- Authority
- AT
- Austria
- Prior art keywords
- general formula
- alkyl
- production
- aralkyl
- cycloalkyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 4
- 229940124530 sulfonamide Drugs 0.000 title claims description 4
- 150000003456 sulfonamides Chemical class 0.000 title claims description 4
- 125000003545 alkoxy group Chemical group 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 3
- 229910052736 halogen Inorganic materials 0.000 claims description 3
- 125000005843 halogen group Chemical group 0.000 claims description 3
- 150000005006 2-aminopyrimidines Chemical class 0.000 claims description 2
- 239000004215 Carbon black (E152) Substances 0.000 claims description 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 229930195733 hydrocarbon Natural products 0.000 claims description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 230000003178 anti-diabetic effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
<Desc/Clms Page number 1>
Verfahren zur Herstellung von neuen Sulfonamiden
EMI1.1
dass Benzolsulfonylamido-pyrimidine, die im Benzolkern einen Amidoalkyl-Substituenten tragen, sich durch eine besonders starke und langanhaltende antidiabetische Wirkung auszeichnen.
Die Erfindung betrifft die Herstellung von blutzuckersenkenden Sulfonamiden der allgemeinen Formel I :
EMI1.2
in welcher X einen geraden oder verzweigten Kohlenwasserstoffrest von 1 bis 4 C-Atomen, A einen gegebenenfalls durch Halogen, Alkyl, Alkoxy oder Trifluormethyl substituierten Alkyl-, Cycloalkyl-, Aryl-, Aralkyl-, Arylmercaptoalkyl- oder Aryloxyalkyl- Rest und Ri einen gegebenenfalls durch Halogen substituierten Alkyl-, Cycloalkyl-, Aryl-, Aralkyl-, Alkoxy-, Alkoxyalkyl-oder Alkoxyalkoxy-Rest bedeuten.
Die neuen Verbindungen können in an sich üblicher Weise hergestellt werden. Dabei kommt folgende Darstellungsmethode zur Anwendung :
Umsetzung von Verbindungen der allgemeinen Formel II :
EMI1.3
in der A und X die oben angegebene Bedeutung haben, mit 2-Amino-pyrimidinenderallgemeinenFormel III :
EMI1.4
EMI1.5
<Desc/Clms Page number 2>
EMI2.1
<Desc / Clms Page number 1>
Process for the production of new sulfonamides
EMI1.1
that benzenesulfonylamido-pyrimidines, which have an amidoalkyl substituent in the benzene nucleus, are characterized by a particularly strong and long-lasting antidiabetic effect.
The invention relates to the production of blood sugar-lowering sulfonamides of the general formula I:
EMI1.2
in which X is a straight or branched hydrocarbon radical of 1 to 4 carbon atoms, A is an optionally substituted by halogen, alkyl, alkoxy or trifluoromethyl alkyl, cycloalkyl, aryl, aralkyl, arylmercaptoalkyl or aryloxyalkyl radical and Ri is an optionally alkyl, cycloalkyl, aryl, aralkyl, alkoxy, alkoxyalkyl or alkoxyalkoxy radical substituted by halogen.
The new compounds can be prepared in a conventional manner. The following display method is used:
Implementation of compounds of the general formula II:
EMI1.3
in which A and X have the meanings given above, with 2-amino-pyrimidines of the general formula III:
EMI1.4
EMI1.5
<Desc / Clms Page number 2>
EMI2.1
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEB0076848 | 1964-05-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT256847B true AT256847B (en) | 1967-09-11 |
Family
ID=6979235
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT595366A AT256862B (en) | 1964-05-20 | 1965-05-19 | Process for the production of new sulfonamides |
| AT595266A AT256861B (en) | 1964-05-20 | 1965-05-19 | Process for the production of new sulfonamides |
| AT455565A AT256847B (en) | 1964-05-20 | 1965-05-19 | Process for the production of new sulfonamides |
| AT595166A AT256860B (en) | 1964-05-20 | 1965-05-19 | Process for the production of new sulfonamides |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT595366A AT256862B (en) | 1964-05-20 | 1965-05-19 | Process for the production of new sulfonamides |
| AT595266A AT256861B (en) | 1964-05-20 | 1965-05-19 | Process for the production of new sulfonamides |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT595166A AT256860B (en) | 1964-05-20 | 1965-05-19 | Process for the production of new sulfonamides |
Country Status (2)
| Country | Link |
|---|---|
| AT (4) | AT256862B (en) |
| DK (3) | DK109038C (en) |
-
1965
- 1965-05-19 DK DK429266A patent/DK109038C/en active
- 1965-05-19 AT AT595366A patent/AT256862B/en active
- 1965-05-19 AT AT595266A patent/AT256861B/en active
- 1965-05-19 AT AT455565A patent/AT256847B/en active
- 1965-05-19 DK DK429466A patent/DK109039C/en active
- 1965-05-19 DK DK250265A patent/DK109599C/en active
- 1965-05-19 AT AT595166A patent/AT256860B/en active
Also Published As
| Publication number | Publication date |
|---|---|
| DK109038C (en) | 1968-03-11 |
| DK109599C (en) | 1968-05-20 |
| AT256860B (en) | 1967-09-11 |
| AT256861B (en) | 1967-09-11 |
| DK109039C (en) | 1968-03-11 |
| AT256862B (en) | 1967-09-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE1792776A1 (en) | POULTRY REPRODUCTOR WITH INSECTICIDAL, MICROBICIDAL AND HERBICIDAL EFFECT | |
| DE1265918B (en) | Core sand binding agent for foundry purposes | |
| CH440292A (en) | Process for the preparation of new aminopyrazoles | |
| DE2022820A1 (en) | Process for the production of highly coercive chromium dioxide | |
| AT265286B (en) | Process for the production of new sulfonamides | |
| EP0173258A3 (en) | Substituted 2-phenyl-1,3-dioxolanes | |
| AT243444B (en) | Process for the production of new 3α-phenyl-garnetan derivatives | |
| AT48347B (en) | Process for the preparation of azidyl compounds of alkylated iminopyrimidines. | |
| AT149170B (en) | Seed dressing. | |
| DE1160234B (en) | Fungicides | |
| AT221517B (en) | Process for the production of new, solid, durable diazonium compounds | |
| AT233565B (en) | Process for the production of new derivatives of hydrogenated pyridones | |
| AT164792B (en) | Process for the production of new mercury compounds | |
| AT228202B (en) | Process for the preparation of new pyridine derivatives | |
| AT226229B (en) | Process for the preparation of new 5-nitrofuran derivatives | |
| AT266137B (en) | Process for the production of new pyridyl-dihydroisoquinolines and their salts | |
| AT234709B (en) | Process for the production of new hydrazino-triazines | |
| CH405334A (en) | Process for the preparation of substituted 2- (2'-hydroxyphenyl) benzotriazole compounds | |
| AT250352B (en) | Process for the preparation of new quaternary 4-pyridylthioethers | |
| AT288780B (en) | Pesticides | |
| AT259719B (en) | Process for the preparation of new, water-insoluble monoazo dyes | |
| AT277412B (en) | Process for the preparation of new, water-insoluble monoazo dyes | |
| AT214442B (en) | Process for the preparation of new p-benzoquinone-bis-hydrazones | |
| AT276407B (en) | Process for the preparation of new 1,2,3,4-tetrahydroquinazoline derivatives and their salts | |
| AT326627B (en) | METHOD FOR PRODUCING NEW SUBSTITUTED CUMOLES |