AT69637B - Process for the preparation of therapeutically active substances. - Google Patents
Process for the preparation of therapeutically active substances.Info
- Publication number
- AT69637B AT69637B AT69637DA AT69637B AT 69637 B AT69637 B AT 69637B AT 69637D A AT69637D A AT 69637DA AT 69637 B AT69637 B AT 69637B
- Authority
- AT
- Austria
- Prior art keywords
- preparation
- active substances
- therapeutically active
- bile
- substances
- Prior art date
Links
- 239000013543 active substance Substances 0.000 title claims description 6
- 238000000034 method Methods 0.000 title claims description 4
- 238000002360 preparation method Methods 0.000 title claims description 3
- 210000000941 bile Anatomy 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 238000004040 coloring Methods 0.000 claims 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 239000000126 substance Substances 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 235000011121 sodium hydroxide Nutrition 0.000 description 3
- 239000000203 mixture Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000003613 bile acid Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
<Desc/Clms Page number 1>
Verfahren zur Darstellung therapeutisch wirksamer Substanzen.
Die Gallensubstanz besteht aus einem Gemenge von teils bekannten, teils unbekannten Stoffen. Die Gesamtmenge dieser Stoffe ist für den tierischen Organismus toxisch.
Das vorliegende Verfahren hat nun den Zweck, die therapeutisch wertvollen Substanzen der Galle zu isolieren. Es besteht darin, dass man frische Galle-zweckmässig in verdiinntem Zustande-mit Säure versetzt, von dem ausgefällten Farbstoff und Gallensäuren abfiltriert und aus dem Filtrat mit Alkalien die wirksame Substanz in fester Form abscheidet. Das so erhaltene Produkt besitzt die Eigenschaft, für normale Organismen so gut wie ungiftig zu sein, während es für pathologisch veränderte Organismen toxische Wirkungen besitzt, die sich beispielsweise bei tuberkulös erkrankten Organismen in einer ausgesprochenen Herdreaktion äussern.
Beispiel :
100 g Galle werden mit 400 g Wasser verdünnt und mit 20 9 Salzsäure versetzt.
Das Gemenge wired filtriert und die gebuchte Substanz aus dem Filtrat mit Natronlauge ausgefällt. Die wirksame Substanz scheidet sich in Form eines Niederschlages a) und wird durch Abfiltrierung, Umlösen mit Salzsäjre und Wiederausfällen mit Natronlauge sowie durch Auswaschen mit destilliertem Wasser als leicht bräunlich gefärbtes Pulver erhalten.
An Stelle von Natronlauge körner zur Fallung andere Alkalien und Basen verwendet worden.
**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.
<Desc / Clms Page number 1>
Process for the preparation of therapeutically active substances.
The bile substance consists of a mixture of partly known and partly unknown substances. The total amount of these substances is toxic to the animal organism.
The present method now has the purpose of isolating the therapeutically valuable substances of the bile. It consists in adding acid to fresh bile - expediently in a diluted state - filtering off the precipitated dye and bile acids and separating the active substance in solid form from the filtrate with alkalis. The product obtained in this way has the property of being as good as nontoxic for normal organisms, while it has toxic effects for pathologically altered organisms which, for example, manifest themselves in a pronounced focal reaction in organisms with tuberculosis.
Example:
100 g of bile are diluted with 400 g of water and 20 g of hydrochloric acid are added.
The mixture is filtered and the booked substance is precipitated from the filtrate with sodium hydroxide solution. The active substance separates in the form of a precipitate a) and is obtained as a slightly brownish powder by filtering off, dissolving with hydrochloric acid and reprecipitating with sodium hydroxide solution and washing with distilled water.
Instead of caustic soda grains, other alkalis and bases have been used for precipitation.
** WARNING ** End of DESC field may overlap beginning of CLMS **.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE69637X | 1913-06-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT69637B true AT69637B (en) | 1915-08-25 |
Family
ID=5635091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT69637D AT69637B (en) | 1913-06-13 | 1914-05-16 | Process for the preparation of therapeutically active substances. |
Country Status (1)
| Country | Link |
|---|---|
| AT (1) | AT69637B (en) |
-
1914
- 1914-05-16 AT AT69637D patent/AT69637B/en active
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