AT343818B - PROCESS FOR THE MANUFACTURING OF ANTI-inflammatory Aqueous LIGHT PROTECTION PRODUCTS - Google Patents
PROCESS FOR THE MANUFACTURING OF ANTI-inflammatory Aqueous LIGHT PROTECTION PRODUCTSInfo
- Publication number
- AT343818B AT343818B AT1001373A AT1001373A AT343818B AT 343818 B AT343818 B AT 343818B AT 1001373 A AT1001373 A AT 1001373A AT 1001373 A AT1001373 A AT 1001373A AT 343818 B AT343818 B AT 343818B
- Authority
- AT
- Austria
- Prior art keywords
- light protection
- panthenol
- inflammatory
- manufacturing
- preparations
- Prior art date
Links
- 230000003110 anti-inflammatory effect Effects 0.000 title claims description 8
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- 238000000034 method Methods 0.000 title claims description 3
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 12
- 229940101267 panthenol Drugs 0.000 claims description 12
- 235000020957 pantothenol Nutrition 0.000 claims description 12
- 239000011619 pantothenol Substances 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 9
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 claims description 6
- 239000007921 spray Substances 0.000 claims description 6
- 239000000839 emulsion Substances 0.000 claims description 5
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 4
- 150000002148 esters Chemical class 0.000 claims description 4
- AFDXODALSZRGIH-QPJJXVBHSA-N (E)-3-(4-methoxyphenyl)prop-2-enoic acid Chemical compound COC1=CC=C(\C=C\C(O)=O)C=C1 AFDXODALSZRGIH-QPJJXVBHSA-N 0.000 claims description 3
- 239000006260 foam Substances 0.000 claims description 3
- ZCJLOOJRNPHKAV-ONEGZZNKSA-N (e)-3-(furan-2-yl)prop-2-enoic acid Chemical compound OC(=O)\C=C\C1=CC=CO1 ZCJLOOJRNPHKAV-ONEGZZNKSA-N 0.000 claims description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 2
- MZVQCMJNVPIDEA-UHFFFAOYSA-N [CH2]CN(CC)CC Chemical group [CH2]CN(CC)CC MZVQCMJNVPIDEA-UHFFFAOYSA-N 0.000 claims description 2
- 239000003380 propellant Substances 0.000 claims description 2
- 239000011787 zinc oxide Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 description 10
- 230000000694 effects Effects 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 206010061218 Inflammation Diseases 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 230000000475 sunscreen effect Effects 0.000 description 4
- 239000000516 sunscreening agent Substances 0.000 description 4
- 206010015150 Erythema Diseases 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 231100000321 erythema Toxicity 0.000 description 3
- CFYUBZHJDXXXQE-UHFFFAOYSA-N 2-ethylcyclohexan-1-ol Chemical compound CCC1CCCCC1O CFYUBZHJDXXXQE-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- -1 fatty acid 2-ethylcyclohexyl ester Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 150000004671 saturated fatty acids Chemical class 0.000 description 2
- 235000003441 saturated fatty acids Nutrition 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 241001494479 Pecora Species 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- NBXKRDDJLRBEOV-UHFFFAOYSA-N dichloro(fluoro)methane;1,1-dichloro-1,2,2,2-tetrafluoroethane Chemical compound FC(Cl)Cl.FC(F)(F)C(F)(Cl)Cl NBXKRDDJLRBEOV-UHFFFAOYSA-N 0.000 description 1
- UMNKXPULIDJLSU-UHFFFAOYSA-N dichlorofluoromethane Chemical compound FC(Cl)Cl UMNKXPULIDJLSU-UHFFFAOYSA-N 0.000 description 1
- 229940099364 dichlorofluoromethane Drugs 0.000 description 1
- 125000002541 furyl group Chemical group 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000011814 protection agent Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 230000036561 sun exposure Effects 0.000 description 1
- 230000037072 sun protection Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Description
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Die Erfindung betrifft ein Verfahren zur Herstellung entzündungshemmender wässeriger Lichtschutzpräparate unter Verwendung von Panthenol, insbesondere stabiler, gut hautverträglicher Präparate zur Verhinderung sowie zur Heilung von Hautschäden, die durch den biologisch wirksamen Teil der UV-Strahlung der Sonne verursacht werden können.
Es ist bekannt, die menschliche Haut durch äusserlich anzuwendende Sonnenschutzmittel, die geeignete Lichtschutzsubstanzen enthalten, zu schützen. Der Schutz beruht auf der Absorption oder Abschirmung der erythemer zeugenden Strahlen.
Es ist ferner bekannt, dass Panthenol eine entzündungshemmende Wirkung besitzt, die in Salben und Spraypräparaten für medizinische Zwecke genutzt wird.
So wird in H. Janistyn,"Handbuch der Kosmetika und Riechstoffe", Bd. l, 1969, S. 736, der Einsatz von Panthenol in entzündungshemmenden Lichtschutzmitteln beschrieben. Es wird dort über die reizlindernde Wirkung des Panthenols und deren Ausnutzung in kosmetischen Zubereitungen, wie z. B. Lichtschutzlotionen, Lichtschutzcremes und nicht näher spezifizierten Sonnenbrandmitteln berichtet.
Weiterhin ist bekannt, dass der bei der Verdunstung des Wassers aus wasserhaltigen Präparaten auftretende Kühleffekt entzündungshemmend wirkt.
Zur Zeit befinden sich Sonnenschutzmittel in Form von Emulsionen, Cremes, Ölen, Lösungen und Sprays im Handel. Der Nachteil dieser Erzeugnisse beruht darauf, dass sie nicht gleichzeitig entzündungshemmend und epithelisierend wirken, so dass eine kosmetische Bräune stets mit einem mehr oder weniger starken Erythem erkauft werden muss, das in vielen Fällen eine ärztliche Behandlung erforderlich macht.
Der Erfindung liegt die Aufgabe zugrunde, durch Kombination geeigneter Lichtschutzsubstanzen mit Panthenol in einer wasserhaltigen Grundlage ein Präparat herzustellen, das eine Sonnenschutzwirkung besitzt, bei beginnender Lichtentzündung eine Entzündungshemmung bewirkt, bei bereits bestehender Lichtentzündung zur raschen Epithelisierung führt und das bei lichtbedingten oder lichtprovozierten Hauterkrankungen, z. B. Erythema solare, Erythematodes und polymorphe Lichtdermatosen, Verwendung finden kann.
Die Erfindung betrifft daher ein Verfahren zur Herstellung entzündungshemmender wässeriger Lichtschutzpräparate in Form einer Emulsion unter Einsatz von Panthenol, welches dadurch gekennzeichnet ist, dass in wasserhaltiger Grundlage eine Lichtsehutzsubstanz, u. zw. Paramethoxyzimtsäureester oder Furyl-
EMI1.1
Stoffe zugesetzt werden können und die Lichtschutzpräparate vorzugsweise unter Zusatz von Treibmitteln als Schaum oder Spray ausgebildet werden.
Eine Unterschreitung des angegebenen Mengenverhältnisses von verflüssigtem Wachs in Lichtschutzsubstanz hat die galenische Instabilität der UV-Absorber zur Folge. Bei Überschreitung des Mengenverhältnisses wird die erforderliche Lichtschutzwirkung in Frage gestellt.
Die erfindungsgemäss hergestellte Kombination weist gegenüber dem Stand der Technik folgende Vorteile auf :
Die Haut wird vor übermässiger Sonnenbestrahlung geschützt. Darüber hinaus wird eine beginnende oder bereits entstandene Entzündung wirksam gehemmt.
Ein besonderer Vorzug der Erfindung liegt darin, dass die vorgeschlagene Kombination als Schawnspray appliziert werden kann, wodurch hinsichtlich der Aufnahme des Panthenols durch die Haut und der Kühlwirkung durch denWasseranteil ein Effekt erzielt werden kann, der über dem bekannten Stand der Technik liegt.
Darüber hinaus wird das Auftragen mit mechanischen Hilfsmitteln oder von Hand vermieden. Ein erfindunggemäss hergestelltes Erzeugnis kann daher sowohl für kosmetische als auch für medizinische Zwecke Verwendung finden. Folgende Beispiele sollen die Erfindung näher charakterisieren :
Beispiel l : Folgende Mischungen werden hergestellt : a) In 110 g flüssigem Wachs, u. zw. einer Mischung aus Estern von vorwiegend gesättigten Fett- säuren, die 12 und 14 Kohlenstoffatome enthalten, mit 2-Äthylcyclohexanol (Fettsäure-2-äthyl- cyclohexylester), werden 25 g Lanettewachs bei+80 C gelöst. NachAbkühlen auf+45 C werden
10 g Paramethoxyzimtsäureester zugegeben. b) In 845 g destilliertem Wasser werden bei +45 C 10 g Panthenol gelöst.
Beide Lösungen werden bei +45 C vereinigt und unter Rühren auf Raumtemperatur abgekühlt.
Die Abfüllung im Verhältnis 6 Teile Emulsion : l Teil Dichloridfluormethan oder 5 Teile Emulsion : l Teil Dichloridfluormethan-Tetrafluordichloräthan-Gemisch im Mischungsverhältnis 40 : 60 ergibt einen Schaumspray.
Beispiel 2 : Folgende Mischungen werden hergestellt :
Wie unter Beispiel 1 wird die Mischung a) hergestellt. b) In 745 g destilliertem Wasser werden bei+45 C 10 g Panthenol gelöst und hienach 100 g Barium- sulfat unter Rühren zugefügt.
<Desc/Clms Page number 2>
Die weitere Verarbeitung erfolgt wie unter Beispiel 1.
Beispiel 3 : Die Mischungen a) und b) werden wie im Beispiel 2 beschrieben bereitet, wobei an Stelle des Bariumsulfats 100 g Zinkoxyd in Mischung b) eingetragen werden.
Die weitere Verarbeitung erfolgt wie unter Beispiel 1.
Beispiel 4 : Es werden folgende Mischungen bereitet : a) In 110 g flüssigem Wachs, u. zw. einer Mischung aus Estern von vorwiegend gesättigten Fett- säuren, die 12 und 14 Kohlenstoffatome enthalten, mit 2-Äthylcyclohexanol (Fettsäure-2-äthyl- cyclohexylester), werden 25 g Lanettewachs bei +800C gelöst. b) In 845 g destilliertem Wasser werden bei +450C 10 g Panthenol und 10 g Furylacrylsäurediäthyl- aminoäthylester-Hydrochlorid gelöst.
Beide Mischungen werden bei +45 C vereinigt und, wie unter Beispiel 1 beschrieben, weiterverarbeitet.
<Desc / Clms Page number 1>
The invention relates to a method for producing anti-inflammatory aqueous light protection preparations using panthenol, in particular stable preparations that are well tolerated by the skin for the prevention and healing of skin damage which can be caused by the biologically active part of the sun's UV radiation.
It is known that the human skin can be protected by externally applied sunscreens which contain suitable light protection substances. Protection is based on the absorption or shielding of the erythema-producing rays.
It is also known that panthenol has an anti-inflammatory effect, which is used in ointments and spray preparations for medical purposes.
Thus, in H. Janistyn, "Handbuch der Kosmetik und Riechstoffe", Vol. 1, 1969, p. 736, the use of panthenol in anti-inflammatory light protection agents is described. It is there about the soothing effect of panthenol and its use in cosmetic preparations such. B. sunscreen lotions, sunscreen creams and unspecified sunburn products reported.
It is also known that the cooling effect that occurs when water evaporates from preparations containing water has an anti-inflammatory effect.
Sunscreens are currently available in the form of emulsions, creams, oils, solutions and sprays. The disadvantage of these products is that they do not have an anti-inflammatory and epithelializing effect at the same time, so that a cosmetic tan always has to be bought with a more or less severe erythema, which in many cases requires medical treatment.
The invention is based on the object of combining suitable light protection substances with panthenol in a water-based base to produce a preparation which has a sun protection effect, causes inflammation inhibition when light inflammation begins, leads to rapid epithelialization when light inflammation already exists and which in the case of light-induced or light-provoked skin diseases, e.g. . B. Erythema solare, erythematosus and polymorphic light dermatoses, can be used.
The invention therefore relates to a method for the production of anti-inflammatory aqueous light protection preparations in the form of an emulsion using panthenol, which is characterized in that a light protection substance, u. between paramethoxycinnamate or furyl
EMI1.1
Substances can be added and the light protection preparations are preferably designed as a foam or spray with the addition of propellants.
Falling below the specified ratio of liquefied wax in the light protection substance results in the galenic instability of the UV absorber. If the quantity ratio is exceeded, the required light protection effect is called into question.
The combination produced according to the invention has the following advantages over the prior art:
The skin is protected from excessive sun exposure. In addition, inflammation that is beginning or has already occurred is effectively inhibited.
A particular advantage of the invention is that the proposed combination can be applied as a sheep spray, whereby an effect can be achieved in terms of the absorption of panthenol through the skin and the cooling effect through the water content which is above the known prior art.
In addition, application with mechanical aids or by hand is avoided. A product produced according to the invention can therefore be used for both cosmetic and medical purposes. The following examples are intended to characterize the invention in more detail:
Example 1: The following mixtures are prepared: a) In 110 g of liquid wax, u. Between a mixture of esters of mainly saturated fatty acids containing 12 and 14 carbon atoms with 2-ethylcyclohexanol (fatty acid 2-ethylcyclohexyl ester), 25 g of lanette wax are dissolved at + 80 ° C. After cooling down to + 45 C.
10 g of paramethoxycinnamate were added. b) 10 g of panthenol are dissolved in 845 g of distilled water at +45 C.
Both solutions are combined at +45 ° C. and cooled to room temperature with stirring.
Filling in the ratio 6 parts emulsion: 1 part dichlorofluoromethane or 5 parts emulsion: 1 part dichlorofluoromethane-tetrafluorodichloroethane mixture in a mixing ratio of 40:60 results in a foam spray.
Example 2: The following mixtures are produced:
As in Example 1, mixture a) is prepared. b) 10 g of panthenol are dissolved in 745 g of distilled water at + 45 ° C. and then 100 g of barium sulfate are added with stirring.
<Desc / Clms Page number 2>
Further processing takes place as in example 1.
Example 3: The mixtures a) and b) are prepared as described in Example 2, 100 g of zinc oxide being added to mixture b) instead of the barium sulfate.
Further processing takes place as in example 1.
Example 4: The following mixtures are prepared: a) In 110 g of liquid wax, u. Between a mixture of esters of mainly saturated fatty acids containing 12 and 14 carbon atoms with 2-ethylcyclohexanol (fatty acid 2-ethylcyclohexyl ester), 25 g of lanette wax are dissolved at + 800C. b) 10 g panthenol and 10 g furylacrylic acid diethyl aminoethyl ester hydrochloride are dissolved in 845 g of distilled water at + 450C.
Both mixtures are combined at +45 C and, as described in Example 1, processed further.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT1001373A AT343818B (en) | 1973-11-29 | 1973-11-29 | PROCESS FOR THE MANUFACTURING OF ANTI-inflammatory Aqueous LIGHT PROTECTION PRODUCTS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT1001373A AT343818B (en) | 1973-11-29 | 1973-11-29 | PROCESS FOR THE MANUFACTURING OF ANTI-inflammatory Aqueous LIGHT PROTECTION PRODUCTS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA1001373A ATA1001373A (en) | 1975-06-15 |
| AT343818B true AT343818B (en) | 1978-06-26 |
Family
ID=3619199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT1001373A AT343818B (en) | 1973-11-29 | 1973-11-29 | PROCESS FOR THE MANUFACTURING OF ANTI-inflammatory Aqueous LIGHT PROTECTION PRODUCTS |
Country Status (1)
| Country | Link |
|---|---|
| AT (1) | AT343818B (en) |
-
1973
- 1973-11-29 AT AT1001373A patent/AT343818B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATA1001373A (en) | 1975-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELJ | Ceased due to non-payment of the annual fee |