AT279626B - Verfahren zur herstellung von neuen 3-(4-r-piperazino)-tert.-amino-propiophenonen, ihren quaternaeren ammoniumverbindungen und salzen - Google Patents

Verfahren zur herstellung von neuen 3-(4-r-piperazino)-tert.-amino-propiophenonen, ihren quaternaeren ammoniumverbindungen und salzen

Info

Publication number
AT279626B
AT279626B AT00020/69A AT2069A AT279626B AT 279626 B AT279626 B AT 279626B AT 00020/69 A AT00020/69 A AT 00020/69A AT 2069 A AT2069 A AT 2069A AT 279626 B AT279626 B AT 279626B
Authority
AT
Austria
Prior art keywords
quaternal
propiophenones
piperazino
tert
salts
Prior art date
Application number
AT00020/69A
Other languages
English (en)
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Application granted granted Critical
Publication of AT279626B publication Critical patent/AT279626B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT00020/69A 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-tert.-amino-propiophenonen, ihren quaternaeren ammoniumverbindungen und salzen AT279626B (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58435066A 1966-10-05 1966-10-05
US642718A US3538090A (en) 1966-10-05 1967-06-01 1-(4-tertiaryaminophenyl)-3-(piperazino)-propanols

Publications (1)

Publication Number Publication Date
AT279626B true AT279626B (de) 1970-03-10

Family

ID=27079076

Family Applications (8)

Application Number Title Priority Date Filing Date
AT00015/69A AT277262B (de) 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-tert.aminopropiophenonen, ihren quaternaeren ammoniumverbindungen und salzen
AT00017/69A AT277264B (de) 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-tert.aminopropiophenonen, ihren quaternaeren ammoniumverbindungen und salzen
AT00020/69A AT279626B (de) 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-tert.-amino-propiophenonen, ihren quaternaeren ammoniumverbindungen und salzen
AT00018/69A AT279625B (de) 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-tert.-amino-propiophenonen, ihren quaternaeren ammoniumverbindungen und salzen
AT00019/69A AT277265B (de) 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-tert.aminopropiophenonen, ihren quaternaeren ammoniumverbindungen und salzen
AT04126/69A AT279633B (de) 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-terverfahren zur herstellung von neuen 10,11-dihydrodibenzo<bt.-amino-propiophenonen, ihren quaternaeren ammoniumverbin,f>-azepinderivaten sowie von deren saeureadditionssalzen dungen und salzen und quaternaeren ammoniumverbindungen
AT00016/69A AT277263B (de) 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-tert.aminopropiophenonen, ihren quaternaeren ammoniumverbindungen und salzen
AT901167A AT277250B (de) 1966-10-05 1967-10-04 Verfahren zur Herstellung von neuen 3-(4-R-Piperazino)-tert.amino-propiophenonen, ihren quaternären Ammoniumverbindungen und Salzen

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT00015/69A AT277262B (de) 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-tert.aminopropiophenonen, ihren quaternaeren ammoniumverbindungen und salzen
AT00017/69A AT277264B (de) 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-tert.aminopropiophenonen, ihren quaternaeren ammoniumverbindungen und salzen

Family Applications After (5)

Application Number Title Priority Date Filing Date
AT00018/69A AT279625B (de) 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-tert.-amino-propiophenonen, ihren quaternaeren ammoniumverbindungen und salzen
AT00019/69A AT277265B (de) 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-tert.aminopropiophenonen, ihren quaternaeren ammoniumverbindungen und salzen
AT04126/69A AT279633B (de) 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-terverfahren zur herstellung von neuen 10,11-dihydrodibenzo<bt.-amino-propiophenonen, ihren quaternaeren ammoniumverbin,f>-azepinderivaten sowie von deren saeureadditionssalzen dungen und salzen und quaternaeren ammoniumverbindungen
AT00016/69A AT277263B (de) 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-tert.aminopropiophenonen, ihren quaternaeren ammoniumverbindungen und salzen
AT901167A AT277250B (de) 1966-10-05 1967-10-04 Verfahren zur Herstellung von neuen 3-(4-R-Piperazino)-tert.amino-propiophenonen, ihren quaternären Ammoniumverbindungen und Salzen

Country Status (7)

Country Link
US (2) US3538090A (de)
AT (8) AT277262B (de)
BE (1) BE704696A (de)
ES (1) ES345694A1 (de)
FR (3) FR1549341A (de)
GB (1) GB1173369A (de)
NL (1) NL6713497A (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3933824A (en) * 1970-03-06 1976-01-20 Sumitomo Chemical Company, Limited Piperazinobutyrophenone derivatives
US4613598A (en) * 1984-03-13 1986-09-23 Mitsubishi Chemical Industries Limited Piperazine derivatives and their acid addition salts
USRE35053E (en) * 1985-09-12 1995-10-10 The Upjohn Company Amines useful in producing pharmaceutically active CNS compounds
US5382661A (en) * 1985-09-12 1995-01-17 The Upjohn Company Pyrazinylpiperazinyl steroids
US5099019A (en) * 1985-09-12 1992-03-24 Upjohn Company Amines useful in producing pharmaceutically active CNS compounds
GB8603120D0 (en) * 1986-02-07 1986-03-12 Pfizer Ltd Anti-dysrhythmia agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3317538A (en) * 1965-10-22 1967-05-02 American Home Prod 4, 4'-diamino-butyrophenones

Also Published As

Publication number Publication date
US3538090A (en) 1970-11-03
FR7253M (de) 1969-09-08
AT277263B (de) 1969-12-29
AT277250B (de) 1969-12-10
AT277262B (de) 1969-12-29
AT279625B (de) 1970-03-10
BE704696A (de) 1968-04-04
US3538091A (en) 1970-11-03
AT279633B (de) 1970-03-10
ES345694A1 (es) 1969-03-16
FR6943M (de) 1969-05-12
GB1173369A (en) 1969-12-10
FR1549341A (de) 1968-12-13
NL6713497A (de) 1968-04-08
AT277264B (de) 1969-12-29
AT277265B (de) 1969-12-29

Similar Documents

Publication Publication Date Title
AT262309B (de) Verfahren zur Herstellung von neuen Benzolsulfonylharnstoffen und ihren Salzen
AT278026B (de) Verfahren zur Herstellung von neuen 3,1-Benzoxazin-Derivaten und ihren Salzen
AT267521B (de) Verfahren zur Herstellung von neuen 2-Halogen-benzimidazolen und ihren Salzen
AT278770B (de) Verfahren zur Herstellung von neuen N-substituierten Pyrrylaminoäthanolen und ihren Salzen
AT269166B (de) Verfahren zur Herstellung von neuen p,p&#39;-Dialkanoyldiphenylharnstoff-bis-guanylhydrazonen und ihren Salzen
AT277233B (de) Verfahren zur Herstellung von neuen N-(1-Alkyl-2-pyrrolidylmethyl)-3-alkoxy-indol-2-carboxamiden und ihren Salzen
AT279625B (de) Verfahren zur herstellung von neuen 3-(4-r-piperazino)-tert.-amino-propiophenonen, ihren quaternaeren ammoniumverbindungen und salzen
AT291990B (de) Verfahren zur Herstellung von neuen Nitroimidazolderivaten und ihren Salzen
AT273108B (de) Verfahren zur Herstellung von neuen 2-Phenylamino-2-oxazolinen und ihren Salzen
AT281051B (de) Verfahren zur Herstellung von neuen Benzylsulfonyl-semicarbaziden und ihren Salzen
AT255414B (de) Verfahren zur Herstellung von neuen Hydrazino-2-thiazolinen und ihren Salzen
AT273104B (de) Verfahren zur Herstellung von neuen 2-Phenylamino-2-oxazolinen und ihren Salzen
AT268303B (de) Verfahren zur Herstellung von neuen Benzolsulfonylharnstoffen und ihren Salzen
AT273109B (de) Verfahren zur Herstellung von neuen 2-Phenylimino-oxazolidinen und ihren Salzen
AT276415B (de) Verfahren zur Herstellung von neuen 3,1-Benzothiazin-Derivaten und ihren Salzen
AT258895B (de) Verfahren zur Herstellung von neuen 1,3,3-trisubstituierten Pyrrolidinen und ihren Salzen
AT274829B (de) Verfahren zur Herstellung von neuen azabicycloaliphatischen Verbindungen und ihren Salzen
AT277279B (de) Verfahren zur Herstellung von neuen Guanidino-alkyl-azacycloalkanen und ihren Salzen
AT271473B (de) Verfahren zur Herstellung von neuen 2-Phenylamino-2-oxazolinen und ihren Salzen
AT263004B (de) Verfahren zur Herstellung von neuen, basisch substituierten Aryl-alkyl-ketonen und ihren Salzen
AT273981B (de) Verfahren zur Herstellung von neuen 1,2,8,9-Tetraazaphenalenen und ihren Salzen
AT270643B (de) Verfahren zur Herstellung von neuen Thiazolyl- bzw. Thiazolinyl-formamidinderivaten und ihren Salzen
AT262313B (de) Verfahren zur Herstellung von neuen 2,6-Dihalogen-phenylalkylaminoguanidinen und ihren Säureadditionssalzen
AT277238B (de) Verfahren zur Herstellung von neuen 5-Benzylamino-1,3,4-oxathiazol-3,3-dioxyden und ihren Salzen
AT261591B (de) Verfahren zur Herstellung von neuen 1-Aryl-1-aralkyl-2-aminomethyl-propenolen und ihren Salzen

Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee