AT366573B - METHOD FOR PRODUCING A PHARMACEUTICAL PREPARATION - Google Patents
METHOD FOR PRODUCING A PHARMACEUTICAL PREPARATIONInfo
- Publication number
- AT366573B AT366573B AT0221080A AT221080A AT366573B AT 366573 B AT366573 B AT 366573B AT 0221080 A AT0221080 A AT 0221080A AT 221080 A AT221080 A AT 221080A AT 366573 B AT366573 B AT 366573B
- Authority
- AT
- Austria
- Prior art keywords
- sep
- producing
- pharmaceutical preparation
- polyethylene glycol
- ester
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title description 2
- 239000000825 pharmaceutical preparation Substances 0.000 title description 2
- 150000002148 esters Chemical class 0.000 claims description 9
- 239000002202 Polyethylene glycol Substances 0.000 claims description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims description 6
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 5
- 229930195729 fatty acid Natural products 0.000 claims description 5
- 239000000194 fatty acid Substances 0.000 claims description 5
- 150000004665 fatty acids Chemical group 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
- 239000000203 mixture Substances 0.000 description 6
- QXKHYNVANLEOEG-UHFFFAOYSA-N Methoxsalen Chemical compound C1=CC(=O)OC2=C1C=C1C=COC1=C2OC QXKHYNVANLEOEG-UHFFFAOYSA-N 0.000 description 5
- PCWZKQSKUXXDDJ-UHFFFAOYSA-N Xanthotoxin Natural products COCc1c2OC(=O)C=Cc2cc3ccoc13 PCWZKQSKUXXDDJ-UHFFFAOYSA-N 0.000 description 5
- 229960004469 methoxsalen Drugs 0.000 description 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- MNQZXJOMYWMBOU-UHFFFAOYSA-N glyceraldehyde Chemical compound OCC(O)C=O MNQZXJOMYWMBOU-UHFFFAOYSA-N 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 229960000956 coumarin Drugs 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- VCKSNYNNVSOWEE-UHFFFAOYSA-N 1,3-dioxan-5-ol Chemical compound OC1COCOC1 VCKSNYNNVSOWEE-UHFFFAOYSA-N 0.000 description 1
- BOHGAOWOIJMTPZ-UHFFFAOYSA-N 1,3-dioxolan-4-ylmethanol Chemical compound OCC1COCO1 BOHGAOWOIJMTPZ-UHFFFAOYSA-N 0.000 description 1
- WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical class C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 description 1
- CTPDSKVQLSDPLC-UHFFFAOYSA-N 2-(oxolan-2-ylmethoxy)ethanol Chemical compound OCCOCC1CCCO1 CTPDSKVQLSDPLC-UHFFFAOYSA-N 0.000 description 1
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 239000001089 [(2R)-oxolan-2-yl]methanol Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- -1 alkylene glycol Chemical compound 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000019445 benzyl alcohol Nutrition 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 229920000223 polyglycerol Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
<Desc/Clms Page number 1>
Die Erfindung betrifft ein Verfahren zur Herstellung einer oral applizierbaren und stabilen Lösung, welche den zur Photochemotherapie der Psoriasis verwendbaren Wirkstoff Methoxsalen (8-Methoxy-furo - 3', 2 ! : 6, 7"j-cumarin) mit der Formel
EMI1.1
EMI1.2
<Desc/Clms Page number 2>
Beispiel 3 :
EMI2.1
<tb>
<tb> 0, <SEP> 34 <SEP> g <SEP> Methoxsalen
<tb> 6, <SEP> 50 <SEP> g <SEP> Polyäthylenglykol <SEP> 300
<tb> 1, <SEP> 80 <SEP> g <SEP> Partialestergemisch <SEP> von <SEP> Ca <SEP> -C'2- <SEP> Fettsäuren <SEP> mit <SEP> oxyäthyliertem <SEP> Glycerin
<tb> 1, <SEP> 06 <SEP> g <SEP> Benzylalkohol
<tb> 0, <SEP> 92 <SEP> g <SEP> Glycerinformal*)
<tb> 0, <SEP> 16 <SEP> g <SEP> Aromastoff <SEP>
<tb>
Beispiel 4 :
EMI2.2
<tb>
<tb> 0, <SEP> 42 <SEP> g <SEP> Methoxsalen
<tb> 4, <SEP> 80 <SEP> g <SEP> Glycerinformal*)
<tb> 2, <SEP> 20 <SEP> g <SEP> Glycofurol**)
<tb> 1, <SEP> 84 <SEP> g <SEP> Pfefferminzöl <SEP>
<tb> 1, <SEP> 56 <SEP> g <SEP> Partialestergemisch <SEP> hydrierter <SEP> Ricinusölfettsäuren <SEP> mit <SEP> oxyäthyliertem <SEP> Glycerin
<tb>
Beispiel 5 :
EMI2.3
<tb>
<tb> 0, <SEP> 43 <SEP> g <SEP> Methoxsalen
<tb> 5, <SEP> 00 <SEP> g <SEP> Glycerinformal*)
<tb> 2, <SEP> 32 <SEP> g <SEP> Polyäthylenglykol <SEP> 300
<tb> 2, <SEP> 06 <SEP> g <SEP> Partial <SEP> estergemisch <SEP> von <SEP> Ricinusölfettsäuren <SEP> mit <SEP> oxyäthyliertem <SEP> Glycerin
<tb> 1, <SEP> 34 <SEP> g <SEP> Dimethylsulfoxyd
<tb> 0, <SEP> 16 <SEP> g <SEP> Aromastoff <SEP>
<tb>
Beispiel 6 :
Man löst 10 g pulverisiertes Methoxsalen durch Rühren in einer Mischung von 365 g Polyäthylenglykol 400,50 g Dimethylacetamid, 50 g Glycerin und 40 g Glycerintriacetat auf, verdünnt mit 30 g Wasser, rührt gut durch und füllt jeweils 0, 5 ml der erhaltenen Lösung mittels einer Dosiervorrichtung in Kapseln ab. Diese enthalten dann 10 mg Wirkstoff/Kapsel.
*) Glycerinformal stellt ein Gemisch aus 4-Hydroxymethyl-1, 3-dioxolan und 5-Hydroxy-1, 3-dioxan dar.
**) Glycofurole sind Polyäthylenglykoläther des Tetrahydrofurfurylalkohols (H. Janistyn, Handbuch der Kosmetika und Riechstoffe, 3. Auflage, 1. Band, pp. 443,444).
PATENTANSPRÜCHE :
1. Verfahren zur Herstellung einer pharmazeutischen Zubereitung zur oralen Verabreichung, gegebenenfalls in. Form von Kapseln, welche den Wirkstoff 8-Methoxy-furo- [ 3', 2' : 6, -cumarin und gewünschtenfalls pharmazeutisch verwendbare Geschmackskorrigentien, Antioxydantien und/oder Konservierungsmittel enthält, dadurch gekennzeichnet, dass man eine stabile Lösung des Wirkstoffes herstellt, wobei als Lösungsmittel ein pharmazeutisch verwendbares ätherisches Öl, ein Ester oder Partialester einer C2- bis C30-Fettsäure mit einem zwei-bis achtwertigen Alkohol oder mit Polyglycerin, ein 3 bis 6 C-Atome enthaltendes Dialkylamid oder das Dimethylsulfoxyd bzw.
Mischungen dieser Lösungsmittel untereinander und gegebenenfalls in Kombination mit Polyäthylen- glykol (en) bzw. dessen (deren) Ester oder Äther, l, 3-Dioxolan-Derivat (en), Alkylenglykol (en), Wasser und/oder Alkoholen eingesetzt werden.
<Desc / Clms Page number 1>
The invention relates to a method for producing an orally administrable and stable solution which contains the active ingredient methoxsalen (8-methoxy-furo-3 ', 2!: 6, 7 "j-coumarin) with the formula which can be used for photochemotherapy of psoriasis
EMI1.1
EMI1.2
<Desc / Clms Page number 2>
Example 3:
EMI2.1
<tb>
<tb> 0, <SEP> 34 <SEP> g <SEP> methoxsalen
<tb> 6, <SEP> 50 <SEP> g <SEP> polyethylene glycol <SEP> 300
<tb> 1, <SEP> 80 <SEP> g <SEP> partial ester mixture <SEP> of <SEP> Ca <SEP> -C'2- <SEP> fatty acids <SEP> with <SEP> oxyethylated <SEP> glycerol
<tb> 1, <SEP> 06 <SEP> g <SEP> benzyl alcohol
<tb> 0, <SEP> 92 <SEP> g <SEP> glycerin formal *)
<tb> 0, <SEP> 16 <SEP> g <SEP> flavor <SEP>
<tb>
Example 4:
EMI2.2
<tb>
<tb> 0, <SEP> 42 <SEP> g <SEP> methoxsalen
<tb> 4, <SEP> 80 <SEP> g <SEP> glycerin formal *)
<tb> 2, <SEP> 20 <SEP> g <SEP> glycofurol **)
<tb> 1, <SEP> 84 <SEP> g <SEP> peppermint oil <SEP>
<tb> 1, <SEP> 56 <SEP> g <SEP> partial ester mixture <SEP> hydrogenated <SEP> castor oil fatty acids <SEP> with <SEP> oxyethylated <SEP> glycerol
<tb>
Example 5:
EMI2.3
<tb>
<tb> 0, <SEP> 43 <SEP> g <SEP> methoxsalen
<tb> 5, <SEP> 00 <SEP> g <SEP> glycerin formal *)
<tb> 2, <SEP> 32 <SEP> g <SEP> polyethylene glycol <SEP> 300
<tb> 2, <SEP> 06 <SEP> g <SEP> Partial <SEP> ester mixture <SEP> of <SEP> castor oil fatty acids <SEP> with <SEP> oxyethylated <SEP> glycerol
<tb> 1, <SEP> 34 <SEP> g <SEP> dimethyl sulfoxide
<tb> 0, <SEP> 16 <SEP> g <SEP> flavor <SEP>
<tb>
Example 6:
10 g of pulverized methoxsalen are dissolved by stirring in a mixture of 365 g of polyethylene glycol, 400.50 g of dimethylacetamide, 50 g of glycerol and 40 g of glycerol triacetate, diluted with 30 g of water, stirred well and filled with 0.5 ml of the solution obtained a dosing device in capsules. These then contain 10 mg of active ingredient / capsule.
*) Glycerin formal is a mixture of 4-hydroxymethyl-1, 3-dioxolane and 5-hydroxy-1, 3-dioxane.
**) Glycofurols are polyethylene glycol ethers of tetrahydrofurfuryl alcohol (H. Janistyn, Handbook of Cosmetics and Fragrances, 3rd edition, 1st volume, pp. 443,444).
PATENT CLAIMS:
1. A process for the preparation of a pharmaceutical preparation for oral administration, optionally in the form of capsules which contain the active ingredient 8-methoxy-furo- [3 ', 2': 6, -coumarin and, if desired, pharmaceutically usable taste correctives, antioxidants and / or preservatives contains, characterized in that a stable solution of the active ingredient is prepared, the solvent used being a pharmaceutically usable essential oil, an ester or partial ester of a C2 to C30 fatty acid with a dihydric or octane alcohol or with polyglycerol, a 3 to 6 C. Dialkylamide containing atoms or the dimethyl sulfoxide or
Mixtures of these solvents with one another and optionally in combination with polyethylene glycol (s) or their (their) ester or ether, 1,3-dioxolane derivative (s), alkylene glycol (s), water and / or alcohols are used.
Claims (1)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0221080A AT366573B (en) | 1980-04-24 | 1980-04-24 | METHOD FOR PRODUCING A PHARMACEUTICAL PREPARATION |
| SE8004383A SE445422B (en) | 1979-06-25 | 1980-06-12 | PHARMACEUTICAL PREPARATION FOR ORAL ADMINISTRATION CONTAINING 8-METOXY-FURO- / 3 ', 2': 6,7 / -CUMARIN |
| NO801759A NO153951C (en) | 1979-06-25 | 1980-06-13 | PROCEDURE FOR THE PREPARATION OF A PHARMACEUTICAL PREPARATION CONTAINING 8-METOXY-FURO- (3 [, 2 [: 6,7) -CUMARIN. |
| FR8013490A FR2459658A1 (en) | 1979-06-25 | 1980-06-18 | PROCESS FOR THE PREPARATION OF AN ORAL-ADMINISTRATIVE METHOXSALEN-BASED PHARMACEUTICAL COMPOSITION |
| FI801988A FI72428C (en) | 1979-06-25 | 1980-06-19 | FRAMSTAELLNINGSFOERFARANDE FOER ETT STABILT, FARMACEUTISKT 8-METOXIFURO- (3 ', 2': 6,7) -COUMIN PREPARATION. |
| DE19803023109 DE3023109A1 (en) | 1979-06-25 | 1980-06-20 | METHOXAL SALES PREPARATION FOR ORAL ADMINISTRATION |
| GB8020457A GB2052980B (en) | 1979-06-25 | 1980-06-23 | Pharmaceutical composition for oral administration comprising methoxsalen |
| US06/594,060 US4913901A (en) | 1979-06-25 | 1984-03-28 | Pharmaceutical composition for oral administration and process for the use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0221080A AT366573B (en) | 1980-04-24 | 1980-04-24 | METHOD FOR PRODUCING A PHARMACEUTICAL PREPARATION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA221080A ATA221080A (en) | 1981-09-15 |
| AT366573B true AT366573B (en) | 1982-04-26 |
Family
ID=3530055
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0221080A AT366573B (en) | 1979-06-25 | 1980-04-24 | METHOD FOR PRODUCING A PHARMACEUTICAL PREPARATION |
Country Status (1)
| Country | Link |
|---|---|
| AT (1) | AT366573B (en) |
-
1980
- 1980-04-24 AT AT0221080A patent/AT366573B/en active
Also Published As
| Publication number | Publication date |
|---|---|
| ATA221080A (en) | 1981-09-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3500103C2 (en) | Pharmaceutical preparation containing an active ingredient that is poorly soluble in water and digestive juices | |
| DE3544692C2 (en) | ||
| DE69822295T2 (en) | USE OF MISOPROSTOL AND / OR MISOPROSTOLIC ACID FOR THE TREATMENT OF EFFECTS OF DISORDER | |
| EP0697881B2 (en) | New cyclosporine-containing pharmaceutical compositions for oral administration | |
| DE3027933A1 (en) | PHARMACEUTICAL PREPARATION BASED ON BLUEBERRY EXTRACTS | |
| DE2704081A1 (en) | MEDIUM WITH A SILICON DERIVATIVES CONTENT | |
| DE2947624A1 (en) | BETA, GAMMA -DIHYDROPOLYPRENYL ALCOHOL AND HEM-PRESSURING MEDICINE CONTAINING THEM | |
| DE3109783A1 (en) | WITH WATER TO AN APPROXIMATELY ISOTONIC NITROGLYCERIN SOLUTION AND THIS NITROGLYCER SOLUTION | |
| AT366573B (en) | METHOD FOR PRODUCING A PHARMACEUTICAL PREPARATION | |
| EP0114051B1 (en) | Use of sebosuppressive cosmetic products containing alkoxybenzoic esters | |
| DE2719581A1 (en) | MEDICINAL PRODUCTS CONTAINING POLYHYDROXYPHENYLCHROMANONE | |
| US4913901A (en) | Pharmaceutical composition for oral administration and process for the use thereof | |
| DE68906205T2 (en) | COSMETIC AND PARAMEDICAL PREPARATIONS. | |
| EP0156968B1 (en) | Silane-modified ester mixtures, process for their preparation and their use in pharmaceutical and cosmetic preparations | |
| DE602004007164T2 (en) | TRANSPORT AND ABSORPTION AGENTS AND THE METHOD OF ITS MANUFACTURE FROM HEMS | |
| EP0288895B1 (en) | Medicinal formulation | |
| DE3445237C1 (en) | Soft gelatin capsules and process for their manufacture | |
| EP0101879A2 (en) | Stable ergotalcaloids solutions | |
| DE4410637C1 (en) | Injectable solutions of dirithromycin | |
| DE4131313A1 (en) | Medicament from camomile flowers - contains non-polar active agent obtd. by aq. extn. in presence of ascorbic acid | |
| DE2708419C3 (en) | Use of 1,2-butanediol methyl ether as a solvent for pharmaceutical injection solutions | |
| WO1995002410A1 (en) | Method of preparing liquid plant extracts | |
| EP0111137A2 (en) | Rectal preparations containing indomethacin | |
| DE4027227A1 (en) | Production of ethanol@-free liq. thyme extract - comprises evapn. of ethanol@-contgextract and addn. of thyme oil and glycerol or propylene glycol as solvent | |
| DE2531260A1 (en) | D-panthenol anhydrous spray solutions - contg an oil as solvent and an alcohol and a chlorinated hydrocarbon as solubilisers |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |