AT328105B - PROCESS FOR THE PRODUCTION OF NEW PROSTANOIC ACID DERIVATIVES - Google Patents

PROCESS FOR THE PRODUCTION OF NEW PROSTANOIC ACID DERIVATIVES

Info

Publication number
AT328105B
AT328105B AT539173*7A AT539173A AT328105B AT 328105 B AT328105 B AT 328105B AT 539173 A AT539173 A AT 539173A AT 328105 B AT328105 B AT 328105B
Authority
AT
Austria
Prior art keywords
production
acid derivatives
prostanoic acid
new
new prostanoic
Prior art date
Application number
AT539173*7A
Other languages
German (de)
Other versions
ATA539173A (en
Original Assignee
Ici Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB3967272A external-priority patent/GB1348036A/en
Application filed by Ici Ltd filed Critical Ici Ltd
Publication of ATA539173A publication Critical patent/ATA539173A/en
Application granted granted Critical
Publication of AT328105B publication Critical patent/AT328105B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/42—Singly bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/535—Organo-phosphoranes
    • C07F9/5352—Phosphoranes containing the structure P=C-

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT539173*7A 1971-05-11 1973-05-12 PROCESS FOR THE PRODUCTION OF NEW PROSTANOIC ACID DERIVATIVES AT328105B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1413971 1971-05-11
GB3967272A GB1348036A (en) 1970-05-15 1972-01-05 Transistorized vertical deflection circuit

Publications (2)

Publication Number Publication Date
ATA539173A ATA539173A (en) 1975-05-15
AT328105B true AT328105B (en) 1976-03-10

Family

ID=26235892

Family Applications (4)

Application Number Title Priority Date Filing Date
AT538973*7A AT328103B (en) 1971-05-11 1972-05-12 PROCESS FOR THE PRODUCTION OF NEW PROSTANOIC ACID DERIVATIVES
AT419172A AT333447B (en) 1971-05-11 1972-05-12 Process for the production of new prostanoic acid derivatives and their salts
AT539173*7A AT328105B (en) 1971-05-11 1973-05-12 PROCESS FOR THE PRODUCTION OF NEW PROSTANOIC ACID DERIVATIVES
AT539073*7A AT328104B (en) 1971-05-11 1973-05-12 PROCESS FOR THE PRODUCTION OF NEW PROSTANOIC ACID DERIVATIVES

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT538973*7A AT328103B (en) 1971-05-11 1972-05-12 PROCESS FOR THE PRODUCTION OF NEW PROSTANOIC ACID DERIVATIVES
AT419172A AT333447B (en) 1971-05-11 1972-05-12 Process for the production of new prostanoic acid derivatives and their salts

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT539073*7A AT328104B (en) 1971-05-11 1973-05-12 PROCESS FOR THE PRODUCTION OF NEW PROSTANOIC ACID DERIVATIVES

Country Status (26)

Country Link
JP (1) JPS5611699B1 (en)
AR (4) AR194952A1 (en)
AT (4) AT328103B (en)
AU (1) AU462755B2 (en)
BE (1) BE783292A (en)
CA (1) CA1077033A (en)
CH (3) CH596165A5 (en)
CS (1) CS192456B2 (en)
DD (1) DD99155A5 (en)
DE (1) DE2223365C3 (en)
DK (1) DK134598B (en)
EG (1) EG10752A (en)
ES (1) ES402627A1 (en)
FI (1) FI63221C (en)
FR (1) FR2137712A1 (en)
HK (1) HK50176A (en)
HU (1) HU166717B (en)
IE (1) IE37602B1 (en)
IL (1) IL39376A (en)
KE (1) KE2634A (en)
NL (1) NL164272C (en)
NO (1) NO139521C (en)
SE (4) SE399705B (en)
SU (1) SU662007A3 (en)
YU (1) YU35876B (en)
ZM (1) ZM8172A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929740A (en) * 1984-10-09 1990-05-29 Syntex (U.S.A.) Inc. Process for making 16-phenoxy- and 16-(substituted phenoxy)-prostatrienoic acid derivatives

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4304907A (en) * 1972-05-10 1981-12-08 The Upjohn Company Bicyclo lactone intermediates for prostaglandin analogs
DD118856A5 (en) * 1972-11-08 1976-03-20
US3966795A (en) * 1973-05-21 1976-06-29 The Upjohn Company 5-Oxa-11-deoxyphenyl- and phenoxy-substituted prostaglandin F1.sub.α analogs
US3968144A (en) * 1973-05-21 1976-07-06 The Upjohn Company 5-Oxa-11-deoxy phenyl- and phenoxy-substituted prostalandin E1 analogs
US4387241A (en) * 1974-11-01 1983-06-07 American Cyanamid Company Novel 16-aryloxy-17,18,19,20-tetranorprostanoic acids and derivatives
US4149006A (en) * 1977-01-24 1979-04-10 G. D. Searle & Co. Prostaglandin derivatives having alkynyl, hydroxy and aryloxy junctions in the 2β side chain
US4191774A (en) * 1978-01-18 1980-03-04 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. Novel 17-aza-PGF2α derivatives and pharmaceutical compositions containing the same
US4228296A (en) * 1979-01-24 1980-10-14 American Cyanamid Company Novel 16-aryloxy-17,18,19,20-tetranorprostanoic acids and derivatives
CS264861B1 (en) * 1986-12-12 1989-09-12 Kral Josef Agent for cow natality increase
CS265947B1 (en) * 1987-06-16 1989-11-14 Kral Josef Means for farming animals' ovarian functions control
US5565492A (en) * 1988-07-18 1996-10-15 Alcon Laboratories, Inc. Prostaglandin combinations in glaucoma therapy
CS276003B6 (en) * 1988-09-28 1992-03-18 Spolana method of production of (+)-isomer of cloprostenol
US5688819A (en) * 1992-09-21 1997-11-18 Allergan Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5352708A (en) * 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5510383A (en) * 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
US6531504B2 (en) * 2001-05-17 2003-03-11 Allergan, Inc. Prostanoic acid derivatives as agents for lowering intraocular pressure
CA2705150C (en) * 2007-11-09 2016-06-14 Allergan, Inc. Substituted cyclopentanes having prostaglandin activity

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929740A (en) * 1984-10-09 1990-05-29 Syntex (U.S.A.) Inc. Process for making 16-phenoxy- and 16-(substituted phenoxy)-prostatrienoic acid derivatives

Also Published As

Publication number Publication date
DK134598C (en) 1977-05-16
CH590223A5 (en) 1977-07-29
AT328103B (en) 1976-03-10
DD99155A5 (en) 1973-07-20
EG10752A (en) 1976-05-31
DE2223365B2 (en) 1980-07-31
ATA539073A (en) 1975-05-15
BE783292A (en) 1972-11-10
DE2223365A1 (en) 1972-12-07
ATA539173A (en) 1975-05-15
IL39376A (en) 1975-07-28
AU4202472A (en) 1973-11-15
AR200484A1 (en) 1974-11-15
SE399705B (en) 1978-02-27
SE7504336L (en) 1975-04-15
CS192456B2 (en) 1979-08-31
FI63221B (en) 1983-01-31
AU462755B2 (en) 1975-07-03
AR197101A1 (en) 1974-03-15
CH596166A5 (en) 1978-02-28
YU35876B (en) 1981-08-31
JPS5611699B1 (en) 1981-03-16
YU125072A (en) 1981-02-28
CA1077033A (en) 1980-05-06
CH596165A5 (en) 1978-02-28
ATA538973A (en) 1975-05-15
IL39376A0 (en) 1972-07-26
IE37602L (en) 1972-11-11
KE2634A (en) 1976-06-11
FR2137712A1 (en) 1972-12-29
NL164272C (en) 1980-12-15
DE2223365C3 (en) 1981-06-04
AT333447B (en) 1976-11-25
NO139521B (en) 1978-12-18
NO139521C (en) 1979-03-28
FI63221C (en) 1983-05-10
ES402627A1 (en) 1975-11-01
SE7504335L (en) 1975-04-15
HK50176A (en) 1976-08-13
IE37602B1 (en) 1977-08-31
ATA419172A (en) 1976-03-15
SU662007A3 (en) 1979-05-05
FR2137712B1 (en) 1976-04-16
DK134598B (en) 1976-12-06
ZM8172A1 (en) 1973-01-22
HU166717B (en) 1975-05-28
NL7206361A (en) 1972-11-14
SE7504337L (en) 1975-04-15
AR194952A1 (en) 1973-08-30
NL164272B (en) 1980-07-15
AT328104B (en) 1976-03-10
AR197100A1 (en) 1974-03-15

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Legal Events

Date Code Title Description
EIH Change in the person of patent owner
ELA Expired due to lapse of time