AT73354B - Process for preparing a blood coagulation agent from blood. - Google Patents
Process for preparing a blood coagulation agent from blood.Info
- Publication number
- AT73354B AT73354B AT73354DA AT73354B AT 73354 B AT73354 B AT 73354B AT 73354D A AT73354D A AT 73354DA AT 73354 B AT73354 B AT 73354B
- Authority
- AT
- Austria
- Prior art keywords
- blood
- preparing
- preparation
- coagulation agent
- evaporation
- Prior art date
Links
- 239000008280 blood Substances 0.000 title claims description 7
- 210000004369 blood Anatomy 0.000 title claims description 7
- 230000023555 blood coagulation Effects 0.000 title description 3
- 238000004519 manufacturing process Methods 0.000 title description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 10
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 8
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- 238000004821 distillation Methods 0.000 claims description 3
- 239000000839 emulsion Substances 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 238000001704 evaporation Methods 0.000 claims 2
- 230000008020 evaporation Effects 0.000 claims 2
- 150000008280 chlorinated hydrocarbons Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000002244 precipitate Substances 0.000 claims 1
- 239000000446 fuel Substances 0.000 description 5
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- QPFMBZIOSGYJDE-UHFFFAOYSA-N 1,1,2,2-tetrachloroethane Chemical compound ClC(Cl)C(Cl)Cl QPFMBZIOSGYJDE-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 1
- CYTYCFOTNPOANT-UHFFFAOYSA-N Perchloroethylene Chemical group ClC(Cl)=C(Cl)Cl CYTYCFOTNPOANT-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- QGJOPFRUJISHPQ-NJFSPNSNSA-N carbon disulfide-14c Chemical compound S=[14C]=S QGJOPFRUJISHPQ-NJFSPNSNSA-N 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229950011008 tetrachloroethylene Drugs 0.000 description 1
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Description
<Desc/Clms Page number 1>
Verfahren zur Darstellung eines die Blutgerinnung befördernden Mittels aus Blut.
Es wurde gefunden, dass sich aus Blut ein Präparat herstellen lässt, welches in hohem Gr & de die Eigenschaft besitzt, die Blutgerinnung zu befördern. Zu dessen Isolierung verfährt man wie folgt :
In 40 1 Magnesium-und Oxalatblut gibt man 120 I hochprozentigen Sprit und lässt unter stetem Rühren und unter Kühlen mit Rückflusskühler 5 Stunden kochen. Hierauf wird der Spritextrakt bei 700 C filtriert, der in Sprit unlösliche Anteil wird leicht ausausgepresst und nochmals mit 40 l hochprozentigem Sprit 5 Stunden in der oben angegebenen Weise gekocht. Es wird wiederum bei 700 C filtriert und der Rückstand scharf ausgepresst.
Die Spritlösung wird sofort in hohem Vakuum und bei niedriger Temperatur ein- gedampft und gegen das Ende der Destillation werden 10 l destilliertes Wasser eingesaugt und die Destillation so geleitet, dass zum Schluss noch 16 bis 20 1 Emulsion verbleiben. Diese Emulsion wird : 1. mit 5 1 Chloroform, 2. mit 3 I Chloroform je 10 Minuten aus-
EMI1.1
Kohlenwasserstoffe, wie Tetrachlorkohlenstoff, Tetrachloräthan, Perchloräthylen. Pentachlor- äthen usw. angewendet werden.
Die Chloroformlösung wird mit Aceton versetzt. wobe eine starke Fällung entsteht,
EMI1.2
wird mit Äther extrahiert und die resultierende Ätherlösung im Vakuum zur Trockne eingedampft. Für die praktische Verwendung wird das erhaltene Präparat in geeigneter Weise verdünnt.
Reaktion.
EMI1.3
physiologische Kochsalzlösung nach 55 Minuten nicht fest wird.
Das so erhaltene hochwirksame und haltbare Präparat ist eine llpoidartigf Substanz von hellbrauner bis gelblichweisser Farbe (je nach der H) ntart. aus der es hergestellt wurde), welche Kohlenstoff, Wasserstoff. Phosphor und Spuren von Eisen enthält. In Benzol und Tetrachlorkohlenstoff ist dieselbe sehr leicht, in Chloroform, Äther, Toluol und Schwefelkohlenstoff ziemlich leicht, in Alkohol nur teilweise löslich mit gelber Farbe ; in Aceton
EMI1.4
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**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.
<Desc / Clms Page number 1>
Process for preparing a blood coagulation agent from blood.
It has been found that a preparation can be made from blood which has the property to a large extent of promoting blood clotting. To isolate it, proceed as follows:
In 40 l of magnesium and oxalate blood, 120 l of high-proof fuel are added and the mixture is left to boil for 5 hours while stirring and cooling with a reflux condenser. The fuel extract is then filtered at 700 ° C., the portion that is insoluble in fuel is gently squeezed out and boiled again with 40 l of high-proof fuel for 5 hours in the manner indicated above. It is again filtered at 700 ° C. and the residue is squeezed out sharply.
The fuel solution is immediately evaporated in a high vacuum and at low temperature and towards the end of the distillation 10 l of distilled water are sucked in and the distillation is conducted in such a way that 16 to 20 l of emulsion remain at the end. This emulsion is: 1. with 5 l of chloroform, 2. with 3 l of chloroform for 10 minutes
EMI1.1
Hydrocarbons such as carbon tetrachloride, tetrachloroethane, perchlorethylene. Pentachlorethylene etc. are used.
Acetone is added to the chloroform solution. where a heavy precipitation occurs,
EMI1.2
is extracted with ether and the resulting ether solution is evaporated to dryness in vacuo. For practical use, the obtained preparation is appropriately diluted.
Reaction.
EMI1.3
physiological saline solution does not set after 55 minutes.
The highly effective and durable preparation obtained in this way is a poid-like substance of light brown to yellowish-white color (depending on the species). from which it was made), which carbon, hydrogen. Contains phosphorus and traces of iron. It is very light in benzene and carbon tetrachloride, fairly light in chloroform, ether, toluene, and carbon disulfide, and only partially soluble in alcohol, with a yellow color; in acetone
EMI1.4
EMI1.5
** WARNING ** End of DESC field may overlap beginning of CLMS **.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT73354T | 1915-07-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT73354B true AT73354B (en) | 1917-05-10 |
Family
ID=3594997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT73354D AT73354B (en) | 1915-07-14 | 1915-07-14 | Process for preparing a blood coagulation agent from blood. |
Country Status (1)
| Country | Link |
|---|---|
| AT (1) | AT73354B (en) |
-
1915
- 1915-07-14 AT AT73354D patent/AT73354B/en active
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