AT7109U3 - Verfahren zur herstellung von amlodipinmaleat - Google Patents

Verfahren zur herstellung von amlodipinmaleat Download PDF

Info

Publication number
AT7109U3
AT7109U3 AT0093403U AT9342003U AT7109U3 AT 7109 U3 AT7109 U3 AT 7109U3 AT 0093403 U AT0093403 U AT 0093403U AT 9342003 U AT9342003 U AT 9342003U AT 7109 U3 AT7109 U3 AT 7109U3
Authority
AT
Austria
Prior art keywords
amlodipinmaleat
production
Prior art date
Application number
AT0093403U
Other languages
English (en)
Other versions
AT7109U2 (de
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29740325&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AT7109(U3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of AT7109U2 publication Critical patent/AT7109U2/de
Publication of AT7109U3 publication Critical patent/AT7109U3/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT0093403U 2000-12-29 2003-12-29 Verfahren zur herstellung von amlodipinmaleat AT7109U3 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25861200P 2000-12-29 2000-12-29
US80934301A 2001-03-16 2001-03-16
BE2001/0709A BE1014452A6 (nl) 2000-12-29 2001-11-05 Werkwijze voor het maken van amlodipinemaleaat.

Publications (2)

Publication Number Publication Date
AT7109U2 AT7109U2 (de) 2004-10-25
AT7109U3 true AT7109U3 (de) 2005-05-25

Family

ID=29740325

Family Applications (3)

Application Number Title Priority Date Filing Date
AT01972796T ATE300520T1 (de) 2000-12-29 2001-08-15 Verfahren zur herstellung amlodipinmaleat
AT0093403U AT7109U3 (de) 2000-12-29 2003-12-29 Verfahren zur herstellung von amlodipinmaleat
AT0093503U AT7110U9 (de) 2000-12-29 2003-12-29 Verfahren zur herstellung von amlodipinmaleat

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT01972796T ATE300520T1 (de) 2000-12-29 2001-08-15 Verfahren zur herstellung amlodipinmaleat

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT0093503U AT7110U9 (de) 2000-12-29 2003-12-29 Verfahren zur herstellung von amlodipinmaleat

Country Status (24)

Country Link
US (2) US6600047B2 (de)
EP (1) EP1309555B1 (de)
CN (1) CN1272319C (de)
AP (1) AP2003002820A0 (de)
AT (3) ATE300520T1 (de)
BE (1) BE1014452A6 (de)
BR (1) BR0116557A (de)
CA (1) CA2433288C (de)
DE (2) DE60112305T2 (de)
DK (3) DK1309555T3 (de)
ES (1) ES2243553T3 (de)
FI (1) FI6788U1 (de)
HR (1) HRP20030526A2 (de)
IL (1) IL156692A0 (de)
IS (1) IS6834A (de)
MA (1) MA25984A1 (de)
MX (1) MXPA03005885A (de)
NO (1) NO20032518L (de)
NZ (1) NZ526506A (de)
PL (1) PL362660A1 (de)
PT (1) PT1309555E (de)
RS (1) RS53403A (de)
SI (1) SI1309555T1 (de)
WO (1) WO2002053542A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2433193C (en) * 2000-12-29 2006-01-31 Pfizer Limited Amide derivative of amlodipine
WO2002053540A1 (en) * 2000-12-29 2002-07-11 Pfizer Limited Aspartate derivative of amlodipine as calcium channel antagonist
US6653481B2 (en) 2000-12-29 2003-11-25 Synthon Bv Process for making amlodipine
MXPA03005882A (es) * 2000-12-29 2005-04-19 Pfizer Ltd Derivado amida de amlodipina.
PL362660A1 (en) * 2000-12-29 2004-11-02 Pfizer Limited Process for making amlodipine maleate
GB0114709D0 (en) * 2001-06-15 2001-08-08 Pfizer Ltd Stabilised formulations of amlodipine maleate
US20030027848A1 (en) * 2001-06-15 2003-02-06 Anne Billotte Stabilized formulations
US20030180354A1 (en) * 2001-10-17 2003-09-25 Dr. Reddy's Laboratories Limited Amlodipine maleate formulations
KR100496436B1 (ko) 2002-07-30 2005-06-20 씨제이 주식회사 암로디핀의 유기산염
KR100538641B1 (ko) * 2002-07-30 2005-12-22 씨제이 주식회사 암로디핀의 유기산염
KR100467669B1 (ko) * 2002-08-21 2005-01-24 씨제이 주식회사 암로디핀의 유기산염
AU2003253460A1 (en) 2002-09-19 2004-04-08 Cj Corporation Crystalline organic acid salt of amlodipine
EP1407773A1 (de) * 2002-10-08 2004-04-14 Council of Scientific and Industrial Research Verfahren zur Herstellung von s(-)Amlodipin-Salzen
US20040072879A1 (en) * 2002-10-10 2004-04-15 Dr. Reddy's Laboratories Limited Crystalline 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine maleate salt (Amlodipine)
AU2002368531A1 (en) * 2002-12-30 2004-07-22 Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S. Isolation of dihydropyridine derivative and preparation salts thereof
WO2005023769A1 (en) * 2003-09-04 2005-03-17 Cipla Limited Process for the preparation of amlodipine salts
WO2005049571A1 (en) * 2003-11-20 2005-06-02 Council Of Scientific And Industrial Research Process for preparation of chiral amlodipine salts
US20060030602A1 (en) * 2004-03-16 2006-02-09 Sepracor Inc. (S)-amlodipine malate
CN101595092B (zh) * 2006-11-02 2012-02-01 米伦纽姆医药公司 合成因子xa抑制剂的医药盐的方法
KR100843400B1 (ko) * 2006-11-14 2008-07-04 씨제이제일제당 (주) 결정성 ｓ-(-)-암로디핀 말레익산 염 무수물 및 이의제조방법
US20090062352A1 (en) * 2007-08-29 2009-03-05 Protia, Llc Deuterium-enriched amlodipine
CN102344409B (zh) * 2011-07-20 2013-04-03 海南锦瑞制药股份有限公司 一种氨氯地平晶体、其与贝那普利药用组合物及制备方法
CN102382041B (zh) * 2011-12-02 2016-01-20 东北制药集团股份有限公司 一种马来酸氨氯地平的制备方法
CN103044314A (zh) * 2013-01-06 2013-04-17 先声药业有限公司 马来酸氨氯地平的制备方法
CN104529877A (zh) * 2015-01-22 2015-04-22 华东理工常熟研究院有限公司 氨氯地平-癸酸离子液体及其制备方法和用途
EP3960158B1 (de) 2016-10-07 2025-05-21 Silvergate Pharmaceuticals, Inc. Amlodipinformulierungen
CN108358833A (zh) * 2018-03-15 2018-08-03 上海峰林生物科技有限公司 一种马来酸氨氯地平的合成工艺
WO2019200143A1 (en) 2018-04-11 2019-10-17 Silvergate Pharmaceuticals, Inc. Amlodipine formulations
CN109651236A (zh) * 2019-01-24 2019-04-19 浙江尖峰药业有限公司 门冬氨酸氨氯地平的晶型及其制备和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4572909A (en) * 1982-03-11 1986-02-25 Pfizer Inc. 2-(Secondary aminoalkoxymethyl) dihydropyridine derivatives as anti-ischaemic and antihypertensive agents
WO1999025688A1 (en) * 1997-11-14 1999-05-27 A/S Gea Farmaceutisk Fabrik Process for the preparation of 1,4-dihydropyridines and compounds used in this process
WO1999025689A1 (en) * 1997-11-14 1999-05-27 A/S Gea Farmaceutisk Fabrik Process for the preparation of acetal derivatives of 1,4-dihydropyridines

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4294969A (en) * 1979-01-29 1981-10-13 Merck & Co., Inc. Process for producing 2-bromo-3,5-disubstituted pyridines
CS228917B2 (en) * 1981-03-14 1984-05-14 Pfizer Method of preparing substituted derivatives of 1,4-dihydropyridine
GR851819B (de) * 1984-08-17 1985-11-26 Wyeth John & Brother Ltd
IT1201454B (it) * 1985-08-19 1989-02-02 Boehringer Biochemia Srl 1,4-diidropiridine-2-sostituite
GB8608335D0 (en) 1986-04-04 1986-05-08 Pfizer Ltd Pharmaceutically acceptable salts
FR2602231B1 (fr) * 1986-08-04 1988-10-28 Adir Nouveaux derives de la dihydro-1,4 pyridine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
US4983740A (en) 1986-08-04 1991-01-08 Adir Et Compagnie Process for 1,4-dihydropyridine compounds
GB8710493D0 (en) 1987-05-02 1987-06-03 Pfizer Ltd Dihydropyridines
US5155120A (en) 1991-01-14 1992-10-13 Pfizer Inc Method for treating congestive heart failure
WO1993006082A1 (en) 1991-09-13 1993-04-01 Merck & Co., Inc. Process for the preparation of 4-substituted-1,4-dihydropyridines
US5389654A (en) 1992-11-26 1995-02-14 Lek, Tovarna, Farmacevtskih In Kemicnih . . . 3-ethyl 5-methyl(±)2-[2-(N-tritylamino)ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-6-methyl-3,5-pyridinedicarboxylate
HU221810B1 (hu) 1997-08-12 2003-01-28 EGIS Gyógyszergyár Rt. Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei
PL189666B1 (pl) * 1998-04-09 2005-09-30 Adamed Sp Z Oo Sposób otrzymywania benzenosulfonianu amlodypiny
GB9812413D0 (en) 1998-06-10 1998-08-05 Glaxo Group Ltd Compound and its use
ES2151850B1 (es) 1998-10-26 2001-08-16 Esteve Quimica Sa Intermedio para la sintesis de amlodipino para su obtencion y utilizacion correspondiente.
GB9827431D0 (en) 1998-12-11 1999-02-03 Smithkline Beecham Plc Novel compound
GB9827387D0 (en) 1998-12-11 1999-02-03 Smithkline Beecham Plc Novel process
EP1309556B1 (de) * 2000-12-29 2004-11-24 Pfizer Limited Amlodipinfumarat
PL362660A1 (en) 2000-12-29 2004-11-02 Pfizer Limited Process for making amlodipine maleate
CA2433193C (en) * 2000-12-29 2006-01-31 Pfizer Limited Amide derivative of amlodipine
EP1309557B9 (de) * 2000-12-29 2006-11-15 Pfizer Limited Amlodipin-hemimaleat
WO2002053540A1 (en) * 2000-12-29 2002-07-11 Pfizer Limited Aspartate derivative of amlodipine as calcium channel antagonist

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4572909A (en) * 1982-03-11 1986-02-25 Pfizer Inc. 2-(Secondary aminoalkoxymethyl) dihydropyridine derivatives as anti-ischaemic and antihypertensive agents
WO1999025688A1 (en) * 1997-11-14 1999-05-27 A/S Gea Farmaceutisk Fabrik Process for the preparation of 1,4-dihydropyridines and compounds used in this process
WO1999025689A1 (en) * 1997-11-14 1999-05-27 A/S Gea Farmaceutisk Fabrik Process for the preparation of acetal derivatives of 1,4-dihydropyridines

Also Published As

Publication number Publication date
ATE300520T1 (de) 2005-08-15
FI6788U1 (fi) 2005-09-14
AT7110U9 (de) 2004-11-25
IS6834A (is) 2003-05-30
MA25984A1 (fr) 2003-12-31
CA2433288A1 (en) 2002-07-11
WO2002053542A1 (en) 2002-07-11
HK1064671A1 (en) 2005-02-04
DK1309555T3 (da) 2005-10-24
ES2243553T3 (es) 2005-12-01
US20030199559A1 (en) 2003-10-23
BR0116557A (pt) 2003-10-28
DK200300344U4 (da) 2005-09-09
DK200300345U3 (da) 2004-03-12
BE1014452A6 (nl) 2003-10-07
SI1309555T1 (sl) 2005-12-31
EP1309555A1 (de) 2003-05-14
RS53403A (sr) 2006-10-27
MXPA03005885A (es) 2005-04-19
CA2433288C (en) 2006-06-13
FIU20030476U0 (fi) 2003-12-17
EP1309555B1 (de) 2005-07-27
HRP20030526A2 (en) 2005-06-30
DK200300344U1 (da) 2003-12-12
NO20032518D0 (no) 2003-06-04
AT7110U2 (de) 2004-10-25
AT7110U3 (de) 2005-05-25
AP2003002820A0 (en) 2003-06-30
DE20115704U1 (de) 2002-02-14
PL362660A1 (en) 2004-11-02
NO20032518L (no) 2003-06-26
NZ526506A (en) 2004-11-26
CN1505614A (zh) 2004-06-16
DE60112305T2 (de) 2006-05-24
CN1272319C (zh) 2006-08-30
AT7109U2 (de) 2004-10-25
US20020086888A1 (en) 2002-07-04
IL156692A0 (en) 2004-01-04
US6600047B2 (en) 2003-07-29
DE60112305D1 (de) 2005-09-01
PT1309555E (pt) 2005-10-31
HK1055965A1 (en) 2004-01-30

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